This list contains a list of EC numbers for the third group, EC 3,

hydrolases In biochemistry, hydrolases constitute a class of enzymes that commonly function as biochemical catalysts that use water to break a chemical bond: :\ce \quad \xrightarrowtext\quad \ce This typically results in dividing a larger molecule into s ...

, placed in numerical order as determined by the Nomenclature Committee of the

International Union of Biochemistry and Molecular Biology The International Union of Biochemistry and Molecular Biology (IUBMB) is an international non-governmental organisation concerned with biochemistry and molecular biology. Formed in 1955 as the International Union of Biochemistry (IUB), the union ...

. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 3.1: Acting on Ester Bonds

EC 3.1.1: Carboxylic Ester Hydrolases

* :

carboxylesterase The enzyme carboxylesterase (or carboxylic-ester hydrolase, EC 3.1.1.1; systematic name carboxylic-ester hydrolase) catalysis, catalyzes reactions of the following form: :a Ester, carboxylic ester + H2O \rightleftharpoons an Alcohol (chemistry), ...

* : arylesterase * : triacylglycerol lipase * : phospholipase A₂ * : lysophospholipase * : acetylesterase * :

acetylcholinesterase Acetylcholinesterase (HUGO Gene Nomenclature Committee, HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme th ...

* :

cholinesterase The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters: : an acylcholine + H2O = choline + a carboxylate Several of these serve as neurotransmitte ...

* EC 3.1.1.9: deleted, a side reaction of cholinesterase * : tropinesterase * :

pectinesterase Pectinesterase (EC 3.1.1.11; systematic name pectin pectylhydrolase) is a ubiquitous cell-wall-associated enzyme that presents several isoforms that facilitate plant cell wall modification and subsequent breakdown. It catalyzes the following rea ...

* EC 3.1.1.12: deleted, identical with carboxylesterase * : sterol esterase * : chlorophyllase * : L-arabinonolactonase * EC 3.1.1.16: deleted, mixture of (muconolactone Δ-isomerase) and (3-oxoadipate enol-lactonase) * : gluconolactonase * EC 3.1.1.18: deleted, now included with gluconolactonase * :

uronolactonase The enzyme uronolactonase (EC 3.1.1.19) catalyzes the reaction :D-glucurono-6,2-lactone + H2O \rightleftharpoons D-glucuronate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic ...

* :

tannase The enzyme tannase (EC 3.1.1.20) catalyzes the following reaction: : digallate + H2O = 2 gallate It is a key enzyme in the degradation of gallotannins and ellagicitannins, two types of hydrolysable tannins. Specifically, tannase catalyzes the ...

* EC 3.1.1.21: deleted, now known to be catalysed by , carboxylesterase and , triacylglycerol lipase. * : hydroxybutyrate-dimer hydrolase * : acylglycerol lipase * :

3-oxoadipate enol-lactonase The enzyme 3-oxoadipate enol-lactonase (EC 3.1.1.24) catalyzes the reaction :3-oxoadipate enol-lactone + H2O \rightleftharpoons 3-oxoadipate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. T ...

* :

1,4-lactonase The enzyme 1,4-lactonase (EC 3.1.1.25) catalyzes the generic reaction :a 1,4-lactone + H2O \rightleftharpoons a 4-hydroxyacid This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic n ...

* :

galactolipase The enzyme galactolipase (EC 3.1.1.26) catalyzes the reaction :1,2-diacyl-3-β-D-galactosyl-''sn''-glycerol + 2 H2O \rightleftharpoons 3-β-D-galactosyl-''sn''-glycerol + 2 carboxylates This enzyme belongs to the family of hydrolases, specificall ...

* :

4-pyridoxolactonase The enzyme 4-pyridoxolactonase (EC 3.1.1.27) catalyzes the reaction :4-pyridoxolactone + H2O \rightleftharpoons 4-pyridoxate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic na ...

* :

acylcarnitine hydrolase The enzyme acylcarnitine hydrolase (EC 3.1.1.28) catalyzes the reaction :''O''-acylcarnitine + H2O \rightleftharpoons a fatty acid + L-carnitine This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bond ...

* :

aminoacyl-tRNA hydrolase The enzyme aminoacyl-tRNA hydrolase (EC 3.1.1.29) catalyzes the reaction :''N''-substituted aminoacyl-tRNA + H2O \rightleftharpoons ''N''-substituted amino acid + tRNA This enzyme belongs to the family of hydrolases, specifically those acting on ...

* : D-arabinonolactonase * :

6-phosphogluconolactonase 6-Phosphogluconolactonase (EC 3.1.1.31, 6PGL, PGLS, systematic name 6-phospho-D-glucono-1,5-lactone lactonohydrolase) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid ...

* : phospholipase A₁ * :

6-acetylglucose deacetylase The enzyme 6-acetylglucose deacetylase (EC 3.1.1.33) catalyzes the reaction :6-acetyl-D-glucose + H2O \rightleftharpoons D-glucose + acetate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. ...

* :

lipoprotein lipase Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-solubl ...

* : dihydrocoumarin hydrolase * : limonin-D-ring-lactonase * : steroid-lactonase * : triacetate-lactonase * : actinomycin lactonase * : orsellinate-depside hydrolase * : cephalosporin-C deacetylase * : chlorogenate hydrolase * : α-amino-acid esterase * : 4-methyloxaloacetate esterase * : carboxymethylenebutenolidase * : deoxylimonate A-ring-lactonase * : 1-alkyl-2-acetylglycerophosphocholine esterase * : fusarinine-C ornithinesterase * :

sinapine esterase The enzyme sinapine esterase (EC 3.1.1.49) catalysis, catalyzes the reaction :sinapoylcholine + H2O \rightleftharpoons sinapate + choline This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The L ...

* : wax-ester hydrolase * : phorbol-diester hydrolase * : phosphatidylinositol deacylase * : sialate ''O''-acetylesterase * : acetoxybutynylbithiophene deacetylase * : acetylsalicylate deacetylase * : methylumbelliferyl-acetate deacetylase * : 2-pyrone-4,6-dicarboxylate lactonase * : ''N''-acetylgalactosaminoglycan deacetylase * : juvenile-hormone esterase * : bis(2-ethylhexyl)phthalate esterase * : protein-glutamate methylesterase * EC 3.1.1.62: Now listed as , ''N''-acetyldiaminopimelate deacetylase * : 11-''cis''-retinyl-palmitate hydrolase * : retinoid isomerohydrolase * : L-rhamnono-1,4-lactonase * : 5-(3,4-diacetoxybut-1-ynyl)-2,2′-bithiophene deacetylase * : fatty-acyl-ethyl-ester synthase * : xylono-1,4-lactonase * EC 3.1.1.69: Now , ''N''-acetylglucosaminylphosphatidylinositol deacetylase * : cetraxate benzylesterase * : acetylalkylglycerol acetylhydrolase * : acetylxylan esterase * : feruloyl esterase * : cutinase * : poly(3-hydroxybutyrate) depolymerase * : poly(3-hydroxyoctanoate) depolymerase * : acyloxyacyl hydrolase * : polyneuridine-aldehyde esterase * :

hormone-sensitive lipase Hormone-sensitive lipase (, HSL), also previously known as cholesteryl ester hydrolase (CEH), sometimes referred to as triacylglycerol lipase, is an enzyme that, in humans, is encoded by the ''LIPE'' gene, and catalyzes the following reaction: ...

* : acetylajmaline esterase * : quorum-quenching ''N''-acyl-homoserine lactonase * : pheophorbidase * : monoterpene ε-lactone hydrolase * :

cocaine esterase The chloride cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2; systematic name cocaine benzoylhydrolase) catalyses the reaction : cocaine + H2O \rightleftharpoons ecgonine methyl ester + benzoate ''Rhodococcus'' sp. s ...

* : pimelyl-(acyl-carrier protein) methyl ester esterase * : rhamnogalacturonan acetylesterase * : fumonisin B1 esterase * : pyrethroid hydrolase * : protein phosphatase methylesterase-1 * : ''all-trans''-retinyl ester 13-''cis'' isomerohydrolase * : 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase * : 4-sulfomuconolactone hydrolase * : mycophenolic acid acyl-glucuronide esterase * : versiconal hemiacetal acetate esterase * * : aclacinomycin methylesterase * * : D-aminoacyl-tRNA deacylase * * : methylated diphthine methylhydrolase * * : nt protein''O''-palmitoleoyl-L-serine hydrolase * * : 6-deoxy-6-sulfogluconolactonase * * : chlorophyllide a hydrolase * * : poly(ethylene terephthalate) hydrolase * * : mono(ethylene terephthalate) hydrolase * * : teichoic acid D-alanine hydrolase * * : 5-phospho-D-xylono-1,4-lactonase * * : 3-''O''-acetylpapaveroxine carboxylesterase * * : ''O''-acetyl-ADP-ribose deacetylase * * : apo-salmochelin esterase * * : iron(III)-enterobactin esterase * * : iron(III)-salmochelin esterase * * : xylono-1,5-lactonase * * : phosphatidylserine ''sn''-1 acylhydrolase * * : isoamyl acetate esterase * * : ethyl acetate hydrolase * * : methyl acetate hydrolase * : D-apionolactonase * * : ''sn''-1-specific diacylglycerol lipase * * : (4-''O''-methyl)-D-glucuronate—lignin esterase * * : phospholipid ''sn''-1 acylhydrolase * : *No Wikipedia article

EC 3.1.2: Thioester Hydrolases

* : acetyl-CoA hydrolase * : palmitoyl-CoA hydrolase * : succinyl-CoA hydrolase * : 3-hydroxyisobutyryl-CoA hydrolase * : hydroxymethylglutaryl-CoA hydrolase * : hydroxyacylglutathione hydrolase * : glutathione thiolesterase * EC 3.1.2.8: Now included with hydroxyacylglutathione hydrolase * EC 3.1.2.9: ''S''-acetoacetylhydrolipoate hydrolase deleted * : formyl-CoA hydrolase * : acetoacetyl-CoA hydrolase * : ''S''-formylglutathione hydrolase * : ''S''-succinylglutathione hydrolase * : oleoyl- cyl-carrier-proteinhydrolase * EC 3.1.2.15: covered by , ubiquitinyl hydrolase 1 * : citrate lyase deacetylase * : (''S'')-methylmalonyl-CoA hydrolase * : ADP-dependent short-chain-acyl-CoA hydrolase * : ADP-dependent medium-chain-acyl-CoA hydrolase * : acyl-CoA hydrolase * : dodecanoyl-(acyl-carrier-protein) hydrolase * : palmitoyl roteinhydrolase * : 4-hydroxybenzoyl-CoA thioesterase * EC 3.1.2.24: transferred entry now , 2′-hydroxybiphenyl-2-sulfinate desulfinase. * : phenylacetyl-CoA hydrolase * EC 3.1.2.26: Now , bile acid CoA transferase * : choloyl-CoA hydrolase * : 1,4-dihydroxy-2-naphthoyl-CoA hydrolase * : fluoroacetyl-CoA thioesterase * : (3''S'')-malyl-CoA thioesterase * * : dihydromonacolin L- ovastatin nonaketide synthasethioesterase * * : 2-aminobenzoylacetyl-CoA thioesterase * : *No Wikipedia article

EC 3.1.3: Phosphoric Monoester Hydrolases

* :

alkaline phosphatase The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase, also abbreviated PhoA) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryo ...

* :

acid phosphatase Acid phosphatase (EC 3.1.3.2, systematic name ''phosphate-monoester phosphohydrolase (acid optimum)'') is an enzyme that frees attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphoric monoeste ...

EC 3.1.4: Phosphoric Diester Hydrolases

* :

phosphodiesterase I Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and calmodulin-dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1- ...

* : glycerophosphocholine phosphodiesterase * : lecithinase C * :

phospholipase D Phospholipase D (PLD) (EC 3.1.4.4; also known as lipophosphodiesterase II, lecithinase D, choline phosphatase; systematic name: phosphatidylcholine phosphatidohydrolase) is an anesthetic-sensitive and mechanosensitive enzyme of the phospholipa ...

* EC 3.1.4.5: Now , deoxyribonuclease I * EC 3.1.4.6: Now , deoxyribonuclease II * EC 3.1.4.7: Now , micrococcal nuclease * EC 3.1.4.8: Now , ribonuclease T1 * EC 3.1.4.9: Now , ''Serratia marcescens'' nuclease * EC 3.1.4.10: Now , phosphatidylinositol diacylglycerol-lyase * :

phosphoinositide phospholipase C Phosphoinositide phospholipase C (PLC, EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospho ...

* :

sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase; systematic name sphingomyelin cholinephosphohydrolase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. ...

* : serine-ethanolaminephosphate phosphodiesterase * : cyl-carrier-proteinphosphodiesterase * : transferred to EC 2.7.7.89, adenylyl- lutamateammonia ligasephosphorylase * : 2′,3′-cyclic-nucleotide 2′-phosphodiesterase * : 3′,5′-cyclic-nucleotide phosphodiesterase * EC 3.1.4.18: Now , spleen exonuclease * EC 3.1.4.19: Now , oligonucleotidase * EC 3.1.4.20: Now , exoribonuclease II * EC 3.1.4.21: Now , ''Aspergillus'' nuclease S₁ * EC 3.1.4.22: Now , pancreatic ribonuclease * EC 3.1.4.23: Now , ribonuclease T₂ * EC 3.1.4.24: deleted * EC 3.1.4.25: Now , exodeoxyribonuclease I * EC 3.1.4.26: deleted * EC 3.1.4.27: Now , exodeoxyribonuclease III * EC 3.1.4.28: Now , exodeoxyribonuclease (lambda-induced) * EC 3.1.4.29: deleted * EC 3.1.4.30: Now , deoxyribonuclease IV (phage-T₄-induced) * EC 3.1.4.31: Now * EC 3.1.4.32: deleted * EC 3.1.4.33: deleted * EC 3.1.4.34: deleted * : 3′,5′-cyclic-GMP phosphodiesterase * EC 3.1.4.36: Now with * : 2′,3′-cyclic-nucleotide 3'-phosphodiesterase * : glycerophosphocholine cholinephosphodiesterase * : alkylglycerophosphoethanolamine phosphodiesterase * : CMP-''N''-acylneuraminate phosphodiesterase * : sphingomyelin phosphodiesterase D * : glycerol-1,2-cyclic-phosphate 2-phosphodiesterase * : glycerophosphoinositol inositolphosphodiesterase * : glycerophosphoinositol glycerophosphodiesterase * : ''N''-acetylglucosamine-1-phosphodiester α-''N''-acetylglucosaminidase * : glycerophosphodiester phosphodiesterase * EC 3.1.4.47: Now , glycosylphosphatidylinositol diacylglycerol-lyase * : dolichylphosphate-glucose phosphodiesterase * : dolichylphosphate-mannose phosphodiesterase * : glycosylphosphatidylinositol phospholipase D * : glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase * : cyclic-guanylate-specific phosphodiesterase * : 3′,5′-cyclic-AMP phosphodiesterase * : ''N''-acetylphosphatidylethanolamine-hydrolysing phospholipase D * : phosphoribosyl 1,2-cyclic phosphate phosphodiesterase * * : 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase * : phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase * : RNA 2′,3′-cyclic 3′-phosphodiesterase * * : cyclic-di-AMP phosphodiesterase * * : pApA phosphodiesterase * * : cyclic 2,3-diphosphoglycerate hydrolase * : *No Wikipedia article

EC 3.1.5: Triphosphoric Monoester Hydrolases

* : dGTPase

EC 3.1.6: Sulfuric Ester Hydrolases

* : arylsulfatase (type I) * : steryl-sulfatase * : glycosulfatase * : ''N''-acetylgalactosamine-6-sulfatase * EC 3.1.6.5: deleted * : choline-sulfatase * : cellulose-polysulfatase * : cerebroside-sulfatase * : chondro-4-sulfatase * : chondro-6-sulfatase * : disulfoglucosamine-6-sulfatase * : ''N''-acetylgalactosamine-6-sulfatase * :

iduronate-2-sulfatase Iduronate 2-sulfatase (EC 3.1.6.13; systematic name L-iduronate-2-sulfate 2-sulfohydrolase) is a sulfatase enzyme associated with Hunter syndrome. It catalyses hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfa ...

* : ''N''-acetylglucosamine-6-sulfatase * : ''N''-sulfoglucosamine-3-sulfatase * : monomethyl-sulfatase * : D-lactate-2-sulfatase * : Glucuronate-2-sulfatase * : (''R'')-specific secondary-alkylsulfatase (type III) * * : ''S''-sulfosulfanyl-L-cysteine sulfohydrolase * * : linear primary-alkylsulfatase * * : branched primary-alkylsulfatase * : *No Wikipedia article

EC 3.1.7: Diphosphoric Monoester Hydrolases

* : prenyl-diphosphatase * : guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase * : monoterpenyl-diphosphatase * EC 3.1.7.4: Now recognized as two enzymes , copal-8-ol diphosphate synthase and , sclareol synthase * : geranylgeranyl diphosphate diphosphatase * : farnesyl diphosphatase * EC 3.1.7.7: Now , (–)-drimenol synthase * EC 3.1.7.8: Now known to be a partial activity of , adenosine tuberculosinyltransferase. * EC 3.1.7.9: Now known to be a partial activity of , adenosine tuberculosinyltransferase * : (13''E'')-labda-7,13-dien-15-ol synthase * : geranyl diphosphate diphosphatase * : (+)-kolavelool synthase * : *No Wikipedia article

EC 3.1.8: Phosphoric Triester Hydrolases

* :

aryldialkylphosphatase Aryldialkylphosphatase (EC 3.1.8.1, also known as phosphotriesterase, organophosphate hydrolase, parathion hydrolase, paraoxonase, and parathion aryl esterase; systematic name aryltriphosphate dialkylphosphohydrolase) is a Metalloprotein, metalloen ...

* : diisopropyl-fluorophosphatase

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters

* : exodeoxyribonuclease I * : exodeoxyribonuclease III * : exodeoxyribonuclease (lambda-induced) * : exodeoxyribonuclease (phage SP₃-induced) * : exodeoxyribonuclease V * : exodeoxyribonuclease VII * EC 3.1.11.7: Now , adenosine-5′-diphospho-5′- NAdiphosphatase * EC 3.1.11.8: Now , guanosine-5′-diphospho-5′- NAdiphosphatase

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters

* :

exoribonuclease II Exoribonuclease II (, ''ribonuclease II'', ''ribonuclease Q'', ''BN ribonuclease'', ''Escherichia coli exo-RNase II'', ''RNase II'', ''exoribonuclease (misleading)'', ''5'-exoribonuclease'') is an enzyme. This enzyme catalyses the following chemic ...

* : exoribonuclease H * :

oligonucleotidase Oligonucleotidase (, ''oligoribonuclease'') is an exoribonuclease derived from ''Flammulina velutipes''. This enzyme catalyses the following chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformat ...

* : poly(A)-specific ribonuclease * : ribonuclease D

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters

* : yeast ribonuclease

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

* : venom exonuclease

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

* : spleen exonuclease

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters

* :

deoxyribonuclease I Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5 ...

* :

deoxyribonuclease IV Deoxyribonuclease IV (phage-T4-induced) (, ''endodeoxyribonuclease IV (phage T4-induced)'', ''E. coli endonuclease IV'', ''endodeoxyribonuclease'', ''redoxyendonuclease'', ''deoxriboendonuclease'', ''Escherichia coli endonuclease II'', ''endonucle ...

* : type I site-specific deoxyribonuclease * : type II site-specific deoxyribonuclease * : type III site-specific deoxyribonuclease * : CC-preferring endodeoxyribonuclease * : deoxyribonuclease V * : T₄ deoxyribonuclease II * * : T₄ deoxyribonuclease IV * * : crossover junction endodeoxyribonuclease * : *No Wikipedia article

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters

* : deoxyribonuclease II * : Aspergillus deoxyribonuclease K1 * EC 3.1.22.3: now * : crossover junction endodeoxyribonuclease * : deoxyribonuclease X

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases

* : deoxyribonuclease (pyrimidine dimer) * EC 3.1.25.2: Now , DNA-(apurinic or apyrimidinic site) lyase

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters

* : ''Physarum polycephalum'' ribonuclease * : ribonuclease α * : ribonuclease III * :

ribonuclease H Ribonuclease H (abbreviated RNase H or RNH) is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. Members of the RNase H family can be found in nearly al ...

* : ribonuclease P * : ribonuclease IV * : ribonuclease P4 * : ribonuclease M5 * : ribonuclease (poly-(U)-specific) * : ribonuclease IX * : tRNase Z * : ribonuclease E * : retroviral ribonuclease H

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters

* EC 3.1.27.1: Now , ribonuclease T₂, since the primary reaction is that of a lyase * EC 3.1.27.2: Now , ''Bacillus subtilis'' ribonuclease, since the reaction catalysed is that of a lyase * EC 3.1.27.3: Now , ribonuclease T₁, since the primary reaction is that of a lyase * EC 3.1.27.4: Now , ribonuclease U₂, since the primary reaction is that of a lyase * EC 3.1.27.5: Now , pancreatic ribonuclease. * EC 3.1.27.6: Now , ''Enterobacter'' ribonuclease, since the primary reaction is that of a lyase * : ribonuclease F * : ribonuclease V * EC 3.1.27.9: Now , tRNA-intron lyase * EC 3.1.27.10: Now , ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

* : ''Aspergillus'' nuclease S₁ * : ''Serratia marcescens'' nuclease

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

* : micrococcal nuclease

EC 3.2: Glycosylases

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing ''O''- and ''S''-glycosyl compounds

* : α-amylase * : β-amylase * : glucan 1,4-α-glucosidase * :

cellulase Cellulase (; systematic name 4-β-D-glucan 4-glucanohydrolase) is any of several enzymes produced chiefly by fungi, bacteria, and protozoans that catalyze cellulolysis, the decomposition of cellulose and of some related polysaccharides: : Endo ...

* : deleted * : endo-1,3(4)-β-glucanase * :

inulinase Inulinase ( and , inulase, endoinulinase, endo-inulinase, exoinulinase, 2,1-β-D-fructan fructanohydrolase) is an enzyme with systematic name 1-β-D-fructan fructanohydrolase. It catalyses the reaction: : Endohydrolysis of (2→1)-β-D-fructos ...

* : endo-1,4-β-xylanase * : deleted * : oligo-1,6-glucosidase * : dextranase * : Now included with ,

cyclomaltodextrinase The enzyme cyclomaltodextrinase () catalyzes the chemical reaction :cyclomaltodextrin + H2O \rightleftharpoons linear maltodextrin It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse ''O''- and ''S''-glycosyl c ...

* : Now included with ,

* :

chitinase Chitinases (, chitodextrinase, 1,4-β-poly-N-acetylglucosaminidase, poly-β-glucosaminidase, β-1,4-poly-N-acetyl glucosamidinase, poly ,4-(N-acetyl-β-D-glucosaminide)glycanohydrolase, (1→4)-2-acetamido-2-deoxy-β-D-glucan glycanohydrola ...

* :

polygalacturonase Endo-polygalacturonase (, pectin depolymerase, pectolase, pectin hydrolase, and poly-α-1,4-galacturonide glycanohydrolase; systematic name (1→4)-α-D-galacturonan glycanohydrolase (endo-cleaving)) is an enzyme that hydrolyzes the α-1,4 glycos ...

* : deleted * :

lysozyme Lysozyme (, muramidase, ''N''-acetylmuramide glycanhydrolase; systematic name peptidoglycan ''N''-acetylmuramoylhydrolase) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. It is a glycoside hydrolase ...

* : exo-α-sialidase * : deleted * :

α-glucosidase In biochemistry, glycoside hydrolases (also called glycosidases or glycosyl hydrolases) are a class of enzymes which catalyze the hydrolysis of glycosidic bonds in complex sugars. They are extremely common enzymes, with roles in nature includi ...

* : β-glucosidase * : α-galactosidase * :

β-galactosidase β-Galactosidase (EC 3.2.1.23, beta-gal or β-gal; systematic name β-D-galactoside galactohydrolase) is a glycoside hydrolase enzyme that catalyzes hydrolysis of terminal non-reducing β-D-galactose residues in β-D-galactosides. (This enzym ...

* : α-mannosidase * : β-mannosidase * : β-fructofuranosidase (

invertase β-Fructofuranosidase is an enzyme that catalyzes the hydrolysis (breakdown) of the table sugar sucrose into fructose and glucose. Sucrose is a fructoside. Alternative names for β-fructofuranosidase include invertase, saccharase, glucosucrase ...

) * : deleted * : α,α-trehalase * : Now included with , β-''N''-acetylhexosaminidase * : Now included with , β-''N''-acetylhexosaminidase * : β-glucuronidase * : endo-1,3-β-xylanase * : amylo-α-1,6-glucosidase * : Now included with , hyaluronoglucosaminidase * : hyaluronoglucosaminidase * : hyaluronoglucuronidase * : xylan 1,4-β-xylosidase * : β-D-fucosidase * : glucan endo-1,3-β-D-glucosidase * : α-L-rhamnosidase * :

pullulanase Pullulanase (, ''limit dextrinase'', ''amylopectin 6-glucanohydrolase'', ''bacterial debranching enzyme'', ''debranching enzyme'', ''α-dextrin endo-1,6-α-glucosidase'', ''R-enzyme'', ''pullulan α-1,6-glucanohydrolase'') is a specific kind of g ...

* : GDP-glucosidase * : β-L-rhamnosidase * : Now , endo-(13)-fucoidanase and , endo-(14)-fucoidanase * : glucosylceramidase * : galactosylceramidase * : Now known to be catalyzed by , α-galactosidase * : sucrose α-glucosidase * : α-''N''-acetylgalactosaminidase * : α-''N''-acetylglucosaminidase * : α-L-fucosidase * : β-''N''-acetylhexosaminidase * : β-''N''-acetylgalactosaminidase * :

* : non-reducing end α-L-arabinofuranosidase * : glucuronosyl-disulfoglucosamine glucuronidase * : isopullulanase * : glucan 1,3-β-glucosidase * : glucan endo-1,3-α-glucosidase * : glucan 1,4-α-maltotetraohydrolase * : mycodextranase * : glycosylceramidase * : 1,2-α-L-fucosidase * : 2,6-β-fructan 6-levanbiohydrolase * : levanase * : Deleted entry: The activity is covered by , α-L-rhamnosidase * : galacturan 1,4-α-galacturonidase * : isoamylase * : Now included with ,

* : glucan 1,6-α-glucosidase * : glucan endo-1,2-β-glucosidase * : xylan 1,3-β-xylosidase * : licheninase * : glucan 1,4-β-glucosidase * : glucan endo-1,6-β-glucosidase * : L-iduronidase * : mannan 1,2-(1,3)-α-mannosidase * : mannan endo-1,4-β-mannosidase * : Now included with , non-reducing end α-L-arabinofuranosidase * : fructan β-fructosidase * : β-agarase * : exo-poly-α-digalacturonosidas * : κ-carrageenase * : glucan 1,3-α-glucosidase * : 6-phospho-β-galactosidase * : 6-phospho-β-glucosidase * : capsular-polysaccharide endo-1,3-α-galactosidase * : non-reducing end β-L-arabinopyranosidase * : arabinogalactan endo-β-1,4-galactanase * : Deleted, not sufficiently characterised. * : cellulose 1,4-β-cellobiosidase (non-reducing end) * : peptidoglycan β-''N''-acetylmuramidase * : α,α-phosphotrehalase * : glucan 1,6-α-isomaltosidase * : dextran 1,6-α-isomaltotriosidase * : mannosyl-glycoprotein endo-β-''N''-acetylglucosaminidase * : endo-α-''N''-acetylgalactosaminidase * : glucan 1,4-α-maltohexaosidase * : arabinan endo-1,5-α-L-arabinanase * : mannan 1,4-mannobiosidase * : mannan endo-1,6-α-mannosidase * : blood-group-substance endo-1,4-β-galactosidase * : keratan-sulfate endo-1,4-β-galactosidase * : steryl-β-glucosidase * : 3α(''S'')-strictosidine β-glucosidase * :

mannosyl-oligosaccharide glucosidase Mannosyl-oligosaccharide glucosidase (MOGS) (, ''processing α-glucosidase I,'' ''Glc3Man9NAc2 oligosaccharide glucosidase'', ''trimming glucosidase I, GCS1'') is an enzyme with systematic name ''mannosyl-oligosaccharide glucohydrolase''. MOGS is ...

* : protein-glucosylgalactosylhydroxylysine glucosidase * :

lactase Lactase () is an enzyme produced by many organisms and is essential to the complete digestion of whole milk. It breaks down the sugar lactose into its component parts, galactose and glucose. Lactase is found in the brush border of the small ...

* : endogalactosaminidase * : identical to , endo-α-''N''-acetylgalactosaminidase * : 1,3-α-L-fucosidase * : 2-deoxyglucosidase * : mannosyl-oligosaccharide 1,2-α-mannosidase * : mannosyl-oligosaccharide 1,3-1,6-α-mannosidas * : branched-dextran exo-1,2-α-glucosidase * : glucan 1,4-α-maltotriohydrolase * : amygdalin β-glucosidase * : prunasin β-glucosidase * : vicianin β-glucosidase * : oligoxyloglucan β-glycosidase * : polymannuronate hydrolase * : maltose-6′-phosphate glucosidase * : endoglycosylceramidase * : 3-deoxy-2-octulosonidase * : raucaffricine β-glucosidase * : coniferin β-glucosidase * : 1,6-α-L-fucosidase * : glycyrrhizin hydrolase * : endo-α-sialidase * : glycoprotein endo-α-1,2-mannosidase * : xylan α-1,2-glucuronosidase * : chitosanase * : glucan 1,4-α-maltohydrolase * : difructose-anhydride synthase * : neopullulanase * : glucuronoarabinoxylan endo-1,4-β-xylanase * : mannan exo-1,2-1,6-α-mannosidase * EC 3.2.1.138: Now , anhydrosialidase * : α-glucuronidase * : lacto-''N''-biosidase * : 4-α-D-trehalose trehalohydrolase * : limit dextrinase * : poly(ADP-ribose) glycohydrolase * : 3-deoxyoctulosonase * : galactan 1,3-β-galactosidase * : β-galactofuranosidase * : thioglucosidase * EC 3.2.1.148: The activity is most probably attributable to , ''S''-ribosylhomocysteine lyase * : β-primeverosidase * : oligoxyloglucan reducing-end-specific cellobiohydrolase * : xyloglucan-specific endo-β-1,4-glucanase * : mannosylglycoprotein endo-β-mannosidase * : fructan β-(2,1)-fructosidase * : fructan β-(2,6)-fructosidase * : xyloglucan-specific endo-processive β-1,4-glucanase * : oligosaccharide reducing-end xylanase * : ι-carrageenase * : α-agarase * : α-neoagaro-oligosaccharide hydrolase * EC 3.2.1.160: identical to , xyloglucan-specific exo-β-1,4-glucanase * : β-apiosyl-β-glucosidase * : λ-carrageenase * : 1,6-α-D-mannosidase * : galactan endo-1,6-β-galactosidase * : exo-1,4-β-D-glucosaminidase * :

heparanase Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Synthesis and structure The protei ...

* : baicalin-β-D-glucuronidase * : hesperidin 6-''O''-α-L-rhamnosyl-β-D-glucosidase * : protein ''O''-GlcNAcas * : mannosylglycerate hydrolase * : rhamnogalacturonan hydrolase * : unsaturated rhamnogalacturonyl hydrolase * : rhamnogalacturonan galacturonohydrolase * : rhamnogalacturonan rhamnohydrolase * : β-D-glucopyranosyl abscisate β-glucosidase * : cellulose 1,4-β-cellobiosidase (reducing end) * : α-D-xyloside xylohydrolase * : β-porphyranase * : gellan tetrasaccharide unsaturated glucuronyl hydrolase * : unsaturated chondroitin disaccharide hydrolase * : galactan endo-β-1,3-galactanase * : 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2''H''-1,4-benzoxazin-2-yl glucoside β-D-glucosidase * : UDP-''N''-acetylglucosamine 2-epimerase (hydrolysing) * : UDP-''N,N''′-diacetylbacillosamine 2-epimerase (hydrolysing) * : non-reducing end β-L-arabinofuranosidase * * : protodioscin 26-''O''-β-D-glucosidase * * : (Ara-f)3-Hyp β-L-arabinobiosidase * * : avenacosidase * * : dioscin glycosidase (diosgenin-forming) * * : dioscin glycosidase (3-''O''-β-D-Glc-diosgenin-forming) * * : ginsenosidase type III * * : ginsenoside Rb1 β-glucosidase * * : ginsenosidase type I * * : ginsenosidase type IV * * : 20-''O''-multi-glycoside ginsenosidase * * : limit dextrin α-1,6-maltotetraose-hydrolase * * : β-1,2-mannosidase * * : α-mannan endo-1,2-α-mannanase * * : sulfoquinovosidase * * : exo-chitinase (non-reducing end) * * : exo-chitinase (reducing end) * * : endo-chitodextinase * * : carboxymethylcellulase * * : 1,3-α-isomaltosidase * * : isomaltose glucohydrolase * * : oleuropein β-glucosidase * * : mannosyl-oligosaccharide α-1,3-glucosidase * * : glucosylglycerate hydrolase * * : endoplasmic reticulum Man9GlcNAc2 1,2-α-mannosidase * * : endoplasmic reticulum Man8GlcNAc2 1,2-α-mannosidase * * : endo-(1→3)-fucoidanase * * : endo-(1→4)-fucoidanase * * : galactan exo-1,6-β-galactobiohydrolase (non-reducing end) * * : exo β-1,2-glucooligosaccharide sophorohydrolase (non-reducing end) * : *No Wikipedia article

EC 3.2.2: Hydrolysing ''N''-Glycosyl Compounds

* : purine nucleosidase * : inosine nucleosidase * : uridine nucleosidase * : AMP nucleosidase * : NAD⁺ glycohydrolase * : ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase * : adenosine nucleosidase * : ribosylpyrimidine nucleosidase * : adenosylhomocysteine nucleosidase * : pyrimidine-5′-nucleotide nucleosidase * : β-aspartyl-''N''-acetylglucosaminidase * : inosinate nucleosidase * : 1-methyladenosine nucleosidase * : NMN nucleosidase * : DNA-deoxyinosine glycosylase * :

methylthioadenosine nucleosidase In enzymology, a methylthioadenosine nucleosidase () is an enzyme that catalyzes the chemical reaction :S-methyl-5'-thioadenosine + H2O \rightleftharpoons S-methyl-5-thio-D-ribose + adenine Thus, the two substrates of this enzyme are S-methyl-5 ...

* : deoxyribodipyrimidine endonucleosidase * EC 3.2.2.18: Now included with , peptide-N⁴-(''N''-acetyl-β-glucosaminyl)asparagine amidase * : ADP-ribosylarginine hydrolase * : DNA-3-methyladenine glycosylase I * : DNA-3-methyladenine glycosylase II, MAG1 * : rRNA N''-glycosylase * : DNA-formamidopyrimidine glycosylase * : ADP-ribosyl- initrogen reductasehydrolase * : ''N''-methyl nucleosidase * : futalosine hydrolase * :

uracil-DNA glycosylase Uracil-DNA glycosylase (also known as UNG or UDG) is an enzyme. Its most important function is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosidic bond and initiating the base-excision repair (BER) pathway ...

* : double-stranded uracil-DNA glycosylase * : thymine-DNA glycosylase * : aminodeoxyfutalosine nucleosidase * * : adenine glycosylase * : *No Wikipedia article

EC 3.2.3: Hydrolysing ''S''-Glycosyl Compounds

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds

EC 3.3.1: Thioether and trialkylsulfonium hydrolases

* : adenosylhomocysteinase * : ''S''-adenosyl-L-methionine hydrolase (L-homoserine-forming) * EC 3.3.1.3: The activity is most probably attributable to , ''S''-ribosylhomocysteine lyase

EC 3.3.2: Ether Hydrolases

* : isochorismatase * : alkenylglycerophosphocholine hydrolase * EC 3.3.2.3: Now known to comprise two enzymes, microsomal epoxide hydrolase () and soluble epoxide hydrolase () * : ''trans''-epoxysuccinate hydrolase * EC 3.3.2.5: Now included in , lysoplasmalogenase * : leukotriene-A₄ hydrolase * : hepoxilin-epoxide hydrolase * : limonene-1,2-epoxide hydrolase * :

microsomal epoxide hydrolase In enzymology, a microsomal epoxide hydrolase (mEH) () is an enzyme that catalysis, catalyzes the hydrolysis reaction between an epoxide and water to form a diol. This enzyme plays a role in the uptake of bile salts within the large intestine. ...

* :

soluble epoxide hydrolase Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the ''EPHX2'' gene. sEH is a member of the epoxide hydrolase family. This enzyme, found in both the cytosol and peroxisomes, binds to specific epoxides and con ...

* : cholesterol-5,6-oxide hydrolase * : oxepin-CoA hydrolase * * : chorismatase * * : 2,4-dinitroanisole ''O''-demethylase * * : ''trans''-2,3-dihydro-3-hydroxyanthranilic acid synthase * : *No Wikipedia article

EC 3.4: Acting on
peptide bond In organic chemistry, a peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one) of one alpha-amino acid and N2 (nitrogen number two) of another, along a peptide or protein cha ...
s –
Peptidase A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. They do ...

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)

* EC 3.4.1.1: Now , leucyl aminopeptidase * EC 3.4.1.2: Now , membrane alanyl aminopeptidase * EC 3.4.1.3: Now , tripeptide aminopeptidase * EC 3.4.1.4: Now , prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)

* EC 3.4.2.1: Now , carboxypeptidase A * EC 3.4.2.2: Now , carboxypeptidase B * EC 3.4.2.3: Now , Gly-Xaa carboxypeptidase

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)

* EC 3.4.3.1: Now , cytosol nonspecific dipeptidase * EC 3.4.3.2: Now , cytosol nonspecific dipeptidase * EC 3.4.3.3: Now , Xaa-His dipeptidase * EC 3.4.3.4: Now , Xaa-methyl-His dipeptidase * EC 3.4.3.5: Now , membrane alanyl aminopeptidase * EC 3.4.3.6: Now , cytosol nonspecific dipeptidase * EC 3.4.3.7: Now , Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)

* EC 3.4.4.1: Now , pepsin A * EC 3.4.4.2: Now , pepsin B * EC 3.4.4.3: Now , chymosin * EC 3.4.4.4: Now , trypsin * EC 3.4.4.5: Now , chymotrypsin * EC 3.4.4.6: Now , chymotrypsin * EC 3.4.4.7: Now covered by , pancreatic elastase and , leukocyte elastase * EC 3.4.4.8: Now , enteropeptidase * EC 3.4.4.9: Now , dipeptidyl-peptidase I * EC 3.4.4.10: Now , papain * EC 3.4.4.11: Now , chymopapain * EC 3.4.4.12: Now , ficain * EC 3.4.4.13: Now , thrombin * EC 3.4.4.14: Now , plasmin * EC 3.4.4.15: Now , renin * EC 3.4.4.16: Now covered by the microbial serine proteinases (subtilisin), (oryzin), (endopeptidase K), (thermomycolin), (thermitase) and (endopeptidase So) * EC 3.4.4.17: Now covered by the microbial aspartic proteinases (penicillopepsin), (rhizopuspepsin), (endothiapepsin), (mucorpepsin), (candidapepsin), (saccharopepsin), (rhodotorulapepsin), (physarolisin), (acrocylindropepsin), (polyporopepsin) and (pycnoporopepsin) * EC 3.4.4.18: Now , streptopain * EC 3.4.4.19: Now , microbial collagenase * EC 3.4.4.20: Now , clostripain * EC 3.4.4.21: Now (plasma kallikrein) and (tissue kallikrein) * EC 3.4.4.22: Now , gastricsin * EC 3.4.4.23: Now , cathepsin D * EC 3.4.4.24: Now covered by (stem bromelain) and (fruit bromelain) * EC 3.4.4.25: deleted

EC 3.4.11
Aminopeptidase Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the N-terminus (beginning), of proteins or peptides. They are found in many organisms; in the cell, they are found in many organelles, in the cytosol (internal cellular f ...
s

* : leucyl aminopeptidase * : membrane alanyl aminopeptidase * : cystinyl aminopeptidase * : tripeptide aminopeptidase * : prolyl aminopeptidase * : aminopeptidase B * :

glutamyl aminopeptidase Glutamyl aminopeptidase (, ''aminopeptidase A'', ''aspartate aminopeptidase'', ''angiotensinase A'', ''glutamyl peptidase'', ''Ca2+-activated glutamate aminopeptidase'', ''membrane aminopeptidase II'', ''antigen BP-1/6C3 of mouse B lymphocytes'', ...

* EC 3.4.11.8: Now EC 3.4.19.3, pyroglutamyl-peptidase I * : Xaa-Pro aminopeptidase * : bacterial leucyl aminopeptidase * EC 3.4.11.11: Deleted * EC 3.4.11.12: Deleted * : Clostridial aminopeptidase * : cytosol alanyl aminopeptidase * : aminopeptidase Y * : Xaa-Trp aminopeptidase * : tryptophanyl aminopeptidase * : methionyl aminopeptidase * : D-stereospecific aminopeptidase * : aminopeptidase Ey * : aspartyl aminopeptidase * : aminopeptidase I * : PepB aminopeptidase * : aminopeptidase S * : β-peptidyl aminopeptidase * : intermediate cleaving peptidase 55

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)

* EC 3.4.12.1: Now (carboxypeptidase C) and (carboxypeptidase D) * EC 3.4.12.2: Now , carboxypeptidase A * EC 3.4.12.3: Now , carboxypeptidase B * EC 3.4.12.4: Now , lysosomal Pro-Xaa carboxypeptidase * EC 3.4.12.5: Now , ''N''-acetylmuramoyl-L-alanine amidase * EC 3.4.12.6: Now , muramoyl-pentapeptidase carboxypeptidase * EC 3.4.12.7: Now , lysine carboxypeptidase * EC 3.4.12.8: Now , Gly-Xaa carboxypeptidase * EC 3.4.12.9: aspartate carboxypeptidase * EC 3.4.12.10: Now , γ-glutamyl hydrolase * EC 3.4.12.11: Now , alanine carboxypeptidase * EC 3.4.12.12: Now (carboxypeptidase C) and (carboxypeptidase D) * EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases

* EC 3.4.13.1: Now , cytosol nonspecific dipeptidase * EC 3.4.13.2: Now , cytosol nonspecific dipeptidase * EC 3.4.13.3: The activity is covered by , cytosol nonspecific dipeptidase and , β-Ala-His dipeptidase * : Xaa-Arg dipeptidase * : Xaa-methyl-His dipeptidase * EC 3.4.13.6: Now , membrane alanyl aminopeptidase * : Glu-Glu dipeptidase * EC 3.4.13.8: Now , cytosol nonspecific dipeptidase * : Xaa-Pro dipeptidase * EC 3.4.13.10: Now , β-aspartyl-peptidase * EC 3.4.13.11: Now , membrane dipeptidase * : Met-Xaa dipeptidase * EC 3.4.13.13: Now , Xaa-His dipeptidase * EC 3.4.13.14: Deleted * EC 3.4.13.15: Now , cytosol nonspecific dipeptidase * : Deleted * : non-stereospecific dipeptidase * : cytosol nonspecific dipeptidase * :

membrane dipeptidase Membrane dipeptidase (, ''renal dipeptidase'', ''dehydropeptidase I (DPH I)'', ''dipeptidase'', ''aminodipeptidase'', ''dipeptide hydrolase'', ''dipeptidyl hydrolase'', ''nonspecific dipeptidase'', ''glycosyl-phosphatidylinositol-anchored renal di ...

* : β-Ala-His dipeptidase * : dipeptidase E * : D-Ala-D-Ala dipeptidase * : cysteinylglycine-''S''-conjugate dipeptidase * : *No Wikipedia article

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases

* : dipeptidyl-peptidase I * : dipeptidyl-peptidase II * EC 3.4.14.3: Now , acylaminoacyl-peptidase * : dipeptidyl-peptidase III * : dipeptidyl-peptidase IV * : dipeptidyl-dipeptidase * EC 3.4.14.7: Deleted * EC 3.4.14.8: Now , tripeptidyl-peptidase II * : tripeptidyl-peptidase I * : tripeptidyl-peptidase II * : Xaa-Pro dipeptidyl-peptidase * : Xaa-Xaa-Pro tripeptidyl-peptidase * : γ-D-glutamyl-Llysine dipeptidyl-peptidase * : ycofactocin precursor peptidepeptidase * : *No Wikipedia article

EC 3.4.15 Peptidyl dipeptidases

* : peptidyl-dipeptidase A * EC 3.4.15.2: Now , peptidyl-glycinamidase * EC 3.4.15.3: Now , peptidyl-dipeptidase Dcp * : Peptidyl-dipeptidase B * : Peptidyl-dipeptidase Dcp * : cyanophycinase

EC 3.4.16 Serine type carboxypeptidases

* EC 3.4.16.1: Transferred entry: serine carboxypeptidase. Now , carboxypeptidase D * : lysosomal Pro-Xaa carboxypeptidase * EC 3.4.16.3: Now included with , carboxypeptidase C * : serine-type D-Ala-D-Ala carboxypeptidase * : carboxypeptidase C * : carboxypeptidase D

EC 3.4.17 Metallocarboxypeptidases

* :

carboxypeptidase A Carboxypeptidase A usually refers to the pancreatic exopeptidase that hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic Side chain, side-chains. Most scientists in the field now refer to this enzyme as CPA1, and to a relat ...

* :

carboxypeptidase B Carboxypeptidase B (, ''protaminase'', ''pancreatic carboxypeptidase B'', ''tissue carboxypeptidase B'', ''peptidyl-L-lysine -arginineydrolase'') is a carboxypeptidase that preferentially cleaves off basic amino acids arginine and lysine f ...

* : lysine carboxypeptidase * : Gly-Xaa carboxypeptidase * EC 3.4.17.5: Deleted * : alanine carboxypeptidase * EC 3.4.17.7: Now , ''N''-acetylmuramoyl-L-alanine amidase * : muramoylpentapeptide carboxypeptidase * EC 3.4.17.9: Now included with , Gly-Xaa carboxypeptidase * :

carboxypeptidase E Carboxypeptidase E (CPE), also known as carboxypeptidase H (CPH) and enkephalin convertase, is an enzyme that in humans is encoded by the ''CPE'' gene. This enzyme catalyzes the release of C-terminal arginine or lysine residues from polypeptides. ...

* : glutamate carboxypeptidase * : carboxypeptidase M * : Muramoyltetrapeptide carboxypeptidase * : zinc D-Ala-D-Ala carboxypeptidase * : carboxypeptidase A₂ * : membrane Pro-Xaa carboxypeptidase * : tubulinyl-Tyr carboxypeptidase * : carboxypeptidase T * : Carboxypeptidase Taq * : carboxypeptidase U * : Glutamate carboxypeptidase II * : metallocarboxypeptidase D * :

angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2). Both membrane bound and soluble ACE2 ...

* : tubulin-glutamate carboxypeptidase * : *No Wikipedia article

EC 3.4.18 Cysteine type carboxypeptidases

* : cathepsin X

EC 3.4.19 Omega peptidases

* : acylaminoacyl-peptidase * : peptidyl-glycinamidase * : pyroglutamyl-peptidase I * EC 3.4.19.4: Deleted * : β-aspartyl-peptidase * : pyroglutamyl-peptidase II * : ''N''-formylmethionyl-peptidase * EC 3.4.19.8: now , glutamate carboxypeptidase II * : folate γ-glutamyl hydrolase * EC 3.4.19.10: Now , ''N''-acetylmuramoyl-L-alanine amidase * : γ-Dglutamyl-''meso''-diaminopimelate peptidase * : ubiquitinyl hydrolase 1 * : glutathione γ-glutamate hydrolase * : leukotriene-C₄ hydrolase * : desampylase * * : glucosinolate γ-glutamyl hydrolase * : *No Wikipedia article

EC 3.4.21:
Serine protease Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serin ...
s

* :

chymotrypsin Chymotrypsin (, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenu ...

* : chymotrypsin C * : metridin * :

trypsin Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the dig ...

* :

thrombin Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (, fibrose, thrombase, throm ...

* :

coagulation factor Xa Coagulation factor X (), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by ''F10'' gene. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for ...

* :

plasmin Plasmin is an important enzyme () present in blood that degrades many blood plasma proteins, including fibrin thrombus, clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) i ...

* EC 3.4.21.8: Now (plasma kallikrein) and (tissue kallikrein) * :

enteropeptidase Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the ...

* : acrosin * EC 3.4.21.11: Now , leukocyte elastase * : α-lytic endopeptidase * EC 3.4.21.13: Now , carboxypeptidase D * EC 3.4.21.14: now , endopeptidase So * EC 3.4.21.15: Now , oryzin * EC 3.4.21.16: Deleted * EC 3.4.21.17: Deleted * EC 3.4.21.18: Deleted * : glutamyl endopeptidase * :

cathepsin G Cathepsin G is a protein that in humans is encoded by the ''CTSG'' gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family. Cathepsi ...

* :

coagulation factor VIIa Coagulation factor VII (, formerly known as proconvertin) is a protein involved in coagulation and, in humans, is encoded by gene ''F7''. It is an enzyme of the serine protease class. Once bound to tissue factor released from damaged tissues, ...

* : coagulation factor IXa * EC 3.4.21.23: Deleted * EC 3.4.21.24: Deleted * : cucumisin * :

prolyl oligopeptidase Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the ''PREP'' gene. Function Prolyl endopeptidase is a large cytosolic enzyme that belongs to a distinct cl ...

* : coagulation factor XIa * EC 3.4.21.28: Now , venombin A * EC 3.4.21.29: Now , venombin A * EC 3.4.21.30: Now , venombin A * EC 3.4.21.31: Now , u-plasminogen activator * : brachyurin * EC 3.4.21.33: Deleted * :

plasma kallikrein Plasma kallikrein () is an enzyme that catalyses the following chemical reaction: : Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg- Ser in (human) kininogen to release bradykinin Plasma kallikrein and its precursor ...

* : tissue kallikrein * : pancreatic elastase * : leukocyte elastase * : coagulation factor XIIa * :

chymase Chymases (, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granul ...

* EC 3.4.21.40: Deleted * : Complement subcomponent C^1r * : complement subcomponent C^1s * : classical-complement-pathway C3/C5 convertase * EC 3.4.21.44: Now , classical-complement-pathway C3/C5 convertase * : complement factor I * :

complement factor D Factor D (, ''C3 proactivator convertase'', ''properdin factor D esterase'', ''factor D (complement)'', ''complement factor D'', ''CFD'', ''adipsin'') is a protein which in humans is encoded by the ''CFD'' gene. Factor D is involved in the alterna ...

* : alternative-complement-pathway C3/C5 convertase * : cerevisin * : hypodermin C * : lysyl endopeptidase * EC 3.4.21.51: Deleted * EC 3.4.21.52: Deleted * : edopeptidase La * : γ-renin * : venombin AB * EC 3.4.21.56: Now considered to be , cucumisin * : leucyl endopeptidase * EC 3.4.21.58: Deleted * :

tryptase Tryptase () is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation. Club cells contain tryptase, which is believed to be responsible for cleaving the hemagglu ...

* : scutelarin * : kexin * :

subtilisin Subtilisin is a protease (a protein-digesting enzyme) initially obtained from ''Bacillus subtilis''. Subtilisins belong to subtilases, a group of serine proteases that – like all serine proteases – initiate the nucleophilic attack on the ...

* : oryzin * : endopeptidase K * : thermomycolin * : thermitase * : endopeptidase So * : ''t''-plasminogen activator * : protein C (activated) * : pancreatic endopeptidase E * : pancreatic elastase II * : IgA-specific serine endopeptidase * : u-plasminogen activator * :

venombin A Venombin A (, ''alpha-fibrinogenase'', ''habutobin'', ''zinc metalloproteinase Cbfib1.1'', ''zinc metalloproteinase Cbfib1.2'', ''zinc metalloproteinase Cbfib2'', '' ancrod'') is an enzyme. This enzyme catalyses the following chemical reaction : ...

* : furin * : myeloblastin * : semenogelase * : granzyme A * :

granzyme B Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptos ...

* : streptogrisin A * : streptogrisin B * : glutamyl endopeptidase II * : oligopeptidase B * : limulus clotting factor C * : limulus clotting factor B * : limulus clotting enzyme * EC 3.4.21.87: Now , omptin * :

repressor LexA The LexA repressor or LexA (Locus for X-ray sensitivity A) is a transcriptional repressor () that represses SOS response genes coding primarily for error-prone DNA polymerases, DNA repair enzymes and cell division inhibitors. LexA forms ''de fact ...

* : signal peptidase I * : togavirin * : flavivirin * : endopeptidase Clp * : proprotein convertase 1 * : proprotein convertase 2 * : snake venom factor V activator * : lactocepin * : assemblin * : hepacivirin * : spermosin * : sedolisin * : xanthomonalisin * : ''C''-terminal processing peptidase * : physarolisin * : mannan-binding lectin-associated serine protease-2 * :

rhomboid protease The rhomboid proteases are a family of enzymes that exist in almost all species. They are proteases: they cut the polypeptide chain of other proteins. This proteolytic cleavage is irreversible in cell (biology), cells, and an important type of cel ...

* : hepsin * : peptidase Do * :

HtrA2 peptidase HtrA2 peptidase (, ''high temperature requirement protein A2'', '' HtrA2'', ''Omi stress-regulated endoprotease'', ''serine proteinase OMI'', ''OMI/HtrA2 protease'', ''HtrA2/Omi'', ''Omi/HtrA2'') is an enzyme. This enzyme catalyses the following c ...

* : matriptase * : C5a peptidase * : aqualysin 1 * : site-1 protease * :

pestivirus NS3 polyprotein peptidase Pestivirus NS3 polyprotein peptidase (, ''border disease virus NS3 endopeptidase'', ''BDV NS3 endopeptidase'', ''bovine viral diarrhea virus NS3 endopeptidase'', ''BVDV NS3 endopeptidase'', ''classical swine fever virus NS3 endopeptidase'', ''CSFV ...

* : equine arterivirus serine peptidase * : infectious pancreatic necrosis birnavirus Vp4 peptidase * : SpoIVB peptidase * : stratum corneum chymotryptic enzyme * : kallikrein 8 * : kallikrein 13 * : oviductin * : Lys-Lys/Arg-Xaa endopeptidase * : *No Wikipedia article

EC 3.4.22
Cysteine protease Cysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Discovered by Gopal Chu ...
s

* : cathepsin B * :

papain Papain, also known as papaya proteinase I, is a cysteine protease () enzyme present in papaya (''Carica papaya'') and mountain papaya (''Vasconcellea cundinamarcensis''). It is the namesake member of the papain-like protease family. It has wi ...

* :

ficain Ficain also known as ficin, debricin, or higueroxyl delabarre () is a proteolytic enzyme extracted from the latex sap from the stems, leaves, and unripe fruit of the American wild fig tree ''Ficus insipida''. Ficain was originally called ficin, an ...

* EC 3.4.22.4: Now (stem bromelain) and (fruit bromelain) * EC 3.4.22.5: Now (stem bromelain) and (fruit bromelain) * : chymopapain * : asclepain * : clostripain * EC 3.4.22.9: Now , cerevisin * : streptopain * EC 3.4.22.11: Now , insulysin * EC 3.4.22.12: Now , γ-glutamyl hydrolase * EC 3.4.22.13: Deleted * : actinidain * : cathepsin L * : cathepsin H * EC 3.4.22.17: Now , calpain-2 * EC 3.4.22.18: Now , prolyl oligopeptidase * EC 3.4.22.19: Now , thimet oligopeptidase * EC 3.4.22.20: Deleted * EC 3.4.22.21: Now , proteasome endopeptidase complex * EC 3.4.22.22: Now , saccharolysin * EC 3.4.22.23: Now , kexin * : Cathepsin T * : Glycyl endopeptidase * : Cancer procoagulant * :

cathepsin S Cathepsin S is a protein that in humans is encoded by the ''CTSS'' gene. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Cathepsin S is a member of the peptidase C1 family of cysteine cathepsins, a lysosom ...

* : picornain 3C * : picornain 2A * : Caricain * : Ananain * :

Stem bromelain Stem bromelain (SBM) ( EC 3.4.22.32), a proteolytic enzyme, is a widely accepted phytotherapeutical drug member of the bromelain family of proteolytic enzymes obtained from ''Ananas comosus''. Some of the therapeutic uses of SBM are reversible ...

* :

Fruit bromelain Fruit bromelain (, ''juice bromelain'', ''ananase'', ''Bromelase'' (a trademark), ''bromelin'', ''extranase'', ''pinase'', ''pineapple enzyme'', ''traumanase'', ''fruit bromelain FA2'') is an enzyme. This enzyme catalyses the following chemical re ...

* : Legumain * : Histolysain * : caspase-1 * :

Gingipain R Gingipain R (, ''Arg-gingipain'', ''gingipain-1'', ''argingipain'', ''Arg-gingivain-55 proteinase'', ''Arg-gingivain-70 proteinase'', ''Arg-gingivain-75 proteinase'', ''arginine-specific cysteine protease'', ''arginine-specific gingipain'', ''argi ...

* :

Cathepsin K Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the ''CTSK'' gene. Function The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease involved in bone remodeling and resorption. This pr ...

* : adenain * : bleomycin hydrolase * : cathepsin F * : cathepsin O * : cathepsin V * : nuclear-inclusion-a endopeptidase * : helper-component proteinase * : L-peptidase, L-peptidase * : gingipain K * : staphopain * : separase * : V-cath endopeptidase * : cruzipain * : calpain-1 * : calpain-2 * : calpain-3 * : caspase-2 * : caspase-3 * : caspase-4 * : caspase-5 * : caspase-6 * : caspase-7 * : caspase-8 * : caspase-9 * : caspase-10 * : caspase-11 * : peptidase 1 (mite) * : calicivirin * : zingipain * : Ulp1 peptidase * : SARS coronavirus main proteinase * : sortase A * : sortase B

EC 3.4.23 Aspartic endopeptidases

* : pepsin A * : pepsin B * : gastricsin * : chymosin * : cathepsin D * EC 3.4.23.6: Now , pycnoporopepsin * EC 3.4.23.7: Now , penicillopepsin * EC 3.4.23.8: Now , saccharopepsin * EC 3.4.23.9: Now , rhizopuspepsin * EC 3.4.23.10: Now , endothiapepsin * EC 3.4.23.11: Deleted entry * : nepenthesin * EC 3.4.23.13: Deleted * EC 3.4.23.14: Deleted * : renin * : HIV-1 retropepsin * : Pro-opiomelanocortin converting enzyme, ''pro''-opiomelanocortin converting enzyme * : aspergillopepsin I * : aspergillopepsin II * : penicillopepsin * : rhizopuspepsin * : endothiapepsin * : mucorpepsin * : candidapepsin * : saccharopepsin * : rhodotorulapepsin * EC 3.4.23.27: Now , physarolisin * : acrocylindropepsin * : polyporopepsin * : pycnoporopepsin * : scytalidopepsin A * : scytalidopepsin B * EC 3.4.23.33: Now , xanthomonalisin * : cathepsin E * : barrierpepsin * : signal peptidase II * EC 3.4.23.37: Now , pseudomonalisin * : plasmepsin I * : plasmepsin II * : phytepsin * : yapsin 1 * : thermopsin * : prepilin peptidase * : nodavirus endopeptidase * : memapsin 1 * : memapsin 2 * : HIV-2 retropepsin * : plasminogen activator Pla * : omptin * : human endogenous retrovirus K endopeptidase * : HycI peptidase * : preflagellin peptidase

EC 3.4.24: Metallopeptidases

* : atrolysin A * : Deleted entry: Sepia proteinase * : microbial collagenase * : now serralysin * EC 3.4.24.5: Deleted entry: lens neutral proteinase. Now included with (calpain-2) and (proteasome endopeptidase complex) * : leucolysin * : interstitial collagenase * EC 3.4.24.8: Transferred entry: ''Achromobacter iophagus'' collagenase. Now , microbial collagenase * EC 3.4.24.9: Deleted entry: Trichophyton schoenleinii collagenase * EC 3.4.24.10: Deleted entry: Trichophyton mentagrophytes keratinase * : neprilysin * : envelysin * : IgA-specific metalloendopeptidase * : procollagen N-endopeptidase * : thimet oligopeptidase * : neurolysin * : stromelysin 1 * : meprin A * : procollagen C-endopeptidase * : peptidyl-Lys metalloendopeptidase * : astacin * : stromelysin 2 * : matrilysin * : gelatinase a * : vibriolysin * : pseudolysin * : thermolysin * : bacillolysin * : aureolysin * : coccolysin * : mycolysin * : beta-Lytic metalloendopeptidase, β-lytic metalloendopeptidase * : peptidyl-Asp metalloendopeptidase * : neutrophil collagenase * : gelatinase B * : leishmanolysin * : saccharolysin * : gametolysin * : deuterolysin * : serralysin * : atrolysin B * : atrolysin C * : atroxase * : atrolysin E * : atrolysin F * : adamalysin * : horrilysin * : ruberlysin * : bothropasin * : bothrolysin * : ophiolysin * : trimerelysin I * : trimerelysin II * : mucrolysin * : pitrilysin * : insulysin * : O-sialoglycoprotein endopeptidase, ''O''-sialoglycoprotein endopeptidase * : russellysin * : mitochondrial intermediate peptidase * : dactylysin * : nardilysin * : magnolysin * : meprin B * : mitochondrial processing peptidase * : macrophage elastase * : choriolysin L * : choriolysin H * : tentoxilysin * : bontoxilysin * : oligopeptidase A * : endothelin-converting enzyme 1 * : fibrolase * : jararhagin * : fragilysin * : lysostaphin * : flavastacin * : snapalysin * : gpr endopeptidase * : pappalysin-1 * : membrane-type matrix metalloproteinase-1 * : ADAM10 endopeptidase * : ADAMTS-4 endopeptidase * : anthrax lethal factor endopeptidase * : Ste24 endopeptidase * : S2P endopeptidase * : ADAM 17 endopeptidase * : ADAMTS13 endopeptidase

EC 3.4.25 Threonine endopeptidases

* : proteasome endopeptidase complex * : HslU—HslV peptidase * EC 3.4.99.7: Deleted entry: euphorbain * EC 3.4.99.8: Deleted entry: Gliocladium proteinase * EC 3.4.99.9: Deleted entry: hurain. Now considered to be , cucumisin * EC 3.4.99.10: Transferred entry: insulinase. Now , insulysin * EC 3.4.99.11: Deleted entry: Streptomyces alkalophilic keratinase * EC 3.4.99.12: Deleted entry: ''Trichophyton mentagrophytes'' keratinase * EC 3.4.99.13: Transferred entry: β-lytic proteinase (''Mycobacterium sorangium''). Now , β-lytic metalloendopeptidase * EC 3.4.99.14: Deleted entry: mexicanain * EC 3.4.99.15: Deleted entry: Paecilomyces proteinase * EC 3.4.99.16: Deleted entry: ''Penicillium notatum'' extracellular proteinase * EC 3.4.99.17: Deleted entry: peptidoglycan endopeptidase * EC 3.4.99.18: Deleted entry: pinguinain * EC 3.4.99.19: Transferred entry: renin. Now , renin * EC 3.4.99.20: Deleted entry: scopulariopsis proteinase * EC 3.4.99.21: Deleted entry: solanain. Now considered , cucumisin * EC 3.4.99.22: Transferred entry: staphylokinase. , aureolysin * EC 3.4.99.23: Deleted entry: tabernamontanain. Now considered EC 3.4.21.25, cucumisin * EC 3.4.99.24: Deleted entry: Tenebrio α-proteinase * EC 3.4.99.25: Transferred entry: trametes acid proteinase. , rhizopuspepsin * EC 3.4.99.26: Transferred entry: urokinase. Now , t-plasminogen activator * EC 3.4.99.27: Deleted entry: ''Echis carinatus'' prothrombin-activating proteinase * EC 3.4.99.28: Transferred entry: ''Oxyuranus scutellatus'' prothrombin-activating proteinase. , scutelarin * EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I * EC 3.4.99.30: Transferred entry: Myxobacter AL-1 proteinase II. , peptidyl-Lys metalloendopeptidase * EC 3.4.99.31: Transferred entry: tissue endopeptidase degrading collagenase synthetic substrate. , thimet oligopeptidase * EC 3.4.99.32: Transferred entry: ''Armillaria mellea'' neutral proteinase. Now , peptidyl-Lys metalloendopeptidase * EC 3.4.99.33: Deleted entry: cathepsin R * EC 3.4.99.34: Deleted entry: mytilidase * EC 3.4.99.35: Transferred entry: premurein-leader peptidase. Now , signal peptidase II * EC 3.4.99.36: Transferred entry: leader peptidase. Now , signal peptidase I * EC 3.4.99.37: Deleted entry: RecA peptidase * EC 3.4.99.38: Transferred entry: pro-opiomelanotropin-converting proteinase. Now , pro-opiomelanocortin converting enzyme * EC 3.4.99.39: Deleted entry: pseudomurein endopeptidase * EC 3.4.99.40: Deleted entry: pro-gonadoliberin proteinase * EC 3.4.99.41: Transferred entry: mitochondrial processing peptidase. Now , mitochondrial processing peptidase * EC 3.4.99.42: Deleted entry: leucyllysine endopeptidase * EC 3.4.99.43: Transferred entry: thermopsin. Npw , thermopsin * EC 3.4.99.44: Transferred entry: pitrilysin. Now , pitrilysin * EC 3.4.99.45: Transferred entry: insulinase. Now , insulysin * EC 3.4.99.46: Transferred entry: multicatalytic endopeptidase complex. Now , proteasome endopeptidase complex

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1: In linear amides

* : asparaginase * : glutaminase * : omega-amidase, ω-amidase * : amidase * : urease * : beta-ureidopropionase, β-ureidopropionase * : ureidosuccinase * : formylaspartate deformylase * : arylformamidase * : formyltetrahydrofolate deformylase * : penicillin amidase * : biotinidase * : aryl-acylamidase * : aminoacylase, ''N''-acyl-aliphatic-L-amino acid amidohydrolase * : aspartoacylase * : acetylornithine deacetylase * : acyl-lysine deacylase * : succinyl-diaminopimelate desuccinylase * : nicotinamidase * : citrullinase * : N-acetyl-beta-alanine deacetylase, ''N''-acetyl-β-alanine deacetylas * : pantothenase * : ceramidase * : choloylglycine hydrolase * : N-acetylglucosamine-6-phosphate deacetylase, ''N''-acetylglucosamine-6-phosphate deacetylase * : N4-(beta-N-acetylglucosaminyl)-L-asparaginase, ''N''⁴-(β-''N''-acetylglucosaminyl)-L-asparaginase * EC 3.5.1.27: The activity is covered by , peptide deformylase * : N-acetylmuramoyl-L-alanine amidase, ''N''-acetylmuramoyl-L-alanine amidase * : 2-(acetamidomethylene)succinate hydrolase * : 5-aminopentanamidase * : formylmethionine deformylase * : hippurate hydrolase * : N-acetylglucosamine deacetylase, ''N''-acetylglucosamine deacetylase * EC 3.5.1.34: Identical with , Xaa-methyl-His dipeptidase * : D-glutaminase, D-glutaminase * : N-methyl-2-oxoglutaramate hydrolase, ''N''-methyl-2-oxoglutaramate hydrolase * EC 3.5.1.37: Delete, identical with ''N''⁴-(β-''N''-acetylglucosaminyl)-L-asparaginase * : glutamin-(asparagin-)ase * : alkylamidase * : acylagmatine amidase * : chitin deacetylase * : nicotinamide-nucleotide amidase * : peptidyl-glutaminase * : protein-glutamine glutaminase * EC 3.5.1.45: Now listed only as urea carboxylase * : 6-aminohexanoate-dimer hydrolase * : N-acetyldiaminopimelate deacetylase, ''N''-acetyldiaminopimelate deacetylase * : acetylspermidine deacetylase * : formamidase * : pentanamidase * : 4-acetamidobutyryl-CoA deacetylase * : peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase, peptide-''N''⁴-(''N''-acetyl-β-glucosaminyl)asparagine amidase * : N-carbamoylputrescine amidase, ''N''-carbamoylputrescine amidase * : allophanate hydrolase * : long-chain-fatty-acyl-glutamate deacylase * : N,N-dimethylformamidase, ''N,N''-dimethylformamidase * : tryptophanamidase * : N-benzyloxycarbonylglycine hydrolase, ''N''-benzyloxycarbonylglycine hydrolase * : N-carbamoylsarcosine amidase, ''N''-carbamoylsarcosine amidase * : N-(long-chain-acyl)ethanolamine deacylase, ''N''-(long-chain-acyl)ethanolamine deacylase * : mimosinase * : acetylputrescine deacetylase * : 4-acetamidobutyrate deacetylase * : Nalpha-benzyloxycarbonylleucine hydrolase, ''N''^α-benzyloxycarbonylleucine hydrolase * : theanine hydrolase * : 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase * : 4-methyleneglutaminase * : N-formylglutamate deformylase, ''N''-formylglutamate deformylase * : glycosphingolipid deacylase * : aculeacin-A deacylase * : N-feruloylglycine deacylase, ''N''-feruloylglycine deacylase * : D-benzoylarginine-4-nitroanilide amidase, D-benzoylarginine-4-nitroanilide amidase * : carnitinamidase * : chenodeoxycholoyltaurine hydrolase * : urethanase * : arylalkyl acylamidase * : N-carbamoyl-D-amino acid hydrolase, ''N''-carbamoyl-D-amino-acid hydrolase * : glutathionylspermidine amidase * : phthalyl amidase * EC 3.5.1.80: Identical to , ''N''-acetylglucosamine-6-phosphate deacetylase * : N-acyl-D-amino-acid deacylase, ''N''-acyl-D-amino-acid deacylase * : N-acyl-D-glutamate deacylase, ''N''-acyl-D-glutamate deacylase * : N-acyl-D-aspartate deacylase, ''N''-acyl-D-aspartate deacylase * : biuret amidohydrolase * : (S)-N-acetyl-1-phenylethylamine hydrolase, (''S'')-''N''-acetyl-1-phenylethylamine hydrolase * : mandelamide amidase * : N-carbamoyl-L-amino-acid hydrolase, ''N''-carbamoyl-L-amino-acid hydrolase * : peptide deformylase * : N-acetylglucosaminylphosphatidylinositol deacetylase, ''N''-acetylglucosaminylphosphatidylinositol deacetylase * : adenosylcobinamide hydrolase * : N-substituted formamide deformylase, ''N''-substituted formamide deformylase * : pantetheine hydrolase * : glutaryl-7-aminocephalosporanic-acid acylase * : gamma-glutamyl-gamma-aminobutyrate hydrolase, γ-glutamyl-γ-aminobutyrate hydrolase * : N-malonylurea hydrolase, ''N''-malonylurea hydrolase * : succinylglutamate desuccinylase * : acyl-homoserine-lactone acylase * : histone deacetylase * : fatty acid amide hydrolase * : (R)-amidase, (''R'')-amidase * : L-proline amide hydrolase, L-proline amide hydrolase * : 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase, 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3''H'')-one 5′-monophosphate deformylase * : N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, ''N''-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase * : peptidoglycan-N-acetylglucosamine deacetylase, peptidoglycan-''N''-acetylglucosamine deacetylase * : chitin disaccharide deacetylase * : N-formylmaleamate deformylase, ''N''-formylmaleamate deformylase * : maleamate amidohydrolase * : UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-''O''-acyl-''N''-acetylglucosamine deacetylase * : sphingomyelin deacylase * : peroxyureidoacrylate/ureidoacrylate amidohydrolase, ureidoacrylate amidohydrolase * : 2-oxoglutaramate amidase * : 2'-N-acetylparomamine deacetylase, 2′-''N''-acetylparomamine deacetylase * : 2-acetyl-6-hydroxyneomycin C deacetylase, 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase * : ''N''-acyl-aromatic-L-amino acid amidohydrolase * * : mycothiol ''S''-conjugate amidase * * : ureidoglycolate amidohydrolase * * : 6-aminohexanoate-oligomer endohydrolase * * : γ-glutamyl hercynylcysteine ''S''-oxide hydrolase * * : Pup amidohydrolase * * EC 3.5.1.120: Now , 2-aminomuconate deaminase (2-hydroxymuconate-forming) * : protein ''N''-terminal asparagine amidohydrolase * * : protein ''N''-terminal glutamine amidohydrolase * * : γ-glutamylanilide hydrolase * * : protein deglycase * * : ''N''²-acetyl-L-2,4-diaminobutanoate deacetylase * * : oxamate amidohydrolase * * : jasmonoyl-L-amino acid hydrolase * * : deaminated glutathione amidase * * : ''N''⁵-(cytidine 5′-diphosphoramidyl)-L-glutamine hydrolase * * : [amino group carrier protein]-lysine hydrolase * * : 1-carboxybiuret hydrolase * * : [amino group carrier protein]-ornithine hydrolase * * : ''N''^α-acyl-L-glutamine aminoacylase * * : (indol-3-yl)acetyl-L-aspartate hydrolase * * : ''N''⁴-acetylcytidine amidohydrolase * * : ''N,N′''-diacetylchitobiose non-reducing end deacetylase * : *No Wikipedia article

3.5.2: In cyclic amides

* : barbiturase * : dihydropyrimidinase * : dihydroorotase * : carboxymethylhydantoinase * : allantoinase * : beta-lactamase, β-lactamase * : imidazolonepropionase * EC 3.5.2.8: Now included with , β-lactamase * : 5-oxoprolinase (ATP-hydrolysing) * : creatininase * : L-lysine-lactamase, L-lysine-lactamase * : 6-aminohexanoate-cyclic-dimer hydrolase * : 2,5-dioxopiperazine hydrolase * : N-methylhydantoinase (ATP-hydrolysing), ''N''-methylhydantoinase (ATP-hydrolysing) * : cyanuric acid amidohydrolase * : maleimide hydrolase * : hydroxyisourate hydrolase * : enamidase * : streptothricin hydrolase * : isatin hydrolase * : *No Wikipedia article

3.5.3: In linear amidines

* : arginase * : guanidinoacetase * : creatinase * : allantoicase * : formimidoylaspartate deiminase * : arginine deiminase * : guanidinobutyrase * : formimidoylglutamase * : allantoate deiminase * : D-arginase, D-arginase * : agmatinase * : agmatine deiminase * : formimidoylglutamate deiminase * : amidinoaspartase * : protein-arginine deiminase * : methylguanidinase * : guanidinopropionase * : dimethylargininase * EC 3.5.3.19: Now , ureidoglycolate amidohydrolase * : diguanidinobutanase * : Methylenediurea deaminase * : proclavaminate amidinohydrolase * : N-succinylarginine dihydrolase, ''N''-succinylarginine dihydrolase * : ''N''¹-aminopropylagmatine ureohydrolase * * : ''N''^ω-hydroxy-L-arginine amidinohydrolase * * : (''S'')-ureidoglycine aminohydrolase * : *No Wikipedia article

3.5.4: In cyclic amidines

* : cytosine deaminase * : adenine deaminase * : guanine deaminase * : adenosine deaminase * : cytidine deaminase * : AMP deaminase * : ADP deaminase * : aminoimidazolase * : methenyltetrahydrofolate cyclohydrolase * : IMP cyclohydrolase * : pterin deaminase * : dCMP deaminase * : dCTP deaminase * EC 3.5.4.14: Now included in , (deoxy)cytidine deaminase * : guanosine deaminase * : GTP cyclohydrolase I * : adenosine-phosphate deaminase * : ATP deaminase * : phosphoribosyl-AMP cyclohydrolase * : pyrithiamine deaminase * : creatinine deaminase * : 1-pyrroline-4-hydroxy-2-carboxylate deaminase * : blasticidin-S deaminase * : sepiapterin deaminase * : GTP cyclohydrolase II * : diaminohydroxyphosphoribosylaminopyrimidine deaminase * : methenyltetrahydromethanopterin cyclohydrolase * : S-adenosylhomocysteine deaminase, ''S''-adenosylhomocysteine deaminase * : GTP cyclohydrolase IIa * : dCTP deaminase (dUMP-forming) * : S-methyl-5'-thioadenosine deaminase, ''S''-methyl-5′-thioadenosine deaminase * : 8-oxoguanine deaminase * : tRNA(adenine³⁴) deaminase * * : tRNA^Ala(adenine³⁷) deaminase * * : tRNA(cytosine⁸) deaminase * * : mRNA(cytosine⁶⁶⁶⁶) deaminase * * : double-stranded RNA adenine deaminase * * : single-stranded DNA cytosine deaminase * * : GTP cyclohydrolase IV * * : aminodeoxyfutalosine deaminase * * : 5'-deoxyadenosine deaminase * : ''N''-isopropylammelide isopropylaminohydrolase * * : hydroxydechloroatrazine ethylaminohydrolase * * : ectoine hydrolase * * : melamine deaminase * * : cAMP deaminase * : *No Wikipedia article

3.5.5: In nitriles

* : nitrilase * : ricinine nitrilase * EC 3.5.5.3: Now , cyanate hydratase * : cyanoalanine nitrilase * : arylacetonitrilase * : bromoxynil nitrilase * : aliphatic nitrilase * : thiocyanate hydrolase

3.5.99: In other compounds

* : riboflavinase * : aminopyrimidine aminohydrolase * EC 3.5.99.3: Now , hydroxydechloroatrazine ethylaminohydrolase * EC 3.5.99.4: Now , ''N''-isopropylammelide isopropylaminohydrolase * : 2-aminomuconate deaminase * : glucosamine-6-phosphate deaminase * : 1-aminocyclopropane-1-carboxylate deaminase * : 5-nitroanthranilic acid aminohydrolase * : 2-nitroimidazole nitrohydrolase * : 2-iminobutanoate/2-iminopropanoate deaminase * * : 2-aminomuconate deaminase (2-hydroxymuconate-forming) * : *No Wikipedia article

EC 3.6: Acid anhydride hydrolases, Acting on acid anhydrides

3.6.1: In phosphorus-containing anhydrides

* : inorganic diphosphatase * : trimetaphosphatase * : adenosinetriphosphatase * EC 3.6.1.4: Now included with , adenosinetriphosphatase * : apyrase * : nucleoside-diphosphatase, nucleoside diphosphate phosphatase * : acylphosphatase * : ATP diphosphatase * : nucleotide diphosphatase * : endopolyphosphatase * : exopolyphosphatase * : dCTP diphosphatase * : ADP-ribose diphosphatase * : adenosine-tetraphosphatase * : nucleoside-triphosphatase * : CDP-glycerol diphosphatase * : bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), bis(5′-nucleosyl)-tetraphosphatase (asymmetrical)) * : FAD diphosphatase * EC 3.6.1.19: Now , nucleotide diphosphatase * : 5'-acylphosphoadenosine hydrolase, 5′-acylphosphoadenosine hydrolase * : ADP-sugar diphosphatase * : NAD+ diphosphatase, NAD⁺ diphosphatase * : dUTP diphosphatase * : nucleoside phosphoacylhydrolase * : triphosphatase * : CDP-diacylglycerol diphosphatase * : undecaprenyl-diphosphatase * : thiamine-triphosphatase * : bis(5'-adenosyl)-triphosphatase, bis(5′-adenosyl)-triphosphatase * EC 3.6.1.30: Now covered by [m⁷GpppX diphosphatase] and [m⁷GpppN-mRNA hydrolase]. * : phosphoribosyl-ATP diphosphatase * EC 3.6.1.32: Now , myosin ATPase * EC 3.6.1.33: Now , dynein ATPase * EC 3.6.1.34: Transferred entry: H⁺-transporting ATP synthase. Now , H⁺-transporting two-sector ATPase * EC 3.6.1.35: Now , H⁺-exporting ATPase * EC 3.6.1.36: Now , H⁺/K⁺-exchanging ATPase * EC 3.6.1.37: Now , Na⁺/K⁺-exchanging ATPase * EC 3.6.1.38: Now , Ca²⁺-transporting ATPase * : thymidine-triphosphatase * : guanosine-5'-triphosphate,3'-diphosphate diphosphatase, guanosine-5′-triphosphate,3′-diphosphate phosphatase * : bis(5'-nucleosyl)-tetraphosphatase (symmetrical), bis(5′-nucleosyl)-tetraphosphatase (symmetrical) * : guanosine-diphosphatase * : dolichyldiphosphatase * : oligosaccharide-diphosphodolichol diphosphatase * : UDP-sugar diphosphatase * EC 3.6.1.46: Now , heterotrimeric G-protein GTPase * EC 3.6.1.47: Now , protein-synthesizing GTPase * EC 3.6.1.49: Now , signal-recognition-particle GTPase * EC 3.6.1.50: Now , dynamin GTPase * EC 3.6.1.51: Now , tubulin GTPase * : diphosphoinositol-polyphosphate diphosphatase * : Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, Mn²⁺-dependent ADP-ribose/CDP-alcohol diphosphatase * : UDP-2,3-diacylglucosamine diphosphatase * : 8-oxo-dGTP diphosphatase * : 2-hydroxy-dATP diphosphatase * : UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase * : 8-oxo-dGDP phosphatase * : m7GpppX diphosphatase, 5′-(N⁷-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase * : diadenosine hexaphosphate hydrolase (AMP-forming) * : diadenosine hexaphosphate hydrolase (ATP-forming) * : m7GpppN-mRNA hydrolase, 5′-(N⁷-methylguanosine 5′-triphospho)-[mRNA] hydrolase * : alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase, α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase * : inosine diphosphate phosphatase * * : (d)CTP diphosphatase * * : XTP/dITP diphosphatase * * : dihydroneopterin triphosphate diphosphatase * * : geranyl diphosphate phosphohydrolase * * : 8-oxo-(d)GTP phosphatase * * : guanosine-5′-diphospho-5′- NAdiphosphatase * * : adenosine-5′-diphospho-5′- NAdiphosphatase * * : DNA-3′-diphospho-5′-guanosine diphosphatase * * : inosine/xanthosine triphosphatase * * : mRNA 5′-phosphatase * : *No Wikipedia article

3.6.2: In sulfonyl-containing anhydrides

* : adenylylsulfatase * : phosphoadenylylsulfatase

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances

* : phospholipid-translocating ATPase * EC 3.6.3.2: Now , P-type Mg²⁺ transporter * EC 3.6.3.3: Now , Cd²⁺-exporting ATPase * EC 3.6.3.4: Now , Cu²⁺-exporting ATPase * EC 3.6.3.5: Now , Zn²⁺-exporting ATPase * EC 3.6.3.6: Now , P-type H⁺-exporting transporter * EC 3.6.3.7: Now , P-type Na⁺ transporter * EC 3.6.3.8: Now , Ca²⁺-transporting ATPase * EC 3.6.3.9: Now , Na⁺/K⁺-exchanging ATPase * EC 3.6.3.10: Now , H⁺/K⁺-exchanging ATPase * EC 3.6.3.11: Cl^–-transporting ATPase. The activity was only ever studied in crude extracts, and is an artifact * EC 3.6.3.12: Now , K⁺-transporting ATPase * EC 3.6.3.13:Identical to , phospholipid-translocating ATPase * EC 3.6.3.14: Now , H⁺-transporting two-sector ATPase * EC 3.6.3.15: Now , Na⁺-transporting two-sector ATPase * EC 3.6.3.16: Now , arsenite-transporting ATPase * EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2 * EC 3.6.3.18: Now , ABC-type oligosaccharide transporter * EC 3.6.3.19: Now , ABC-type maltose transporter * EC 3.6.3.20: Now , glycerol-3-phosphate-transporting ATPase * EC 3.6.3.21: Now , ABC-type polar-amino-acid transporter * EC 3.6.3.22: Now , ABC-type nonpolar-amino-acid transporter * EC 3.6.3.23: Now , oligopeptide-transporting ATPase * EC 3.6.3.24: Now , nickel-transporting ATPase * EC 3.6.3.25: Now , sulfate-transporting ATPase * EC 3.6.3.26: Now , nitrate-transporting ATPase * EC 3.6.3.27: Now , ABC-type phosphate transporter * EC 3.6.3.28: Now , ABC-type phosphonate transporter * EC 3.6.3.29: Now , molybdate-transporting ATPase * EC 3.6.3.30: Now , Fe³⁺-transporting ATPase * EC 3.6.3.31: Now , polyamine-transporting ATPase * EC 3.6.3.32: Now , quaternary-amine-transporting ATPase * EC 3.6.3.33: Now , vitamin B₁₂-transporting ATPase * EC 3.6.3.34: now recognized to be at least three separate enzymes , iron(III) hydroxamate ABC transporter, , ferric enterobactin ABC transporter, and , ferric citrate ABC transporter * EC 3.6.3.35: Now , manganese-transporting ATPase * EC 3.6.3.36: Now , taurine-transporting ATPase * EC 3.6.3.37: Now , guanine-transporting ATPase * EC 3.6.3.38: Now , ABC-type capsular-polysaccharide transporter * EC 3.6.3.39: Now , lipopolysaccharide-transporting ATPase * EC 3.6.3.40: Now , teichoic-acid-transporting ATPase * EC 3.6.3.41: Now , heme-transporting ATPase * EC 3.6.3.42: Now , β-glucan-transporting ATPase * EC 3.6.3.43: Now , peptide-transporting ATPase * EC 3.6.3.44: Now , ABC-type xenobiotic transporter * EC 3.6.3.45: Now included with , xenobiotic-transporting ATPase * EC 3.6.3.46: Now , ABC-type Cd²⁺ transporter * EC 3.6.3.47: Now , fatty-acyl-CoA-transporting ATPase * EC 3.6.3.48: Now as α-factor-pheromone transporting ATPase * EC 3.6.3.49: Now , channel-conductance-controlling ATPase * EC 3.6.3.50: Now , protein-secreting ATPase * EC 3.6.3.51: Now , mitochondrial protein-transporting ATPase * EC 3.6.3.52: Now , chloroplast protein-transporting ATPase * EC 3.6.3.53: Now , Ag⁺-exporting ATPase * EC 3.6.3.54: Now , Cu⁺-exporting ATPase * EC 3.6.3.55: Now , tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement

* EC 3.6.4.1: Now , myosin ATPase * EC 3.6.4.2: Now , dynein ATPase * EC 3.6.4.3: Now , microtubule-severing ATPase * EC 3.6.4.4: Now , plus-end-directed kinesin ATPase * EC 3.6.4.5: Now , minus-end-directed kinesin ATPase * : vesicle-fusing ATPase * : peroxisome-assembly ATPase * EC 3.6.4.8: Now , proteasome ATPase * EC 3.6.4.9: Now , chaperonin ATPase * : non-chaperonin molecular chaperone ATPase * EC 3.6.4.11: Deleted, the activity has been shown not to take place * : DNA helicase * : RNA helicase

3.6.5: Acting on GTP to facilitate cellular and subcellular movement

* : heterotrimeric G-protein GTPase * : small monomeric GTPase * : protein-synthesizing GTPase * : signal-recognition-particle GTPase * : dynamin GTPase * : tubulin GTPase

EC 3.7: Acting on carbon-carbon bonds

EC 3.7.1: In ketonic substances

* : oxaloacetase * : fumarylacetoacetase * : kynureninase * : phloretin hydrolase * : acylpyruvate hydrolase * : acetylpyruvate hydrolase * : beta-diketone hydrolase, β-diketone hydrolase * : 2,6-dioxo-6-phenylhexa-3-enoate hydrolase * : 2-hydroxymuconate-semialdehyde hydrolase * : cyclohexane-1,3-dione hydrolase * : cyclohexane-1,2-dione hydrolase * : cobalt-precorrin 5A hydrolase * : 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase * : 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase * EC 3.7.1.15: Now , (+)-caryolan-1-ol synthase * EC 3.7.1.16: Now , oxepin-CoA hydrolase * : 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase * : 6-oxocamphor hydrolase * : 2,6-dihydroxypseudooxynicotine hydrolase * : 3-fumarylpyruvate hydrolase * : 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase * * : 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening) * : maleylpyruvate hydrolase * * : 2,4-diacetylphloroglucinol hydrolase * * : 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase * * : 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase * * : neryl diphosphate diphosphatase * * : 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase * : *No Wikipedia article

EC 3.8: Acting on halide bonds

EC 3.8.1: Acting on halide bonds

* EC 3.8.1.1: Covered by , haloalkane dehalogenase. * : 2-haloacid dehalogenase, (''S'')-2-haloacid dehalogenase * : haloacetate dehalogenase * EC 3.8.1.4: Now , thyroxine 5′-deiodinase * : haloalkane dehalogenase * : 4-chlorobenzoate dehalogenase * : 4-chlorobenzoyl-CoA dehalogenase * : atrazine chlorohydrolase * : (R)-2-haloacid dehalogenase, (''R'')-2-haloacid dehalogenase * : 2-haloacid dehalogenase (configuration-inverting) * : 2-haloacid dehalogenase (configuration-retaining)

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)

* EC 3.8.2.1: Now , diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)

* : phosphoamidase * : protein arginine phosphatase * * : phosphohistidine phosphatase * : *No Wikipedia article

EC 3.10: Acting on sulfur-nitrogen bonds

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

* : N-sulfoglucosamine sulfohydrolase, ''N''-sulfoglucosamine sulfohydrolase * : cyclamate sulfohydrolase

EC 3.11: Acting on carbon-phosphorus bonds

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)

* : phosphonoacetaldehyde hydrolase * : phosphonoacetate hydrolase * : phosphonopyruvate hydrolase

EC 3.12: Acting on sulfur-sulfur bonds

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)

* : trithionate hydrolase

EC 3.13: Acting on carbon-sulfur bonds

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)

* : UDP-sulfoquinovose synthase * EC 3.13.1.2: Deleted, the activity is most probably attributable to , ''S''-ribosylhomocysteine lyase * : 2'-hydroxybiphenyl-2-sulfinate desulfinase, 2′-hydroxybiphenyl-2-sulfinate desulfinase * : 3-sulfinopropanoyl-CoA desulfinase * * : carbon disulfide hydrolase * : [CysO sulfur-carrier protein]-''S''-L-cysteine hydrolase * * : Carbonyl sulfide hydrolase * : ''S''-adenosyl-L-methionine hydrolase (adenosine-forming * * : ''S''-inosyl-L-homocysteine hydrolase * : *No Wikipedia article

References

{{Reflist Hydrolases, * Biology-related lists, EC3