Snake Venom Factor V Activator
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Snake Venom Factor V Activator
Snake venom factor V activator () is an enzyme. This enzyme catalyses the following chemical reaction : Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn-Gly bond. This enzyme is present in venom of ''Daboia russelii Russell's viper (''Daboia russelii)'' is a species of highly venomous snake in the family Viperidae. The species is native to South Asia. It was described in 1797 by George Shaw and Frederick Polydore Nodder. It is named after Patrick Russell ...''. References External links * {{Portal bar, Biology, border=no EC 3.4.21 ...
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Enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecules known as product (chemistry), products. Almost all metabolism, metabolic processes in the cell (biology), cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme, pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts include Ribozyme, catalytic RNA molecules, also called ribozymes. They are sometimes descr ...
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Catalysis
Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quickly, very small amounts of catalyst often suffice; mixing, surface area, and temperature are important factors in reaction rate. Catalysts generally react with one or more reactants to form intermediates that subsequently give the final reaction product, in the process of regenerating the catalyst. The rate increase occurs because the catalyst allows the reaction to occur by an alternative mechanism which may be much faster than the noncatalyzed mechanism. However the noncatalyzed mechanism does remain possible, so that the total rate (catalyzed plus noncatalyzed) can only increase in the presence of the catalyst and never decrease. Catalysis may be classified as either homogeneous, whose components are dispersed in the same phase (usual ...
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Chemical Reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, energy change as new products are generated. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the Atomic nucleus, nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive Chemical element, elements where both electronic and nuclear changes can occur. The substance (or substances) initially involved in a chemical reaction are called reagent, reactants or reagents. Chemical reactions are usually characterized by a chemical change, and they yield one or more Product (c ...
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Clotting Factor
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation begins almost instantly after an injury to the endothelium that lines a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called ''primary hemostasis. Secondary hemostasis'' occurs simultaneously: additional coagulation factors beyond factor VII ( listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug. Coagulation is high ...
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Venom
Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved ''venom apparatus'', such as fangs or a stinger, in a process called ''envenomation''. Venom is often distinguished from ''poison'', which is a toxin that is passively delivered by being ingested, inhaled, or absorbed through the skin, and ''toxungen'', which is actively transferred to the external surface of another animal via a physical delivery mechanism. Venom has evolved in terrestrial and marine environments and in a wide variety of animals: both predators and prey, and both vertebrates and invertebrates. Venoms kill through the action of at least four major classes of toxin, namely necrosis, necrotoxins and cytotoxins, which kill cells; neurotoxins, which affect nervous systems; myotoxins, which damage muscles; and Hemotoxin, haemotoxins, which disrupt Thrombus, blood clotti ...
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Daboia Russelii
Russell's viper (''Daboia russelii)'' is a species of highly venomous snake in the family Viperidae. The species is native to South Asia. It was described in 1797 by George Shaw and Frederick Polydore Nodder. It is named after Patrick Russell. Known for its extremely painful bite, it is considered one of the most dangerous big four snakes in India. Taxonomy English naturalist George Shaw—with illustrator Frederick Polydore Nodder—in ''The Naturalist's Miscellany: Or, Coloured Figures Of Natural Objects; Drawn and Described Immediately From Nature'' formally described the species in 1797 as ''Coluber russelii'', from a specimen presented to the British Museum by Scottish herpetologist Patrick Russell. Russell had written of the species in his 1796 work ''An account of Indian serpents, collected on the coast of Coromandel'', confirming its highly venomous nature by experimenting on chickens and dogs. He added the native people called it ''katuka retula poda''. Analysis ...
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