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Inositol-phosphate Phosphatase
The enzyme Inositol phosphate-phosphatase (EC 3.1.3.25) is of the phosphodiesterase family of enzymes. It is involved in the phosphophatidylinositol signaling pathway, which affects a wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing. Inhibition of inositol monophosphatase may be key in the action of lithium in treating bipolar disorder, specifically manic depression. The catalyzed reaction: :''myo''-inositol phosphate + H2O \rightleftharpoons ''myo''-inositol + phosphate Nomenclature This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is ''myo''-inositol-phosphate phosphohydrolase. Other names in common use include: * ''myo''-inositol-1(or 4)-monophosphatase, * inositol 1-phosphatase, * L-''myo''-inositol-1-phosphate phosphatase, * ''myo''-inositol 1-phosphatase, * inositol phosphatase, * inositol monophosphate phosphatase, * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inositol Monophosphatase 1
Inositol monophosphatase 1 is an enzyme that in humans is encoded by the ''IMPA1'' gene. Structure Inositol monophosphatase 1 (IMPA1) is a homodimeric enzyme with each subunit consisting of approximately 277 amino acids and a molecular weight of ~30 kDa. The protein adopts a penta-layered αβαβα core structure, characteristic of the metallophosphatase superfamily, which is also observed in related enzymes like fructose 1,6-bisphosphatase. Each monomer's active site contains three magnesium ions arranged in an octahedral coordination geometry, bound by conserved residues including Glu70, Asp90, Asp93, and Asp220. Structural studies using X-ray crystallography (e.g., PDB entries 1IMA, 1IMB) reveal that the dimeric arrangement facilitates substrate recognition and catalysis. The enzyme features an Inositol_P domain (Pfam: PF00459), which mediates its magnesium-dependent phosphatase activity and interaction with substrates like myo-inositol monophosphate. These structural feat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |