List Of Dog Diseases
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This list of dog diseases is a selection of diseases and other conditions found in the
dog The dog (''Canis familiaris'' or ''Canis lupus familiaris'') is a domesticated descendant of the gray wolf. Also called the domestic dog, it was selectively bred from a population of wolves during the Late Pleistocene by hunter-gatherers. ...
. Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. Not all of the articles listed here contain information specific to dogs. Articles with non-dog information are marked with an asterisk (*).


Infectious diseases


Viral infections

*
Rabies Rabies is a viral disease that causes encephalitis in humans and other mammals. It was historically referred to as hydrophobia ("fear of water") because its victims panic when offered liquids to drink. Early symptoms can include fever and abn ...
(hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a
zoonotic A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a virus, bacterium, parasite, fungi, or prion) that can jump from a non-human vertebrate to a human. When h ...
concern. Vaccination of dogs for rabies is commonly required by law. Please see the article
dog health The health of dogs is a well studied area in veterinary medicine. Dog health is viewed holistically; it encompasses many different aspects, including disease processes, genetics, and nutritional health, for example. Infectious diseases that aff ...
for information on this disease in dogs. *
Canine parvovirus Canine parvovirus (also referred to as CPV, CPV2, or parvo) is a contagious virus mainly affecting dogs and wolves. CPV is highly contagious and is spread from dog to dog by direct or indirect contact with their feces. Vaccines can prevent thi ...
is a sometimes fatal gastrointestinal infection that mainly affects puppies. It occurs worldwide. *
Canine coronavirus Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species ''Alphacoronavirus suis''. It causes a highly contagious intestinal disease worldwide in dogs. The infecting virus enters it ...
is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. The signs are worse in puppies. *
Canine distemper Canine distemper (CDV) (sometimes termed "footpad disease") is a viral disease that affects a wide variety of mammal families, including domestic and wild species of dogs, coyotes, foxes, pandas, wolves, ferrets, skunks, raccoons, and felin ...
is an often fatal infectious disease that mainly has respiratory and neurological signs. *
Canine influenza Canine influenza (dog flu) is influenza occurring in canine animals. Canine influenza is caused by varieties of influenzavirus A, such as equine influenza virus H3N8, which was discovered to cause disease in canines in 2004. Because of the ...
is a newly emerging infectious respiratory disease. Up to 80 percent of dogs infected will have symptoms, but the mortality rate is only 5 to 8 percent. * Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. * Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. * Pseudorabies (Morbus Aujeszky) is an infectious disease that primarily affects swine, but can also cause a fatal disease in dogs with signs similar to rabies. * Canine minute virus is an infectious disease that can cause respiratory and gastrointestinal signs in young puppies.


Bacterial infections

*
Brucellosis Brucellosis is a zoonosis spread primarily via ingestion of raw milk, unpasteurized milk from infected animals. It is also known as undulant fever, Malta fever, and Mediterranean fever. The bacteria causing this disease, ''Brucella'', are small ...
is a sexually transmitted
bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...
l disease that can cause
uveitis Uveitis () is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and ...
, abortion, and
orchitis Orchitis is inflammation of the testicles. It can also involve swelling, pains, and frequent infection, particularly of the epididymis, as in epididymitis. The term is from the Ancient Greek ὄρχις meaning "testicle"; same root as ''orchid ...
in dogs. *
Leptospirosis Leptospirosis is a blood infection caused by the bacterium ''Leptospira'' that can infect humans, dogs, rodents and many other wild and domesticated animals. Signs and symptoms can range from none to mild (headaches, Myalgia, muscle pains, a ...
is an infectious disease caused by a
spirochaete A spirochaete () or spirochete is a member of the phylum Spirochaetota (also called Spirochaetes ), which contains distinctive diderm (double-membrane) Gram-negative bacteria, most of which have long, helically coiled (corkscrew-shaped or ...
. Symptoms include liver and kidney failure and
vasculitis Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both artery, arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. Vasculitis is primarily c ...
. *
Lyme disease Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of ''Borrelia'' bacteria, Disease vector, transmitted by blood-feeding ticks in the genus ''Ixodes''. It is the most common disease spread by ticks in th ...
* is a disease caused by ''
Borrelia burgdorferi ''Borrelia burgdorferi'' is a bacterial species of the spirochete class in the genus '' Borrelia'', and is one of the causative agents of Lyme disease in humans. Along with a few similar genospecies, some of which also cause Lyme disease, it m ...
'', a
spirochaete A spirochaete () or spirochete is a member of the phylum Spirochaetota (also called Spirochaetes ), which contains distinctive diderm (double-membrane) Gram-negative bacteria, most of which have long, helically coiled (corkscrew-shaped or ...
, and spread by ticks of the genus ''
Ixodes ''Ixodes'' is a genus of hard-bodied ticks (family Ixodidae). It includes important disease vectors of animals and humans ( tick-borne disease), and some species (notably '' Ixodes holocyclus'') inject toxins that can cause paralysis. Som ...
''. Symptoms in dogs include acute arthritis, anorexia and lethargy. There is no rash as is typically seen in humans. * Ehrlichiosis is a disease caused by '' Ehrlichia canis'' and spread by the brown dog tick, ''
Rhipicephalus sanguineus ''Rhipicephalus sanguineus'', commonly called the brown dog tick, kennel tick, or pantropical dog tick, is a species of tick found worldwide, but more commonly in warmer climates. This species is unusual among ticks in that its entire biological ...
''. Signs include fever, vasculitis, and low blood counts. *
Rocky Mountain spotted fever Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a fever and headache, which is followed a few days later with the development of a rash. The rash is generally Petechial rash, made up of small s ...
* is a
rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The genus was n ...
l disease that occurs in dogs and humans. It is caused by ''
Rickettsia rickettsii ''Rickettsia rickettsii'' is a Gram-negative, intracellular, cocco-bacillus bacterium that was first discovered in 1902. Having a reduced genome, the bacterium harvests nutrients from its host cell to carry out respiration, making it an organo ...
'' and spread by ticks of the genus ''
Dermacentor ''Dermacentor'' is a genus of ticks in the family Ixodidae, the hard ticks. The genus has a cosmopolitan distribution, with native species on all continents except Australia. Most are found in North America. Hosts of ''Dermacentor'' ticks inclu ...
''. Signs are similar to human disease, including anorexia, fever, and
thrombocytopenia In hematology, thrombocytopenia is a condition characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive bleeding. It is the most common coag ...
. *''
Clostridium ''Clostridium'' is a genus of anaerobic, Gram-positive bacteria. Species of ''Clostridium'' inhabit soils and the intestinal tracts of animals, including humans. This genus includes several significant human pathogens, including the causative ...
'' species can cause diarrhea in dogs. Associated species include '' C. perfringens'' and ''
Clostridioides difficile ''Clostridioides difficile'' ( syn. ''Clostridium difficile'') is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. It is known also as ''C. difficile'', or ''C. diff'' (), and is a Gram-positive spec ...
''. * Kennel cough is an infectious respiratory disease that can be caused by one of several viruses or by '' Bordetella bronchiseptica''. It most commonly occurs in dogs in close confinement such as in kennels.


Fungal infections

*
Blastomycosis Blastomycosis, also known as Gilchrist's disease, is a fungal infection, typically of the lungs, which can spread to brain, stomach, intestine and skin, where it appears as crusting purplish warty plaques with a roundish bumpy edge and central ...
* is a
fungal A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as one of the tradit ...
disease caused by ''
Blastomyces dermatitidis ''Blastomyces dermatitidis'' is a dimorphic fungus that causes blastomycosis, an invasive and often serious fungal infection found occasionally in humans and other animals. It lives in soil and wet, decaying wood, often in an area close to a wa ...
'' that affects both dogs and humans. Dogs are ten times more likely to be infected than humans. The disease in dogs can affect the eyes, brain, lungs, skin, or bones. *
Histoplasmosis Histoplasmosis is a fungal infection caused by ''Histoplasma capsulatum''. Symptoms of this infection vary greatly, but the disease affects primarily the lungs. Occasionally, other organs are affected; called disseminated histoplasmosis, it can ...
* is a fungal disease caused by ''
Histoplasma capsulatum ''Histoplasma capsulatum'' is a species of dimorphic fungus. Its sexual form is called ''Ajellomyces capsulatus''. It can cause pulmonary and disseminated histoplasmosis. ''Histoplasma capsulatum'' is "distributed worldwide, except in Antarc ...
'' that affects both dogs and humans. The disease in dogs usually affects the lungs and small intestine. *
Coccidioidomycosis Coccidioidomycosis (, ) is a mammalian mycosis, fungal disease caused by ''Coccidioides immitis'' or ''Coccidioides posadasii''. It is commonly known as cocci, Valley fever, California fever, desert rheumatism, or San Joaquin Valley fever. Cocci ...
* is a fungal disease caused by ''
Coccidioides immitis ''Coccidioides immitis'' is a pathogenic fungus that resides in the soil in certain parts of the southwestern United States, northern Mexico, and a few other areas in the Western Hemisphere. Epidemiology ''C. immitis'', along with its relativ ...
'' or '' Coccidioides posadasii'' that affects a variety of species, including dogs. In dogs signs of primary pulmonary disease include a cough, fever, weight loss, anorexia, and lethargy. Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. Diagnosis of Valley Fever may include multiple tests, including serology and radiology. According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. There is an increased risk of infection associated with amount of time spent outdoors, a larger roaming space accessed by the dog, and increasing age. *
Cryptococcosis Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and in the brain, where it appears as a meningitis. Coughing, difficulty breathing, chest pain and fever are seen when the lungs are infect ...
* is a fungal disease caused by ''
Cryptococcus neoformans ''Cryptococcus neoformans'' is an encapsulated basidiomycetous yeast belonging to the class Tremellomycetes and an obligate aerobe that can live in both plants and animals. Its teleomorph is a filamentous fungus, formerly referred to ''Filob ...
'' that affects both dogs and humans. It is a rare disease in dogs, with cats seven to ten times more likely to be infected. The disease in dogs can affect the lungs and skin, but more commonly the eye and central nervous system. *
Ringworm Dermatophytosis, also known as tinea and ringworm, is a mycosis, fungal infection of the skin (a dermatomycosis), that may affect skin, hair, and nails. Typically it results in a red, itchy, scaly, circular rash. Hair loss may occur in the a ...
is a fungal skin disease that in dogs is caused by ''
Microsporum canis ''Microsporum canis'' is a pathogenic, asexual fungus in the phylum Ascomycota that infects the upper, dead layers of skin on domesticated cats, and occasionally dogs and humans. The species has a worldwide distribution. Taxonomy and evolution ...
'' (70%), ''
Microsporum gypseum ''Microsporum gypseum'' is a soil-associated dermatophyte that occasionally is known to colonise and infect the upper dead layers of the skin of mammals. The name refers to an asexual "form-taxon" that has been associated with four related biol ...
'' (20%), and ''
Trichophyton mentagrophytes ''Trichophyton mentagrophytes'' is a species in the fungal genus '' Trichophyton''. It is one of three common fungi which cause ringworm in companion animals. It is also the second-most commonly isolated fungus causing tinea infections in human ...
'' (10%). Typical signs in dogs include hair loss and scaly skin. * Sporotrichosis is a fungal disease caused by '' Sporothrix schenckii'' that affects both dogs and humans. It is a rare disease in dogs, with cat and horse infections predominating in veterinary medicine. The disease in dogs is usually nodular skin lesions of the head and trunk. *
Aspergillosis Aspergillosis is a fungal infection of usually the lungs, caused by the genus ''Aspergillus'', a common mold that is breathed in frequently from the air, but does not usually affect most people. It generally occurs in people with lung diseases su ...
* is a fungal disease that in dogs is caused primarily by ''
Aspergillus fumigatus ''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in ...
''. Infection is usually in the nasal cavity. Typical signs in dogs include sneezing, nasal discharge, bleeding from the nose, and ulcerations of the nose. *
Pythiosis Pythiosis is a rare and deadly tropical disease caused by the oomycete '' Pythium insidiosum''. Long regarded as being caused by a fungus, the causative agent was not discovered until 1987. It occurs most commonly in horses, dogs, and humans, wit ...
is a disease caused by a water mould of the genus ''
Pythium ''Pythium'' is a genus of parasitic oomycetes. They were formerly classified as fungi. Most species are plant parasites, but '' Pythium insidiosum'' is an important pathogen of animals, causing pythiosis. The feet of the fungus gnat are fre ...
'', '' P. insidiosum''. It occurs primarily in dogs and horses, but can also affect humans. In dogs it affects the gastrointestinal system and lymph nodes, and rarely the skin. *
Mucormycosis Mucormycosis, also known as black fungus, is a severe fungal infection that comes under fulminant fungal sinusitis, usually in people who are immunocompromised. It is curable only when diagnosed early. Symptoms depend on where in the body the ...
is a collection of fungal and mold diseases in dogs including pythiosis, zygomycosis, and lagenidiosis that affect the gastrointestinal tract and skin.


Protozoal diseases

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Giardiasis Giardiasis is a parasitic disease caused by the protist enteropathogen ''Giardia duodenalis'' (also known as ''G. lamblia'' and ''G. intestinalis''), especially common in children and travellers. Infected individuals experience steatorrhea, a typ ...
* is an intestinal infection in dogs caused by the
protozoa Protozoa (: protozoan or protozoon; alternative plural: protozoans) are a polyphyletic group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic debris. Historically ...
''
Giardia lamblia ''Giardia duodenalis'', also known as ''Giardia intestinalis'' and ''Giardia lamblia'', is a flagellated Parasitism, parasitic protozoan microorganism of the genus ''Giardia'' that colonizes the small intestine, causing a diarrheal condition kn ...
''. The most common symptom is diarrhea. The
zoonotic A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a virus, bacterium, parasite, fungi, or prion) that can jump from a non-human vertebrate to a human. When h ...
potential of giardiasis is controversial. *
Coccidiosis Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody ...
can be caused by a variety of coccidian organisms in dogs, most commonly '' Isospora''. There are usually no symptoms, but diarrhea and weight loss may occur. *
Leishmaniasis Leishmaniasis is a wide array of clinical manifestations caused by protozoal parasites of the Trypanosomatida genus ''Leishmania''. It is generally spread through the bite of Phlebotominae, phlebotomine Sandfly, sandflies, ''Phlebotomus'' an ...
* is spread by the
sandfly Sandfly or sand fly is a colloquial name for any species or genus of flying, biting, blood-sucking dipteran (fly) encountered in sandy areas. In the United States, ''sandfly'' may refer to certain horse flies that are also known as "greenhea ...
, and in the dog as well as human has both cutaneous and visceral forms. The dog is considered to be the reservoir for human disease in the Americas. *
Babesiosis Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic parasite in the order Piroplasmida, typically a ''Babesia'' or '' Theileria'', in the phylum Apicomplexa. Human babesiosis transmission via ...
* is spread by members of the family
Ixodidae The Ixodidae are the family of hard ticks or scale ticks, one of the three families of ticks, consisting of 771 species, . They are known as 'hard ticks' because they have a scutum or hard shield, which the other major family of ticks, the 'sof ...
, or hard ticks. The two species of the genus ''
Babesia ''Babesia'', also called ''Nuttallia'', is an apicomplexan parasite that infects red blood cells and is transmitted by ticks. Originally discovered by Romanian bacteriologist Victor Babeș in 1888; over 100 species of ''Babesia'' have since ...
'' that affect dogs are '' B. canis'' and '' B. gibsoni''. Babesiosis can cause
hemolytic anemia Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). This most commonl ...
in dogs. * Neosporosis* is caused by '' Neospora caninum'' * Protothecosis in dogs is caused by a mutant form of
green algae The green algae (: green alga) are a group of chlorophyll-containing autotrophic eukaryotes consisting of the phylum Prasinodermophyta and its unnamed sister group that contains the Chlorophyta and Charophyta/ Streptophyta. The land plants ...
and is usually disseminated. Symptoms include weight loss,
uveitis Uveitis () is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and ...
,
retinal detachment Retinal detachment is a condition where the retina pulls away from the tissue underneath it. It may start in a small area, but without quick treatment, it can spread across the entire retina, leading to serious vision loss and possibly blindness. ...
, and anal seepage.


Parasites


Internal parasites (endoparasites)

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Trichinosis Trichinosis, also known as trichinellosis, is a parasitic disease caused by roundworms of the '' Trichinella'' genus. During the initial infection, invasion of the intestines can result in diarrhea, abdominal pain, and vomiting. Migration of ...
caused by ''
Trichinella spiralis ''Trichinella spiralis'' is a viviparous nematode parasite, occurring in rodents, pigs, bears, hyenas and humans, and is responsible for the disease trichinosis. It is sometimes referred to as the "pork worm" due to it being typically encount ...
'', '' T. britovi''. *
Echinococcosis Echinococcosis is a parasitic disease caused by tapeworms of the ''Echinococcus'' type. The two main types of the disease are ''cystic echinococcosis'' and ''alveolar echinococcosis''. Less common forms include ''polycystic echinococcosis'' an ...
is an infectious disease infecting dogs and sheep. *
Heartworm ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a parasitic roundworm that is a type of filarial worm, a small thread-like worm, and which causes dirofilariasis. It is spread from host to host through the bites of mosqui ...
disease is caused by ''
Dirofilaria immitis ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a Parasitism, parasitic Nematode, roundworm that is a type of Filarioidea, filarial worm, a small thread-like worm, and which causes dirofilariasis. It is spread from host (bi ...
'', which uses the mosquito as its vector. Heartworms live in the pulmonary artery and right ventricle of the heart. Heartworm disease in dogs is spread by mosquitoes that harbor the parasite Dirofilaria immitis. Signs include cough, difficulty breathing, and death.  * Gnathostomiasis is a disease from mammal feces and undercooked seafood. *Intestinal
parasites Parasitism is a close relationship between species, where one organism, the parasite, lives (at least some of the time) on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The en ...
**
Hookworm Hookworms are Gastrointestinal tract, intestinal, Hematophagy, blood-feeding, parasitic Nematode, roundworms that cause types of infection known as helminthiases. Hookworm infection is found in many parts of the world, and is common in areas with ...
s* are a common parasite of dogs. The most common is '' Ancylostoma caninum'', followed by ''
Uncinaria stenocephala ''Uncinaria stenocephala'' is a nematode that parasitizes dogs, cats, and foxes, as well as humans. It is rare to find in cats in the United States. ''U. stenocephala'' is the most common canine hookworm in cooler regions, such as Canada and th ...
'' and '' A. braziliense''. Signs include diarrhea, vomiting, and weight loss. **
Tapeworm Eucestoda, commonly referred to as tapeworms, is the larger of the two subclasses of flatworms in the class Cestoda (the other subclass being Cestodaria). Larvae have six posterior hooks on the scolex (head), in contrast to the ten-hooked Ce ...
s* are also common and in the dog are usually '' Dipylidium caninum'', which is spread by ingesting
flea Flea, the common name for the order (biology), order Siphonaptera, includes 2,500 species of small flightless insects that live as external parasites of mammals and birds. Fleas live by hematophagy, ingesting the blood of their hosts. Adult f ...
s and
lice Louse (: lice) is the common name for any member of the infraorder Phthiraptera, which contains nearly 5,000 species of wingless parasitic insects. Phthiraptera was previously recognized as an order, until a 2021 genetic study determined th ...
. Also common is '' Taenia pisiformis'', spread by ingesting rabbits and rodents. Rare tapeworm infections are caused by species of the genera ''
Echinococcus ''Echinococcus'' is a genus within Cestoda, a parasitic class of the platyhelminthes phylum (colloquially known as flatworms). Human echinococcosis is an infectious disease caused by the following species: '' E. granulosus'', '' E. multilocul ...
'', '' Mesocestoides'', and '' Spirometra''. There are usually no symptoms. **
Toxocariasis Toxocariasis is an illness of humans caused by the dog roundworm ('' Toxocara canis'') and, less frequently, the cat roundworm ('' Toxocara cati'').https://academic.oup.com/ajcp/article/142/suppl_1/A104/1771175 Eosinophilic Pseudoleukemia Due to ...
is an infection of '' Toxocara canis'' or '' Toxascaris leonina''. Signs are usually mild, but may include diarrhea, pot-bellied appearance, poor growth, and vomiting. **
Whipworms ''Trichuris trichiura, Trichocephalus trichiuris'' or whipworm, is a parasitic roundworm (a type of helminth) that causes trichuriasis (a type of helminthiasis which is one of the neglected tropical diseases) when it infects a human large inte ...
are parasites that live in the cecum and large intestine. The canine whipworm is '' Trichuris vulpis''.


External parasites (ectoparasites)

*
Flea Flea, the common name for the order (biology), order Siphonaptera, includes 2,500 species of small flightless insects that live as external parasites of mammals and birds. Fleas live by hematophagy, ingesting the blood of their hosts. Adult f ...
s* cause itching and hair loss. The most common flea in dogs is the
cat flea The cat flea (scientific name ''Ctenocephalides felis'') is an extremely common parasitic insect whose principal host is the cat, domestic cat, although a high proportion of the fleas found on dogs also belong to this species. This is despite the ...
, ''
Ctenocephalides felis The cat flea (scientific name ''Ctenocephalides felis'') is an extremely common parasitic insect whose principal host is the domestic cat, although a high proportion of the fleas found on dogs also belong to this species. This is despite the wide ...
'', followed by the
dog flea The dog flea (''Ctenocephalides canis'') is a species of flea that lives as an ectoparasite on a wide variety of mammals, particularly the domestic dog and cat. It closely resembles the cat flea, ''Ctenocephalides felis'', which can live on a wid ...
, '' C. canis''. *
Tick Ticks are parasitic arachnids of the order Ixodida. They are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, and species, but can become larger when engorged. Ticks a ...
s* are an external parasite of the dog and can spread diseases such as
Lyme disease Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of ''Borrelia'' bacteria, Disease vector, transmitted by blood-feeding ticks in the genus ''Ixodes''. It is the most common disease spread by ticks in th ...
,
Rocky Mountain spotted fever Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a fever and headache, which is followed a few days later with the development of a rash. The rash is generally Petechial rash, made up of small s ...
,
babesiosis Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic parasite in the order Piroplasmida, typically a ''Babesia'' or '' Theileria'', in the phylum Apicomplexa. Human babesiosis transmission via ...
, and ehrlichiosis. They can also cause a neurological disorder known as
tick paralysis Tick paralysis is a type of paralysis caused by specific types of ticks. Unlike tick-borne diseases caused by infectious organisms, the illness is caused by a neurotoxin produced in the tick's salivary gland. After prolonged attachment, the en ...
. * *
Mite Mites are small arachnids (eight-legged arthropods) of two large orders, the Acariformes and the Parasitiformes, which were historically grouped together in the subclass Acari. However, most recent genetic analyses do not recover the two as eac ...
s **
Ear mite Ear mites are mites that live in the ears of animals. The most commonly seen species in veterinary medicine is '' Otodectes cynotis'' (Gk. ''oto''=ear, ''dectes''=biter, ''cynotis''=of the dog). This species, despite its name, is also responsibl ...
s are microscopic members of the species '' Otodectes cynotis''. Symptoms include itching, inflammation, and black debris in the ear. ** Cheyletiellosis is a mild pruritic skin disease caused by '' Cheyletiella yasguri''. Humans can be transiently infected. **
Chiggers ''Trombicula'', known as chiggers, red bugs, scrub-itch mites, or berry bugs, are small arachnids (eight-legged arthropods) in the Trombiculidae family. In their larval stage, they attach to various animals and humans, then feed on skin, often ...
*, also known as harvest mites, can cause itching, redness and crusting of the skin. **
Demodicosis Demodicosis , also called Demodex folliculitis in humans and demodectic mange () or red mange in animals, is caused by a sensitivity to and overpopulation of ''Demodex'' as the host's immune system is unable to keep the mites under control. '' ...
, also known as demodectic mange, is caused by ''
Demodex canis ''Demodex'' is a genus of tiny mites that live in or near hair follicles of mammals. Around 65 species of ''Demodex'' are known. Two species live on humans: ''Demodex folliculorum'' and ''Demodex brevis'', both frequently referred to as eyelash ...
'' mites which live in small numbers in sebaceous glands and hair follicles. These mites can cause inflammation and hair loss, and may also lead to secondary bacterial infections such as fever, lethargy, and enlarged lymph nodes. ** Sarcoptic mange is caused by '' Sarcoptes scabiei canis''. Signs include intense itching and scaling, and is contagious to humans.


Diseases and disorders by system


Skeletal and muscular disorders

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Osteoarthritis Osteoarthritis is a type of degenerative joint disease that results from breakdown of articular cartilage, joint cartilage and underlying bone. A form of arthritis, it is believed to be the fourth leading cause of disability in the world, affect ...
*, also known as degenerative arthritis, is a common condition in dogs characterized by progressive deterioration of articular cartilage in the joints of the limbs. It can cause a great deal of pain and lameness. Treatment options include medications such as
NSAID Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...
s,
corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...
s, and joint fluid modifiers such as
glycosaminoglycan Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units). The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case o ...
s. Other treatments include surgery, massage, warm compresses, chiropractic, and acupuncture. * Hip dysplasia is an inherited disease in dogs that is characterized by abnormal development of the
acetabulum The acetabulum (; : acetabula), also called the cotyloid cavity, is a wikt:concave, concave surface of the pelvis. The femur head, head of the femur meets with the pelvis at the acetabulum, forming the Hip#Articulation, hip joint. Structure The ...
and head of the
femur The femur (; : femurs or femora ), or thigh bone is the only long bone, bone in the thigh — the region of the lower limb between the hip and the knee. In many quadrupeds, four-legged animals the femur is the upper bone of the hindleg. The Femo ...
. It is more common in large breeds. *
Elbow dysplasia Elbow dysplasia is a condition involving multiple developmental abnormalities of the elbow-joint in the dog, specifically the growth of cartilage or the structures surrounding it. These abnormalities, known as 'primary lesions', give rise to oste ...
is a condition found more commonly in large breeds. It incorporates several different hereditary conditions of the elbow, including osteochondritis of the medial condyle of the
humerus The humerus (; : humeri) is a long bone in the arm that runs from the shoulder to the elbow. It connects the scapula and the two bones of the lower arm, the radius (bone), radius and ulna, and consists of three sections. The humeral upper extrem ...
, fragmentation of the medial coronoid process of the ulna, and ununited anconeal process of the ulna. *
Luxating patella A luxating patella, sometimes called a trick knee, is a condition in which the patella, or kneecap, dislocates or moves out of its normal location. It can be associated with damage to the anterior cruciate ligament. Patellar luxation is a common ...
is a medial or lateral displacement of the patella, or kneecap. It is strongly suspected to be inherited, but can also result from trauma. It is more common in smaller breeds of dog

*
Osteochondritis dissecans Osteochondritis dissecans (OCD or OD) is a joint disorder primarily of the subchondral bone in which cracks form in the articular cartilage and the underlying subchondral bone. OCD usually causes pain during and after sports. In later stages o ...
(OCD) is separation of immature articular cartilage from underlying bone. It is caused by osteochondrosis, which is characterized by abnormal endochondral ossification of epiphyseal cartilage. It is most commonly seen in the stifle, elbow, shoulder, and hock. *
Panosteitis Panosteitis, sometimes shortened to pano among breeders, is an occasionally seen long bone condition in large breed dogs. Pan (means all or entire) oste (refers to bone) and itis (signifies inflammation). It manifests with sudden, unexplained pain ...
is a common disease of unknown cause that causes pain and a shifting leg lameness in medium and large breed dogs. It affects the long bones of the hind and forelimbs. * Legg–Calvé–Perthes syndrome, also known as Perthes disease or avascular necrosis of the femoral head, is characterized by a deformity of the head of the femur and hip pain. It occurs in small-breed puppies. *
Back pain Back pain (Latin: ''dorsalgia'') is pain felt in the back. It may be classified as neck pain (cervical), middle back pain (thoracic), lower back pain (lumbar) or coccydynia (tailbone or sacral pain) based on the segment affected. The lumbar area ...
* in dogs, particularly in long-backed breeds, such as
Basset Hound The Basset Hound is a short-legged breed of scent hound. The Basset Hound was developed in Great Britain from several now-extinct strains of France, French basset breeds. It was bred primarily for hunting rabbit and hare on foot, moving slowly en ...
s and
Dachshund The dachshund ( or ; German: 'badger dog'), also known as the wiener dog or sausage dog, badger dog, doxen and doxie, is a short-legged, long-bodied, hound-type dog breed. The dog may be smooth-haired, wire-haired, or long-haired, with varie ...
s, is usually caused by intervertebral disk disease. It is caused by degeneration and protrusion of the disk and compression of the spinal cord. It occurs most commonly in the cervical and thoracolumbar regions. Signs include back pain, hind limb weakness, and paralysis. * Congenital vertebral anomalies, including butterfly, block, and transitional vertebrae, and hemivertebrae, are a collection of malformations of the spine in animals. Most are not clinically significant, but they can cause compression of the spinal cord by deforming the vertebral canal or causing instability. * Craniomandibular osteopathy is a hereditary disease in
West Highland White Terrier The West Highland White Terrier (commonly shortened to Westie) is a dog breed, breed of dog from Scotland with a distinctive white harsh coat and somewhat soft white undercoat. It is a medium-sized terrier, though with longer legs than other ...
s and also occurs in other terrier breeds. It is a developmental disease in puppies causing extensive bony changes in the mandible and skull. Signs include pain upon opening the mouth. * Hypertrophic osteopathy is a bone disease secondary to disease in the lungs. It is characterized by new bone formation on the outside of the long bones. * Hypertrophic osteodystrophy is a bone disease in rapidly growing large breed dogs. Signs include swelling of the
metaphysis The metaphysis (: metaphyses) is the neck portion of a long bone between the epiphysis and the diaphysis. It contains the growth plate, the part of the bone that grows during childhood, and as it grows it ossifies near the diaphysis and the ep ...
(the part of the bone adjacent to the joint), pain, depression, loss of appetite, and fever. The disease is usually bilateral in the limb bones. *
Spondylosis Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense, it refers to spinal osteoarthritis, the age-related degeneration of the spinal column, which is the most common cause of spondylosis. The degener ...
*, known as spondylosis deformans in dogs, is growth of
osteophyte Osteophytes are Exostosis, exostoses (bony projections) that form along joint margins. They are distinct from enthesophytes, which are bone, bony projections that form at the attachment of a tendon or ligament. Osteophytes are not always distingui ...
s on the ventral and lateral surfaces of the vertebral bodies. It is usually an incidental finding on radiographs and rarely causes symptoms. * Masticatory muscle myositis (MMM) is an inflammatory disease in dogs affecting the muscles of the jaw. Signs include swelling of the jaw muscles and pain on opening the mouth. In chronic MMM there is atrophy of the jaw muscles, and scarring of the masticatory muscles due to fibrosis may result in inability to open the mouth (trismus).


Cardiovascular and circulatory

*
Platelet Platelets or thrombocytes () are a part of blood whose function (along with the coagulation#Coagulation factors, coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a thrombus, blood clot. Platelets have no ...
disorders **
von Willebrand disease Von Willebrand disease (VWD) is the most common heredity, hereditary coagulopathy, blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. It arises from a deficiency in the quality or quantity of ...
* is a common inherited disease in dogs caused by a deficiency of a protein called
von Willebrand factor Von Willebrand factor (VWF) () is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thro ...
, which is involved in blood clotting. The disease varies from mild to severe, depending on the amount of von Willebrand factor present in the dog. Signs include spontaneous bleeding and excessive bleeding following surgery, injury, or during an
estrous cycle The estrous cycle (, originally ) is a set of recurring physiological changes induced by reproductive hormones in females of mammalian subclass Theria. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phase ...
. **
Thrombocytopenia In hematology, thrombocytopenia is a condition characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive bleeding. It is the most common coag ...
* is a common condition in dogs characterized by low
platelet Platelets or thrombocytes () are a part of blood whose function (along with the coagulation#Coagulation factors, coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a thrombus, blood clot. Platelets have no ...
counts. Platelets are used in clotting the blood, so dogs with this condition may have spontaneous bleeding or prolonged bleeding following surgery, injury, or during an
estrous cycle The estrous cycle (, originally ) is a set of recurring physiological changes induced by reproductive hormones in females of mammalian subclass Theria. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phase ...
. Causes include some
rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The genus was n ...
l infections such as ehrlichiosis, cancers such as
hemangiosarcoma Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans (vinyl chloride toxicity). It is a sarcoma arising from the lining of blood vessels; ...
, or immune-mediated disease. **
Thrombocytosis In hematology, thrombocythemia is a condition of high platelet (thrombocyte) count in the blood. Normal count is in the range of 150 to 450 platelets per liter of blood, but investigation is typically only considered if the upper limit exceeds 7 ...
* is a condition characterized by an excess of platelets. Most cases are physiologic (caused by exercise) or reactive (secondary to some cancers, blood loss, or certain drugs). Rarely the condition is caused by a primary bone marrow disorder. In this last case, the platelets may not function normally, causing the blood to not clot properly. *
Hemolytic anemia Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). This most commonl ...
* is a type of regenerative
anemia Anemia (also spelt anaemia in British English) is a blood disorder in which the blood has a reduced ability to carry oxygen. This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin availabl ...
found in dogs characterized by destruction of the red blood cell. The most important type is immune-mediated hemolytic anemia, which can be a primary disease or secondary to cancer, infection, drugs, or vaccinations.
Antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ...
are present on the cell surface, leading to
lysis Lysis ( ; from Greek 'loosening') is the breaking down of the membrane of a cell, often by viral, enzymic, or osmotic (that is, "lytic" ) mechanisms that compromise its integrity. A fluid containing the contents of lysed cells is called a ...
and severe anemia. Other causes of hemolytic lesion include
hypophosphatemia Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. Symptoms may include weakness, trouble breathing, and loss of appetite. Complications may include seizures, coma, rhabdomyolysis, or soft ...
, exposure to toxins such as
lead Lead () is a chemical element; it has Chemical symbol, symbol Pb (from Latin ) and atomic number 82. It is a Heavy metal (elements), heavy metal that is density, denser than most common materials. Lead is Mohs scale, soft and Ductility, malleabl ...
, infections such as ehrlichiosis or
babesiosis Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic parasite in the order Piroplasmida, typically a ''Babesia'' or '' Theileria'', in the phylum Apicomplexa. Human babesiosis transmission via ...
, and rarely, neonatal isoerythrolysis. The behavioral condition pica, especially when involving the eating of
concrete Concrete is a composite material composed of aggregate bound together with a fluid cement that cures to a solid over time. It is the second-most-used substance (after water), the most–widely used building material, and the most-manufactur ...
dust, tile
grout Grout is a dense substance that flows like a liquid yet hardens upon application, often used to fill gaps or to function as reinforcement in existing structures. Grout is generally a mixture of water, cement, and sand, and is frequently employe ...
, or
sand Sand is a granular material composed of finely divided mineral particles. Sand has various compositions but is usually defined by its grain size. Sand grains are smaller than gravel and coarser than silt. Sand can also refer to a textural ...
, may be a sign of hemolytic anemia, indicating the need for a
complete blood count A complete blood count (CBC), also known as a full blood count (FBC) or full haemogram (FHG), is a set of medical laboratory tests that provide cytometry, information about the cells in a person's blood. The CBC indicates the counts of white blo ...
to investigate a possible diagnosis. *
Heart The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...
diseases **Degenerative (myxomatous)
mitral valve The mitral valve ( ), also known as the bicuspid valve or left atrioventricular valve, is one of the four heart valves. It has two Cusps of heart valves, cusps or flaps and lies between the atrium (heart), left atrium and the ventricle (heart), ...
disease* is a common cause of congestive heart failure in dogs, especially small, older dogs. The leaflets of the valve become thickened and nodular, leading to mitral valve regurgitation and volume overload of the left side of the heart.
Cavalier King Charles Spaniel The Cavalier King Charles Spaniel (CKCS) is a British list of dog breeds, breed of toy dog of spaniel type. Four colours are recognised: Blenheim (chestnut and white), Tricolor (dog), tricolour (black/white/tan), black and tan, and ruby; the coa ...
s and
Dachshund The dachshund ( or ; German: 'badger dog'), also known as the wiener dog or sausage dog, badger dog, doxen and doxie, is a short-legged, long-bodied, hound-type dog breed. The dog may be smooth-haired, wire-haired, or long-haired, with varie ...
s have an inherited form of this disease. **
Dilated cardiomyopathy Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. C ...
(DCM) is a disease of heart muscle resulting in decreased myocardial
contractility Contractility refers to the ability for self- contraction, especially of the muscles or similar active biological tissue *Contractile ring in cytokinesis *Contractile vacuole *Muscle contraction **Myocardial contractility *See contractile cell fo ...
. The left ventricle compensates for this disease by growing larger (eccentric or volume overload hypertrophy; AKA dilation). The left
atrial The atrium (; : atria) is one of the two upper chambers in the heart that receives blood from the circulatory system. The blood in the atria is pumped into the heart ventricles through the atrioventricular mitral and tricuspid heart valves. ...
is also dilated when the disease is severe. It is seen in large/giant dog breeds such as Boxers,
Great Dane The Great Dane is a German list of dog breeds, breed of large mastiff-sighthound, which descends from hunting dogs of the Middle Ages used to hunt bears, wild boar, and deer. They were also used as guardian dogs of German nobility. It is one o ...
s, and
Doberman Pinscher The Dobermann is a German breed of medium-large working dog of pinscher type. It was originally bred in Thuringia in about 1890 by Louis Dobermann, a tax collector.
s. It is usually
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
, but can also be caused by
taurine Taurine (), or 2-aminoethanesulfonic acid, is a naturally occurring amino sulfonic acid that is widely distributed in animal tissues. It is a major constituent of bile and can be found in the large intestine. It is named after Latin (cogna ...
deficiency in American Cocker Spaniels or
doxorubicin Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used toge ...
use. A mutation in the gene that encodes for pyruvate dehydrogenase kinase 4 is associated with DCM in Doberman Pinschers in the USA. Dilated cardiomyopathy usually ultimately results in congestive heart failure.
Atrial fibrillation Atrial fibrillation (AF, AFib or A-fib) is an Heart arrhythmia, abnormal heart rhythm (arrhythmia) characterized by fibrillation, rapid and irregular beating of the Atrium (heart), atrial chambers of the heart. It often begins as short periods ...
is common in giant breed dogs with DCM. Doberman Pinschers more commonly have ventricular arrhythmias (e.g., premature ventricular complexes;
ventricular tachycardia Ventricular tachycardia (V-tach or VT) is a cardiovascular disorder in which fast heart rate occurs in the ventricles of the heart. Although a few seconds of VT may not result in permanent problems, longer periods are dangerous; and multiple ...
) that predispose them to sudden death (i.e., ventricular fibrillation). **
Congestive heart failure Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood. Although symptoms vary based on which side of the heart is affected, HF typically pr ...
* is the result of any severe, overwhelming heart disease that most commonly results in pulmonary edema (fluid in the lungs), pleural effusion (fluid around the lungs), and/or ascites (fluid in the abdomen). It can be caused by the above two diseases,
congenital heart defect A congenital heart defect (CHD), also known as a congenital heart anomaly, congenital cardiovascular malformation, and congenital heart disease, is a defect in the structure of the heart or great vessels that is present at birth. A congenital h ...
s such as
patent ductus arteriosus Patent ductus arteriosus (PDA) is a medical condition in which the ''ductus arteriosus'' fails to close after childbirth, birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs from the aorta, which has a h ...
,
pulmonary hypertension Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure in the pulmonary artery, arteries of the lungs. Symptoms include dypsnea, shortness of breath, Syncope (medicine), fainting, tiredness, chest pain, pedal edema, swell ...
, heartworm (''
Dirofilaria immitis ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a Parasitism, parasitic Nematode, roundworm that is a type of Filarioidea, filarial worm, a small thread-like worm, and which causes dirofilariasis. It is spread from host (bi ...
'') disease, or pericardial effusion. Signs depend on which side of the heart is affected. Left-sided heart failure results in rapid and/or difficulty breathing and sometimes coughing from a build-up of fluid in the lungs (
pulmonary edema Pulmonary edema (British English: oedema), also known as pulmonary congestion, is excessive fluid accumulation in the tissue or air spaces (usually alveoli) of the lungs. This leads to impaired gas exchange, most often leading to shortness ...
). Right-sided heart failure results in a large liver (congestion) and build-up of fluid in the abdomen (
ascites Ascites (; , meaning "bag" or "sac") is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in the peritoneal cavity, although volumes greater than one liter may occur. Symptoms may include increased abdo ...
), uncommonly fluid around the lungs (
pleural effusion A pleural effusion is accumulation of excessive fluid in the pleural space, the potential space that surrounds each lung. Under normal conditions, pleural fluid is secreted by the parietal pleural capillaries at a rate of 0.6 millilitre per kilog ...
), or, rarely, peripheral edema. **
Sick sinus syndrome Sinus node dysfunction (SND), also known as sick sinus syndrome (SSS), is a group of abnormal heart rhythms (arrhythmias) usually caused by a malfunction of the sinus node, the heart's primary pacemaker. Tachycardia-bradycardia syndrome is a varia ...
* is most commonly seen in female
Miniature Schnauzer The Miniature Schnauzer is a dog breed, breed of small dog of the Schnauzer type that originated in Germany in the mid-to-late 19th century. Miniature Schnauzers may have been developed from the smallest specimens of the Standard Schnauzer, or c ...
s. It is characterized by
sinoatrial node The sinoatrial node (also known as the sinuatrial node, SA node, sinus node or Keith–Flack node) is an ellipse, oval shaped region of special cardiac muscle in the upper back wall of the right atrium made up of Cell (biology), cells known as pa ...
dysfunction and may include
atrioventricular node The atrioventricular node (AV node, or Aschoff-Tawara node) electrically connects the heart's atria and ventricles to coordinate beating in the top of the heart; it is part of the electrical conduction system of the heart. The AV node lies at the ...
disease and
bundle branch block A bundle branch block is a partial or complete interruption in the flow of electrical impulses in either of the bundle branches of the heart's electrical system. Anatomy and physiology The heart's electrical activity begins in the sinoatri ...
. Electrocardiogram findings include
sinus bradycardia Sinus bradycardia is a sinus rhythm with a reduced rate of electrical discharge from the sinoatrial node, resulting in a bradycardia, a heart rate that is lower than the normal range (60–100 beats per minute for adult humans). Signs and sympt ...
, sinus arrest, sinoatrial heart block, and
atrial tachycardia Atrial tachycardia is a type of heart rhythm problem in which the heart's electrical impulse comes from an ectopic pacemaker (that is, an abnormally located cardiac pacemaker) in the upper chambers ( atria) of the heart, rather than from the sin ...
. The major clinical sign is fainting (syncope). ** Heart defects *** Subvalvular aortic stenosis (Subaortic stenosis; SAS) is a
congenital disease A birth defect is an abnormal condition that is present at birth, regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can range from mild to severe. Birth de ...
in dogs characterized by left
ventricular outflow tract A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of ...
obstruction by a discrete ring or tunnel of fibrous tissue immediately below the aortic valve. It is inherited in
Newfoundland Newfoundland and Labrador is the easternmost province of Canada, in the country's Atlantic region. The province comprises the island of Newfoundland and the continental region of Labrador, having a total size of . As of 2025 the population ...
s, and also found in Golden Retrievers,
Rottweiler The Rottweiler (, , ) is a breed of domestic dog, regarded as medium-to-large or large. The dogs were known in German as , meaning Rottweil butchers' dogs, because their main use was to herd livestock and pull carts laden with butchered mea ...
s, Boxers,
Bulldog The Bulldog is a British breed of dog of mastiff type. It may also be known as the English Bulldog or British Bulldog. It is a stocky, muscular dog of medium size, with a large head, thick folds of skin around the face and shoulders and a rel ...
s,
German Shepherd The German Shepherd, also known in Britain as an Alsatian, is a German Dog breed, breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various Old German herding dogs, traditional German herding dog ...
s, and Samoyeds. Signs include a left basilar systolic heart murmur, weak femoral pulse, fainting and exercise intolerance. Dogs with severe SAS are predisposed to dying suddenly. *** Pulmonic stenosis* is a congenital heart disease in dogs characterized by right ventricular outflow tract obstruction. Most commonly the narrowing occurs at the
pulmonary valve The pulmonary valve (sometimes referred to as the pulmonic valve) is a valve of the heart that lies between the right ventricle and the pulmonary artery, and has three cusps. It is one of the four valves of the heart and one of the two semiluna ...
but it can also occur below the valve (subvalvular) or above the valve (supravalvular). The most commonly affected breeds include terriers,
Bulldog The Bulldog is a British breed of dog of mastiff type. It may also be known as the English Bulldog or British Bulldog. It is a stocky, muscular dog of medium size, with a large head, thick folds of skin around the face and shoulders and a rel ...
s,
Miniature Schnauzer The Miniature Schnauzer is a dog breed, breed of small dog of the Schnauzer type that originated in Germany in the mid-to-late 19th century. Miniature Schnauzers may have been developed from the smallest specimens of the Standard Schnauzer, or c ...
s, Chihuahuas, Samoyeds,
Beagle The Beagle is a small breed of scent hound, similar in appearance to the much larger foxhound. The beagle was developed primarily for hunting rabbit or hare, known as beagling. Possessing a great sense of smell and superior tracking inst ...
s,
Keeshond The Keeshond ( , plur. Keeshonden) is a medium-sized dog with a plush, two-layer Coat (dog), coat of silver and black fur with a Ruff (clothing), ruff and a curled tail. Their closest relatives are the German spitzes such as the ''Großspitz ...
s,
Mastiff A mastiff is a large and powerful Dog type, type of dog. Mastiffs are among the largest dogs, and typically have a short Coat (dog), coat, a long low-set tail and large feet; the skull is large and bulky, the muzzle broad and short (brachycephal ...
s, and Bullmastiffs. Signs may include exercise intolerance, but often there is only a
heart murmur Heart murmurs are unique heart sounds produced when blood flows across a heart valve or blood vessel. This occurs when turbulent blood flow creates a sound loud enough to hear with a stethoscope. The sound differs from normal heart sounds by th ...
. ***
Ventricular septal defect A ventricular septal defect (VSD) is a defect in the ventricular septum, the wall dividing the left and right ventricles of the heart. It's a common heart problem present at birth ( congenital heart defect). The extent of the opening may vary ...
* is a hole in the division between the heart ventricles (interventricular septum). It is a congenital heart disease in dogs. There usually are no signs in dogs except for a heart murmur. However, a large defect can result in heart failure or in pulmonary hypertension leading to a right-to-left shunt. ***
Atrial septal defect Atrial septal defect (ASD) is a congenital heart defect in which blood flows between the atrium (heart), atria (upper chambers) of the heart. Some flow is a normal condition both pre-birth and immediately post-birth via the Foramen ovale (heart) ...
* is a hole in the division between the heart atria (upper chambers of the heart). It is an uncommon abnormality in dogs. Most are not clinically significant, but large defects can cause right heart failure and exercise intolerance. Standard Poodles are the most common breed diagnosed with ASD in the USA. ***
Tetralogy of Fallot Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are: * Pulmonary stenosis, which is narrowing of the exit from the r ...
* is a congenital heart defect in dogs that includes four separate defects: pulmonic stenosis, a ventricular septal defect, right
ventricular hypertrophy Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the heart. Although left ventricular hypertrophy (LVH) is more common, right ventricular hypertrophy (RVH), as well as concurrent hypertrophy of both vent ...
, and an overriding aorta. Keeshonds and Bulldogs are predisposed. Signs include cyanosis and exercise intolerance. Polycythemia is often present and, if severe, needs to be controlled with phlebotomy or drugs to suppress red blood cell production. ***
Patent ductus arteriosus Patent ductus arteriosus (PDA) is a medical condition in which the ''ductus arteriosus'' fails to close after childbirth, birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs from the aorta, which has a h ...
* is one of the most common congenital heart defect in dogs around the world. It is inherited in toy and miniature
Poodle The Poodle, called the in German () and the in French, is a breed of water dog. The breed is divided into four varieties based on size, the Standard Poodle, Medium Poodle, Miniature Poodle and Toy Poodle, although the Medium Poodle is no ...
s, and seen commonly in
German Shepherd The German Shepherd, also known in Britain as an Alsatian, is a German Dog breed, breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various Old German herding dogs, traditional German herding dog ...
s, Pomeranians,
Bichon Frise A bichon is a distinct Dog type, type of toy dog; it is typically kept as a companion dog. Believed to be descended from the Barbet (dog), Barbet, it is believed the bichon-type dates to at least the 11th century; it was relatively common in 14t ...
s, and
Maltese Maltese may refer to: * Someone or something of, from, or related to Malta * Maltese alphabet * Maltese cuisine * Maltese culture * Maltese language, the Semitic language spoken by Maltese people * Maltese people, people from Malta or of Maltese ...
s. Signs include a continuous heart murmur, bounding (strong) femoral pulse, tachypnea (increased breathing rate), dyspnea (labored breathing), and exercise intolerance. ***
Heart valve dysplasia Heart valve dysplasia is a congenital heart defect which affects the aortic, pulmonary, mitral, and tricuspid heart valves. Dysplasia of the mitral and tricuspid valves can cause leakage of blood or stenosis. Dysplasia of the mitral and tricuspid ...
(including mitral and tricuspid valve dysplasia) is a congenital heart abnormality in dogs. Dysplasia of the mitral and tricuspid valves - also known as the atrioventricular (AV) valves - can appear as thickened, shortened, or notched valves.
Chordae tendineae The chordae tendineae (: chorda tendinea) or tendinous cords, colloquially known as the heart strings, are inelastic cords of fibrous connective tissue that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart. ...
are also usually abnormal. *** Cor triatriatum*, specifically cor triatriatum dexter, occurs in dogs and is characterized by a fibrous division of the right atrium into two chambers, usually with a hole in between them. It results in right heart failure (ascites). It can be treated by balloon valvuloplasty or surgical resection. *
Pericardial effusion A pericardial effusion is an abnormal accumulation of fluid in the pericardial cavity. The pericardium is a two-part membrane surrounding the heart: the outer fibrous Connective tissue, connective membrane and an inner two-layered serous membrane ...
* is a collection of fluid in the
pericardium The pericardium (: pericardia), also called pericardial sac, is a double-walled sac containing the heart and the roots of the great vessels. It has two layers, an outer layer made of strong inelastic connective tissue (fibrous pericardium), ...
. It is usually serosanguinous (bloody fluid). Serosanguinous accumulation can be caused by cancer, usually
hemangiosarcoma Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans (vinyl chloride toxicity). It is a sarcoma arising from the lining of blood vessels; ...
or a heart base tumor,
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
pericarditis. Rare causes include trauma, clotting disorders, and left atrial rupture. Serous accumulation is rare and caused by heart failure, peritoneopericardial
diaphragmatic hernia Diaphragmatic hernia is a defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity. Treatment is usually surgical. Types * Congenital diaphragmatic hernia ** Morgagni's hernia ** Bochdalek hernia * Hi ...
s,
uremia Uremia is the condition of having high levels of urea in the blood. Urea is one of the primary components of urine. It can be defined as an excess in the blood of amino acid and protein metabolism end products, such as urea and creatinine, which ...
, pericardial cysts, or
hypoalbuminemia Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the concentration, level of human serum albumin, albumin in the blood is low. This can be due to decreased production in the liver, increased loss in the gastrointestinal tract or ki ...
. Rarely pericardial effusion can be caused by infection and consist of
pus Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during infections, regardless of cause. An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collect ...
. An
echocardiogram Echocardiography, also known as cardiac ultrasound, is the use of ultrasound to examine the heart. It is a type of medical imaging, using standard ultrasound or Doppler ultrasound. The visual image formed using this technique is called an echo ...
should be done prior to draining the fluid, if possible, to identify the cause (e.g., tumor). Drainage of the fluid (
pericardiocentesis Pericardiocentesis (PCC), also called pericardial tap, is a medical procedure where fluid is aspirated from the pericardium (the sac enveloping the heart). Anatomy and physiology The pericardium is a fibrous sac surrounding the heart composed o ...
) relieves the clinical signs and, in the case of idiopathic pericarditis, can be curative. *
Pulmonary hypertension Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure in the pulmonary artery, arteries of the lungs. Symptoms include dypsnea, shortness of breath, Syncope (medicine), fainting, tiredness, chest pain, pedal edema, swell ...
* is high pressure in the
pulmonary artery A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs. The largest pulmonary artery is the ''main pulmonary artery'' or ''pulmonary trunk'' from the heart, and ...
. In dogs it can be caused by
heartworm ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a parasitic roundworm that is a type of filarial worm, a small thread-like worm, and which causes dirofilariasis. It is spread from host to host through the bites of mosqui ...
disease, pulmonary thromboembolism, or chronic
hypoxemia Hypoxemia (also spelled hypoxaemia) is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia is usually caused by pulmonary disease. Sometimes the concentration of oxygen in the ...
(low oxygen). It can result in right-sided heart disease (
cor pulmonale Pulmonary heart disease, also known as cor pulmonale, is the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance (such as from pulmonic stenosis) or high blood pressure in the lungs. Chroni ...
). Signs include difficulty breathing, cyanosis, and exercise intolerance. *Trapped Neutrophil Syndrome* is an autosomal recessive disease which results in mature
neutrophil Neutrophils are a type of phagocytic white blood cell and part of innate immunity. More specifically, they form the most abundant type of granulocytes and make up 40% to 70% of all white blood cells in humans. Their functions vary in differe ...
s being unable to migrate from the
bone marrow Bone marrow is a semi-solid biological tissue, tissue found within the Spongy bone, spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It i ...
into the
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...
. Affected pups have chronic
infection An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
s and fail to thrive. Other symptoms can include stunted growth and a ferret like facial appearance. The disease is common in Border collies.


Nervous system

*
Syringomyelia Syringomyelia is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord. Often, syringomyelia is used as a generic term before an etiology is determined. This cyst, called a syrinx, can expand and elongate ...
* is a condition where a fluid filled sac develops in the spinal cord. The most important cause in dogs is by a Chiari I malformation, which is when an underdeveloped
occipital bone The occipital bone () is a neurocranium, cranial dermal bone and the main bone of the occiput (back and lower part of the skull). It is trapezoidal in shape and curved on itself like a shallow dish. The occipital bone lies over the occipital lob ...
interferes with spinal fluid circulation and results in fluid accumulation in the cervical spinal cord. This is a
congenital disease A birth defect is an abnormal condition that is present at birth, regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can range from mild to severe. Birth de ...
most commonly found in small breeds such as the Brussels Griffon and the
Cavalier King Charles Spaniel The Cavalier King Charles Spaniel (CKCS) is a British list of dog breeds, breed of toy dog of spaniel type. Four colours are recognised: Blenheim (chestnut and white), Tricolor (dog), tricolour (black/white/tan), black and tan, and ruby; the coa ...
. Other breeds known to be affected include the
Bichon Frise A bichon is a distinct Dog type, type of toy dog; it is typically kept as a companion dog. Believed to be descended from the Barbet (dog), Barbet, it is believed the bichon-type dates to at least the 11th century; it was relatively common in 14t ...
,
Boston terrier The Boston Terrier is a breed of dog originating in the United States of America. This "American Gentleman" was accepted in 1893 by the American Kennel Club as a non-sporting breed. Boston Terriers are small and compact with a short tail and ere ...
, bull terrier, Chihuahua,
French bulldog The French Bulldog () is a French breed of companion dog or toy dog. It appeared in Paris in the mid-nineteenth century, apparently the result of cross-breeding of Toy Bulldogs imported from England and local Parisian ratters.Havanese,
King Charles spaniel The King Charles Spaniel (also known as the English Toy Spaniel) is a small dog breed of the spaniel type. In 1903, The Kennel Club combined four separate toy spaniel breeds under this single title. The other varieties merged into this breed wer ...
(the English toy spaniel),
Maltese Maltese may refer to: * Someone or something of, from, or related to Malta * Maltese alphabet * Maltese cuisine * Maltese culture * Maltese language, the Semitic language spoken by Maltese people * Maltese people, people from Malta or of Maltese ...
, miniature dachshunds, miniature and toy poodles, Papillon, Pomeranian, Pugs, Shih Tzu,
Staffordshire bull terrier The Staffordshire Bull Terrier, also called the Staffy or Stafford, is a purebred dog of small to medium size in the terrier group that originated in the northern parts of Birmingham and in the Black Country of Staffordshire, for which it ...
, and the
Yorkshire terrier The Yorkshire Terrier, also known as a Yorkie, is a British breed of toy dog of terrier type. It is among the smallest of the terriers and indeed of all dog breeds, with a weight of no more than . It originated in the nineteenth century in the ...
. Signs may include
ataxia Ataxia (from Greek α- negative prefix+ -τάξις rder= "lack of order") is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in e ...
, weakness, and neck pain. * Epilepsy in dogs can be a primary,
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
, inherited disorder or secondary to previous head trauma or CNS infections. Idiopathic epilepsy is commonly found in breeds such as
German Shepherd Dog The German Shepherd, also known in Britain as an Alsatian, is a German breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various traditional German herding dogs from 1899. It was originally b ...
s,
Beagle The Beagle is a small breed of scent hound, similar in appearance to the much larger foxhound. The beagle was developed primarily for hunting rabbit or hare, known as beagling. Possessing a great sense of smell and superior tracking inst ...
s, and
Dachshund The dachshund ( or ; German: 'badger dog'), also known as the wiener dog or sausage dog, badger dog, doxen and doxie, is a short-legged, long-bodied, hound-type dog breed. The dog may be smooth-haired, wire-haired, or long-haired, with varie ...
s. The most common sign recurring generalized
seizure A seizure is a sudden, brief disruption of brain activity caused by abnormal, excessive, or synchronous neuronal firing. Depending on the regions of the brain involved, seizures can lead to changes in movement, sensation, behavior, awareness, o ...
s beginning at a young adult age. * Rage syndrome is a rare inherited seizure disorder characterized by explosive aggression and focal neurologic symptoms. It is associated with
English Springer Spaniel The English Springer Spaniel is a breed of gun dog in the Spaniel group traditionally used for flushing and retrieving game. They are descended from the Norfolk or Shropshire Spaniels of the mid-19th century; the breed has diverged into sepa ...
s,
English Cocker Spaniel The English Cocker Spaniel is a breed of gun dog. It is noteworthy for producing one of the most varied numbers of pups in a litter among all dog breeds. The English Cocker Spaniel is an active, good-natured, sporting dog standing well up at ...
s, and Belgian Malinois, and a genetic polymorphism has been linked to the condition in Malinois. Seizures occur in the
temporal lobe The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain. The temporal lobe is involved in pr ...
. It is treatable with
Phenobarbital Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of ...
and supportive
antiepileptics Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatment ...
. *
Cerebellar hypoplasia Cerebellar hypoplasia is characterized by reduced cerebellar volume, even though cerebellar shape is (near) normal. It consists of a heterogeneous group of disorders of cerebellum, cerebellar maldevelopment presenting as early-onset Non-progress ...
is an incomplete development of the
cerebellum The cerebellum (: cerebella or cerebellums; Latin for 'little brain') is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as it or eve ...
. The most common cause in dogs is an
in utero The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic and fetal development of one or more fertilized eggs until bir ...
infection with canine herpesvirus. It is also seen associated with
lissencephaly Lissencephaly (, meaning 'smooth brain') is a set of rare brain disorders whereby the whole or parts of the surface of the brain are smooth. It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a ...
in Wire-haired Fox Terriers and
Irish Setter The Irish Setter (, literally "red setter") is a setter, a breed of gundog, and family dog originating in Ireland. The term ''Irish Setter'' is commonly used to encompass the show-bred dog recognised by the American Kennel Club as well a ...
s, and as a separate condition in
Chow Chow The Chow Chow is a spitz-type of dog breed originally from Northern China. The Chow Chow is a sturdily built dog, square in profile, with a broad skull and small, triangular, erect ears with rounded tips. The breed is known for a very dense do ...
s. *
Polyneuropathy Polyneuropathy () is damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain. It usually begins in the hands and feet and may prog ...
is a collection of peripheral nerve disorders that often are breed-related in dogs. Polyneuropathy indicates that multiple nerves are involved, unlike mononeuropathy. Polyneuropathy usually involves motor nerve dysfunction, also known as lower motor neuron disease. * Canine cognitive dysfunction is a progressive disease occurring in older dogs, which is similar to the dementia which occurs in humans with
Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...
. * Scotty Cramp is a disease in
Scottish Terrier The Scottish Terrier (; also known as the Aberdeen Terrier), popularly called the Scottie, is a dog breed, breed of dog. Initially one of the highland breeds of terrier that were grouped under the name of ''Skye Terrier'', it is one of five br ...
s causing spasms and hyperflexion and hyperextension of the legs. It is caused by a disorder in
serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...
metabolism that causes a deficiency of available serotonin. *
Cauda equina syndrome Cauda equina syndrome (CES) is a condition that occurs when the bundle of nerves below the end of the spinal cord known as the cauda equina is damaged. Signs and symptoms include low back pain, sciatica, pain that radiates down the leg, numbness ...
*, also known as degenerative lumbosacral stenosis, in dogs is a compression of the
cauda equina The cauda equina () is a bundle of spinal nerves and spinal nerve rootlets, consisting of the second through fifth lumbar nerve pairs, the first through fifth sacral nerve pairs, and the coccygeal nerve, all of which arise from the lumbar enl ...
by a narrowing of the lumbosacral
vertebral canal In human anatomy, the spinal canal, vertebral canal or spinal cavity is an elongated body cavity enclosed within the dorsal bony arches of the vertebral column, which contains the spinal cord, spinal roots and dorsal root ganglia. It is a proc ...
. It is most commonly seen in German Shepherd Dogs. Signs include pain, weakness, and rear limb muscle atrophy. * Coonhound paralysis is a type of polyradiculoneuritis seen in Coonhounds. The cause has been related to a raccoon bite. Signs include rear leg weakness progressing rapidly to paralysis, and decreased reflexes. *
Tick paralysis Tick paralysis is a type of paralysis caused by specific types of ticks. Unlike tick-borne diseases caused by infectious organisms, the illness is caused by a neurotoxin produced in the tick's salivary gland. After prolonged attachment, the en ...
* is a disease in dogs caused by a
neurotoxin Neurotoxins are toxins that are destructive to nervous tissue, nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological insult (medical), insultsSpencer 2000 that can adversely affect function ...
found in the saliva of female ticks. ''
Dermacentor ''Dermacentor'' is a genus of ticks in the family Ixodidae, the hard ticks. The genus has a cosmopolitan distribution, with native species on all continents except Australia. Most are found in North America. Hosts of ''Dermacentor'' ticks inclu ...
'' species predominate as a cause in North America, while ''
Ixodes ''Ixodes'' is a genus of hard-bodied ticks (family Ixodidae). It includes important disease vectors of animals and humans ( tick-borne disease), and some species (notably '' Ixodes holocyclus'') inject toxins that can cause paralysis. Som ...
'' mainly causes the disease in Australia. There is a gradual onset of signs, which include incoordination progressing to paralysis, changed voice, and difficulty eating. * Dancing Dobermann disease is a type of
myopathy In medicine, myopathy is a disease of the muscle in which the muscle fibers do not function properly. ''Myopathy'' means muscle disease ( Greek : myo- ''muscle'' + patheia '' -pathy'' : ''suffering''). This meaning implies that the primary defec ...
that primarily affects the
gastrocnemius muscle The gastrocnemius muscle (plural ''gastrocnemii'') is a superficial two-headed muscle that is in the back part of the lower leg of humans. It is located superficial to the soleus in the posterior (back) compartment of the leg. It runs from its t ...
in
Dobermann The Dobermann is a German list of dog breeds, breed of medium-large working dog of pinscher type. It was originally bred in Thuringia in about 1890 by Karl Friedrich Louis Dobermann, Louis Dobermann, a tax collector.Granulomatous meningoencephalitis (GME) (including Pug Dog encephalitis and other noninfectious causes of meningoencephalitis) is an inflammatory disease of the central nervous system of dogs. It is a form of
meningoencephalitis Meningoencephalitis (; from ; ; and the medical suffix ''-itis'', "inflammation"), also known as herpes meningoencephalitis, is a medical condition that simultaneously resembles both meningitis, which is an infection or inflammation of the mening ...
. The disease is more common in female toy dogs of young and middle age. *
Facial nerve paralysis Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by the facial nerve. The pathway of the facial nerve is long and relatively convoluted, so there are a number of causes that may result in facia ...
* is most commonly caused in dogs by trauma,
otitis media Otitis media is a group of Inflammation, inflammatory diseases of the middle ear. One of the two main types is acute otitis media (AOM), an infection of rapid onset that usually presents with ear pain. In young children this may result in pullin ...
, or as an idiopathic condition. Signs include an inability to blink, drooping of the ear, and drooping of the lips on the affected side, although in chronic conditions
fibrosis Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective tissue deposition or excessive tissue deposition caused by a disease. Repeated injuries, ch ...
occurs and the ear and lips may appear to be in an abnormal position. * Laryngeal paralysis is unilateral or bilateral paralysis of the
larynx The larynx (), commonly called the voice box, is an organ (anatomy), organ in the top of the neck involved in breathing, producing sound and protecting the trachea against food aspiration. The opening of larynx into pharynx known as the laryngeal ...
. In dogs it can be congenital, seen in the
Bouvier des Flandres The Bouvier des Flandres is a herding dog dog breed, breed originating in Flanders, Belgium. They were originally used for general farm work including cattle Drover (Australian), droving, Livestock guardian dog, sheep herding, and dogcart (dog-dr ...
, Bull Terrier, Dalmatian,
Rottweiler The Rottweiler (, , ) is a breed of domestic dog, regarded as medium-to-large or large. The dogs were known in German as , meaning Rottweil butchers' dogs, because their main use was to herd livestock and pull carts laden with butchered mea ...
and Huskies, or an acquired, idiopathic disease, seen in older
Labrador Retriever The Labrador Retriever or simply Labrador or Lab is a British list of dog breeds, breed of water dog retriever gun dog. It was developed in the United Kingdom from St. John's water dogs imported from the Newfoundland Colony, colony of Newfoun ...
s, Golden Retrievers, St. Bernards, and
Irish Setter The Irish Setter (, literally "red setter") is a setter, a breed of gundog, and family dog originating in Ireland. The term ''Irish Setter'' is commonly used to encompass the show-bred dog recognised by the American Kennel Club as well a ...
s. Signs include change in voice and difficulty breathing. * White dog shaker syndrome causes full body tremors in small, white dog breeds. It is most common in
West Highland White Terrier The West Highland White Terrier (commonly shortened to Westie) is a dog breed, breed of dog from Scotland with a distinctive white harsh coat and somewhat soft white undercoat. It is a medium-sized terrier, though with longer legs than other ...
s,
Maltese Maltese may refer to: * Someone or something of, from, or related to Malta * Maltese alphabet * Maltese cuisine * Maltese culture * Maltese language, the Semitic language spoken by Maltese people * Maltese people, people from Malta or of Maltese ...
,
Bichon A bichon is a distinct type of toy dog; it is typically kept as a companion dog. Believed to be descended from the Barbet, it is believed the bichon-type dates to at least the 11th century; it was relatively common in 14th-century France, wh ...
s, and
Poodle The Poodle, called the in German () and the in French, is a breed of water dog. The breed is divided into four varieties based on size, the Standard Poodle, Medium Poodle, Miniature Poodle and Toy Poodle, although the Medium Poodle is no ...
s. * Wobbler disease (cervical instability) is a condition of the cervical vertebrae that causes an unsteady gait and weakness in dogs. *
Cerebellar abiotrophy Cerebellar abiotrophy (CA), also called cerebellar cortical abiotrophy (CCA), is a genetic neurological disease in animals, best known to affect certain breeds of horses, dogs and cats. It can also develop in humans. It develops when the neurons ...
is caused by the death of
Purkinje cell Purkinje cells or Purkinje neurons, named for Czech physiologist Jan Evangelista Purkyně who identified them in 1837, are a unique type of prominent, large neuron located in the Cerebellum, cerebellar Cortex (anatomy), cortex of the brain. Wi ...
s in the
cerebellum The cerebellum (: cerebella or cerebellums; Latin for 'little brain') is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as it or eve ...
. It results in progressive
ataxia Ataxia (from Greek α- negative prefix+ -τάξις rder= "lack of order") is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in e ...
beginning at a young age. It is most commonly seen in
Kerry Blue Terrier The Kerry Blue Terrier (also known as the Irish Blue Terrier) () is a breed of dog. Originally bred to control vermin including rats, rabbits, badgers, ferrets, foxes, otters, hares, deer, and even wolves, over time the Kerry became a general wo ...
s and Gordon Setters.


Eyes

*
Eyelid An eyelid ( ) is a thin fold of skin that covers and protects an eye. The levator palpebrae superioris muscle retracts the eyelid, exposing the cornea to the outside, giving vision. This can be either voluntarily or involuntarily. "Palpebral ...
diseases **
Ectropion Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable aspects of newborns exhibiting congenital harlequin-type ichthyosis, but ectropion can occur due to any weakening of tissue of the lower eyelid ...
(eyelid folding outward) is a common condition in dogs, usually affecting the lower lid. Breeds associated with ectropion include the Cocker Spaniel, the St. Bernard, the
Bloodhound The bloodhound is a large scent hound, originally bred for hunting deer, wild boar, rabbits, and since the Middle Ages, for tracking people. Believed to be descended from hounds once kept at the Abbey of Saint-Hubert, Belgium, in French it is ...
, and the
Basset Hound The Basset Hound is a short-legged breed of scent hound. The Basset Hound was developed in Great Britain from several now-extinct strains of France, French basset breeds. It was bred primarily for hunting rabbit and hare on foot, moving slowly en ...
. **
Entropion Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very uncomfortable, as the eyelashes continuously rub against the cornea causing irritation. Entropion is usually caused by Genetics, genetic factors. ...
(eyelid folding inward) is a common condition in dogs, especially the
Chow Chow The Chow Chow is a spitz-type of dog breed originally from Northern China. The Chow Chow is a sturdily built dog, square in profile, with a broad skull and small, triangular, erect ears with rounded tips. The breed is known for a very dense do ...
,
Shar Pei The Shar Pei () is a dog breed from southern China. Traditionally kept as a property guardian, the shar pei was driven to the brink of extinction in the 20th century. The breed is known in the West for its deep wrinkles, while a traditional less ...
, St. Bernard, and Cocker Spaniel. Upper lid entropion involves the eyelashes rubbing on the eye, but the lower lid usually has no eyelashes, so hair rubs on the eye. Surgical correction is used in more severe cases. **
Distichia A distichia is an eyelash that arises from an abnormal part of the eyelid. This abnormality, attributed to a genetic mutation, is known to affect dogs and humans. Distichiae usually exit from the duct of the meibomian gland at the eyelid margin. ...
(including ectopic cilia) is an eyelash that arises from an abnormal spot on the eyelid. Distichiae usually cause no symptoms because the lashes are soft, but they can irritate the eye and cause tearing, squinting, inflammation, and
corneal ulcer Corneal ulcer, often resulting from keratitis is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. It is a common condition in humans part ...
s. **
Chalazion A chalazion (; plural chalazia or chalazions) or meibomian cyst is not a cyst but a granuloma in the eyelid that results from a blocked meibomian gland. It typically occurs in the middle of the eyelid, red, and not painful. They tend to come ...
* is a
granuloma A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such sub ...
that forms in the eyelid due to blocked secretions from the
meibomian gland Meibomian glands (also called tarsal glands, palpebral glands, and tarsoconjunctival glands) are sebaceous glands along the rims of the eyelid inside the tarsal plate. They produce meibum, an oily substance that prevents evaporation of the eye, ...
. Inflammation of the eyelid may result. **
Trichiasis Trichiasis ( , ) is a medical term for abnormally positioned eyelashes that grow back toward the eye, touching the cornea or conjunctiva. This can be caused by infection, inflammation, autoimmune conditions, congenital defects, eyelid agenesis an ...
in dogs is hair from the eyelid growing in the wrong direction and rubbing on the eye, causing irritation. It usually occurs at the lateral upper eyelid, especially in the English Cocker Spaniel. *
Lens A lens is a transmissive optical device that focuses or disperses a light beam by means of refraction. A simple lens consists of a single piece of transparent material, while a compound lens consists of several simple lenses (''elements'') ...
diseases **
Cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...
s* are an
opacity Opacity is the measure of impenetrability to electromagnetic or other kinds of radiation, especially visible light. In radiative transfer, it describes the absorption and scattering of radiation in a medium, such as a plasma, dielectric, shie ...
in the
lens A lens is a transmissive optical device that focuses or disperses a light beam by means of refraction. A simple lens consists of a single piece of transparent material, while a compound lens consists of several simple lenses (''elements'') ...
of the eye. Most cataracts in dogs are caused by a genetic predisposition, but
diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ...
is also a common cause. The only effective treatment is surgical removal. ** Lens luxation is a displacement of the lens from its normal position. Terrier breeds are predisposed. ** Nuclear sclerosis is a consistent finding in dogs greater than seven years old. Nuclear sclerosis appears as a bilateral bluish-grey haziness at the nucleus, or center of the lens, and has little effect on vision. This is may be confused with
cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...
s. *
Retina The retina (; or retinas) is the innermost, photosensitivity, light-sensitive layer of tissue (biology), tissue of the eye of most vertebrates and some Mollusca, molluscs. The optics of the eye create a focus (optics), focused two-dimensional ...
l diseases **
Progressive retinal atrophy Progressive retinal atrophy (PRA) is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, it is characterized by the bilateral degeneration of the retina, causing progressi ...
(PRA) is a genetic disease of the retina that occurs bilaterally and is seen in certain breeds of dogs. It causes progressive vision loss culminating in blindness. **
Retinal dysplasia Retinal dysplasia is an eye disease affecting the retina of animals and, less commonly, humans. It is usually a nonprogressive disease and can be caused by viral infections, drugs, vitamin A deficiency, or genetic defects. Retinal dysplasia is ...
is an eye disease affecting the retina. It is usually a nonprogressive disease and can be caused by viral infections, drugs, vitamin A deficiency, or genetics. Retinal dysplasia is characterized by folds or rosettes (round clumps) of the retinal tissue. ** Sudden acquired retinal degeneration (SARD) is a disease in dogs causing sudden blindness. It can occur in any breed. The cause is unknown, but possibly involves either
autoimmune disease An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated tha ...
, a toxin, or
Cushing's disease Cushing's disease is one cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (spec ...
. Symptoms include sudden permanent blindness, dilated pupils, and loss of the
pupillary light reflex The pupillary light reflex (PLR) or photopupillary reflex is a reflex that controls the diameter of the pupil, in response to the intensity ( luminance) of light that falls on the retinal ganglion cells of the retina in the back of the eye, t ...
. **
Retinal detachment Retinal detachment is a condition where the retina pulls away from the tissue underneath it. It may start in a small area, but without quick treatment, it can spread across the entire retina, leading to serious vision loss and possibly blindness. ...
* is caused in dogs by genetic disorders such as
retinal dysplasia Retinal dysplasia is an eye disease affecting the retina of animals and, less commonly, humans. It is usually a nonprogressive disease and can be caused by viral infections, drugs, vitamin A deficiency, or genetic defects. Retinal dysplasia is ...
or Collie eye anomaly, trauma, inflammation or cancer. Reattachment may occur spontaneously or with medical or surgical therapy. *
Cornea The cornea is the transparency (optics), transparent front part of the eyeball which covers the Iris (anatomy), iris, pupil, and Anterior chamber of eyeball, anterior chamber. Along with the anterior chamber and Lens (anatomy), lens, the cornea ...
l diseases **
Corneal dystrophy Corneal dystrophy is a group of rare hereditary disorders characterised by bilateral abnormal deposition of substances in the transparent front part of the eye called the cornea. Signs and symptoms Corneal dystrophy may not significantly affect ...
is a condition characterized by bilateral, noninflammatory opacity of the cornea. It appears as grayish white lines, circles, or clouding of the
cornea The cornea is the transparency (optics), transparent front part of the eyeball which covers the Iris (anatomy), iris, pupil, and Anterior chamber of eyeball, anterior chamber. Along with the anterior chamber and Lens (anatomy), lens, the cornea ...
. Corneal dystrophy can also have a crystalline appearance. **
Corneal ulcer Corneal ulcer, often resulting from keratitis is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. It is a common condition in humans part ...
, or ulcerative keratitis, is an inflammatory condition of the cornea involving loss of its outer layer. They are caused by trauma, detergent burns, and infections. Other eye conditions can cause corneal ulcers, such as
entropion Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very uncomfortable, as the eyelashes continuously rub against the cornea causing irritation. Entropion is usually caused by Genetics, genetic factors. ...
,
distichia A distichia is an eyelash that arises from an abnormal part of the eyelid. This abnormality, attributed to a genetic mutation, is known to affect dogs and humans. Distichiae usually exit from the duct of the meibomian gland at the eyelid margin. ...
,
corneal dystrophy Corneal dystrophy is a group of rare hereditary disorders characterised by bilateral abnormal deposition of substances in the transparent front part of the eye called the cornea. Signs and symptoms Corneal dystrophy may not significantly affect ...
, and
keratoconjunctivitis sicca Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occas ...
. ** Florida keratopathy an eye condition characterized by the presence of multiple spots within both corneas. In the United States, it is found most commonly in the southeastern part of the country. ** Chronic superficial keratitis (pannus) is a form of superficial
keratitis Keratitis is a condition in which the human eye, eye's cornea, the clear dome on the front surface of the eye, becomes inflammation, inflamed. The condition is often marked by moderate to intense pain and usually involves any of the following sy ...
, or inflammation of the cornea, found most commonly in
German Shepherd The German Shepherd, also known in Britain as an Alsatian, is a German Dog breed, breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various Old German herding dogs, traditional German herding dog ...
s,
Greyhound The English Greyhound, or simply the Greyhound, is a dog breed, breed of dog, a sighthound which has been bred for coursing, greyhound racing and hunting. Some are kept as show dogs or pets. Greyhounds are defined as a tall, muscular, smooth-c ...
s, and Siberian Huskies. * Collie eye anomaly (CEA) is a congenital, inherited, bilateral eye disease of dogs involving the retina, choroid, and sclera. It can be a mild disease or cause blindness. It is known to occur in Smooth and
Rough Collie The Rough Collie (also known as the Long-Haired Collie) is a long-coated dog breed of medium to large size that, in its original form, was a type of collie used and bred for herding sheep in Scotland. More recent breeding has focused on the Co ...
s,
Shetland Sheepdog The Shetland Sheepdog, also known as the Sheltie, is a breed of herding dog that originated in the Shetland Islands of Scotland. It was formally recognized by the Kennel Club in 1909. It was originally called the ''Shetland Collie'', but this c ...
s,
Australian Shepherd The Australian Shepherd is a breed of herding dog from the United States. The name of the breed is technically a misnomer, as it was developed in California in the 19th century. It is believed to have its origins in sheepdog breeds from northwe ...
s,
Border Collie The Border Collie is a British list of dog breeds, breed of herding dog of the collie type of medium size. It originates in the region of the Anglo-Scottish border, and descends from the traditional Sheep dog, sheepdogs once found all over the ...
s, and
Nova Scotia Duck Tolling Retriever The Nova Scotia Duck Tolling Retriever is a medium-sized gundog bred primarily for hunting. It is often referred to as a "toller". It is the smallest of the retrievers, and is often mistaken for a small Golden Retriever. Tollers are intelligent ...
s. * Cherry eye is the term used to refer to canine nictitans gland prolapse, a common eye condition in various dog breeds where the gland of the third eyelid prolapses and becomes visible. * Canine glaucoma is an increase of pressure within the eye. It is a common condition in dogs. It can be caused by abnormal development of the drainage angle of the eye, lens luxation,
uveitis Uveitis () is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and ...
, or cancer. Cocker Spaniels,
Poodle The Poodle, called the in German () and the in French, is a breed of water dog. The breed is divided into four varieties based on size, the Standard Poodle, Medium Poodle, Miniature Poodle and Toy Poodle, although the Medium Poodle is no ...
s, and
Basset Hound The Basset Hound is a short-legged breed of scent hound. The Basset Hound was developed in Great Britain from several now-extinct strains of France, French basset breeds. It was bred primarily for hunting rabbit and hare on foot, moving slowly en ...
s are predisposed. * Ocular melanosis (OM) is a disease of the eye which in dogs is almost found exclusively in the Cairn Terrier. The disease is caused by an increase of melanocytes in the iris, sclera, and surrounding structures. *
Keratoconjunctivitis sicca Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occas ...
(dry eye) is common in dogs. Symptoms include eye redness, a yellow or greenish discharge, ulceration of the cornea, pigmented cornea, and blood vessels on the cornea. * Vogt–Koyanagi–Harada syndrome is a condition seen in dogs characterized by
uveitis Uveitis () is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and ...
(inflammation of the inside of the eye),
poliosis Poliosis circumscripta, commonly referred to as a "white forelock", is a condition characterized by localized patches of white hair due to a reduction or absence of melanin in hair follicles. Although traditionally associated with the scalp, polios ...
(whitening of hair), and
vitiligo Vitiligo (, ) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure, and susceptibili ...
(loss of pigment in the skin). *
Conjunctivitis Conjunctivitis, also known as pink eye or Madras eye, is inflammation of the conjunctiva, the thin, clear layer that covers the white surface of the eye and the inner eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness ...
* is inflammation of the
conjunctiva In the anatomy of the eye, the conjunctiva (: conjunctivae) is a thin mucous membrane that lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with gobl ...
. In dogs it is most commonly caused by mechanical irritation (such as by
entropion Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very uncomfortable, as the eyelashes continuously rub against the cornea causing irritation. Entropion is usually caused by Genetics, genetic factors. ...
,
ectropion Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable aspects of newborns exhibiting congenital harlequin-type ichthyosis, but ectropion can occur due to any weakening of tissue of the lower eyelid ...
, or
trichiasis Trichiasis ( , ) is a medical term for abnormally positioned eyelashes that grow back toward the eye, touching the cornea or conjunctiva. This can be caused by infection, inflammation, autoimmune conditions, congenital defects, eyelid agenesis an ...
), allergies, and
keratoconjunctivitis sicca Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occas ...
. Any bacterial infection is usually secondary. * Eye proptosis is a condition resulting in forward displacement and entrapment of the eye from behind by the eyelids. It is a common result of head trauma in dogs. Most commonly it occurs in
brachycephalic Brachycephaly (derived from the Ancient Greek '' βραχύς'', 'short' and '' κεφαλή'', 'head') is the shape of a skull shorter than average in its species. It is perceived as a cosmetically desirable trait in some domesticated dog and ...
(short nosed) breeds. *
Horner's syndrome Horner's syndrome, also known as oculosympathetic paresis, is a combination of symptoms that arises when a group of nerves known as the sympathetic trunk is damaged. The signs and symptoms occur on the same side (ipsilateral) as it is a lesion ...
* results from damage to the sympathetic innervation of the eye. Signs include enophthalmos (sunken eye),
miosis Miosis, or myosis (), is excessive constriction of the pupil.Farlex medical dictionary
citing: ...
(small pupil), elevated third eyelid, and ptosis (drooping of the upper eyelid). Usually the syndrome in dogs is
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
, but it can also be caused by trauma, tumors, or ear infections. *
Optic neuritis Optic neuritis (ON) is a debilitating condition that is defined as inflammation of cranial nerve II which results in disruption of the neurologic pathways that allow visual sensory information received by the retina to be able to be transmitted to ...
* is inflammation of the optic nerves. In dogs this is most commonly caused by granulomatous meningoencephalitis or infection. * Persistent pupillary membrane is a condition of the eye involving remnants of a fetal membrane that persist as strands of tissue crossing the pupil. *
Uveitis Uveitis () is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and ...
* is inflammation within the eye. Anterior uveitis (inflammation of the iris and
ciliary body The ciliary body is a part of the eye that includes the ciliary muscle, which controls the shape of the lens, and the ciliary epithelium, which produces the aqueous humor. The aqueous humor is produced in the non-pigmented portion of the ciliary ...
) is most common in dogs. The disease is usually immune-mediated in dogs, but may also be caused by trauma, cataracts, infectious canine hepatitis,
leptospirosis Leptospirosis is a blood infection caused by the bacterium ''Leptospira'' that can infect humans, dogs, rodents and many other wild and domesticated animals. Signs and symptoms can range from none to mild (headaches, Myalgia, muscle pains, a ...
, ehrlichiosis, or systemic fungal infections. * Asteroid hyalosis is a degenerative condition of the eye involving small white opacities in the vitreous humor. The cause is unknown. * Synchysis scintillans is a degenerative condition of the eye resulting in liquified vitreous humor and the accumulation of cholesterol crystals within the vitreous. * Iris cysts are small hollow structures either attached to the iris of the eye or floating free in the anterior chamber. * Imperforate lacrimal punctum is a congenital disorder of dogs involving the lack of an opening to the
nasolacrimal duct The nasolacrimal duct (also called the tear duct) carries tears from the lacrimal sac of the eye into the nasal cavity. The duct begins in the eye socket between the maxillary and lacrimal bones, from where it passes downwards and backwards. ...
(tear duct) in the
conjunctiva In the anatomy of the eye, the conjunctiva (: conjunctivae) is a thin mucous membrane that lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with gobl ...
. *
Exophthalmos Exophthalmos (also called exophthalmus, exophthalmia, proptosis, or exorbitism) is a bulging of the eye anteriorly out of the orbit. Exophthalmos can be either bilateral (as is often seen in Graves' disease) or unilateral (as is often seen in ...
is a normal condition in
brachycephalic Brachycephaly (derived from the Ancient Greek '' βραχύς'', 'short' and '' κεφαλή'', 'head') is the shape of a skull shorter than average in its species. It is perceived as a cosmetically desirable trait in some domesticated dog and ...
(short nosed) dog breeds because of the shallow orbit. However, it can lead to
keratitis Keratitis is a condition in which the human eye, eye's cornea, the clear dome on the front surface of the eye, becomes inflammation, inflamed. The condition is often marked by moderate to intense pain and usually involves any of the following sy ...
secondary to exposure of the cornea.


Ears

*
Ear infection Otitis is a general term for inflammation in ear or ear infection, inner ear infection, middle ear infection of the ear, in both humans and other animals. When infection is present, it may be viral or bacterial. When inflammation is present due t ...
s are common in dogs, particularly breeds with hanging ears, such as
Beagle The Beagle is a small breed of scent hound, similar in appearance to the much larger foxhound. The beagle was developed primarily for hunting rabbit or hare, known as beagling. Possessing a great sense of smell and superior tracking inst ...
s, and dogs with narrow ear canals, such as Cocker Spaniels. Other predisposing factors include allergies, ear parasites, and
hypothyroidism Hypothyroidism is an endocrine disease in which the thyroid gland does not produce enough thyroid hormones. It can cause a number of symptoms, such as cold intolerance, poor ability to tolerate cold, fatigue, extreme fatigue, muscle aches, co ...
. *
Deafness Deafness has varying definitions in cultural and medical contexts. In medical contexts, the meaning of deafness is hearing loss that precludes a person from understanding spoken language, an audiological condition. In this context it is writte ...
* in dogs can be either acquired or congenital. Predisposing factors for acquired deafness include chronic infection, use of certain drugs, and most commonly, age-related changes in the
cochlea The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus (cochlea), modiolus. A core component of the cochlea is the organ of Cort ...
. Congenital deafness can be genetic, seen sometimes in dogs with
merle Merle may refer to: People and fictional characters *Merle (given name), a list of men, women and fictional characters *Merle (surname), a list of people Others *Merle (dog coat), a pattern in dogs’ coats *Merle (grape), another name for the w ...
or white coats, or caused by
in utero The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic and fetal development of one or more fertilized eggs until bir ...
damage from infections or toxins. * Fly strike dermatitis occurs at the tip and folds of the ear in dogs. It is caused by bites of the stable fly, ''Stomoxys calcitrans''.


Skin

*
Allergies Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
* **
Atopy Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment. Allergic diseases are clinical manifestations of such inappropriate, atopic responses. Atopy may have ...
* is an allergy to a substance with which the dog is not necessarily in direct contact. It is a
type I hypersensitivity Type I hypersensitivity (or immediate hypersensitivity), in the Hypersensitivity, Gell and Coombs classification of allergic reactions, is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen. Type ...
to a substance that is inhaled or absorbed through the skin. Up to 10 percent of dogs are affected. It is common in dogs, especially seen in breeds such as
Labrador Retriever The Labrador Retriever or simply Labrador or Lab is a British list of dog breeds, breed of water dog retriever gun dog. It was developed in the United Kingdom from St. John's water dogs imported from the Newfoundland Colony, colony of Newfoun ...
s, Golden Retrievers, and Shih Tzus. The most common symptom is itching. Affected areas include the underside, the face, the feet, and the ears. ** Flea allergy dermatitis is the most common skin disease of dogs in the United States. It is caused by sensitivity to
flea Flea, the common name for the order (biology), order Siphonaptera, includes 2,500 species of small flightless insects that live as external parasites of mammals and birds. Fleas live by hematophagy, ingesting the blood of their hosts. Adult f ...
saliva. **
Food allergy A food allergy is an abnormal immune system, immune response to food. The symptoms of the allergic reaction may range from mild to severe. They may include pruritus, itchiness, swelling of the tongue, vomiting, diarrhea, hives, trouble breathi ...
* in dogs is commonly manifested as itching, especially of the face, paws, and the underside. Skin testing has proved unreliable, and a trial of a hypoallergenic diet is usually used for diagnosis. * Follicular dysplasia is a genetic disease of dogs causing alopecia, or hair loss. It is caused by hair follicles that are misfunctioning due to structural abnormality. * Dermoid sinus a genetic, autosomal skin condition in dogs. It can appear as single or multiple lumps on the dorsal midline. *
Lick granuloma A lick granuloma, also known as acral lick dermatitis, is a skin disorder found most commonly in dogs, but also in cats. In dogs, it results typically from the dog's urge to lick the lower portion of one of their legs. The lesion can initially be ...
also known as acral lick dermatitis, is a skin disorder in dogs resulting from an urge to lick the lower portion of the leg. The lesion from the incessant licking is a thickened, firm, oval plaque. *
Pemphigus Pemphigus ( or ) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root ''pemphix'', meaning "blister". In pemphigus, autoantibody, autoantibodies form against de ...
is an uncommon
autoimmune In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an " autoimmune disease" ...
skin disease. The most common form in dogs is pemphigus foliaceus, which manifests as erosions and crusting of the skin and mucocutaneous junctions. Pemphigus vulgaris is more rare and manifests as blister-like lesions in the mouth and at mucocutaneous junctions.
Bullous pemphigoid Bullous pemphigoid (a type of pemphigoid) is an autoimmune pruritic skin disease that typically occurs in people aged over 60, that may involve the formation of blisters ( bullae) in the space between the epidermal and dermal skin layers. It is ...
is most commonly seen in
Dobermann The Dobermann is a German list of dog breeds, breed of medium-large working dog of pinscher type. It was originally bred in Thuringia in about 1890 by Karl Friedrich Louis Dobermann, Louis Dobermann, a tax collector.Collie Collies form a distinctive type of herding dogs, including many related landraces and standardized breeds. The type originated in Scotland and Northern England. Collies are medium-sized, fairly lightly-built dogs, with pointed snouts. Many type ...
s and appears as a scald-like lesion of the groin. * Sebaceous adenitis is an uncommon
autoimmune In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an " autoimmune disease" ...
skin disease. Most commonly found in Akitas and Standard Poodles. * Dermal fragility syndrome, also known as Ehlers–Danlos-like syndrome, is a rare condition in dogs characterized by increased skin elasticity and poor wound healing. There appears to be a genetic basis for the disease. *
Discoid lupus erythematosus Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. It presents with red, painful, inflamed and coin-shaped patches of skin with a sc ...
is an uncommon autoimmune disease of the skin in dogs. It does not progress to
systemic lupus erythematosus Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common ...
in dogs. The most common initial symptom is scaling and loss of pigment on the nose. * Juvenile cellulitis, also known as puppy strangles, is a disease that affects puppies. Its cause is unknown, but it is likely to have a hereditary component related to the immune system.


Endocrine diseases

*
Diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ...
in dogs is type 1, or insulin dependent diabetes: a lack of
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...
production due to destruction of pancreatic
beta cell Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin and amylin. Constituting ~50–70% of cells in human islets, beta cells play a vi ...
s. Current research indicates no evidence of type 2 diabetes in dogs. Among the causes of diabetes mellitus in dogs are
autoimmune disease An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated tha ...
or severe
pancreatitis Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormone A hormone (from the Ancient Greek, Greek participle , "se ...
. Forms of diabetes which may not be permanent, depending on the amount of damage to the beta cells of the endocrine pancreas, are transient and secondary diabetes. Some causes of transient or secondary diabetes are
Cushing's syndrome Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, ...
,
glucocorticoid Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebra ...
,
progestin A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. A progestin is a '' synthetic'' progestogen. ...
or other steroid use, and the hormones of pregnancy or heat. In these cases, correcting the primary medical issue may mean a return to non-diabetic status. Common signs include weight loss, increased
drinking Drinking is the act of ingesting water or other liquids into the body through the mouth, proboscis, or elsewhere. Humans drink by swallowing, completed by peristalsis in the esophagus. The physiological processes of drinking vary widely among ...
and
urination Urination is the release of urine from the bladder through the urethra in Placentalia, placental mammals, or through the cloaca in other vertebrates. It is the urinary system's form of excretion. It is also known medically as micturition, v ...
, and
cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...
s. Treatment involves insulin replacement therapy, and use of a diet high in fiber and
complex carbohydrate A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' m ...
s. Oral diabetes medications cannot be used for dogs because none repair or surmount the permanent damage to the beta cells of the pancreas. *
Thyroid The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans, it is a butterfly-shaped gland located in the neck below the Adam's apple. It consists of two connected lobes. The lower two thirds of the lobes are connected by ...
diseases, including: **
Hyperthyroidism Hyperthyroidism is a endocrine disease in which the thyroid gland produces excessive amounts of thyroid hormones. Thyrotoxicosis is a condition that occurs due to elevated levels of thyroid hormones of any cause and therefore includes hyperth ...
is rare in dogs. The most common cause is thyroid carcinoma, a malignant tumor. Signs include weight loss, increased appetite, and enlargement of the thyroid gland. **
Hypothyroidism Hypothyroidism is an endocrine disease in which the thyroid gland does not produce enough thyroid hormones. It can cause a number of symptoms, such as cold intolerance, poor ability to tolerate cold, fatigue, extreme fatigue, muscle aches, co ...
is the most common endocrine disease in dogs. It can be caused by autoimmune destruction (lymphocytic thyroiditis) or
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
atrophy of the thyroid gland. These two causes are responsible for over 95% of the hypothyroidism cases in dogs. Signs include decreased appetite, weight gain, hair loss, dry skin/coat, skin that is cold to the touch, recurring skin infections, and lethargy. The dog may also seek out warm places to lie. The symptoms of hypothyroidism are shared with many other medical conditions; it may not be the first thought when a diagnosis is made. Symptoms may not appear until 75% or more of the gland is non-functional. In less than 10% of hypothyroidism cases, the problem is not with the thyroid gland itself, but with the pituitary gland in the brain. The pituitary gland produces a thyroid stimulating hormone (TSH); without this hormone to signal the thyroid gland to produce its thyroid hormone, the thyroid gland remains inactive. Treatment is with oral thyroid hormone supplementation. Lack of enough
iodine Iodine is a chemical element; it has symbol I and atomic number 53. The heaviest of the stable halogens, it exists at standard conditions as a semi-lustrous, non-metallic solid that melts to form a deep violet liquid at , and boils to a vi ...
in the diet can produce a form of hypothyroidism; without the proper amount of it, the thyroid gland fails to produce enough thyroid hormone. Myxedema coma is a rare but serious aspect of the disease that is a medical emergency. * Hypoadrenocorticism, also known as Addison's disease, is a reduction of production of
glucocorticoid Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebra ...
s and
mineralocorticoid Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. Mineralocorticoids are produced in the adrenal cortex and influence salt and water balances (electrolyte balance and fluid balance). The primary ...
s by the
adrenal gland The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer adrenal corte ...
s. There is more familiarity with the glucocortcoids, such as
cortisol Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. When used as medication, it is known as hydrocortisone. Cortisol is produced in many animals, mainly by the ''zona fasciculata'' of the adrenal corte ...
; mineralocorticoids control the amount of
potassium Potassium is a chemical element; it has Symbol (chemistry), symbol K (from Neo-Latin ) and atomic number19. It is a silvery white metal that is soft enough to easily cut with a knife. Potassium metal reacts rapidly with atmospheric oxygen to ...
, salt and water in the body. It is most commonly caused by destruction of adrenal tissue, probably by autoimmune disease. Signs include increased drinking and urination, vomiting, diarrhea, collapse, shivering and weight loss; at times neither the causes nor symptoms are especially specific. Because of this it is sometimes referred to as "the Great Mimic" or "the Great Imitator". (
PDF Portable document format (PDF), standardized as ISO 32000, is a file format developed by Adobe Inc., Adobe in 1992 to present documents, including text formatting and images, in a manner independent of application software, computer hardware, ...
)
It is possible not to see any symptoms of the disease until the adrenal cortex is 90% dysfunctional. Addison's can occur when regular steroid use is abruptly discontinued; during their use, the system the adrenal gland does not function at 100%. The system senses sufficient levels of these hormones in the body and does not signal for their production. Tapering the medication off gradually allows them to return to full production after discontinuation. About 35% of affected dogs are not diagnosed until they experience an Addisonian crisis, which outwardly appears to be a "classic" shock and is a medical emergency.
Hyperkalemia Hyperkalemia is an elevated level of potassium (K+) in the blood. Normal potassium levels are between 3.5 and 5.0 mmol/L (3.5 and 5.0 mEq/L) with levels above 5.5mmol/L defined as hyperkalemia. Typically hyperkalemia does not cause symptoms. Oc ...
can develop and cause severe
bradycardia Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM). While bradycardia can result from various pathological processes, it is commonly a physiological response to cardiovascular conditioning or due ...
. Only typical Addison's patients have the risk of Addisonian crisis due to the lack of mineralocorticoids. Treatment is with supplementation of mineralocorticoids in daily pills or a monthly injection. The atypical form and the form caused by abrupt withdrawal of steroids do not need mineralocorticoids. Glucocorticoids are usually supplemented with oral
prednisone Prednisone is a glucocorticoid medication mostly used to immunosuppressive drug, suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium ...
. *
Cushing's syndrome Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, ...
, also known as hyperadrenocorticism, is characterized by an increase in glucocorticoids secreted by the adrenal glands. About 85 percent of cases are caused by a tumor in the
pituitary gland The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the human brain, brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus contr ...
, while 15 percent are caused by an adrenal tumor. The pituitary gland produces a hormone that signals the adrenal gland to produce cortisol; a tumor can cause it to produce the adrenal-stimulating hormone even when it is not needed. Signs include increased appetite, increased drinking and urination, a pot-bellied appearance, muscle weakness, and lethargy. Cushing's can be caused by overuse of steroid medications; in some cases, stopping the medication is enough to solve the problem. Diagnosis can be difficult as there are no tests with both high sensitivity and specificity. Treatments include mitotane, trilostane, (
PDF Portable document format (PDF), standardized as ISO 32000, is a file format developed by Adobe Inc., Adobe in 1992 to present documents, including text formatting and images, in a manner independent of application software, computer hardware, ...
)
ketoconazole Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal drug, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin inf ...
, or
selegiline Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. It has also been studied and us ...
. Surgery is used in some cases of adrenal tumors. *
Diabetes insipidus Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst. The amount of urine produced can be nearly 20 liters per day. Reduction of fluid has little effect on the concentration of the urine. ...
* in dogs can be central, caused by a lack of
antidiuretic hormone Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the ''AVP'' gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It ...
(ADH), or nephrogenic, caused by a lack of response of the kidneys to ADH. Neither form is common. Central diabetes insipidus (CDI) is usually idiopathic, but can also be caused by head trauma or tumors of the brain. Nephrogenic diabetes insipidus (NDI) can be primary (hereditary) or secondary (caused by a variety of metabolic and renal diseases, including Cushing's syndrome and
pyometra Pyometra or pyometritis is a uterine infection. Though it is most commonly known as a disease of the unaltered female dog, it is also a notable human disease. It is also seen in female cattle, horses, goats, sheep, swine, cats, rabbits, hamsters, ...
). Because the disease is characterized by an inability to concentrate urine, the most common sign is increased drinking and urinating. Treatment of CDI is to use
desmopressin Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. In hemophilia A and von Willebrand disease, it should ...
, a synthetic analog of ADH. Treatment of NDI is to treat the underlying cause, if any. *
Acromegaly Acromegaly is a disorder that results in excess growth of certain parts of the human body. It is caused by excess growth hormone (GH) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. There ...
(also known as hypersomatotropism) is a hormonal condition resulting from over-secretion of the growth hormone somatotropin from the
pituitary gland The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the human brain, brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus contr ...
. The hormone is responsible for growth from birth to adulthood. Normally in adulthood, the growth plates of the bones close and the secretion of the hormone slows considerably. Because the bone plates close when entering maturity, the continued growth of acromegaly is not of normal proportions.(
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)
Most dogs with the disease are unspayed females, but the condition can come about with use of medications containing
progesterone Progesterone (; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the ma ...
. Acromegaly patients often also have
diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ...
. There is a transient form of acromegaly which can affect females at the diestrus portion of the reproductive cycle. This condition is brought about by the mammary glands excreting excess growth hormone, which is triggered by progesterone from the ovaries. As with non-transient acromegaly, spaying is necessary. The symptoms can include overgrowth or enlargement of gums with wide spaces between teeth, increased drinking, increased urination, thickening of the skin and skin folds, enlargement of the tongue and excessive panting.(
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)
Acromegaly is also possible from a somatotroph adenoma. The hormone
somatostatin Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by #Nomenclature, several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G ...
can also be useful in treatment. Since hypothyroidism is connected with the release of excess growth hormone, hypothyroidism can be mistaken for acromegaly. (
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Gastrointestinal diseases

* Megaesophagus is a disease of the
esophagus The esophagus (American English), oesophagus (British English), or œsophagus (Œ, archaic spelling) (American and British English spelling differences#ae and oe, see spelling difference) all ; : ((o)e)(œ)sophagi or ((o)e)(œ)sophaguses), c ...
characterized by low motility and dilation. Most cases in adult dogs are
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
. It is the most common cause of regurgitation in dogs. Other causes of megaesophagus include
myasthenia gravis Myasthenia gravis (MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, ...
,
lead poisoning Lead poisoning, also known as plumbism and saturnism, is a type of metal poisoning caused by lead in the body. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, infertility, numbness and paresthesia, t ...
, and
Addison's disease Addison's disease, also known as primary adrenal insufficiency, is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adr ...
. *
Gastric dilatation volvulus Gastric dilatation volvulus (GDV), also known as gastric dilation, twisted stomach, or gastric torsion, is a medical condition that affects dogs and rarely cats and guinea pigs, in which the stomach becomes overstretched and rotated by excessive ...
, commonly known as bloat, is a serious condition in which the stomach swells with air (gastric dilatation), sometimes twisting on itself (volvulus). Deep-chested breeds are at a higher risk of bloating. Factors that predispose dogs to this condition are intestinal
foreign bodies A foreign body (FB) is any object originating outside the body of an organism. In machinery, it can mean any unwanted intruding object. Most references to foreign bodies involve propulsion through natural orifices into hollow organs. Foreign b ...
, intestinal cancer, intussusception, and other intestinal diseases. It has a poor prognosis. *
Foreign body A foreign body (FB) is any object originating outside the body of an organism. In machinery, it can mean any unwanted intruding object. Most references to foreign bodies involve propulsion through natural orifices into hollow organs. Foreign b ...
is an object foreign to the body that becomes lodged in the gastrointestinal tract (or other part of the dog). Dogs are susceptible to gastrointestinal obstruction due to their ability to swallow relatively large objects and pass them through the esophagus. Foreign bodies most commonly become lodged in the stomach because of the inability to pass through the pyloric sphincter, and in the jejunum. *
Anal fistula Anal fistula is a chronic fistula, abnormal communication between the anal canal and the perianal skin. An anal fistula can be described as a narrow tunnel with its internal opening in the anal canal and its external opening in the skin near the a ...
e*, known as perianal fistulae in dogs, are most common in German Shepherd Dogs. They are characterized by draining tracts in the skin around the anus. The cause is unknown. Surgical treatment is common, but recently use of
cyclosporine Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, ecz ...
in combination with
ketoconazole Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal drug, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin inf ...
has been shown to be effective. *
Exocrine pancreatic insufficiency Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas. EPI can occur in humans and is prevalent in many conditions such as cystic fibrosis, Shwach ...
is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. This disease is found frequently in dogs. *
Pancreatitis Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormone A hormone (from the Ancient Greek, Greek participle , "se ...
*, or inflammation of the
pancreas The pancreas (plural pancreases, or pancreata) is an Organ (anatomy), organ of the Digestion, digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a ...
, is common in dogs. It is most commonly seen in middle-aged and older overweight dogs.
Miniature Schnauzer The Miniature Schnauzer is a dog breed, breed of small dog of the Schnauzer type that originated in Germany in the mid-to-late 19th century. Miniature Schnauzers may have been developed from the smallest specimens of the Standard Schnauzer, or c ...
s are predisposed. Contributing factors include
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
,
hyperlipidemia Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. citing: and The term ''hyperlipidemia'' refers to the laboratory finding itself and is also use ...
, obesity, and dietary indiscretion. Signs include vomiting, diarrhea, abdominal pain, lethargy, and anorexia. *
Inflammatory bowel disease Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine ...
(IBD)* is a group of diseases in dogs that are
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
and characterized by the presence of inflammatory cell infiltrates in the stomach and/or intestinal walls. It is a common condition. Signs include vomiting, diarrhea, and weight loss. Treatment is with dietary modification and use of medications such as
corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...
s,
metronidazole Metronidazole, sold under the brand name Flagyl and Metrogyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vagino ...
,
sulfasalazine Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. It is ...
, and
azathioprine Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. It is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus er ...
. * Bilious vomiting syndrome is vomiting in response to bile-induced inflammation of the stomach. Bile salts interfere with the gastric mucosal barrier, allowing acid to irritate the stomach lining and cause gastritis. * Intussusception* is characterized by telescoping of one part of the gastrointestinal tract into another part, forming an obstruction. It is most common in dogs six to eight months old. Surgery is necessary for treatment. * Lymphangiectasia is an intestinal disease of dogs characterized by chronic diarrhea and loss of proteins such as
serum albumin Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood. Human serum albumin is encoded by the ''ALB'' gene. Other mammalian forms, such as bovine serum albumin, are chem ...
and
globulin The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but dissolve in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune ...
. It is considered to be a chronic form of
protein-losing enteropathy Protein losing enteropathy (PLE) is a syndrome in which blood proteins are lost excessively via the gastrointestinal (GI) tract. It may be caused by many different underlying diseases that damage the lining of the GI tract (mucosa) or cause blocka ...
. Breeds commonly affected include the Soft-Coated Wheaten Terrier, Norwegian Lundehund, Basenji, and
Yorkshire Terrier The Yorkshire Terrier, also known as a Yorkie, is a British breed of toy dog of terrier type. It is among the smallest of the terriers and indeed of all dog breeds, with a weight of no more than . It originated in the nineteenth century in the ...
. * Hemorrhagic gastroenteritis is a disease of dogs characterized by sudden vomiting and bloody diarrhea. The symptoms are usually severe and can be fatal if not treated. It is most common in young adult dogs of any breed, but especially small dogs such as the Toy Poodle and
Miniature Schnauzer The Miniature Schnauzer is a dog breed, breed of small dog of the Schnauzer type that originated in Germany in the mid-to-late 19th century. Miniature Schnauzers may have been developed from the smallest specimens of the Standard Schnauzer, or c ...
. * Gallbladder mucocele is a disease whereby the
gallbladder In vertebrates, the gallbladder, also known as the cholecyst, is a small hollow Organ (anatomy), organ where bile is stored and concentrated before it is released into the small intestine. In humans, the pear-shaped gallbladder lies beneath t ...
becomes extended with bile and mucus, which can lead to the blockage of bile outflow from the liver.


Urinary and reproductive systems

*
Kidney In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organ (anatomy), organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and rig ...
diseases **
Fanconi syndrome Fanconi syndrome or Fanconi's syndrome (, ) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from t ...
is a type of
renal tubule The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure ...
disease found in Basenjis. Findings include the inability to concentrate urine, and the presence of
glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...
,
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
, and
amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...
s in the urine. **
Kidney failure Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney fa ...
* is common in dogs and may be found in acute or chronic forms. It is defined by a loss of function of about 75 percent of the filtration system of the kidney and characterized by
azotemia Azotemia (), also spelled azotaemia, is a medical condition characterized by abnormally high levels of nitrogen-containing compounds (such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the blood. It is ...
and low
specific gravity Relative density, also called specific gravity, is a dimensionless quantity defined as the ratio of the density (mass of a unit volume) of a substance to the density of a given reference material. Specific gravity for solids and liquids is nea ...
of the urine.
Acute kidney injury Acute kidney injury (AKI), previously called acute renal failure (ARF), is a sudden decrease in renal function, kidney function that develops within seven days, as shown by an increase in serum creatinine or a decrease in urine output, or both. ...
can be caused by loss of blood supply,
hypercalcemia Hypercalcemia, also spelled hypercalcaemia, is a high calcium (Ca2+) level in the blood serum. The normal range for total calcium is 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L), with levels greater than 2.6 mmol/L def ...
, or toxins such as
ethylene glycol Ethylene glycol ( IUPAC name: ethane-1,2-diol) is an organic compound (a vicinal diol) with the formula . It is mainly used for two purposes: as a raw material in the manufacture of polyester fibers and for antifreeze formulations. It is an odo ...
(
antifreeze An antifreeze is an additive which lowers the freezing point of a water-based liquid. An antifreeze mixture is used to achieve freezing-point depression for cold environments. Common antifreezes also increase the boiling point of the liquid, allow ...
) or
aminoglycoside Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). The term can also refer ...
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
s (see: ''
ethylene glycol poisoning Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outco ...
''). Chronic kidney failure can be
congenital A birth defect is an abnormal condition that is present at childbirth, birth, regardless of its cause. Birth defects may result in disability, disabilities that may be physical disability, physical, intellectual disability, intellectual, or dev ...
and/or inherited or caused by cancer, infection,
hypertension Hypertension, also known as high blood pressure, is a Chronic condition, long-term Disease, medical condition in which the blood pressure in the artery, arteries is persistently elevated. High blood pressure usually does not cause symptoms i ...
,
glomerulonephritis Glomerulonephritis (GN) is a term used to refer to several kidney diseases (usually affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, hence the ...
,
amyloidosis Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs and symptoms associated with amyloidosis. These include fatigue, peripheral edema, weigh ...
, progressive interstitial
fibrosis Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective tissue deposition or excessive tissue deposition caused by a disease. Repeated injuries, ch ...
, or any of the causes of acute kidney injury. **
Glomerulonephritis Glomerulonephritis (GN) is a term used to refer to several kidney diseases (usually affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, hence the ...
* is the presence of
immune complex An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to antibodies. The bound antigen and antibody act as a unitary object, effectively an antigen of ...
es in the
glomerulus ''Glomerulus'' (; : glomeruli) is a common term used in anatomy to describe globular structures of entwined vessels, fibers, or neurons. ''Glomerulus'' is the diminutive of the Latin ''glomus'', meaning "ball of yarn". ''Glomerulus'' may refer to ...
, resulting in leakage of protein into the urine. It can be caused by cancer,
heartworm ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a parasitic roundworm that is a type of filarial worm, a small thread-like worm, and which causes dirofilariasis. It is spread from host to host through the bites of mosqui ...
disease,
pyometra Pyometra or pyometritis is a uterine infection. Though it is most commonly known as a disease of the unaltered female dog, it is also a notable human disease. It is also seen in female cattle, horses, goats, sheep, swine, cats, rabbits, hamsters, ...
,
rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The genus was n ...
l infection, or
systemic lupus erythematosus Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common ...
. It can result in chronic kidney failure,
hypoalbuminemia Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the concentration, level of human serum albumin, albumin in the blood is low. This can be due to decreased production in the liver, increased loss in the gastrointestinal tract or ki ...
, which can cause
ascites Ascites (; , meaning "bag" or "sac") is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in the peritoneal cavity, although volumes greater than one liter may occur. Symptoms may include increased abdo ...
and peripheral
edema Edema (American English), also spelled oedema (British English), and also known as fluid retention, swelling, dropsy and hydropsy, is the build-up of fluid in the body's tissue (biology), tissue. Most commonly, the legs or arms are affected. S ...
, and
nephrotic syndrome Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes proteinuria, protein in the urine, hypoalbuminemia, low blood albumin levels, hyperlipidemia, high blood lipids, and significant edema, swelling. Other symptoms ...
, which can cause hypertension or
hypercoagulability Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). Such abnormalities can be identified in 50% of people who ...
. ** Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited. ** Samoyed hereditary glomerulopathy (SHG) is an hereditary noninflammatory disease, of the
renal In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retrop ...
glomeruli occurring in the Samoyed breed of dog. The disease has been shown to be a model for hereditary nephritis (HN) in humans *
Urinary bladder The bladder () is a hollow organ in humans and other vertebrates that stores urine from the Kidney (vertebrates), kidneys. In placental mammals, urine enters the bladder via the ureters and exits via the urethra during urination. In humans, the ...
diseases **
Bladder stone A bladder stone is a stone found in the urinary bladder. Signs and symptoms Bladder stones are small mineral deposits that can form in the bladder. In most cases bladder stones develop when the urine becomes very concentrated or when one is ...
s or uroliths are common in dogs. The stones form in the urinary bladder in varying size and numbers secondary to infection, dietary influences, and genetics. Types of stones include struvite,
calcium oxalate Calcium oxalate (in archaic terminology, oxalate of lime) is a calcium salt of oxalic acid with the chemical formula or . It forms hydrates , where ''n'' varies from 1 to 3. Anhydrous and all hydrated forms are colorless or white. The monohydr ...
,
urate Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of ...
,
cystine Cystine is the oxidized derivative of the amino acid cysteine and has the formula (SCH2CH(NH2)CO2H)2. It is a white solid that is poorly soluble in water. As a residue in proteins, cystine serves two functions: a site of redox reactions and a mec ...
,
calcium phosphate The term calcium phosphate refers to a family of materials and minerals containing calcium ions (Ca2+) together with inorganic phosphate anions. Some so-called calcium phosphates contain oxide and hydroxide as well. Calcium phosphates are white ...
, and
silicate A silicate is any member of a family of polyatomic anions consisting of silicon and oxygen, usually with the general formula , where . The family includes orthosilicate (), metasilicate (), and pyrosilicate (, ). The name is also used ...
. Struvite and calcium oxalate stones are by far the most common. **
Urinary tract infection A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. Lower urinary tract infections may involve the bladder (cystitis) or urethra (urethritis) while upper urinary tract infections affect the kidney (pyel ...
*, specifically
cystitis A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. Lower urinary tract infections may involve the bladder (cystitis) or urethra ( urethritis) while upper urinary tract infections affect the kidney (py ...
or bladder infection, is common in dogs and usually caused by
bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...
. Signs include blood in the urine (
hematuria Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. "Gross hematuria" occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable with ...
), difficulty urinating (
dysuria Dysuria refers to painful or uncomfortable urination. It is one of a constellation of ''irritative'' bladder symptoms (also sometimes referred to as lower urinary tract symptoms), which includes nocturia and urinary frequency. Diagnosis The cl ...
), and frequent urination (
polyuria Polyuria () is excessive or an abnormally large production or Frequent urination, passage of urine (greater than 2.5 L or 3 L over 24 hours in adults). Increased production and passage of urine may also be termed as diuresis. Polyuria often appe ...
). The most common types of bacteria cultured from the urine of dogs with cystitis are ''
E. coli ''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly foun ...
'', ''
Staphylococcus ''Staphylococcus'', from Ancient Greek σταφυλή (''staphulḗ''), meaning "bunch of grapes", and (''kókkos''), meaning "kernel" or " Kermes", is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillale ...
'' spp., ''
Proteus mirabilis ''Proteus mirabilis'' is a Gram-negative, facultatively Anaerobic organism, anaerobic, rod-shaped bacterium. It shows swarming motility and urease activity. ''P. mirabilis'' causes 90% of all ''Proteus (bacterium), Proteus'' infections in human ...
'', ''
Streptococcus ''Streptococcus'' is a genus of gram-positive spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Bacillota. Cell division in streptococci occurs along a sing ...
'' spp., ''
Klebsiella pneumoniae ''Klebsiella pneumoniae'' is a Gram-negative, non-motile, encapsulated, lactose- fermenting, facultative anaerobic, rod-shaped bacterium. It appears as a mucoid lactose fermenter on MacConkey agar. Although found in the normal flora of the mo ...
'', ''
Pseudomonas aeruginosa ''Pseudomonas aeruginosa'' is a common Bacterial capsule, encapsulated, Gram-negative bacteria, Gram-negative, Aerobic organism, aerobic–facultative anaerobe, facultatively anaerobic, Bacillus (shape), rod-shaped bacteria, bacterium that can c ...
'', and ''
Enterobacter ''Enterobacter'' is a genus of common Gram-negative, Facultative anaerobic organism, facultatively anaerobic, bacillus (shape), rod-shaped, non-spore-forming bacteria of the family Enterobacteriaceae. Cultures are found in soil, water, sewage, ...
'' spp. **
Urinary incontinence Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a significant effect on quality of life. Urinary incontinence is common in older women ...
* is leakage of urine, usually due to incompetence of the
urethral sphincter The urethral sphincters are two muscles used to control the exit of urine in the urinary bladder through the urethra. The two muscles are either the external sphincter muscle of male urethra, male or external sphincter muscle of female urethra, fe ...
in adult dogs and ectopic ureter (a congenital condition in which the
ureter The ureters are tubes composed of smooth muscle that transport urine from the kidneys to the urinary bladder. In an adult human, the ureters typically measure 20 to 30 centimeters in length and about 3 to 4 millimeters in diameter. They are lin ...
enters the urinary tract posterior to the urethral sphincter) in puppies. In adult dogs it is most commonly seen in large spayed females. The lack of
estrogen Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three ...
s in spayed dogs has been linked to development of incontinence. Replacement of estrogens,
phenylpropanolamine Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant. It was once common in prescription and over-the-counter cough and cold preparations. The medication is taken ...
, and surgery have all been used for treatment. *Reproductive diseases ** Prostate disease* in dogs includes
benign prostatic hyperplasia Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, urinary retention, inability t ...
(BPH), prostatitis (infection of the prostate), cancer, and cysts and abscesses. BPH is the most common and is found in older intact (not neutered) dogs. Signs include blood in the urine and straining to urinate and defecate.
Castration Castration is any action, surgery, surgical, chemical substance, chemical, or otherwise, by which a male loses use of the testicles: the male gonad. Surgical castration is bilateral orchiectomy (excision of both testicles), while chemical cas ...
is the treatment of choice. Prostatis can be associated with BPH. Bacteria causing prostatitis include ''
E. coli ''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly foun ...
'', ''
Staphylococcus ''Staphylococcus'', from Ancient Greek σταφυλή (''staphulḗ''), meaning "bunch of grapes", and (''kókkos''), meaning "kernel" or " Kermes", is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillale ...
'' spp., ''
Streptococcus ''Streptococcus'' is a genus of gram-positive spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Bacillota. Cell division in streptococci occurs along a sing ...
'' spp., and ''
Mycoplasma ''Mycoplasma'' is a genus of bacteria that, like the other members of the class ''Mollicutes'', lack a cell wall, and its peptidoglycan, around their cell membrane. The absence of peptidoglycan makes them naturally resistant to antibiotics ...
'' spp. **
Cryptorchidism Cryptorchidism, also known as undescended testis, is the failure of one or both testes to descend into the scrotum. The word is . It is the most common birth defect of the male genital tract. About 3% of full-term and 30% of premature infant boy ...
is when one the testicles is retained in the abdomen or
inguinal canal The inguinal canal is a passage in the anterior abdominal wall on each side of the body (one on each side of the midline), which in males, convey the spermatic cords and in females, the round ligament of the uterus. The inguinal canals are lar ...
past a normal stage of development. It is a common occurrence in dogs and is thought to be a sex-limited
autosomal recessive In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the Phenotype, effect of a different variant of the same gene on Homologous chromosome, the other copy of the chromosome. The firs ...
trait. **
False pregnancy False pregnancy (or pseudocyesis, ) is the appearance of clinical or subclinical signs and symptoms associated with pregnancy although the individual is not physically carrying a fetus. The mistaken impression that one is pregnant includes sign ...
*, or pseudocyesis, is a common condition in female intact dogs. Signs include swelling of the mammary glands, lactation, not eating, and "mothering" small objects. **
Pyometra Pyometra or pyometritis is a uterine infection. Though it is most commonly known as a disease of the unaltered female dog, it is also a notable human disease. It is also seen in female cattle, horses, goats, sheep, swine, cats, rabbits, hamsters, ...
is an infection of the
uterus The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the hollow organ, organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic development, embryonic and prenatal development, f ...
. It is a common and potentially fatal condition in dogs. The main risk period for a female is for eight weeks after her peak standing heat (or
estrus cycle The estrous cycle (, originally ) is a set of recurring physiological changes induced by reproductive hormones in females of mammalian subclass Theria. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phases ...
) has ended. *
Umbilical hernia An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may cause the navel to bulge outwards—the bulge consisting of abdominal fat from the greater omentum or occasionally parts of the small intestine. ...
* is a failure of the umbilical ring of the abdominal wall to close. They are very common and can be caused by genetics or by traction on the
umbilical cord In Placentalia, placental mammals, the umbilical cord (also called the navel string, birth cord or ''funiculus umbilicalis'') is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord i ...
or by the cord being cut too close to the body. They are corrected by surgery. *
Inguinal hernia An inguinal hernia or groin hernia is a hernia (protrusion) of abdominal cavity contents through the inguinal canal. Symptoms, which may include pain or discomfort especially with or following coughing, exercise, or bowel movements, are absen ...
* is a protrusion of abdominal contents through the inguinal canal. They are corrected through surgery.


Cancers

* Canine transmissible venereal tumor is a tumor of the external genitalia (penis, vulva). It is spread by sexual contact and is more common in hot and humid climates. *
Hemangiosarcoma Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans (vinyl chloride toxicity). It is a sarcoma arising from the lining of blood vessels; ...
is an aggressive tumor that most often affects the heart, the spleen, the skin and subcutaneous tissues, and the liver. *
Osteosarcoma An osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchyme, mesenchymal origin (and thus a sarcoma) and that exhi ...
is an aggressive bone tumor that commonly spreads to the lungs. It is more common in large and giant breed dogs. *
Histiocytoma A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the mononuclear phagocytic system, a part of the body's immune system that consists of phagocytic cells, which are responsible for engulfing solid pa ...
is a benign skin tumor that is more frequent in young dogs (<4 years), and often regresses without treatment. *
Malignant histiocytosis Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. His ...
( histiocytic sarcoma) is an aggressive cancer found primarily in certain breeds including the Bernese Mountain Dog,
rottweiler The Rottweiler (, , ) is a breed of domestic dog, regarded as medium-to-large or large. The dogs were known in German as , meaning Rottweil butchers' dogs, because their main use was to herd livestock and pull carts laden with butchered mea ...
, golden retriever and
flat coated retriever The Flat-coated Retriever is a gun dog breed originating from England. It was developed as a retriever both on land and in the water. Description Appearance The Flat-Coated Retriever breed standard calls for males to be tall at the withers, ...
. It is characterized by infiltration of the joints, lungs,
spleen The spleen (, from Ancient Greek '' σπλήν'', splḗn) is an organ (biology), organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter. The spleen plays important roles in reg ...
,
lymph node A lymph node, or lymph gland, is a kidney-shaped organ of the lymphatic system and the adaptive immune system. A large number of lymph nodes are linked throughout the body by the lymphatic vessels. They are major sites of lymphocytes that includ ...
s, and other organs by
malignant Malignancy () is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous benign tumor, ''benign'' tumor in that a malig ...
histiocyte A histiocyte is a vertebrate cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's immune system. The histiocy ...
s. *A mast cell tumor (mastocytoma) is a type of tumor normally found in the skin of dogs. It can also invade the
subcutis The subcutaneous tissue (), also called the hypodermis, hypoderm (), subcutis, or superficial fascia, is the lowermost layer of the integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and ma ...
and spread to the liver, spleen, or bone marrow. *
Lymphoma Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph node ...
(lymphosarcoma) is a malignant cancer that is classified by location, cell type, and histological grade. The most common form in dogs is multicentric, involving the lymph nodes. *
Fibrosarcoma Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform ...
is a malignant tumor that most commonly occurs in the mouth in dogs, and less commonly in the skin, subcutis, and bones. * Aggressive fibromatosis, also known as desmoid fibromatosis, a type of non-metastasizing soft-tissue sarcoma, may occur in dogs. *
Squamous cell carcinoma Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the ...
* is a malignant tumor in dogs that most commonly occurs in the oral cavity, including the tongue, tonsils, and
gingiva The gums or gingiva (: gingivae) consist of the mucosal tissue that lies over the mandible and maxilla inside the mouth. Gum health and disease can have an effect on general health. Structure The gums are part of the soft tissue lining of the ...
. Squamous cell carcinoma accounts for 5 percent of skin tumors in dogs, and are the most common tumor of the toe. Dogs with unpigmented skin on the nose may develop this cancer from long-term sun exposure. * Perianal gland tumor (also called hepatoid tumor) is a type of tumor found near the anus in dogs that arises from specialized glandular tissue found in the perineum. They are most common in intact (not neutered) male dogs. * Anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the tissue of anal sac. *
Melanoma Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). In very rare case ...
s* account for four to six percent of skin tumors in dogs and are usually benign. They are the second most common tumor of the toe and are malignant in this location. Malignant melanoma is also a common oral tumor in dogs. Malignant tumors most commonly spread to the lymph nodes and lungs. *
Leukemia Leukemia ( also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or '' ...
s* are progressive proliferation of cancerous white blood cells within the bone marrow, resulting in destruction of the bone marrow and
pancytopenia Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells (red blood cells, white blood cells, platelets, monocytes, lymphocytes, etc.). If only two parameters from the complete blood cou ...
in many cases. Types of leukemia in dogs include
acute lymphoblastic leukemia Acute lymphoblastic leukemia (ALL) is a cancer of the Lymphocyte, lymphoid line of blood cells characterized by the development of large numbers of lymphoblast, immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, ...
, acute myelocytic leukemia, acute monocytic leukemia,
acute myelomonocytic leukemia Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts. AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of mye ...
, acute megakaryocytic leukemia,
chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. In CLL, the bone marrow makes too many lymphocytes, which are a type of white blood cell. In patients with CLL, B cell lymphocytes can begin to colle ...
,
chronic myelogenous leukemia Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumula ...
, chronic basophilic leukemia, and chronic eosinophilic leukemia (or
hypereosinophilic syndrome Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous sys ...
). *
Plasmacytoma Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton. The International Myeloma Working Group lists three types: Plasma cell dyscrasia#Solitary plasmacytoma, solitary plasma ...
s* are common skin tumors in dogs that derive from B lymphocytes. Most are benign. Tumors of B lymphocyte origin that affect the bone marrow and are diffuse throughout the body are malignant and are called
multiple myeloma Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibody, antibodies. Often, no symptoms are noticed initially. As it progresses, bone ...
*. *
Prostate cancer Prostate cancer is the neoplasm, uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of the prostate tissue is usually detected through Screening (medicine), screening tests, ...
* is rare in dogs and occurs in both intact and neutered animals. It is malignant. The most common type is
adenocarcinoma Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ; AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
. Signs include blood in the urine and straining to urinate or defecate. It most commonly spreads to bone and the lungs. *
Mammary tumor A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spaying and neutering, spayed, but they are found in other animals as well. The mammary glands in dogs and cats are a ...
s in dogs are potentially benign or malignant. They occur most commonly in non-spayed females or female that were spayed later in life. *
Insulinoma An insulinoma is a tumour of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a neuroendocrine tumour. Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a m ...
s* in dogs are
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...
secreting tumors of the
pancreas The pancreas (plural pancreases, or pancreata) is an Organ (anatomy), organ of the Digestion, digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a ...
. The most common sign is
hypoglycemia Hypoglycemia (American English), also spelled hypoglycaemia or hypoglycæmia (British English), sometimes called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L). Whipple's tria ...
. They commonly
metastasize Metastasis is a pathogenic agent's spreading from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, ...
to the liver. *
Oral cancer Oral cancer, also known as oral cavity cancer, tongue cancer or mouth cancer, is a cancer of the lining of the lips, mouth, or upper throat. In the mouth, it most commonly starts as a painless red or white patch, that thickens, gets ulcerated ...
* includes tumors of the tongue, tonsils,
gingiva The gums or gingiva (: gingivae) consist of the mucosal tissue that lies over the mandible and maxilla inside the mouth. Gum health and disease can have an effect on general health. Structure The gums are part of the soft tissue lining of the ...
, and palate. The most common types are squamous cell carcinomas, malignant melanomas, and fibrosarcomas. *Eye cancer, Ocular tumors* in dogs are found in the eyelid,
conjunctiva In the anatomy of the eye, the conjunctiva (: conjunctivae) is a thin mucous membrane that lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with gobl ...
, third eyelid,
cornea The cornea is the transparency (optics), transparent front part of the eyeball which covers the Iris (anatomy), iris, pupil, and Anterior chamber of eyeball, anterior chamber. Along with the anterior chamber and Lens (anatomy), lens, the cornea ...
, sclera, iris,
ciliary body The ciliary body is a part of the eye that includes the ciliary muscle, which controls the shape of the lens, and the ciliary epithelium, which produces the aqueous humor. The aqueous humor is produced in the non-pigmented portion of the ciliary ...
, retina, choroid, optic nerve, and orbit (anatomy), orbit. The most common types are Meibomian gland adenoma (eyelid), papilloma (eyelid), melanoma (eyelid, conjunctiva, sclera, iris, ciliary body, choroid), squamous cell carcinoma (conjunctiva), adenoma (ciliary body),
adenocarcinoma Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ; AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
(ciliary body), lymphoma (retina, choroid, ciliary body), medulloepithelioma (retina, choroid), ganglioglioma (retina, choroid), osteosarcoma (orbit), mast cell tumor (orbit), and optic nerve sheath meningioma. *Nasal cancer makes up one to two percent of all types of tumors in dogs. Adenocarcinoma is the most common type, followed by sarcomas such as fiborsarcoma and chondrosarcoma. Signs include sneezing and bloody nasal discharge. *Thyroid cancer* is rare and usually nonproductive in dogs (unlike in cats, in which it causes hyperthyroidism). One-third of thyroid tumors are small benign adenomas; the rest are malignant carcinomas, usually large and invasive. *Gastrointestinal cancer* is uncommon in dogs. The most common type is lymphoma. Nonlymphomatous esophageal cancer is especially rare, the most common types being squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, and osteogenic sarcoma associated with the parasite ''Spirocerca lupi''. Nonlymphomatous stomach cancer is usually an adenocarcinoma, and nonlymphomatous intestinal cancer is usually polyp (medicine), polyps, adenomas, adenocarcinomas, leiomyosarcomas, and leiomyomas. *Kidney cancer* is uncommon in dogs. The most common type is renal cell carcinoma. *Lung cancer* is usually the result of metastasis in dogs. Primary tumors are rare. The most common type is adenocarcinoma. *Heart tumors* are rare in dogs. Types include hemangiosarcoma, fibrosarcoma, and fibroma. *Testicular cancer, Testicular tumors* are the most common tumor of the canine male reproductive tract. Tumor types include Sertoli cell tumor, seminoma, and interstitial cell tumor. None commonly metastasize. *Ovarian cancer* is uncommon in dogs, with the most common type being the granulosa cell tumor. This type of tumor can metastasize and can cause cystic endometrial hyperplasia. *Uterine cancer* is very rare in dogs. The most common type is benign leiomyoma. *Bladder cancer* is usually malignant in dogs. The most common type is transitional cell carcinoma. *Hepatocellular carcinoma, Liver cancer* is usually metastatic in dogs. Primary tumors are and include benign hepatocellular adenoma (hepatoma) and malignant hepatic carcinoids. *Brain tumors* can be either metastatic or primary in dogs. The incidence of primary tumors is 14.5 per 100,000 dogs at risk. Types include meningioma, astrocytoma, oligodendroglioma, and undifferentiated sarcoma.


Behavioral

*Pica (disorder), Pica is an appetite for, or the behavior of eating, non-nutritive substances (e.g.,
sand Sand is a granular material composed of finely divided mineral particles. Sand has various compositions but is usually defined by its grain size. Sand grains are smaller than gravel and coarser than silt. Sand can also refer to a textural ...
, coal, soil, chalk, paper). Pica can be dangerous to dogs. For example, dogs that eat dirt near roads that existed prior to the phaseout of tetraethyllead in gasoline or prior to the cessation of the use of contaminated oil (containing toxic PCBs) can die. In addition to poisoning, there is a risk of bowel obstruction, gastro-intestinal obstruction or tearing in the stomach or blockage of the
esophagus The esophagus (American English), oesophagus (British English), or œsophagus (Œ, archaic spelling) (American and British English spelling differences#ae and oe, see spelling difference) all ; : ((o)e)(œ)sophagi or ((o)e)(œ)sophaguses), c ...
. Pica in dogs may be a sign of immune-mediated hemolytic anemia, especially when it involves eating substances such as tile
grout Grout is a dense substance that flows like a liquid yet hardens upon application, often used to fill gaps or to function as reinforcement in existing structures. Grout is generally a mixture of water, cement, and sand, and is frequently employe ...
,
concrete Concrete is a composite material composed of aggregate bound together with a fluid cement that cures to a solid over time. It is the second-most-used substance (after water), the most–widely used building material, and the most-manufactur ...
dust, and
sand Sand is a granular material composed of finely divided mineral particles. Sand has various compositions but is usually defined by its grain size. Sand grains are smaller than gravel and coarser than silt. Sand can also refer to a textural ...
. Dogs exhibiting this form of pica should be tested for anemia with a
complete blood count A complete blood count (CBC), also known as a full blood count (FBC) or full haemogram (FHG), is a set of medical laboratory tests that provide cytometry, information about the cells in a person's blood. The CBC indicates the counts of white blo ...
including hematocrit levels, or packed cell volume. *Coprophagia is the ingestion by a dog of feces, either its own or those of another dog or animal. It can be caused by medical conditions such as exocrine pancreatic insufficiency, overfeeding, or malabsorption. It can also be a behavioral problem characterized by attention-seeking, reinforcement, or as a learned behavior. Numerous health problems can arise from this activity, including internal parasites or infection with ''canine parvovirus'' or toxoplasmosis. Treatment includes behavioral modification therapy or altering the feces to affect its taste.


Environmental

*Sensitivity to Veterinary anesthesia, anaesthesia can occur in any breed, but sighthounds have been the breeds most documented to have anesthetic concerns. Sighthounds are known to have prolonged recovery times from ultra short-acting thiobarbiturates such as thiopental. *Dog heat stroke, Heat stroke can occur in dogs, especially in flat-faced breeds such as the
Bulldog The Bulldog is a British breed of dog of mastiff type. It may also be known as the English Bulldog or British Bulldog. It is a stocky, muscular dog of medium size, with a large head, thick folds of skin around the face and shoulders and a rel ...
or in giant breeds. Breed, lack of water, exercise, and high ambient temperature predispose dogs to heat stroke. Signs include vomiting, diarrhea, collapse, difficulty breathing, and body temperature approaching 42 °C to 43 °C. Treatment includes cooling the dogs with wet towels and fans, intravenous therapy, intravenous fluid therapy, and other supportive care. If a dog's temperature begins to drop to around 40 °C, stop the cooling process. Allow the dog only a couple of laps of water until the temperature begins to drop to a more normal level. Do not allow a dog to gulp large quantities of water. If a dog is panting excessively and then drinks a lot of water, large amounts of air may be swallowed along with the water and this can cause an equally life-threatening case of gastric dilatation volvulus (bloat) in the stomach. *Foxtail (raceme), Foxtails and sandburs can penetrate the lining of the mouth or skin and migrate, causing abscesses and draining tracts.


Poisons and overdoses

*Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. *Ibuprofen (Advil)* can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. *Naproxen (Aleve)* has a long Biological half-life, half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting. *Ethylene glycol, Antifreeze* is very dangerous to dogs and causes central nervous system depression and acute kidney injury. Treatment needs to be within eight hours of ingestion to be successful. See Ethylene glycol poisoning. *Rat poison, Mouse and rat poison* ingestion is common in dogs. Most rodenticides in the United States are anticoagulant by depleting vitamin K. This type is the most frequent cause of poisoning in pets. Third generation products contain brodifacoum or bromadiolone and are toxic after a single ingestion. Signs include spontaneous and excessive bleeding internally and externally. Treatment is with vitamin K supplementation. Other rodenticides may contain cholecalciferol which causes
hypercalcemia Hypercalcemia, also spelled hypercalcaemia, is a high calcium (Ca2+) level in the blood serum. The normal range for total calcium is 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L), with levels greater than 2.6 mmol/L def ...
and leads to heart and kidney problems. Newer rodenticides may contain bromethalin which causes central nervous system signs such as seizures, muscle tremors, and depression. *Insecticides* used in dogs for fleas and ticks commonly contain either organophosphates or carbamates. They can be absorbed through the skin,
conjunctiva In the anatomy of the eye, the conjunctiva (: conjunctivae) is a thin mucous membrane that lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with gobl ...
, gastrointestinal tract, and lungs. Organophosphates inhibit acetylcholinesterase irreversibly and carbamates inhibit cholinesterase reversibly. Toxicity occurs through overdosage with an appropriate product or use of an agricultural product. Signs for both include hypersalivation, vomiting, lethargy, tremors, difficulty walking, weakness, and death. *Theobromine poisoning, Chocolate is a common cause of poisoning in dogs. The toxic principles in chocolate are theobromine and caffeine. Baker's Chocolate, Baker's chocolate is the most dangerous form since it contains higher concentrations of these drugs, followed by semi-sweet, dark, and then milk chocolate. Signs include vomiting, diarrhea, tremors, difficulty walking, seizures, and heart problems. *Lead poisoning* is uncommon in dogs. Exposure to lead is from eating paint chips from lead-based paint (found in houses painted prior to 1950), and eating lead objects such as Lead shot, shot, Sinker (fishing), fishing sinkers, or counterweights. Signs of poisoning include vomiting, diarrhea, blindness, seizures, and tremors. *Grape and raisin toxicity in dogs, Raisins and grapes are potential causes of kidney failure in dogs. *Garlic, onions, and chives are toxic to dogs. They cause the destruction of red blood cells known as Heinz body anemia, a form of hemolytic anemia. No clear quantity has been established as to the onset of the anemia. Poisonous reactions can result from raw, cooked or dried onions, garlic, and chives, including those included in powdered or dehydrated forms. Avoid all foods that contain onions or onion variants (such as spaghetti sauce).


Miscellaneous

* Vestibular disease is an uncommon condition in older dogs. Most cases are
idiopathic An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause ...
, but it can also be caused by otitis interna, or inner ear infection, tumors, and encephalitis. Signs include nystagmus, head tilt, circling, vomiting, and falling to one side. Idiopathic vestibular disease will usually resolve in a few days to a few weeks. * Molera (hole in skull), better known as an open fontanelle, may be a sign of hydrocephalus, but is also a normal finding in toy breeds such as Chihuahua. * Anal gland problems are very common, and may include impaction, infection, or abscessation. These glands are normally emptied when the dog defecates. * Shar Pei fever is characterized by recurring fever and swelling of the hocks in
Shar Pei The Shar Pei () is a dog breed from southern China. Traditionally kept as a property guardian, the shar pei was driven to the brink of extinction in the 20th century. The breed is known in the West for its deep wrinkles, while a traditional less ...
s. It can result in renal and liver failure. * Liver failure is common. Signs include vomiting, loss of appetite, weight loss, and jaundice. Causes include bacterial or viral infection, toxic insult, cancer, copper storage diseases, or it may be idiopathic. * Dental disease is very common. Calculus (dental), Calculus is the most obvious sign, but gingivitis progressing to periodontitis is what results in tooth loss. Treatment involves scaling and polishing of the teeth under general anesthesia and treatment of any periodontal disease. Prevention is very important and can be accomplished through the use of special diets or treats, brushing, and plaque prevention gels. * Portosystemic shunt is a bypass of the liver by the body's circulatory system. It can be either a congenital or acquired condition. * Perineal hernia is characterized by herniation of abdominal contents through the pelvic diaphragm, which causes swelling on one side of the anus. * Primary ciliary dyskinesia is a dysfunction of cilia, which manifests as spermatozoon, sperm immotility and respiratory disease. Signs include nasal discharge, recurring pneumonia, and infertility. Symptoms develop soon after birth. * Cleft lip and cleft palate#Other animals, Cleft lip and cleft palate are uncommon and generally cause difficulty with nursing, and, more seriously aspiration pneumonia. * Congenital diaphragmatic hernia is uncommon, and is usually caused by trauma. Congenital diaphragmatic hernias are usually communications between the peritoneum and
pericardium The pericardium (: pericardia), also called pericardial sac, is a double-walled sac containing the heart and the roots of the great vessels. It has two layers, an outer layer made of strong inelastic connective tissue (fibrous pericardium), ...
and are usually incidental findings. * Gingival enlargement#Other animals, Gingival hyperplasia is seen in cephalic index, brachycephalic breeds, especially Boxers. It is generally benign, although food and hair impaction is common. * Salmon poisoning disease is a fatal disease caused by infection with a
rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The genus was n ...
, either ''Neorickettsia helminthoeca'' or ''Neorickettsia elokominica''. Dogs are infected by eating raw salmon from the Pacific Northwest. * Vaccine reactions are adverse events which occur following vaccination, including
granuloma A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such sub ...
formation, but most commonly the term vaccine reaction is used to describe a type I hypersensitivity reaction. The most common signs are facial swelling and urticaria, hives, but more rarely very serious signs such as hypotension and collapse may occur. * Systemic lupus erythematosus (SLE) is an immune system disease characterized by the presence of antibody, antibodies to nucleic acid and/or antibodies to red blood cells,
platelet Platelets or thrombocytes () are a part of blood whose function (along with the coagulation#Coagulation factors, coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a thrombus, blood clot. Platelets have no ...
s, lymphocytes, clotting factors, and thyroglobulin. The disease can result in deposition of
immune complex An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to antibodies. The bound antigen and antibody act as a unitary object, effectively an antigen of ...
es or autoimmunity, autoimmune disease. Immune complex deposition can cause
vasculitis Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both artery, arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. Vasculitis is primarily c ...
, meningitis, neuritis, and joint and skin disease. The most commons signs are
hemolytic anemia Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). This most commonl ...
or
thrombocytopenia In hematology, thrombocytopenia is a condition characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive bleeding. It is the most common coag ...
. * Myasthenia gravis results from the presence of antibodies to the acetylcholine receptor. Signs include megaesophagus and muscle weakness. * Tetanus is a disease caused by the bacteria ''Clostridium tetani'' following wound contamination. Dogs are not very susceptible to tetanus. Signs include difficulty opening the mouth and eating, contraction of the facial muscles, and rigid extension of the limbs. Dogs may also get localized tetanus, signs of which include stiffness of a limb spreading to the rest of the body. * Polydactyly is the occurrence of extra toes, generally on the preaxial (dewclaw) side. This is more common in certain breeds, such as the Great Pyrenees. * Tracheal collapse is characterized by incomplete formation or weakening of the cartilagenous rings of the Vertebrate trachea, trachea. It is most common in small and toy breeds. Signs include a cough (often called a "goose honk cough" due to its sound), especially when excited. * Brachycephalic airway obstructive syndrome is a condition of brachycephalic (short-nosed) dogs, characterized by the presence of stenotic nares, elongated soft palate, narrow trachea, collapsed
larynx The larynx (), commonly called the voice box, is an organ (anatomy), organ in the top of the neck involved in breathing, producing sound and protecting the trachea against food aspiration. The opening of larynx into pharynx known as the laryngeal ...
, and everted laryngeal saccules. Signs include difficult and noisy breathing. Surgical options are available.


See also

* Dog health * Mastocytoma in dogs * Threadworm infections of dogs * Parasites and pathogens of wolves


References

{{DEFAULTSORT:List Of Dog Diseases Dog diseases, * Lists of dogs, Diseases Lists of animal diseases, Dog