In gene-activated matrix technology (GAM), cytokines and growth factors could be delivered not as recombinant proteins but as
plasmid
A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently. They are most commonly found as small circular, double-stranded DNA molecules in bacteria; howev ...
genes.
GAM is one of the
tissue engineering
Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biologi ...
approaches to wound healing. Following
gene delivery
Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Gene delivery must reach the genome of the host cell to induce gene expression. Successful gene delivery requires the foreign gene deliver ...
, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for a prolonged period of time – leading to reproducible tissue regeneration.
References
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External links
Cardium Presents Gene Activated Matrix Technology And Update On Excellarate Clinical Development Program At ASGT Annual Meeting
Tissue engineering