Actin-binding proteins (also known as ABPs) are proteins that bind to

actin Actin is a protein family, family of Globular protein, globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in myofibril, muscle fibrils. It is found in essentially all Eukaryote, eukaryotic cel ...

. This may mean ability to bind actin monomers, or polymers, or both. Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain. This is a list of

-binding

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

s in alphabetical order.

0–9

* 25kDa * 25kDa ABP from aorta p185neu * 30akDA 110 kD dimer ABP * 30bkDa 110 kD (Drebrin) * 34kDA * 45kDa * p53 * p58gag * p116rip

A

a-actinin Actinin is a microfilament protein. Alpha-actinin-1 is necessary for the attachment of actin myofilaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, ...

* Abl * AbLIM Actin-Interacting MAPKKK * ABP120 * ABP140 * Abp1p * ABP280 (Filamin) * ABP50 (EF-1a) * Acan 125 (Carmil) * ActA * Actibind *

Actin Actin is a protein family, family of Globular protein, globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in myofibril, muscle fibrils. It is found in essentially all Eukaryote, eukaryotic cel ...

* Actinfilin * Actinogelin * Actin-regulating kinases * Actin-Related Proteins * Actobindin * Actolinkin * Actopaxin * Actophorin * Acumentin (= L-plastin) * Adducin * ADF/Cofilin * Adseverin (scinderin) * Afadin * AFAP-110 * Affixin * Aginactin * AIP1 * Aldolase * Angiogenin *

Anillin Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ''ANLN'' gene in humans and the scraps gene in ''Drosophila'' encode Anillin. In 1989, anillin was first isolated in embryos of ''Dros ...

Annexins Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms (animal, plant and fungi). In humans, the annexins are found inside the cell. However some annexins (Annexin A1, Annexin A2, and Annexin A5 ...

* Aplyronine * Archvillin *

Arginine kinase In enzymology, arginine kinase () is an enzyme that catalyzes the chemical reaction :ATP + L-arginine \rightleftharpoons ADP + Nω-phospho-L-arginine Thus, the two substrates of this enzyme are ATP and L-arginine, whereas its two products are ...

Arp2/3 complex Arp2/3 complex (Actin Related Protein 2/3 complex) is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton ...

B

* Band 4.1 * Band 4.9(Dematin) * b-actinin * b-Cap73 * Bifocal * Bistramide A * BPAG1 * Brevin ( Gelsolin)

C

* c-Abl * Calpactin (Annexin) * CHO1 *

Cortactin Cortactin (from "''cortical actin'' binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cor ...

* CamKinase II * Calponin * Chondramide * Cortexillin * CAP * Caltropin * CH-ILKBP * CPb3 *

Cap100 "Where U Been?" is a song by American rapper 2 Chainz from his second studio album ''B.O.A.T.S. II: Me Time''. (2013) The song was released as the album's first promotional single on August 1, 2013. It was Record production, produced by frequent c ...

* Calvasculin * Ciboulot * Coactosin *

CAP23 A cap is a flat headgear, usually with a visor. Caps have crowns that fit very close to the head. They made their first appearance as early as 3200 BC. Caps typically have a visor, or no brim at all. They are popular in casual and informal se ...

* CARMIL * Acan125 * Cingulin * Cytovillin (Ezrin) * CapZ/Capping Protein * a-Catenin * Cofilin * CR16 * Caldesmon * CCT * Comitin * Calicin * Centuarin *

Coronin Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans. Discovery Initially, ...

D

* DBP40 * Drebrin * Dematin (Band 4.9) * Dynacortin *

Destrin Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the ''DSTN'' gene. Destrin is a component protein in microfilaments. The product of this gene belongs to the actin-binding proteins A ...

(ADF/cofilin) * Dystonins * Diaphanous * Dystroglycan *

DNase I Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding ...

Dystrophin Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the cos ...

* Doliculide * Dolastatins

E

EAST East or Orient is one of the four cardinal directions or points of the compass. It is the opposite direction from west and is the direction from which the Sun rises on the Earth. Etymology As in other languages, the word is formed from the fa ...

* Endossin * EF-1a (ABP50) * Eps15 * EF-1b * EPLIN * EF-2 * Epsin * EGF receptor * ERK * ENC-1 * ERM proteins ( ezrin, radixin,

moesin Moesin is a protein that in humans is encoded by the ''MSN'' gene. Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linker ...

, plus

merlin Merlin ( cy, Myrddin, kw, Marzhin, br, Merzhin) is a mythical figure prominently featured in the legend of King Arthur and best known as a mage, with several other main roles. His usual depiction, based on an amalgamation of historic and le ...

) * END3p * Ezrin (the E of ERM protein family)

F

* F17R * Fodrin (spectrin) * Fascin * Formins * Fessilin * Frabin * FHL3 *

Fragmin Dalteparin is a low molecular weight heparin. It is marketed as Fragmin. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism to reduce the risk of a stroke ...

* Fhos * FLNA (filamin A) * Fimbrin (plastin)

G

* GAP43 * Glycogenins *

Gas2 Growth arrest-specific protein 2 is a protein that in humans is encoded by the ''GAS2'' gene. The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis ...

* G-proteins * Gastrin-Binding Protein * Gelactins I-IV *

Gelsolins Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency. Cell ...

* Girdin *

Glucokinase Glucokinase () is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role ...

H

Harmonin b Harmonin is a protein that in humans is encoded by the USH1C gene. It is expressed in sensory cells of the inner ear and retina, where it plays a role in hearing, balance, and vision. Mutations at the USH1C locus cause Usher syndrome type ...

* Hrp36 * Hexokinase * Hrp65-2 * Hectochlorin *

HS1 (actin binding protein) High Speed 1 (HS1), legally the Channel Tunnel Rail Link (CTRL), is a high-speed railway linking London with the Channel Tunnel. It is part of a line carrying international passenger traffic between the United Kingdom and mainland Europe ...

Helicase II Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separat ...

* Hsp27 *

HIP1 Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene. Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a protein domain, domain homologous to the death ef ...

(Huntingtin Interacting protein 1) *

Hsp70 The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. Intracellularly localized Hsp70s are an importa ...

* Histactophilin *

Hsp90 Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, ...

* Histidine rich protein II *

Hsp100 Endopeptidase Clp (, ''endopeptidase Ti'', ''caseinolytic protease'', ''protease Ti'', ''ATP-dependent Clp protease'', '' ClpP'', ''Clp protease''). This enzyme catalyses the following chemical reaction : Hydrolysis of proteins to small peptides ...

I

* Inhibitor of apoptosis (IAP) * Insertin * Interaptin * IP3Kinase A (Inositol 1,4,5-trisphosphate 3-kinase A) * IQGAP * Integrins

J

* Jaspisamide A * Jasplakinolide

K

* Kabiramide C * Kaptin * Kettin *

Kelch protein Kelch proteins (and Kelch-like proteins) are a widespread group of proteins that contain multiple Kelch motifs. The kelch domain generally occurs as a set of five to seven kelch tandem repeats that form a β-propeller tertiary structure. Kelch-r ...

L

5-Lipoxygenase Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ''ALOX5'' gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase fa ...

* Limatin * Lim Kinases *

Lim Proteins Lim or LIM may refer to: Name * Lim (Korean surname), a common Korean surname * Lim (Chinese surname), Hokkien, Hakka, Teochew and Hainanese spelling of the Chinese family name "Lin" * Liza Lim (born 1966), Australian classical composer Abbre ...

L-plastin Plastin-2 is a protein that in humans is encoded by the ''LCP1'' gene. Function Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, ...

* Lymphocyte Specific Protein 1 (LSP1)

M

* MACF1 * MacMARKS *

Mena MENA, an acronym in the English language, refers to a grouping of countries situated in and around the Middle East and North Africa. It is also known as WANA, SWANA, or NAWA, which alternatively refers to the Middle East as Western Asia (or a ...

Myopodin Myopodin protein, also called Synaptopodin-2 is a protein that in humans is encoded by the ''SYNPO2'' gene. Myopodin is expressed in cardiac, smooth muscle and skeletal muscle, and localizes to Z-disc structures. Structure Myopodin is a 1 ...

* MAP1A *

Merlin Merlin ( cy, Myrddin, kw, Marzhin, br, Merzhin) is a mythical figure prominently featured in the legend of King Arthur and best known as a mage, with several other main roles. His usual depiction, based on an amalgamation of historic and le ...

(related to the ERM proteins) * Myosins * MAP-1C *

Metavinculin In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cel ...

Moesin Moesin is a protein that in humans is encoded by the ''MSN'' gene. Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linker ...

(the M of ERM proteins) * Myosin light chain kinase * MAL * Mip-90 * Myosin Light Chain A1 * MARKS * MIM * MAYP * Mycalolide (a macroglide drug) * Mayven * Myelin basic protein

N

* Naphthylphthalamic acid binding protein (NPA) N-RAP * Nebulin * N-WASP * Neurabin *Nullo * Neurexins *

Neurocalcin Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains. It possesses a Ca2+/ myristoyl switch The subclass of neurocalcins are brain-specific prote ...

* Nexillin

O

OYE2 Oye is Spanish for "hey" or "listen". Oye or Oye! or OYE may refer to: Geography * Oye, Ekiti, a town and LGA in Ekiti State. *Oye-Plage, a commune in Pas-de-Calais, France *Oyes, a commune in Marne, France People *Kenneth A. Oye, an American po ...

P

* Palladin * Plastin * p30 *

PAK Pak or PAK may refer to: Places * Pakistan (country code PAK) * Pak, Afghanistan * Pak Island, in the Admiralty Islands group of Papua New Guinea * Pak Tea House, a café in Lahore, Punjab, Pakistan Arts and entertainment * PAK (band), an Amer ...

(p21-activated Kinase) * Plectin *

p47PHOX Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the ''NCF1'' gene. Function The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicompone ...

* Parvin (actopaxin) * Prefoldin * p53 *

PASK PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''PASK'' gene. PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. P ...

(Proline, Alanine rich Ste20 related Kinase) * Presenilin I *p58 * Phalloidin (not a protein; a small cyclic peptide) * Profilin * p185neu * Ponticulin *

Protein kinase C In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and ...

* Porin * P.IB * Prk1p (actin regulating kinase)

R

* Radixin (the R of ERM proteins) * Rapsyn * Rhizopodin * RPL45 * RTX toxin (Vibrio cholerae) * RVS 167

S

* Sac6 * Sla1p * Srv2 (CAP) * S-adenosyl-L-homocysteine hydrolase, (SAHH) *

Sla2p SLA may refer to: Geography * Martín Miguel de Güemes International Airport, Salta, Argentina, IATA code Science and engineering * Sealed lead-acid battery * Second-language acquisition * Short long arms suspension, in vehicles *Soluble liver a ...

* Synaptopodin * Scinderin (adseverin) * Synapsins * Scruin * Spectrin *Severin * Spectraplakins * SVSII * Shot (Short stop) *

Spire A spire is a tall, slender, pointed structure on top of a roof of a building or tower, especially at the summit of church steeples. A spire may have a square, circular, or polygonal plan, with a roughly conical or pyramidal shape. Spires are ...

* Shroom * Smitin (Smooth Musc.Titin) * Supervillin * SipA *

Smoothelin Smoothelin is a protein that in humans is encoded by the ''SMTN'' gene. This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskele ...

* Sucrose synthetase * SipC * Sra-1 *

Spinophilin Neurabin-2 is a protein that in humans is encoded by the ''PPP1R9B'' gene. Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions ...

* Ssk2p *

Swinholide Swinholides are Protein dimer, dimeric 42 carbon-ring Polyketide, polyketides that exhibit a 2-fold axis of symmetry. Found mostly in the marine sponge Theonella, swinholides encompass cytotoxic and antifungal activities via disruption of the acti ...

T

* Talin protein * Toxophilin * Twinfilin * Tau * Trabeculin *Twinstar * TCP-1 * Transgelin * Transgelin 2 * Transgelin 3 * Tensin *

Tropomodulin Tropomodulin (TMOD) is a protein which binds and caps the minus end of actin (the "pointed" end), regulating the length of actin filaments in muscle and non-muscle cells. The protein functions by physically blocking the spontaneous dissociation ...

* Thymosin *

Tropomyosin Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in actin-based cytoskeletons. Tropomyosin and the actin skeleton All organisms contain organelles that provide physical integrity to their cells. These type of organelles a ...

Titin Titin (contraction for Titan protein) (also called connectin) is a protein that in humans is encoded by the ''TTN'' gene. Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring that is responsible for t ...

* Troponin * TOR2 *

Tubulin bIV Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cyt ...

U

* Ulapualide * Utrophin * Unc-87 * Unc-60 ( ADF/cofilins)

V

* VASP * Vav * Verprolin *

VDAC Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major pr ...

* Vibrio cholerae RTX toxin *

Villin Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. Villin-1 is encoded by the ''VIL1'' gene. Villin-1 contains multiple gelsolin-like domains capped by a small (8.5 kDa) "headp ...

Vinculin In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cel ...

Vitamin D-binding protein Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the ''GC'' gene. DBP is genetically the oldest member of the albuminoid family and appeared early in the e ...

W

WIP WIP or WiP may refer to: Political parties * Wildrose Independence Party of Alberta, a political party in Alberta, Canada * Western Independence Party of Manitoba, a former Canadian provincial political party * Western Independence Party of Sas ...

WASp A wasp is any insect of the narrow-waisted suborder Apocrita of the order Hymenoptera which is neither a bee nor an ant; this excludes the broad-waisted sawflies (Symphyta), which look somewhat like wasps, but are in a separate suborder. Th ...

Y

* Y-box proteins * YpkA (YopO)

Z

Zipper protein A zipper, zip, fly, or zip fastener, formerly known as a clasp locker, is a commonly used device for binding together two edges of textile, fabric or other flexible material. Used in clothing (e.g. jackets and jeans), luggage and other Bag, ba ...

* Zo-1 * Zyxin

0–9

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See also

References

External links