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Cdc27
Cell division cycle protein 27 homolog is a protein that in humans is encoded by the ''CDC27'' gene. Function The protein encoded by this gene shares strong similarity with ''Saccharomyces cerevisiae'' protein Cdc27, and the gene product of '' Schizosaccharomyces pombe'' nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Interactions CDC27 has been shown to interact with: * ANAPC10, * ANAPC11, * ANAPC1, * ANA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anaphase-promoting Complex
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (ANAPC2, Apc2) and RING (ANAPC11, Apc11) subunit much like SCF complex, SCF. Other parts of the APC/C have unknown functions but are highly Conserved sequence, conserved. It was the discovery of the APC/C (and SCF complex, SCF) and their key role in eukaryotic cell-cycle regulation that established the importance of ubiquitin-mediated proteolysis in cell biology. Once perceived as a system exclusively involved in removing damaged protein from the cell, ubiquitination and subsequent protein degradation by the proteasome is now perceived as a universal regulatory mechanism for signal transduction whose importance approaches that of protein phosphorylation. In 2014, the APC/C was mapped in 3D at a resolution of less than a nanometre, which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC11
Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ''ANAPC11'' gene. Interactions ANAPC11 has been shown to interact with ANAPC2 and CDC27 Cell division cycle protein 27 homolog is a protein that in humans is encoded by the ''CDC27'' gene. Function The protein encoded by this gene shares strong similarity with ''Saccharomyces cerevisiae'' protein Cdc27, and the gene product of '' .... References External links * Further reading * * * * * * * * {{refend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZR1
Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the ''FZR1'' gene. Interactions FZR1 has been shown to interact with CDC27 and FBXO5 F-box only protein 5 is a protein that in humans is encoded by the ''FBXO5'' gene. Function This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins c .... References Further reading * * * * * * * * * * * * * * External links * {{Gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDH1 (gene)
Cadherin-1 or Epithelial cadherin (E-cadherin), is a protein that in humans is encoded by the ''CDH1'' gene (not to be confused with the APC/C activator protein CDH1). Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene. History The discovery of cadherin cell-cell adhesion proteins is attributed to Masatoshi Takeichi, whose experience with adhering epithelial cells began in 1966. His work originally began by studying lens differentiation in chicken embryos at Nagoya University, where he explored how retinal cells regulate lens fiber differentiation. To do this, Takeichi initially collected media that had previously cultured neural retina cells (CM) and suspended lens epithelial cells in it. He observed that cells suspended in the CM media had delayed attachment compared to cells in his regular medium. His interest in cell adherence was spar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDC23
Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the ''CDC23'' gene. Function The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell (biology), cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA (DNA re ... progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B- ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDC20
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the ''CDC20'' gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle. CDC20 appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes: nuclear movement prior to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDC16
Cell division cycle protein 16 homolog is a protein that in humans is encoded by the ''CDC16'' gene. Function This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. Interactions CDC16 has been shown to interact with CDC27 and CDC20 The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the ''CDC20'' gene in humans. To the best of current knowledge its most important function is to activate the anaphase promot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell (biology), cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA (DNA re ... progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Interactions ANAPC7 has been shown to interact with ANAP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC5
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ''ANAPC5'' gene. The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462). upplied by OMIMref name="entrez" /> Interactions ANAPC5 has been shown to interact with ANAPC1, ANAPC4, CDC27 and PABPC1 Polyadenylate-binding protein 1 is a protein that in humans is encoded by the ''PABPC1'' gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stabil .... References External links * Further reading * * * * * * * * * * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC4
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ''ANAPC4'' gene. A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Interactions ANAPC4 has been shown to interact with ANAPC1, ANAPC5, CDC27 and ANAPC7 Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat .... References External links * Further reading ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC1
Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ''ANAPC1'' gene. ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to- anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM). Interactions ANAPC1 has been shown to interact with ANAPC5, ANAPC4, ANAPC2, CDC27 and ANAPC7 Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat .... References External links * Further reading * * * * * * * * * * * {{enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
