Anaphase-promoting complex subunit 7 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''ANAPC7''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a
tetratricopeptide repeat containing component of the
anaphase-promoting complex
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin ...
/cyclosome (APC/C), a large
E3 ubiquitin ligase that controls
cell cycle
The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell (biology), cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA (DNA re ...
progression by targeting a number of cell cycle regulators such as B-type
cyclins for 26S
proteasome-mediated degradation through
ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription
coactivators.
Interactions
ANAPC7 has been shown to
interact with
ANAPC1,
,
[ CDC27]
References
External links
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