Anaphase-promoting complex subunit 4 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''ANAPC4''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.
Interactions
ANAPC4 has been shown to
interact with
ANAPC1
Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ''ANAPC1'' gene.
ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to- anaphase transition of the ...
,
,
[ CDC27]ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a tetratricopeptide repeat ...
.[
]
References
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