Cell division cycle protein 27 homolog is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CDC27''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene shares strong similarity with ''
Saccharomyces cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungal microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have be ...
'' protein Cdc27, and the gene product of ''
Schizosaccharomyces pombe'' nuc 2. This protein is a component of
anaphase-promoting complex
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin ...
(APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the
ubiquitin-mediated
proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (
tetratricopeptide
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate proteinâ ...
repeat), a protein domain important for
protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including
Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of
mitosis.
Interactions
CDC27 has been shown to
interact with:
*
ANAPC10,
[
* ANAPC11,][
* ]ANAPC1
Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ''ANAPC1'' gene.
ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to- anaphase transition of the ...
,ANAPC4
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ''ANAPC4'' gene.
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating ...
,ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a tetratricopeptide repeat ...
,[
* CDC16,]CDC23
Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the ''CDC23'' gene.
Function
The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential ...
,[
* CDH1,][
* FZR1,][ and
* PIN1.]
References
Further reading
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External links
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* {{PDBe-KB2, P30260, Cell division cycle protein 27 homolog