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Human Proteome Project
The Human Proteome Project (HPP) is a collaborative effort coordinated by the Human Proteome Organization. Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome. History The Human Proteome Organization has served as a coordinating body for many long-running proteomics research projects associated with specific human tissues of clinical interest, such as blood plasma, liver, brain and urine. It has also been responsible for projects associated with specific technology and standards necessary for the large scale study of proteins. The structure and goals of a larger project that would parallel the Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a ... has been debated in the scientific literature ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Proteome Organization
The Human Proteome Organization (HUPO) is an international consortium of national proteomics research associations, government researchers, academic institutions, and industry partners. The organization was launched in February 2001, and it promotes the development and awareness of proteomics research, advocates on behalf of proteomics researchers throughout the world, and facilitates scientific collaborations between members and initiatives. Ultimately, it is organized to gain a better and more complete understanding of the human proteome. Congress Since 2002, HUPO organizes one international congress each year, with past congresses held in Cancun in 2022, virtually in 2021 and 2020, Adelaide in 2019, Orlando in 2018, in Dublin in 2017, in Taipei in 2016 and in Vancouver 2015. Awards HUPO awards multiple awards each year, among them the * Distinguished Service Award * Translational Proteomics Award * Science & Technology Award * Discovery in Proteomic Sciences Award * Disting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yu-Ju Chen
Yu-Ju Chen () is a Taiwanese proteomics research scientist, who leads international projects in proteogenomics. Education Yu-Ju Chen received a PhD in physical chemistry at Iowa State University in 1997, under the direction of Cheuk-Yiu Ng. She completed post-doctoral research at Ames Laboratory in 1997, and then at Yuan-Pern Lee's group at National Tsing Hua University in 1999. Career Chen began her career at the Institute of Chemistry of Academia Sinica as assistant research fellow in 1999. She was the Director of the Institute of Chemistry from 2013 to 2019, and is currently a Distinguished Research Fellow. She is also an adjunct professor at National Taiwan University, National Chiayi University, National Taiwan Ocean University, and National Chung Hsing University. She conducts research in mass spectrometry-based bioinformatics, in relation to understanding diseases such as cancer. Since 2016, Chen has participated in the US Cancer Moonshot Initiative, providing prot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of function ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Proteome Folding Project
The Human Proteome Folding Project (HPF) is a collaborative effort between New York University ( Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the Rosetta Commons. The project is managed by the Bonneau lab. HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria. Phase 1 ran on two volunteer computing grids: on United Devices' grid.org, and on the World Community Grid, an IBM philanthropic initiative. Phase 2 of the project ran exclusively on the World Community Grid; it terminated in 2013 after more than 9 years of IBM involvement. The Institute for Systems Biology will u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BioPlex
BioPlex (biophysical interactions of ORFeome-based complexes) is an open access resource for studying protein-protein interactions. It is the result of collaborations between Harvard Medical School and Biogen. BioPlex 1.0 reported 23,744 interactions among 7,668 proteins. BioPlex 2.0 extended those observations to detect over 29,000 new interactions. The basic technology is to express a "bait" protein in human cells. Those bait proteins interact with other proteins, and then the complexes of the bait and "prey" proteins are isolated by affinity purification. The interacting prey proteins are identified using mass spectrometry. Use in research Determining the interaction partners of poorly characterized proteins can provide clues to the function of those proteins, and knowing which "protein community" a disease gene resides in can give better context for its action. See also *Human proteome project *Interactome *Proteome A proteome is the entire set of proteins that is, or ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NeXtProt
neXtProt is an on-line knowledge platform on human proteins. It strives to be a comprehensive resource that provides a variety of types of information on human proteins, such as their function, subcellular location, expression, interactions and role in diseases. The major part of the information in neXtProt is obtained from the UniProt Swiss-Prot database but it is complemented by data originating from high-throughput studies with an emphasis on proteomics. neXtProt offers also an advanced search capacity based on the SPARQL technology as well as an API that allows to programmatically extract the data stored in the resource. It is developed by the CALIPHO group on the web site of the SIB directed by |
Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. In June 2023, version 23 was launched where a new Interaction section was introduced containing human protein-protein interaction networks for more than 11,000 genes that will add new aspects in terms of protein function. The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PeptideAtlas
PeptideAtlas is a proteomics data resource that gathers tandem mass spectrometry datasets from around the world, reprocesses them with the Trans-Proteomic Pipeline, and makes the combined result freely available to the community. Peptide Atlas is one of the founding members of the ProteomeXchange Consortium. History The earliest conception of PeptideAtlas began at the Institute for Systems Biology in the research lab of Ruedi Aebersold by Eric Deutsch and Sharon Chen at the Annotated Peptide Database (APD). The concept was further expanded with additional efforts from Parag Mallick and Frank Desiere. The first instance for an ensemble of human experiments was published in 2004 as the Human PeptideAtlas. The concept was further expanded to many other species over the years with major effort by Nichole King, Zhi Sun, Terry Farrah, and Dave Campbell. Current status PeptideAtlas is still maintained and developed at the Institute for Systems Biology in the research lab of Robert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Akhilesh Pandey
Akhilesh Pandey is an Indian-American proteomicist and a Professor at Department of Laboratory Medicine and Pathology, Center for Individualized Medicine of Mayo Clinic in Rochester, Minnesota, USA. He is also the founding director and chief scientific advisor of the Institute of Bioinformatics in Bangalore, India. Education Pandey earned his medical degree from Armed Forces Medical College in Pune and completed his pathology residency at Brigham and Women's Hospital, Harvard Medical School in Boston, Massachusetts. He received his Ph.D. in Molecular Biology from the University of Michigan in Ann Arbor, Michigan, USA. He was a Postdoctoral Fellow in Harvey Lodish's laboratory at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology in Cambridge, Massachusetts. He was a Visiting Scientist in Matthias Mann's group at the University of Southern Denmark. Career For 16 years, he was a Professor at the Johns Hopkins University School of Med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilbert S
Gilbert may refer to: People and fictional characters *Gilbert (given name), including a list of people and fictional characters * Gilbert (surname), including a list of people Places Australia * Gilbert River (Queensland) * Gilbert River (South Australia) Kiribati * Gilbert Islands, a chain of atolls and islands in the Pacific Ocean United States * Gilbert, Arizona, a town * Gilbert, Arkansas, a town * Gilbert, Florida, the airport of Winterhaven * Gilbert, Iowa, a city * Gilbert, Louisiana, a village * Gilbert, Michigan, and unincorporated community * Gilbert, Minnesota, a city * Gilbert, Nevada, ghost town * Gilbert, Ohio, an unincorporated community * Gilbert, Pennsylvania, an unincorporated community * Gilbert, South Carolina, a town * Gilbert, West Virginia, a town * Gilbert, Wisconsin, an unincorporated community * Mount Gilbert (other), various mountains * Gilbert River (Oregon) Outer space * Gilbert (lunar crater) * Gilbert (Martian crater) Arts and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It was the world's largest collaborative biological project. Planning for the project began in 1984 by the US government, and it officially launched in 1990. It was declared complete on 14 April 2003, and included about 92% of the genome. Level "complete genome" was achieved in May 2021, with only 0.3% of the bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by the Celera Corporation, or Celera Genomics, which was formall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
