PeptideAtlas is a
proteomics
Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replicatio ...
data resource that gathers
tandem mass spectrometry datasets from around the world, reprocesses them with the Trans-Proteomic Pipeline, and makes the combined result
freely available to the community. Peptide Atlas is one of the founding members of the
ProteomeXchange Consortium.
History
The earliest conception of PeptideAtlas began at the
Institute for Systems Biology
Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, ...
in the research lab of
Ruedi Aebersold
Rudolf Aebersold (better known as Ruedi Aebersold; born September 12, 1954) is a Swiss biologist, regarded as a pioneer in the fields of proteomics and systems biology. He has primarily researched techniques for measuring proteins in complex samp ...
by Eric Deutsch and Sharon Chen at the Annotated Peptide Database (APD). The concept was further expanded with additional efforts from Parag Mallick and Frank Desiere. The first instance for an ensemble of human experiments was published in 2004 as the Human PeptideAtlas.
The concept was further expanded to many other species over the years with major effort by Nichole King, Zhi Sun, Terry Farrah, and Dave Campbell.
Current status
PeptideAtlas is still maintained and developed at the Institute for Systems Biology in the research lab of Robert Moritz, led by Eric Deutsch, and with significant efforts by Zhi Sun and Dave Campbell.
See also
*
Human proteome project
The Human Proteome Project (HPP) is a collaborative effort coordinated by the Human Proteome Organization. Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome.
History
The Hu ...
*
Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometr ...
*
NeXtProt
neXtProt is an on-line knowledge platform on human proteins.
It strives to be a comprehensive resource that provides a variety of
types of information on human proteins, such as their function,
subcellular location, expression, interactions and ...
External links
PeptideAtlas web site (www.peptideatlas.org)
References
{{Reflist
Peptides
Proteomics
Protein databases