neXtProt is an on-line knowledge platform on human

proteins Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respondi ...

. It strives to be a comprehensive resource that provides a variety of types of information on human proteins, such as their function, subcellular location, expression, interactions and role in diseases. The major part of the information in neXtProt is obtained from the

UniProt UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived fro ...

Swiss-Prot

database In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spa ...

but it is complemented by data originating from high-throughput studies with an emphasis on

proteomics Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In ...

. neXtProt offers also an advanced search capacity based on the

SPARQL SPARQL (pronounced " sparkle" , a recursive acronym for SPARQL Protocol and RDF Query Language) is an RDF query language—that is, a semantic query language for databases—able to retrieve and manipulate data stored in Resource Description ...

technology as well as an API that allows to programatically extract the data stored in the resource. It is developed by the CALIPHO groupCALIPHO group
on the web site of the SIB directed by

Amos Bairoch Amos Bairoch (born 22 November 1957) is a Swiss bioinformatician and Professor of Bioinformatics at the Department of Human Protein Sciences of the University of Geneva where he leads the CALIPHO group at the Swiss Institute of Bioinformatics ...

and Lydie Lane of the

Swiss Institute of Bioinformatics The SIB Swiss Institute of Bioinformatics is an academic not-for-profit foundation which federates bioinformatics activities throughout Switzerland. The institute was established on 30 March 1998 and its mission is to provide core bioinfor ...

(SIB).

References

External links

neXtProt
- Exploring the universe of human proteins
UniProt
- The Universal protein resource
SIB
- The Swiss Institute of Bioinformatics
GitHub directory for neXtProt code
{{Biology-footer Molecular biology Biological databases Human biology Human proteins