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Eric Westhof
Éric Westhof is a French biochemist born in Uccle (Belgium) on July 25, 1948. He is a member of the Academie des sciences, head of Education and Training (DEF) and a member of the Board of Directors of the "La Main à la pâte" Foundation. He is professor emeritus of structural biochemistry at the University of Strasbourg at the Institute of Molecular and Cellular Biology. Biography After obtaining a bachelor's degree in physical sciences from the University of Liège, he carried out research work at the Regensburg Universität (Germany) on a EURATOM grant with a view to obtaining a doctorate from the University of Liège in 1974. He then became a research associate (on a Fulbright-Hays fellowship) at the University of Wisconsin until 1977 in Professor M. Sundaralingam's laboratory. Thanks to an EMBO grant, he then established himself in 1981 at the Institute of Molecular and Cellular Biology of the Centre national de la recherche scientifique (IBMC-CRNS), affiliated with the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Université De Strasbourg
The University of Strasbourg (french: Université de Strasbourg, Unistra) is a public research university located in Strasbourg, Alsace, France, with over 52,000 students and 3,300 researchers. The French university traces its history to the earlier German-language ''Universität Straßburg'', which was founded in 1538, and was divided in the 1970s into three separate institutions: Louis Pasteur University, Marc Bloch University, and Robert Schuman University. On 1 January 2009, the fusion of these three universities reconstituted a united University of Strasbourg. With as many as 19 Nobel laureates, and two Fields Medal winners, the university is ranked among the best in the League of European Research Universities. History The university emerged from a Lutheran humanist German Gymnasium, founded in 1538 by Johannes Sturm in the Free Imperial City of Strassburg. It was transformed to a university in 1621 (german: Universität Straßburg) and elevated to the ranks of a royal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA (journal)
''RNA'' is a monthly peer-reviewed scientific journal that covers research on all aspects of RNA molecules, including their structures, metabolism, functions, and evolution. The journal was established in 1995 and originally published by Cambridge University Press. Since 2003 it is published by Cold Spring Harbor Laboratory Press on behalf of the RNA Society. The editor-in-chief is Timothy W. Nilsen (Case Western Reserve University Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reser ...). Abstracting and indexing The journal is abstracted and indexed in Science Citation Index, Current Contents/Life Sciences, BIOSIS Previews, Scopus, and Index Medicus/ MEDLINE/ PubMed. According to the '' Journal Citation Reports'', the journal has a 2018 impact factor of 3.949. References Ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminoglycoside
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside ( sugar). The term can also refer more generally to any organic molecule that contains amino sugar substructures. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.ME Levison, MD, 2012, Aminoglycosides, The Merck Manua accessed 22 February 2014. Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from ''Streptomyces griseus'' and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class. Other examples of aminoglycosides include the deoxystreptamine-containi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas Tuschl
Thomas Tuschl (born June 1, 1966) is a German biochemist and molecular biologist, known for his research on RNA. Biography Tuschl was born in Altdorf bei Nürnberg. After graduating in Chemistry from Regensburg University, Tuschl received his PhD in 1995 from the Max Planck Institute for Experimental Medicine in Göttingen. He spent four years as a post-doctoral fellow at the Whitehead Institute of the Massachusetts Institute of Technology (MIT) in Cambridge, USA. In 1999 he returned to Göttingen, to continue his research at the Max Planck Institute for Biophysical Chemistry. There he received international recognition in Genetics for his studies of RNA interference in collaboration with the laboratory of Klaus Weber. This enables "switching off" certain genes by introducing synthetic short RNA into the cell. The mRNA is destroyed and the gene in deactivated. Possible future applications of this method include treatment of tumors or genetic disorders. The function of certain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribozyme
Ribozymes (ribonucleic acid enzymes) are RNA molecules that have the ability to catalyze specific biochemical reactions, including RNA splicing in gene expression, similar to the action of protein enzymes. The 1982 discovery of ribozymes demonstrated that RNA can be both genetic material (like DNA) and a biological catalyst (like protein enzymes), and contributed to the RNA world hypothesis, which suggests that RNA may have been important in the evolution of prebiotic self-replicating systems. The most common activities of natural or in vitro-evolved ribozymes are the cleavage or ligation of RNA and DNA and peptide bond formation. For example, the smallest ribozyme known (GUGGC-3') can aminoacylate a GCCU-3' sequence in the presence of PheAMP. Within the ribosome, ribozymes function as part of the large subunit ribosomal RNA to link amino acids during protein synthesis. They also participate in a variety of RNA processing reactions, including RNA splicing, viral replication, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intron
An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e. a region inside a gene."The notion of the cistron .e., gene... must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger – which I suggest we call introns (for intragenic regions) – alternating with regions which will be expressed – exons." (Gilbert 1978) The term ''intron'' refers to both the DNA sequence within a gene and the corresponding RNA sequence in RNA transcripts. The non-intron sequences that become joined by this RNA processing to form the mature RNA are called exons. Introns are found in the genes of most organisms and many viruses and they can be located in both protein-coding genes and genes that function as RNA (noncoding genes). There are four main types of introns: tRNA introns, group I introns, group II introns, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autocatalysis
A single chemical reaction is said to be autocatalytic if one of the reaction products is also a catalyst for the same or a coupled reaction.Steinfeld J.I., Francisco J.S. and Hase W.L. ''Chemical Kinetics and Dynamics'' (2nd ed., Prentice-Hall 1999) p.151-2 Such a reaction is called an autocatalytic reaction. A ''set'' of chemical reactions can be said to be "collectively autocatalytic" if a number of those reactions produce, as reaction products, catalysts for enough of the other reactions that the entire set of chemical reactions is self-sustaining given an input of energy and food molecules (see autocatalytic set). Chemical reactions A chemical reaction of two reactants and two products can be written as : \alpha A + \beta B \rightleftharpoons \sigma S + \tau T where the Greek letters are stoichiometric coefficients and the capital Latin letters represent chemical species. The chemical reaction proceeds in both the forward and reverse direction. This equation is easily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crystallography
Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids. Crystallography is a fundamental subject in the fields of materials science and solid-state physics (condensed matter physics). The word "crystallography" is derived from the Greek word κρύσταλλος (''krystallos'') "clear ice, rock-crystal", with its meaning extending to all solids with some degree of transparency, and γράφειν (''graphein'') "to write". In July 2012, the United Nations recognised the importance of the science of crystallography by proclaiming that 2014 would be the International Year of Crystallography. denote a direction vector (in real space). * Coordinates in ''angle brackets'' or ''chevrons'' such as <100> denote a ''family'' of directions which are related by symmetry operations. In the cubic crystal system for example, would mean 00 10 01/nowiki> or the negative of any of those directions. * Miller indices in ''parentheses ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for '' in silico'' analyses of biological queries using computational and statistical techniques. Bioinformatics includes biological studies that use computer programming as part of their methodology, as well as specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics. Common uses of bioinformatics include the identification of candidates genes and single nucleotide polymorphisms ( SNPs). Often, such identification is made with the aim to better understand the genetic basis of disease, unique adaptations, desirable propertie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Modelling
Scientific modelling is a scientific activity, the aim of which is to make a particular part or feature of the world easier to understand, define, quantify, visualize, or simulate by referencing it to existing and usually commonly accepted knowledge. It requires selecting and identifying relevant aspects of a situation in the real world and then developing a model to replicate a system with those features. Different types of models may be used for different purposes, such as conceptual models to better understand, operational models to operationalize, mathematical models to quantify, computational models to simulate, and graphical models to visualize the subject. Modelling is an essential and inseparable part of many scientific disciplines, each of which has its own ideas about specific types of modelling. The following was said by John von Neumann. There is also an increasing attention to scientific modelling in fields such as science education, philosophy of scienc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topology
In mathematics, topology (from the Greek words , and ) is concerned with the properties of a geometric object that are preserved under continuous deformations, such as stretching, twisting, crumpling, and bending; that is, without closing holes, opening holes, tearing, gluing, or passing through itself. A topological space is a set endowed with a structure, called a ''topology'', which allows defining continuous deformation of subspaces, and, more generally, all kinds of continuity. Euclidean spaces, and, more generally, metric spaces are examples of a topological space, as any distance or metric defines a topology. The deformations that are considered in topology are homeomorphisms and homotopies. A property that is invariant under such deformations is a topological property. Basic examples of topological properties are: the dimension, which allows distinguishing between a line and a surface; compactness, which allows distinguishing between a line and a circle; connectedne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stereochemistry
Stereochemistry, a subdiscipline of chemistry, involves the study of the relative spatial arrangement of atoms that form the structure of molecules and their manipulation. The study of stereochemistry focuses on the relationships between stereoisomers, which by definition have the same molecular formula and sequence of bonded atoms (constitution), but differ in structural formula (the three-dimensional orientations of their atoms in space). For this reason, it is also known as 3D chemistry—the prefix "stereo-" means "three-dimensionality". Stereochemistry spans the entire spectrum of organic, inorganic, biological, physical and especially supramolecular chemistry. Stereochemistry includes methods for determining and describing these relationships; the effect on the physical or biological properties these relationships impart upon the molecules in question, and the manner in which these relationships influence the reactivity of the molecules in question (dynamic stereochem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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