Thomas Tuschl (born 1 June 1966) is a German

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and

molecular biologist Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

, known for his research on

RNA Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...

Biography

Tuschl was born in

Altdorf bei Nürnberg Altdorf bei Nürnberg ( , ; ) is a town in south-eastern Germany. It is situated east of Nuremberg, in the district Nürnberger Land. Its name literally means “Altdorf near Nuremberg”, to distinguish it from other Altdorfs. History Altdorf ...

. After graduating in Chemistry from Regensburg University, Tuschl received his PhD in 1995 from the Max Planck Institute for Experimental Medicine in

Göttingen Göttingen (, ; ; ) is a college town, university city in Lower Saxony, central Germany, the Capital (political), capital of Göttingen (district), the eponymous district. The River Leine runs through it. According to the 2022 German census, t ...

. He spent four years as a post-doctoral fellow at the

Whitehead Institute Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally indep ...

of the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...

(MIT) in

Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...

, USA. In 1999 he returned to Göttingen, to continue his research at the

Max Planck Institute for Biophysical Chemistry The Max Planck Institute for Biophysical Chemistry (), also known as the Karl-Friedrich Bonhoeffer Institute (), was a research institute of the Max Planck Society, located in Göttingen, Germany. On January 1, 2022, the institute merged with ...

. There he received international recognition in

Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

for his studies of

RNA interference RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by ...

in collaboration with the laboratory of Klaus Weber. This enables "switching off" certain

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

s by introducing synthetic short RNA into the

cell Cell most often refers to: * Cell (biology), the functional basic unit of life * Cellphone, a phone connected to a cellular network * Clandestine cell, a penetration-resistant form of a secret or outlawed organization * Electrochemical cell, a de ...

. The

mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is ...

is destroyed and the gene is deactivated. Possible future applications of this method include treatment of

tumor A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

s or

genetic disorder A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders ...

s. The function of certain genes can be studied more easily. RNA interference is a major step in genetics. In 2003 Tuschl became professor and head of laboratory at

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

in New York, where he continues his research. He is looking into

microRNA Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcr ...

, small RNA-sections, which are formed by the cells and cause RNA interference like introduced synthetic RNA-strains. In 2006, two of Tuschl's fellow researchers, Andrew Z. Fire and Craig C. Mello, received the Nobel Prize in Physiology or Medicine for their discovery of "RNA interference – gene silencing by double-stranded RNA".

Awards

Tuschl received several national and international awards for his work: * 2008:

Ernst Jung Prize The Ernst Jung Prize is a prize awarded annually for excellence in biomedical sciences. The Ernst Jung Foundation, funded by Hamburg merchant Ernst Jung in 1967, has awarded the Ernst Jung Prize in Medicine, now €300,000, since 1976, and the lif ...

* 2007:

Max Delbrück Medal The Max Delbrück Medal has been awarded annually from 1992 to 2013 by the Max Delbrück Center for Molecular Medicine (German: ''Max-Delbrück-Centrum für Molekulare Medizin'' or MDC). Named after the German biophysicist Max Delbrück, it is pr ...

, BerlinThomas Tuschl receives Max-Delbrück-Medal
* 2005:

Ernst Schering Prize The Ernst Schering Prize is awarded annually by the Ernst Schering Foundation for especially outstanding basic research in the fields of medicine, biology or chemistry anywhere in the world. Established in 1991 by the Ernst Schering Research Foun ...

, Berlin * 2005:

Meyenburg Prize The Meyenburg Prize is awarded for outstanding achievements in cancer research by the Meyenburg Foundation in support of the German Cancer Research Center, Heidelberg (DKFZ), which is the largest biomedical research institution in Germany. The pri ...

, Heidelberg * 2005: Dr. Albert Wander Gedenk Prize, Bern, Schweiz * 2003: Mayor's Award for Excellence in Science and Technology, New York, USA * 2003: Co-recipient (with

Craig Mello Craig Cameron Mello (born October 18, 1960) is an American biologist and professor of molecular medicine at the University of Massachusetts Medical School in Worcester, Massachusetts. He was awarded the 2006 Nobel Prize for Physiology or Medicine ...

Andrew Fire Andrew Zachary Fire (born April 27, 1959) is an American biologist and professor of pathology and of genetics at the Stanford University School of Medicine. He was awarded the 2006 Nobel Prize in Physiology or Medicine, along with Craig C. Mell ...

and

David Baulcombe Sir David Charles Baulcombe (born 7 April 1952) is a British plant scientist and geneticist. he was Head of Group, Gene Expression, in the Department of Plant Sciences at the University of Cambridge, and the Edward Penley Abraham Royal Socie ...

) of the Wiley Prize in the Biomedical Sciences, The Wiley Foundation, USA * 2003: Newcomb Cleveland Prize, American Association for the Advancement of Science, USA * 2002: Eppendorf Young Investigator Award, Hamburg * 2002: Otto-Klung-Weberbank-Preis for Chemistry and Physics, Berlin

References

External links

* * with Thomas Tuschl in sciencegarden {{DEFAULTSORT:Tuschl, Thomas 1966 births Living people German biochemists German molecular biologists Howard Hughes Medical Investigators Rockefeller University faculty People from Altdorf bei Nürnberg