The protein kinase domain is a structurally conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

containing the catalytic function of

protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a fu ...

s. Protein kinases are a group of

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...

s that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases. Protein kinases possess a catalytic subunit which transfers the gamma phosphate from nucleoside triphosphates (almost always

ATP ATP may refer to: Companies and organizations * Association of Tennis Professionals, men's professional tennis governing body * American Technical Publishers, employee-owned publishing company * ', a Danish pension * Armenia Tree Project, non ...

) to the side chain of an amino acid in a protein, resulting in a conformational and/or dynamic changes affecting protein function. These enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific and tyrosine specific.

Function

Protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a fu ...

function has been evolutionarily conserved from ''

Escherichia coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Esc ...

'' to ''

Homo sapiens Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, ...

''. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation. Phosphorylation usually results in a functional change of the target protein by changing structure, dynamics, enzyme activity, cellular location, or association with other proteins.

Structure

The catalytic subunits of protein kinases are highly conserved, and the structures of over 280 of the approximately 500 human kinase domains have been determined, leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases. Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. The domain consists of two sub-domains referred to as the N- and C-terminal domains. The N-terminal domain consists of five

beta sheet The beta sheet, (β-sheet) (also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a gen ...

strands and an

alpha helix The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a right hand-helix conformation in which every backbone N−H group hydrogen bonds to the backbone C=O group of the amino acid located four residues earl ...

called the C-helix, and the C-terminal domain usually consists of six alpha helices (labeled D, E, F, G, H, and I). The C-terminal domain contains two long loops, called the catalytic loop and the activation loop, which are essential for catalytic activity. The catalytic loop includes the "HRD motif" (for the amino acid sequence His-Arg-Asp), whose aspartic acid residue interacts directly with the hydroxyl group of the target serine, threonine, or tyrosine residue that is phosphorylated. The activation loop starts with the DFG motif (for the amino acid sequence Asp-Phe-Gly), which helps to bind ATP and magnesium in the active site. Broadly, the state or conformation of the kinase may be classified as DFGin or DFGout, depending on whether the Asp residue of the DFG motif is in or out of the active site. In the active form, the first few residues of the activation loop adopt a specific form of the DFGin conformation. Some inactive structures may adopt one of several other DFGin conformations, while other inactive structures are DFGout.

Examples

The following is a list of human proteins containing the protein kinase domain: AAK1 ;

AATK Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (''AATK'') gene. Structure and expression The gene was identified in 1998. It is located on chromosome 17 (1 ...

; ABL1 ;

ABL2 Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ''ABL2'' gene. Function ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The simila ...

; ACVR1 ;

ACVR1B Activin receptor type-1B is a protein that in humans is encoded by the ''ACVR1B'' gene. ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a ...

; ACVR1C ;

ACVR2A Activin receptor type-2A is a protein that in humans is encoded by the ''ACVR2A'' gene. ACVR2A is an activin type 2 receptor. Function This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors whic ...

; ACVR2B ; ACVRL1 ;

AKT1 RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''AKT1'' gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. I ...

;

AKT2 AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the ''AKT2'' gene. It influences metabolite storage as part of the insulin signal transduction pathway. Function This gene is a putative o ...

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AKT3 RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''AKT3'' gene. Function The protein encoded by this gene is a member of the AKT subfamily of serine/threonine protein kinases. AKT kinases are known to be ...

; ALK ; AMHR2 ; ANKK1 ;

ARAF Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ''ARAF'' gene. A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases. Compared to the other members of this ...

; AURKA ; AURKB ;

AURKC Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the ''AURKC'' gene. Function This gene encodes a member of the highly conserved Aurora subfamily of serine/threonine protein kinases with tw ...

; AXL ; BLK ; BMP2K ; BMPR1A ;

BMPR1B Bone morphogenetic protein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the ''BMPR1B'' gene. Function BMPR1B is a member of the bone morphogenetic protein (BMP) receptor fam ...

; BMPR2 ; BMX ; BRAF ;

BRSK1 BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene. References External links * Further reading * * * * * * * * * * EC 2.7.1 {{gene-19-stub ...

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BRSK2 BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''BRSK2'' gene. References Further reading * * * * * * External links

* EC 2.7.11 {{gene-11-stub ...

; BTK ;

BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the ''BUB1'' gene. Bub1 is a serine/threonine protein kinase first identified in geneti ...

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BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the ''BUB1B'' gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochor ...

; CAMK1 ;

CAMK1D Calcium/calmodulin-dependent protein kinase ID is a protein in humans that is encoded by the CAMK1D gene on chromosome 10 ( locus 10p13). Function This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of se ...

; CAMK1G ; CAMK2A ; CAMK2B ;

CAMK2D Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the ''CAMK2D'' gene. The product of this gene belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent pr ...

; CAMK2G ; CAMK4 ;

CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the ''CAMKK1'' gene. The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein ki ...

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CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the ''CAMKK2'' gene. Function The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca++/ calmodulin-dep ...

; CAMKV ;

CASK A barrel or cask is a hollow cylindrical container with a bulging center, longer than it is wide. They are traditionally made of wooden staves and bound by wooden or metal hoops. The word vat is often used for large containers for liquids, u ...

; CDC42BPA ; CDC42BPB ; CDC42BPG ;

CDC7 Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the ''CDC7'' gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conser ...

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CDK1 Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in t ...

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CDK10 Cell division protein kinase 10 is an enzyme that in humans is encoded by the ''CDK10'' gene. Function The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly s ...

; CDK11A ; CDK11B ;

CDK12 CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the ''CDK12'' gene. This enzyme is a member of cyclin-dependent kinase Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for t ...

; CDK13 ; CDK14 ; CDK15 ; CDK16 ; CDK17 ; CDK18 ; CDK19 ;

CDK2 Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein ...

; CDK20 ; CDK3 ;

CDK4 Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the ''CDK4'' gene. CDK4 is a member of the cyclin-dependent kinase family. Function The protein encoded by this gene is a member o ...

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CDK5 Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago, and it is saliently expressed in post-mitotic central nervous system neurons (CNS). The molecule belongs ...

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CDK6 Cell division protein kinase 6 (CDK6) is an enzyme encoded by the ''CDK6'' gene. It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein encoded by this gene is a member of ...

; CDK7 ; CDK8 ; CDK9 ; CDKL1 ;

CDKL2 Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the ''CDKL2'' gene. This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with low ...

; CDKL3 ; CDKL4 ;

CDKL5 CDKL5 is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/threonine kinase 9 (STK9) that is essential for normal brain development. Mutations in the gene can cause deficiencies in t ...

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CHEK1 Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the ''CHEK1'' gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Ch ...

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CHEK2 CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linke ...

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CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the ''CHUK'' gene. IKK-α is part of the IκB kinase c ...

; CIT ; CLK1 ;

CLK2 Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the ''CLK2'' gene. Function This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and p ...

; CLK3 ;

CLK4 Saint-Michel-des-Saints/Lac Kaiagamac Water Aerodrome is located on Lac Kaiagamac, south southeast of Saint-Michel-des-Saints, Quebec, Canada. References

Airports in Lanaudière Seaplane bases in Quebec {{Quebec-airport-stub ...

; CSF1R ; CSK ;

CSNK1A1 Casein kinase I isoform alpha is an enzyme that in humans is encoded by the ''CSNK1A1'' gene. Interactions Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1 and AXIN1. See also * Casein kinase 1 The Casein kinase ...

; CSNK1A1L ;

CSNK1D Casein kinase I isoform delta also known as CKI-delta or CK1δ is an enzyme that in humans is encoded by the gene ''CSNK1D'', which is located on chromosome 17 (17q25.3). It is a member of the CK1 (formerly named casein kinase 1) family of serine ...

; CSNK1E ; CSNK1G1 ; CSNK1G2 ; CSNK1G3 ;

CSNK2A1 Casein kinase II subunit alpha is an enzyme that in humans is encoded by the ''CSNK2A1'' gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is comp ...

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CSNK2A2 Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the ''CSNK2A2'' gene. Interactions CSNK2A2 has been shown to interact with over 160 different substrates. CSNK2A2 has been shown to interact with: * Activating transcri ...

; CSNK2A3 ; DAPK1 ; DAPK2 ;

DAPK3 Death-associated protein kinase 3 is an enzyme that in humans is encoded by the ''DAPK3'' gene. Function Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis Apoptosis (from grc, ἀπόπτωσις, ap� ...

; DCLK1 ; DCLK2 ; DCLK3 ;

DDR1 Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene. Function Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. ...

; DDR2 ; DMPK ; DSTYK ; DYRK1A ;

DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the ''DYRK1B'' gene. Function DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization s ...

; DYRK2 ; DYRK3 ; DYRK4 ; EGFR ; EIF2AK1 ; EIF2AK2 ;

EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the ''EIF2AK3'' gene. Function The protein encoded by this gene ...

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EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the ''EIF2AK4'' gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 ( ...

; EPHA1 ; EPHA10 ; EPHA2 ;

EPHA3 EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the ''EPHA3'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been ...

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EPHA4 EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the ''EPHA4'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated i ...

; EPHA5 ; EPHA6 ; EPHA7 ; EPHA8 ;

EPHB1 Ephrin type-B receptor 1 is a protein that in humans is encoded by the ''EPHB1'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their str ...

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EPHB2 Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...

; EPHB3 ; EPHB4 ; EPHB6 ;

ERBB2 Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ''ERBB2'' gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently refer ...

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ERBB3 Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ''ERBB3'' gene. ErbB3 is a member of the epidermal growth factor receptor (EGF ...

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ERBB4 Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ''ERBB4'' gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characteriz ...

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ERN1 The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ''ERN1'' gene. Function The protein encoded by this gene is the ER to nucleus signalling 1 protein, a hu ...

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ERN2 Ern or ERN may refer to: Transport * Eirunepé Airport, in Brazil * Engenho da Rainha Station, on the Rio de Janeiro Metro * Ernakulam Town railway station, in Kerala, India * Ernest Airlines, an Italian airline Other uses * Ern (given na ...

; FER ; FES ;

FGFR1 Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and cluster of differentiation, CD331, is a receptor tyrosine kinase whose ligands are specifi ...

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FGFR2 Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the ''FGFR2'' gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. The protei ...

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FGFR3 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the ''FGFR3'' gene. FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location q16.3, is expressed in ...

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FGFR4 Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the ''FGFR4'' gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334). The protein encoded by this gene is a member of the fibroblast growth fact ...

; FGR ;

FLT1 Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the ''FLT1'' gene. Function ''FLT1'' is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEG ...

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FLT3 Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the ''FLT3'' gene. FLT3 is a cyto ...

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FLT4 Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the ''FLT4'' gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involve ...

; FRK ;

FYN Funen ( da, Fyn, ), with an area of , is the third-largest island of Denmark, after Zealand and Vendsyssel-Thy. It is the 165th-largest island in the world. It is located in the central part of the country and has a population of 469,947 as of ...

; GAK ;

GRK1 Rhodopsin kinase (, ''rod opsin kinase'', ''G-protein-coupled receptor kinase 1'', ''GPCR kinase 1'', ''GRK1'', ''opsin kinase'', ''opsin kinase (phosphorylating)'', ''rhodopsin kinase (phosphorylating)'', ''RK'', ''STK14'') is a serine/threonine- ...

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GRK2 G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ''ADRBK1'' gene. GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor kinase subfa ...

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GRK3 G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in humans is encoded by the ''ADRBK2'' gene. GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase subfamily of ...

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GRK4 G protein-coupled receptor kinase 4 (GRK4) is an enzyme that in humans is encoded by the ''GRK4'' gene. This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most similar to GR ...

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GRK5 G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6. The protein phosphorylates the activated forms of G protein-coupled ...

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GRK6 This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK4 and GRK5. The protein phosphorylates the activated forms of G protein-coupled receptors to ...

; GRK7 ; GSG2 ; GSK3A ;

GSK3B Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the ''GSK3B'' gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased suscept ...

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GUCY2C Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the ''GUCY2C'' gene. Guanylyl ...

; GUCY2D ; GUCY2F ; HCK ;

HIPK1 Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the ''HIPK1'' gene. Function The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain ...

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HIPK2 Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the ''HIPK2'' gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belong ...

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HIPK3 Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the ''HIPK3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''g ...

; HIPK4 ; HUNK ;

ICK Ick or ICK may refer to: * William Ick, (1800–1844), botanist *Ichthyophthirius multifiliis, a single-celled parasite. Also known as Ich *Inhibitor cystine knot *Institute of Christ the King Sovereign Priest *Trains in the Netherlands, Intercit ...

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IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2 ...

; IKBKB ; IKBKE ;

ILK Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ''ILK'' are associated with cardiomyopathies. It is a 59kDa protein originally identified in a yeast-t ...

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INSR The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose hom ...

; INSRR ;

IRAK1 Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the ''IRAK1'' gene. IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages ...

; IRAK2 ;

IRAK3 Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the ''IRAK3'' gene. Using ''in vivo'' liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-in ...

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IRAK4 IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures ...

; ITK ; JAK1 ;

JAK2 Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF rec ...

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JAK3 Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the ''JAK3'' gene. Janus kinases Janus kinase 3 is a tyrosine kinase that belongs to the janus family of kinases. Other members of the Janus family include ...

; KALRN ; KDR ;

KIT Kit may refer to: Places *Kitt, Indiana, US, formerly Kit * Kit, Iran, a village in Mazandaran Province * Kit Hill, Cornwall, England People * Kit (given name), a list of people and fictional characters * Kit (surname) Animals * Young animals: ...

; KSR1 ; KSR2 ;

LATS1 Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the ''LATS1'' gene. It has been associated with the Hippo signaling pathway, where it phosphorylates YAP and TAZ to inactivate their function. The protein encoded b ...

; LATS2 ; LCK ; LIMK1 ; LIMK2 ; LMTK2 ;

LMTK3 Lemur tyrosine kinase 3 is a protein that in humans is encoded by the LMTK3 gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''b ...

; LRRK1 ;

LRRK2 Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a large, multifunctional kinase enzyme that in humans i ...

; LTK ;

LYN Ubisoft Montpellier is a French video game developer and a studio of Ubisoft based in Castelnau-le-Lez. Founded in 1994 as Ubi Pictures, it is best known for developing the ''Rayman'' and ''Beyond Good & Evil'' series. At 350 employees as of S ...

; MAK ;

MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the ''MAP2K1'' gene. Function The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mito ...

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MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the ''MAP2K2'' gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2. Function The ...

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MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the ''MAP2K3'' gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This k ...

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MAP2K4 Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the ''MAP2K4'' gene. ''MAP2K4'' encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP ...

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MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP2K5'' gene. Function The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase famil ...

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MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the ''MAP2K6'' gene, on chromosome 17. Function MAPKK 6 is a member of the d ...

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MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the ''MAP2K7'' gene. This protein is a member of the mitogen-activated protein kinase kinase family. T ...

; MAP3K1 ; MAP3K10 ; MAP3K11 ; MAP3K12 ; MAP3K13 ;

MAP3K14 Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the ''MAP3K14'' gene. Function This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, ...

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MAP3K15 Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene. Function The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members func ...

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MAP3K19 Mitogen-activated protein kinase kinase kinase 19 is a protein that in humans is encoded by the MAP3K19 gene. References Sources

{{gene-2-stub ...

; MAP3K2 ;

MAP3K20 Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but ...

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MAP3K21 Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but a ...

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MAP3K3 Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the ''MAP3K3'' gene, which is located on the long arm of chromosome 17 (17q23.3).MAP3K3 in GeneCards – The Human Gene Compendium. https://www.genecards. ...

; MAP3K4 ;

MAP3K5 Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and ...

; MAP3K6 ;

MAP3K7 Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the ''MAP3K7'' gene. Structure TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyro ...

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MAP3K8 Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the ''MAP3K8'' gene. Function The gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/thr ...

; MAP3K9 ; MAP4K1 ;

MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the ''MAP4K2'' gene. Function The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is ...

; MAP4K3 ; MAP4K4 ; MAP4K5 ;

MAPK1 Mitogen-activated protein kinase 1, (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the ''MAPK1'' gene. Function The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extrace ...

; MAPK10 ;

MAPK11 Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the ''MAPK11'' gene. Function The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemica ...

; MAPK12 ; MAPK13 ;

MAPK14 Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the ''MAPK14'' gene. MAPK14 encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs ...

; MAPK15 ;

MAPK3 Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the ''MAPK3'' gene. Function The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAP kinase) famil ...

; MAPK4 ; MAPK6 ;

MAPK7 Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the ''MAPK7'' gene. Function MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical ...

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MAPK8 Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the ''MAPK8'' gene. Function The protein encoded by this gene is a member of the Mitogen-activated protein kinase, MAP kinase and c-Jun ...

; MAPK9 ;

MAPKAPK2 MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the ''MAPKAPK2'' gene. Function This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 M ...

; MAPKAPK3 ; MAPKAPK5 ;

MARK1 Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the ''MARK1'' gene. References Further reading * * * * * * * * * * * * * * * * * * * EC 2.7.11 {{gene-1-stub ...

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MARK2 Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the ''MARK2'' gene. Function EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability ...

; MARK3 ; MARK4 ; MAST1 ; MAST2 ; MAST3 ; MAST4 ;

MASTL ''MASTL'' is an official symbol provided by HGNC for human gene whose official name is micro tubule associated serine/threonine kinase like. This gene is 32,1 kbps long. This gene is also known as GW, GWL, THC2, MAST-L, GREATWALL. This is presen ...

; MATK ;

MELK Melk (; older spelling: ) is a city of Austria, in the federal state of Lower Austria, next to the Wachau valley along the Danube. Melk has a population of 5,257 (as of 2012). It is best known as the site of a massive baroque Benedictine monaste ...

; MERTK ; MET ; MINK1 ;

MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the ''MKNK1'' gene. Interactions MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma Eukaryotic tran ...

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MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''MKNK2'' gene. Interactions MKNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma Eukaryotic tran ...

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MLKL Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. Function This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is ...

; MOK ; MOS ; MST1R ;

MUSK Musk ( Persian: مشک, ''Mushk'') is a class of aromatic substances commonly used as base notes in perfumery. They include glandular secretions from animals such as the musk deer, numerous plants emitting similar fragrances, and artificial s ...

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MYLK Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the ''MYLK'' gene. Function This gene, a muscle member of the immunoglobulin superfamily, encodes a myosi ...

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MYLK2 Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the ''MYLK2'' gene. Function This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed i ...

; MYLK3 ; MYLK4 ; MYO3A ; MYO3B ;

NEK1 NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can b ...

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NEK10 NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be ...

; NEK11 ;

NEK2 Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the ''NEK2'' gene. Interactions NEK2 has been shown to interact with MAPK1 Mitogen-activated protein kinase 1, (MAPK 1), also known as ERK2, is an enzyme that i ...

; NEK3 ; NEK4 ; NEK5 ; NEK6 ; NEK7 ; NEK8 ; NEK9 ; NIM1K ; NLK ;

NPR1 Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the ''NPR1'' gene. Function NPR1 is a membrane-bound guanylat ...

; NPR2 ;

NRBP1 Nuclear receptor-binding protein is a protein that in humans is encoded by the ''NRBP1'' gene. References Further reading

* * * * * * * * * * * * * * * {{gene-2-stub ...

; NRBP2 ; NRK ;

NTRK1 Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the ''NTRK1'' gen ...

; NTRK2 ; NTRK3 ; NUAK1 ; NUAK2 ;

OBSCN Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...

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OXSR1 Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the ''OXSR1'' gene. The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental st ...

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PAK1 Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the ''PAK1'' gene. PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II ...

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PAK2 Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the ''PAK2'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gen ...

; PAK3 ; PAK4 ; PAK5 ; PAK6 ; PAN3 ;

PASK PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''PASK'' gene. PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. P ...

; PBK ;

PDGFRA PDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, or CD140a i.e. Cluster of Differentiation 140a, is a receptor located on the surface of a wide range of cell types. This r ...

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PDGFRB Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the ''PDGFRB'' gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies. Gene The ''PDGFRB'' gene is located on h ...

; PDIK1L ;

PDPK1 In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the ''PDPK1'' gene in humans. It is implicated in the development and progression of melanomas. Function P ...

; PDPK2P ; PEAK1 ; PEAK3 ;

PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the ''PHKG1'' gene. This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain a ...

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PHKG2 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform is an enzyme that in humans is encoded by the ''PHKG2'' gene. The PHKG2 gene provides instructions for making one piece, the gamma subunit, of the phosphorylase b kinase enzyme. ...

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PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or ''VPS15'' is an enzyme that in humans is encoded by the ''PIK3R4'' gene ...

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PIM1 Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the ''PIM1'' gene. Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in ...

; PIM2 ; PIM3 ;

PINK1 PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the ''PINK1'' gene. It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to ...

; PKDCC ;

PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase also known as Myt1 kinase is an enzyme that in humans is encoded by the ''PKMYT1'' gene. Myt 1 is an enzyme in the Wee1 family and found in vertebrates. The Wee 1 fa ...

; PKN1 ; PKN2 ;

PKN3 PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase ( PI3K). It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/ P ...

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PLK1 Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the ''PLK1'' ( polo-like kinase 1) gene. Structure PLK1 consists of 603 am ...

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PLK2 Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the ''PLK2'' gene. Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division Cell divis ...

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PLK3 Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the ''PLK3'' gene. Function Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative ...

; PLK4 ; PLK5 ; PNCK ; POMK ; PRKAA1 ; PRKAA2 ; PRKACA ;

PRKACB cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the ''PRKACB'' gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kin ...

; PRKACG ; PRKCA ; PRKCB ;

PRKCD Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the ''PRKCD'' gene. Function Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenge ...

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PRKCE Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the ''PRKCE'' gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulate ...

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PRKCG Protein kinase C gamma type is an enzyme that in humans is encoded by the ''PRKCG'' gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. ...

; PRKCH ;

PRKCI Protein kinase C iota type is an enzyme that in humans is encoded by the ''PRKCI'' gene. Function This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight membe ...

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PRKCQ Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the ''PRKCQ'' gene. PKC-θ, a member of serine/threonine kinases, is mainly expressed in hematopoietic cells with high levels in platelets and T lymphocytes, where plays a ...

; PRKCZ ; PRKD1 ; PRKD2 ; PRKD3 ; PRKG1 ; PRKG2 ;

PRKX Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene. Function This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded ...

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PRKY Serine/threonine-protein kinase PRKY is an enzyme that in humans is encoded by the ''PRKY'' gene. This gene encodes a member of the cAMP-dependent serine/threonine protein kinase family. This gene is located on chromosome Y, near the boundary o ...

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PRPF4B Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the ''PRPF4B'' gene. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre ...

; PSKH1 ; PSKH2 ;

PTK2 PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the ''PTK2'' gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to ...

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PTK2B Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the ''PTK2B'' gene. Function This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the ...

; PTK6 ; PTK7 ;

PXK PX domain containing serine/threonine kinase also known as PXK is a protein which in humans is encoded by the ''PXK'' gene. Function PXK binds to the Na⁺/K⁺-ATPase beta-1 ( ATP1B1) and beta-3 ( ATP1B3) subunits and modulates both Na⁺/K ...

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RAF1 RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the ''RAF1'' gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase ...

; RET ; RIOK1 ; RIOK2 ; RIOK3 ;

RIPK1 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis and necroptosis. Some of the cell survival ...

; RIPK2 ; RIPK3 ; RIPK4 ;

RNASEL Ribonuclease L or RNase L (for ''latent''), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease — is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (bot ...

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ROCK1 ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effecter of the small GTPase RhoA and is a regulator of the ...

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ROCK2 Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein. Function The protein encoded by this gene is a serine/threonine kinase that regulates ...

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ROR1 Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ''ROR1'' gene. ROR1 is a member of the receptor tyrosine kinase-like orph ...

; ROR2 ; ROS1 ;

RPS6KA1 Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the ''RPS6KA1'' gene. Function This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical ...

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RPS6KA2 Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the ''RPS6KA2'' gene. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase ca ...

; RPS6KA3 ; RPS6KA4 ;

RPS6KA5 Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the ''RPS6KA5'' gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes. I ...

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RPS6KA6 Ribosomal protein S6 kinase, 90kDa, polypeptide 6 is a protein in humans that is encoded by the RPS6KA6 gene. This gene encodes a member of ribosomal S6 kinase family, serine-threonin protein kinases which are regulated by growth factors ...

; RPS6KB1 ;

RPS6KB2 Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the ''RPS6KB2'' gene. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catal ...

; RPS6KC1 ; RPS6KL1 ; RSKR ; RYK ; SBK1 ;

SBK2 SBK may refer to: *SBK Records, former record label * ShoreBank insolvent US community development bank acquired by the Urban Partnership Bank *Silver Bells Killer * Superbike World Championship *'' SBK: Snowboard Kids'', video game * South Brooklyn ...

; SBK3 ; SCYL1 ;

SCYL2 SCY1-like protein 2 is a protein that in humans is encoded by the ''SCYL2'' gene. References Further reading

* * * * * * * {{gene-12-stub ...

; SCYL3 ;

SGK1 Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional co ...

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SGK2 Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the ''SGK2'' gene. This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK ...

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SGK223 Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (comparTreefam family TF320906. In most vertebrates, including humans, there are three isoforms encoded by the genes '' SG ...

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SGK3 Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the ''SGK3'' gene. Function This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The ...

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SIK1 Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the ''SIK1'' gene. References Further reading * * * * * * * EC 2.7.11 {{gene-21-stub ...

; SIK1B ;

SIK2 Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the ''SIK2'' gene. Interactions SNF1LK2 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is ...

; SIK3 ; SLK ;

SNRK SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''SNRK'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...

; SPEG ; SRC ; SRMS ;

SRPK1 Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the ''SRPK1'' gene. Function This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) fami ...

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SRPK2 Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the ''SRPK2'' gene. Interactions SRPK2 has been shown to interact with: * ASF/SF2 and * U2AF2 Splicing factor U2AF 65 kDa subunit is a protein that in humans is ...

; SRPK3 ;

STK10 Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the ''STK10'' gene. This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The pr ...

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STK11 Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the ''STK11'' gene. Expression Testosterone and DHT treatment of murine 3T3-L1 or human ...

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STK16 Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the ''STK16'' gene. Interactions STK16 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501( ...

; STK17A ; STK17B ;

STK24 Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the ''STK24'' gene located in the chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and its ...

; STK25 ; STK26 ; STK3 ;

STK31 In enzymology, a tau-protein kinase () is an enzyme that catalyzes the chemical reaction :ATP + tau protein \rightleftharpoons ADP + O-phospho- tau-protein Thus, the two substrates of this enzyme are ATP and tau protein, whereas its two pr ...

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STK32A Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the ''STK3'' gene. Background Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing ...

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STK32B Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the ''STK3'' gene. Background Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing ag ...

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STK32C Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the ''STK3'' gene. Background Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing ...

; STK33 ; STK35 ; STK36 ;

STK38 Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the ''STK38'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gener ...

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STK38L Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the ''STK38L'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ' ...

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STK39 STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the ''STK39'' gene. This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is ...

; STK4 ;

STK40 Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the ''STK40'' gene. References Further reading * * * * * * * * * EC 2.7.11 {{gene-1-stub ...

; STKLD1 ; STRADA ; STRADB ; STYK1 ;

SYK Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the ''SYK'' gene. Function SYK, along with ZAP70, is a member of the Syk family of tyrosine kinases. These cytoplasmic non-receptor ty ...

; TAOK1 ;

TAOK2 Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the ''TAOK2'' gene. Interactions TAOK2 has been shown to interact with MAP2K6 and MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 is an enzy ...

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TAOK3 Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the ''TAOK3'' gene. References Further reading

* * * * * * * * {{gene-12-stub ...

; TBCK ; TBK1 ;

TEC TEC may refer to: Education * Technology, the subject itself of technology taught at schools * Tertiary Education Commission (disambiguation) *''The East Carolinian'', a campus newspaper of East Carolina University Governmental and public organiz ...

; TEK ; TESK1 ; TESK2 ; TEX14 ;

TGFBR1 Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family The transforming growth factor beta (TGFβ) receptors are a family of se ...

; TGFBR2 ; TIE1 ; TLK1 ; TLK2 ;

TNIK TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the ''TNIK'' gene. Function Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that se ...

; TNK1 ;

TNK2 Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the ''TNK2'' gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and ins ...

; TNNI3K ;

TP53RK TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the ''TP53RK'' gene. This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15. PRPK is part of the KEOPS/EKC complex, which participate ...

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TRIB1 Tribbles homolog 1 is a protein kinase that in humans is encoded by the ''TRIB1'' gene. Orthologs of this protein pseudokinase ( pseudoenzyme) can be found almost ubiquitously throughout the animal kingdom. It exerts its biological functions t ...

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TRIB2 Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the ''TRIB2'' gene. TRIB2 is a pseudokinase member of the ( pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. I ...

; TRIB3 ; TRIO ; TSSK1B ;

TSSK2 Testis-specific serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''TSSK2'' gene. References Further reading * * * * * EC 2.7.11 {{gene-22-stub ...

; TSSK3 ; TSSK4 ; TSSK6 ;

TTBK1 Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene. References Further reading

* * * * * * {{gene-6-stub ...

; TTBK2 ; TTK ; TTN ; TXK ; TYK2 ; TYRO3 ;

UHMK1 U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the ''UHMK1'' gene. Function UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown funct ...

; ULK1 ; ULK2 ; ULK3 ; ULK4 ; VRK1 ;

VRK2 Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the ''VRK2'' gene. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human ti ...

; VRK3 ;

WEE1 Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast ''Schizosaccharomyces pombe'' (''S. pombe'')Wee1has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influence ...

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WEE2 Wee or WEE may refer to: * Wee, a slang term for urine (see also wee-wee) * Wee, short stature, or otherwise small Anthroponym * Wee (surname), Chinese surname and name * Wee Willie Harris, singer * Wee Willie Webber, Philadelphia TV and ra ...

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WNK1 WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the ''WNK1'' gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regu ...

; WNK2 ; WNK3 ; WNK4 ; YES1 ;

ZAP70 ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). It is most prominently known to be recruited upon antigen binding t ...

References

{{DEFAULTSORT:Protein Kinase Domain Protein domains Peripheral membrane proteins