Proboscivirus

''Proboscivirus'' is a genus of viruses in the order '' Herpesvirales'', in the family '' Herpesviridae'', in the subfamily '' Betaherpesvirinae''. Elephants serve as natural hosts. EEHV1 is apathogenic for African elephants but causes fatal haemorrhagic disease in Asian elephants. The name "''Proboscivirus''" comes from the Greek word or " proboscis" meaning "the elephant trunk," for which the virus accordingly uses as its means of contraction and transmission (secretions or openings of the trunk) to enter the elephant's body.

Taxonomy

''Proboscivirus'' is located under the listings of the ICTV Updates as Section §2005.049-050V.04. With the creation of ''Proboscivirus'' as a new genus came the creation and categorization of a new species under this genus, by the name of ''Elephantid betaherpesvirus 1'' (Acronym: EEHV1 and Scientific Name: Elephant endotheliotropic herpesvirus) under ICTV §2005.051-050V.04.

It was suggested by Pellett (2014) that the phylogenetic divergence of ''Proboscivirus'' from other genera in the subfamily ''Betaherpesvirinae'' warrants reassignment of the genus to a new subfamily that would be called ''Deltaherpesvirinae''. However, the genus remains in the ''Betaherpesvirinae'' in currently accepted ICTV taxonomy.

Species

The genus consists of the following species:

* ''Elephantid betaherpesvirus 1''
* ''Elephantid betaherpesvirus 4''
* ''Elephantid betaherpesvirus 5''

Structure

Viruses in ''Proboscivirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented.

Considering ''Proboscivirus'' is a herpesvirus, it is then unique in the sense that morphologically the virus is atypical to other viruses. According to University of Glasgow Immunology & Virology Professor, A.J. Davison, and his research team, the ''Proboscivirus'' morphology is a "linear, double-stranded DNA genome of 125-290 kbp contained within a T=16 icosahedral capsid, which is surrounded by proteinaceous ixtureand lipid envelope containing membrane-associated proteins". Species under the genus ''Proboscivirus'' tend to leave physical symptoms of cyanosis of the tongue, mouth/stomach ulcers, oedema of the head (or trunk for Elephants) on its host - often leading to death afterwards.

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding.
Elephants serve as the natural host.

References

External links

Viralzone: ''Proboscivirus''

ICTV

{{Taxonbar, from=Q16988512

Betaherpesvirinae
Virus genera