Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally designed by clandestine medicinal chemists. These unprecedented synthetic cannabinoids often feature alphanumeric code names intended to mimic the style of chemical nomenclature used by academic laboratories and pharmaceutical companies, and there is generally little, if any, information available regarding their pharmacology and toxicology at the time of first discovery. * 5F-AB-PINACA — the terminally fluorinated (5-fluoropentyl) analogue of AB-PINACA. * 5F-AMB — * 5F-ADB — * 5F-NNE1 — * 5F-PCN — * 5F-SDB-006 — the terminally fluorinated (5-fluoropentyl) analogue of SDB-006. *

AB-001 AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is s ...

— one of the earliest

adamantane Adamantane is an organic compound with formula C10H16 or, more descriptively, (CH)4(CH2)6. Adamantane molecules can be described as the fusion of three cyclohexane rings. The molecule is both rigid and virtually stress-free. Adamantane is the mo ...

derivatives discovered as a designer cannabinoid. AB-001 was unknown in the scientific literature at the time of its discovery, and has since been characterized as a CB₁ and CB₂ agonist with weak cannabimimetic activity in rats. *

AB-005 AB-005 or 1-methylpiperidin-2-yl)methyl.html" ;"title="-[(1-methylpiperidin-2-yl)methyl">-[(1-methylpiperidin-2-yl)methyl1''H''-indol-3-yl2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic ...

— * AB-CHMINACA — * ADAMANTYL-THPINACA — * AMB-FUBINACA * APICA (synthetic cannabinoid drug), APICA — also known as 2NE1 and SDB-001, APICA is the carboxamide analogue of AB-001 and was similarly unknown in the scientific literature at the time of its discovery. Like AB-001, APICA is a CB₁ and CB₂ agonist possessing moderate cannabimimetic potency in rats. *

APINACA APINACA (AKB48, ''N''-(1-adamantyl)-1-pentyl-1''H''-indazole-3-carboxamide) is a drug that acts as a reasonably potent agonist for the cannabinoid receptors. It is a full agonist at CB1 with an EC50 of 142 nM and Ki of 3.24 nM (compared to the ...

— also known as AKB-48.

is the indazole analogue of APICA. * BB-22 — *

BIM-018 BIM-018 is a synthetic cannabinoid that is the benzimidazole analog of JWH-018. It is presumed to be a potent agonist of the CB2 receptor and has been sold online as a designer drug. Related benzimidazole derivatives have been reported to be ...

— also known as JWH-018 benzimidazole analogue, is a 1,2-disubstituted benzimidazole analogue of

JWH-018 JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effe ...

. *

FAB-144 FAB-144 is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug. It is the indazole analogue of XLR-11. Legal status Sweden's public health agency ...

— the indazole analogue of

XLR-11 XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related t ...

. * FDU-NNE1 *

FUB-144 FUB-144 (also known as FUB-UR-144) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug. It is an analogue of UR-144 and XLR-11 where the pentyl chain ...

— the ''N''-(4-fluorobenzyl) analogue of

UR-144 UR-144 (TMCP-018, KM-X1, MN-001, YX-17) is a drug invented by Abbott Laboratories, that acts as a selective full agonist of the peripheral cannabinoid receptor CB2, but with much lower affinity for the psychoactive CB1 receptor. Pharmacology U ...

and

. *

FUBIMINA FUBIMINA (also known as BIM-2201, BZ-2201 and FTHJ) is a synthetic cannabinoid that is the benzimidazole structural analog, analog of AM-2201 and has been used as an active ingredient in synthetic cannabis products. It was first identified in J ...

— the terminally fluorinated (5-fluoro) analogue of

. * MDMB-CHMICA * MDMB-FUBINACA * MMB-2201 * MN-18 — the indazole analogue of NNE1. *

NM-2201 NM-2201 (also known as CBL-2201 and NA-5F-PIC) is an indole-based synthetic cannabinoid that presumably has similar properties to the closely related 5F-PB-22 and NNE1, which are both full agonists and unselectively bind to CB1 and CB2 rece ...

— * NNE1 — also known as NNEI, MN-24 and AM-6527, is the carboxamide analogue of

. NNE1 was first described in a paper by Abbott Laboratories in 2011. * PB-22 — * PX-1 — * PX-2 — *

PX-3 PX-3 (also known as APP-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of ''K''i = 47.6 nM and was originally developed by Pfizer in 2009 as an analgesic m ...

— * SDB-005 — * SDB-006 — is a benzylic analogue of APICA, and was discovered during research related to AB-001 and APICA. *

STS-135 STS-135 ( ISS assembly flight ULF7) was the 135th and final mission of the American Space Shuttle program. It used the orbiter '' Atlantis'' and hardware originally processed for the STS-335 contingency mission, which was not flown. STS-135 ...

— the terminally fluorinated (5-fluoro) analogue of APICA.

is believed to be named after the

jet propulsion system, and functions as an agonist at CB₁ and CB₂ receptors. *

THJ-018 THJ-018 (SGT-17) is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug. Pharmacology THJ-018 acts as a full agonist with a binding affinity of 5.84 nM at CB1 and 4.57 nM at C ...

— the indazole analogue of

. *

THJ-2201 THJ-2201 is an indazole-based synthetic cannabinoid that presumably acts as a potent agonist of the CB1 receptor, CB1 receptor and has been sold online as a designer drug. It is a structural analog of AM-2201 in which the central indole ring h ...

— the indazole analogue of

AM-2201 AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids discovered by Alexandros Makriyann ...

. *

WIN 55,212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. WIN 55,212-2 is a potent cannab ...

— *

— the terminally fluorinated (5-fluoro) analogue of

. *

XLR-12 XLR-12 is an indole-based synthetic cannabinoid drug that was invented by Abbott Laboratories Abbott Laboratories is an American multinational medical devices and health care company with headquarters in Abbott Park, Illinois, in the United ...

— the terminally trifluorinated (4,4,4-trifluorobutyl) analogue of

See also