Hydrogen Peroxide
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Hydrogen peroxide is a
chemical compound A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element ...
with the formula . In its pure form, it is a very pale blue
liquid Liquid is a state of matter with a definite volume but no fixed shape. Liquids adapt to the shape of their container and are nearly incompressible, maintaining their volume even under pressure. The density of a liquid is usually close to th ...
that is slightly more viscous than
water Water is an inorganic compound with the chemical formula . It is a transparent, tasteless, odorless, and Color of water, nearly colorless chemical substance. It is the main constituent of Earth's hydrosphere and the fluids of all known liv ...
. It is used as an oxidizer,
bleach Bleach is the generic name for any chemical product that is used industrially or domestically to remove color from (i.e. to whiten) fabric or fiber (in a process called bleaching) or to disinfect after cleaning. It often refers specifically t ...
ing agent, and
antiseptic An antiseptic ( and ) is an antimicrobial substance or compound that is applied to living tissue to reduce the possibility of sepsis, infection, or putrefaction. Antiseptics are generally distinguished from ''antibiotics'' by the latter's abil ...
, usually as a dilute solution (3%–6% by weight) in water for consumer use and in higher concentrations for industrial use. Concentrated hydrogen peroxide, or "
high-test peroxide High-test peroxide (HTP) is a highly concentrated (85 to 98%) solution of hydrogen peroxide, with the remainder consisting predominantly of water. In contact with a catalyst, it decomposes into a high-temperature mixture of steam and oxygen, with n ...
", decomposes explosively when heated and has been used as both a
monopropellant Monopropellants are propellants consisting of chemicals that release energy through exothermic chemical decomposition. The molecular bond energy of the monopropellant is released usually through use of a catalyst. This can be contrasted with biprop ...
and an oxidizer in
rocket A rocket (from , and so named for its shape) is a vehicle that uses jet propulsion to accelerate without using any surrounding air. A rocket engine produces thrust by reaction to exhaust expelled at high speed. Rocket engines work entirely ...
ry. Hydrogen peroxide is a
reactive oxygen species In chemistry and biology, reactive oxygen species (ROS) are highly Reactivity (chemistry), reactive chemicals formed from diatomic oxygen (), water, and hydrogen peroxide. Some prominent ROS are hydroperoxide (H2O2), superoxide (O2−), hydroxyl ...
and the simplest
peroxide In chemistry, peroxides are a group of Chemical compound, compounds with the structure , where the R's represent a radical (a portion of a complete molecule; not necessarily a free radical) and O's are single oxygen atoms. Oxygen atoms are joined ...
, a compound having an oxygen–oxygen single bond. It decomposes slowly into water and elemental
oxygen Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), non ...
when exposed to light, and rapidly in the presence of organic or reactive compounds. It is typically stored with a stabilizer in a weakly acidic solution in an opaque bottle. Hydrogen peroxide is found in biological systems including the human body. Enzymes that use or decompose hydrogen peroxide are classified as peroxidases.


Properties

The boiling point of has been extrapolated as being , approximately higher than water. In practice, hydrogen peroxide will undergo potentially explosive thermal decomposition if heated to this temperature. It may be safely distilled at lower temperatures under reduced pressure. Hydrogen peroxide forms stable
adduct In chemistry, an adduct (; alternatively, a contraction of "addition product") is a product of a direct addition of two or more distinct molecules, resulting in a single reaction product containing all atoms of all components. The resultant is ...
s with
urea Urea, also called carbamide (because it is a diamide of carbonic acid), is an organic compound with chemical formula . This amide has two Amine, amino groups (–) joined by a carbonyl functional group (–C(=O)–). It is thus the simplest am ...
( hydrogen peroxide–urea), sodium carbonate ( sodium percarbonate) and other compounds. An acid-base adduct with triphenylphosphine oxide is a useful "carrier" for in some reactions.


Structure

Hydrogen peroxide () is a nonplanar molecule with (twisted) C2
symmetry Symmetry () in everyday life refers to a sense of harmonious and beautiful proportion and balance. In mathematics, the term has a more precise definition and is usually used to refer to an object that is Invariant (mathematics), invariant und ...
; this was first shown by Paul-Antoine Giguère in 1950 using
infrared spectroscopy Infrared spectroscopy (IR spectroscopy or vibrational spectroscopy) is the measurement of the interaction of infrared radiation with matter by absorption, emission, or reflection. It is used to study and identify chemical substances or functio ...
. Although the O−O bond is a single bond, the molecule has a relatively high rotational barrier of 386  cm−1 (4.62  kJ/ mol) for rotation between
enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...
s via the ''trans'' configuration, and 2460 cm−1 (29.4 kJ/mol) via the ''cis'' configuration. These barriers are proposed to be due to repulsion between the
lone pair In chemistry, a lone pair refers to a pair of valence electrons that are not shared with another atom in a covalent bondIUPAC ''Gold Book'' definition''lone (electron) pair''/ref> and is sometimes called an unshared pair or non-bonding pair. Lone ...
s of the adjacent oxygen atoms and dipolar effects between the two O–H bonds. For comparison, the rotational barrier for
ethane Ethane ( , ) is a naturally occurring Organic compound, organic chemical compound with chemical formula . At standard temperature and pressure, ethane is a colorless, odorless gas. Like many hydrocarbons, ethane is List of purification methods ...
is 1040 cm−1 (12.4 kJ/mol). The approximately 100° dihedral angle between the two O–H bonds makes the molecule
chiral Chirality () is a property of asymmetry important in several branches of science. The word ''chirality'' is derived from the Greek language, Greek (''kheir''), "hand", a familiar chiral object. An object or a system is ''chiral'' if it is dist ...
. It is the smallest and simplest molecule to exhibit
enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...
ism. It has been proposed that the enantiospecific interactions of one rather than the other may have led to amplification of one enantiomeric form of
ribonucleic acid Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins ( messenger RNA). RNA and deoxyr ...
s and therefore an origin of homochirality in an
RNA world The RNA world is a hypothetical stage in the evolutionary history of life on Earth in which self-replicating RNA molecules proliferated before the evolution of DNA and proteins. The term also refers to the hypothesis that posits the existence ...
. The molecular structures of gaseous and
crystalline A crystal or crystalline solid is a solid material whose constituents (such as atoms, molecules, or ions) are arranged in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions. In addition, macrosc ...
are significantly different. This difference is attributed to the effects of
hydrogen bonding In chemistry, a hydrogen bond (H-bond) is a specific type of molecular interaction that exhibits partial covalent character and cannot be described as a purely electrostatic force. It occurs when a hydrogen (H) atom, Covalent bond, covalently b ...
, which is absent in the gaseous state. Crystals of are
tetragonal In crystallography, the tetragonal crystal system is one of the 7 crystal systems. Tetragonal crystal lattices result from stretching a cubic lattice along one of its lattice vectors, so that the Cube (geometry), cube becomes a rectangular Pri ...
with the
space group In mathematics, physics and chemistry, a space group is the symmetry group of a repeating pattern in space, usually in three dimensions. The elements of a space group (its symmetry operations) are the rigid transformations of the pattern that ...
''D'' or ''P''41212.


Aqueous solutions

In
aqueous solution An aqueous solution is a solution in which the solvent is water. It is mostly shown in chemical equations by appending (aq) to the relevant chemical formula. For example, a solution of table salt, also known as sodium chloride (NaCl), in water ...
s, hydrogen peroxide forms a eutectic mixture, exhibiting
freezing-point depression Freezing-point depression is a drop in the maximum temperature at which a substance freezing, freezes, caused when a smaller amount of another, non-Volatility (chemistry), volatile substance is added. Examples include adding salt into water (u ...
down as low as −56 °C; pure water has a freezing point of 0 °C and pure hydrogen peroxide of −0.43 °C. The boiling point of the same mixtures is also depressed in relation with the mean of both boiling points (125.1 °C). It occurs at 114 °C. This boiling point is 14 °C greater than that of pure water and 36.2 °C less than that of pure hydrogen peroxide.
  • wt% concentrations. The concentrations are sometimes described in terms of the volume of oxygen gas generated; one milliliter of a 20-volume solution generates twenty milliliters of oxygen gas when completely decomposed. For laboratory use, 30 wt% solutions are most common. Commercial grades from 70% to 98% are also available, but due to the potential of solutions of more than 68% hydrogen peroxide to be converted entirely to steam and oxygen (with the temperature of the steam increasing as the concentration increases above 68%) these grades are potentially far more hazardous and require special care in dedicated storage areas. Buyers must typically allow inspection by commercial manufacturers.


    Comparison with analogues

    Hydrogen peroxide has several structural analogues with bonding arrangements (water also shown for comparison). It has the highest (theoretical) boiling point of this series (X = O, S, N, P). Its melting point is also fairly high, being comparable to that of
    hydrazine Hydrazine is an inorganic compound with the chemical formula . It is a simple pnictogen hydride, and is a colourless flammable liquid with an ammonia-like odour. Hydrazine is highly hazardous unless handled in solution as, for example, hydraz ...
    and water, with only hydroxylamine crystallising significantly more readily, indicative of particularly strong hydrogen bonding. Diphosphane and hydrogen disulfide exhibit only weak hydrogen bonding and have little chemical similarity to hydrogen peroxide. Structurally, the analogues all adopt similar skewed structures, due to repulsion between adjacent
    lone pair In chemistry, a lone pair refers to a pair of valence electrons that are not shared with another atom in a covalent bondIUPAC ''Gold Book'' definition''lone (electron) pair''/ref> and is sometimes called an unshared pair or non-bonding pair. Lone ...
    s.


    Natural occurrence

    Hydrogen peroxide is produced by various biological processes mediated by
    enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
    s. Hydrogen peroxide has been detected in surface water, in groundwater, and in the
    atmosphere An atmosphere () is a layer of gases that envelop an astronomical object, held in place by the gravity of the object. A planet retains an atmosphere when the gravity is great and the temperature of the atmosphere is low. A stellar atmosph ...
    . It can also form when water is exposed to UV light. Sea water contains 0.5 to 14 μg/L of hydrogen peroxide, and freshwater contains 1 to 30 μg/L. Concentrations in air are about 0.4 to 4 μg/m3, varying over several
    orders of magnitude In a ratio scale based on powers of ten, the order of magnitude is a measure of the nearness of two figures. Two numbers are "within an order of magnitude" of each other if their ratio is between 1/10 and 10. In other words, the two numbers are wi ...
    depending in conditions such as season, altitude, daylight and water vapor content. In rural nighttime air it is less than 0.014 μg/m3, and in moderate photochemical smog it is 14 to 42 μg/m3.Special Report No. 10. Hydrogen Peroxide. OEL Criteria Document.
    CAS No. 7722-84-1. July 1996.
    The amount of hydrogen peroxide in biological systems can be assayed using a fluorometric assay.


    Discovery

    Alexander von Humboldt Friedrich Wilhelm Heinrich Alexander von Humboldt (14 September 1769 – 6 May 1859) was a German polymath, geographer, natural history, naturalist, List of explorers, explorer, and proponent of Romanticism, Romantic philosophy and Romanticism ...
    is sometimes said to have been the first to report the first synthetic peroxide, barium peroxide, in 1799 as a by-product of his attempts to decompose air, although this is disputed due to von Humboldt's ambiguous wording. Nineteen years later Louis Jacques Thénard recognized that this compound could be used for the preparation of a previously unknown compound, which he described as ("oxygenated water") — subsequently known as hydrogen peroxide. An improved version of Thénard's process used
    hydrochloric acid Hydrochloric acid, also known as muriatic acid or spirits of salt, is an aqueous solution of hydrogen chloride (HCl). It is a colorless solution with a distinctive pungency, pungent smell. It is classified as a acid strength, strong acid. It is ...
    , followed by addition of
    sulfuric acid Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid (English in the Commonwealth of Nations, Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen, ...
    to precipitate the
    barium sulfate Barium sulfate (or sulphate) is the inorganic compound with the chemical formula Ba SO4. It is a white crystalline solid that is odorless and insoluble in water. It occurs in nature as the mineral barite, which is the main commercial source of ...
    byproduct. This process was used from the end of the 19th century until the middle of the 20th century. The bleaching effect of peroxides and their salts on
    natural dye Natural dyes are dyes or colorants derived from plants, invertebrates, or minerals. The majority of natural dyes are vegetable dyes from plant sources—roots, berry, berries, Bark (botany), bark, leaf, leaves, and wood—and other biological sourc ...
    s had been known since Thénard's experiments in the 1820s, but early attempts of industrial production of peroxides failed. The first plant producing hydrogen peroxide was built in 1873 in
    Berlin Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population withi ...
    . The discovery of the synthesis of hydrogen peroxide by
    electrolysis In chemistry and manufacturing, electrolysis is a technique that uses Direct current, direct electric current (DC) to drive an otherwise non-spontaneous chemical reaction. Electrolysis is commercially important as a stage in the separation of c ...
    with
    sulfuric acid Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid (English in the Commonwealth of Nations, Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen, ...
    introduced the more efficient electrochemical method. It was first commercialized in 1908 in Weißenstein,
    Carinthia Carinthia ( ; ; ) is the southernmost and least densely populated States of Austria, Austrian state, in the Eastern Alps, and is noted for its mountains and lakes. The Lake Wolayer is a mountain lake on the Carinthian side of the Carnic Main ...
    , Austria. The
    anthraquinone process The anthraquinone process, also called the Riedl–Pfleiderer process, is a process for the production of hydrogen peroxide, which was developed by IG Farben in the 1940s. The industrial production of hydrogen peroxide is based on the reduction o ...
    , which is still used, was developed during the 1930s by the German chemical manufacturer
    IG Farben I. G. Farbenindustrie AG, commonly known as IG Farben, was a German Chemical industry, chemical and Pharmaceutical industry, pharmaceutical conglomerate (company), conglomerate. It was formed on December 2, 1925 from a merger of six chemical co ...
    in
    Ludwigshafen Ludwigshafen, officially Ludwigshafen am Rhein (; meaning "Ludwig I of Bavaria, Ludwig's Port upon the Rhine"; Palatine German dialects, Palatine German: ''Ludwichshafe''), is a List of cities and towns in Germany, city in the German state of Rh ...
    . The increased demand and improvements in the synthesis methods resulted in the rise of the annual production of hydrogen peroxide from 35,000 tonnes in 1950, to over 100,000 tonnes in 1960, to 300,000 tonnes by 1970; by 1998 it reached 2.7 million tonnes. Early attempts failed to produce neat hydrogen peroxide. Anhydrous hydrogen peroxide was first obtained by vacuum distillation. Determination of the molecular structure of hydrogen peroxide proved to be very difficult. In 1892, the Italian physical chemist Giacomo Carrara (1864–1925) determined its molecular mass by
    freezing-point depression Freezing-point depression is a drop in the maximum temperature at which a substance freezing, freezes, caused when a smaller amount of another, non-Volatility (chemistry), volatile substance is added. Examples include adding salt into water (u ...
    , which confirmed that its molecular formula is . seemed to be just as possible as the modern structure, and as late as in the middle of the 20th century at least half a dozen hypothetical isomeric variants of two main options seemed to be consistent with the available evidence. In 1934, the English mathematical physicist William Penney and the Scottish physicist Gordon Sutherland proposed a molecular structure for hydrogen peroxide that was very similar to the presently accepted one.


    Production

    In 1994, world production of was around 1.9 million tonnes and grew to 2.2 million in 2006, most of which was at a concentration of 70% or less. In that year, bulk 30% sold for around 0.54
    USD The United States dollar (symbol: $; currency code: USD) is the official currency of the United States and several other countries. The Coinage Act of 1792 introduced the U.S. dollar at par with the Spanish silver dollar, divided it int ...
    / kg, equivalent to US$1.50/kg (US$0.68/ lb) on a "100% basis". Today, hydrogen peroxide is manufactured almost exclusively by the
    anthraquinone process The anthraquinone process, also called the Riedl–Pfleiderer process, is a process for the production of hydrogen peroxide, which was developed by IG Farben in the 1940s. The industrial production of hydrogen peroxide is based on the reduction o ...
    , which was originally developed by
    BASF BASF SE (), an initialism of its original name , is a European Multinational corporation, multinational company and the List of largest chemical producers, largest chemical producer in the world. Its headquarters are located in Ludwigshafen, Ge ...
    in 1939. It begins with the reduction of an
    anthraquinone Anthraquinone, also called anthracenedione or dioxoanthracene, is an aromatic hydrocarbon, aromatic organic compound with formula . Several isomers exist but these terms usually refer to 9,10-anthraquinone (IUPAC: 9,10-dioxoanthracene) wherein th ...
    (such as
    2-ethylanthraquinone 2-Ethylanthraquinone is an organic compound that is a derivative of anthraquinone. This pale yellow solid is used in the industrial production of hydrogen peroxide (H2O2).Römpp CD 2006, Georg Thieme Verlag 2006 Production 2-Ethylanthraquinone ...
    or the 2-amyl derivative) to the corresponding anthrahydroquinone, typically by
    hydrogenation Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to redox, reduce or Saturated ...
    on a
    palladium Palladium is a chemical element; it has symbol Pd and atomic number 46. It is a rare and lustrous silvery-white metal discovered in 1802 by the English chemist William Hyde Wollaston. He named it after the asteroid Pallas (formally 2 Pallas), ...
    catalyst Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...
    . In the presence of
    oxygen Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), non ...
    , the anthrahydroquinone then undergoes autoxidation: the labile hydrogen atoms of the
    hydroxy group In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydroxy ...
    s transfer to the oxygen molecule, to give hydrogen peroxide and regenerating the anthraquinone. Most commercial processes achieve oxidation by bubbling
    compressed air Compressed air is air kept under a pressure that is greater than atmospheric pressure. Compressed air in vehicle tires and shock absorbers are commonly used for improved traction and reduced vibration. Compressed air is an important medium for t ...
    through a solution of the anthrahydroquinone, with the hydrogen peroxide then extracted from the solution and the anthraquinone recycled back for successive cycles of hydrogenation and oxidation.H. Riedl and G. Pfleiderer, U.S. Patent 2,158,525 (2 October 1936 in the US, and 10 October 1935 in Germany) to I. G. Farbenindustrie, Germany The net reaction for the anthraquinone-catalyzed process is: : The economics of the process depend heavily on effective recycling of the extraction solvents, the
    hydrogenation Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to redox, reduce or Saturated ...
    catalyst and the expensive
    quinone The quinones are a class of organic compounds that are formally "derived from aromatic compounds benzene.html" ;"title="uch as benzene">uch as benzene or naphthalene] by conversion of an even number of –CH= groups into –C(=O)– groups with ...
    .


    Historical methods

    Hydrogen peroxide was once prepared industrially by
    hydrolysis Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water ...
    of ammonium persulfate: : was itself obtained by the
    electrolysis In chemistry and manufacturing, electrolysis is a technique that uses Direct current, direct electric current (DC) to drive an otherwise non-spontaneous chemical reaction. Electrolysis is commercially important as a stage in the separation of c ...
    of a solution of ammonium bisulfate () in
    sulfuric acid Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid (English in the Commonwealth of Nations, Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen, ...
    .


    Other routes

    Small amounts are formed by electrolysis, photochemistry,
    electric arc An electric arc (or arc discharge) is an electrical breakdown of a gas that produces a prolonged electrical discharge. The electric current, current through a normally Electrical conductance, nonconductive medium such as air produces a plasma ( ...
    , and related methods. A commercially viable route for hydrogen peroxide via the reaction of hydrogen with oxygen favours production of water but can be stopped at the peroxide stage. One economic obstacle has been that direct processes give a dilute solution uneconomic for transportation. None of these has yet reached a point where it can be used for industrial-scale synthesis.


    Reactions


    Acid-base

    Hydrogen peroxide is about 1000 times stronger as an acid than water. : (p''K'' = 11.65)


    Disproportionation

    Hydrogen peroxide disproportionates to form water and oxygen with a Δ''H''o of −2884.5  kJ/ kg and a Δ S of 70.5 J/(mol·K): : The rate of decomposition increases with rise in temperature, concentration, and pH. is unstable under alkaline conditions. Decomposition is catalysed by various redox-active ions or compounds, including most
    transition metal In chemistry, a transition metal (or transition element) is a chemical element in the d-block of the periodic table (groups 3 to 12), though the elements of group 12 (and less often group 3) are sometimes excluded. The lanthanide and actinid ...
    s and their compounds (e.g.
    manganese dioxide Manganese dioxide is the inorganic compound with the formula . This blackish or brown solid occurs naturally as the mineral pyrolusite, which is the main ore of manganese and a component of manganese nodules. The principal use for is for dry-cel ...
    (),
    silver Silver is a chemical element; it has Symbol (chemistry), symbol Ag () and atomic number 47. A soft, whitish-gray, lustrous transition metal, it exhibits the highest electrical conductivity, thermal conductivity, and reflectivity of any metal. ...
    , and
    platinum Platinum is a chemical element; it has Symbol (chemistry), symbol Pt and atomic number 78. It is a density, dense, malleable, ductility, ductile, highly unreactive, precious metal, precious, silverish-white transition metal. Its name origina ...
    ).


    Oxidation reactions

    The
    redox Redox ( , , reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change. Oxidation is the loss of electrons or an increase in the oxidation state, while reduction is t ...
    properties of hydrogen peroxide depend on pH. In acidic solutions, is a powerful oxidizer. Sulfite () is oxidized to
    sulfate The sulfate or sulphate ion is a polyatomic anion with the empirical formula . Salts, acid derivatives, and peroxides of sulfate are widely used in industry. Sulfates occur widely in everyday life. Sulfates are salts of sulfuric acid and many ...
    ().


    Reduction reactions

    Under
    alkaline In chemistry, an alkali (; from the Arabic word , ) is a basic salt of an alkali metal or an alkaline earth metal. An alkali can also be defined as a base that dissolves in water. A solution of a soluble base has a pH greater than 7.0. The ...
    conditions, hydrogen peroxide is a reductant. When acts as a reducing agent,
    oxygen Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), non ...
    gas is also produced. For example, hydrogen peroxide will reduce
    sodium hypochlorite Sodium hypochlorite is an alkaline inorganic chemical compound with the formula (also written as NaClO). It is commonly known in a dilute aqueous solution as bleach or chlorine bleach. It is the sodium salt of hypochlorous acid, consisting of ...
    and
    potassium permanganate Potassium permanganate is an inorganic compound with the chemical formula KMnO4. It is a purplish-black crystalline salt, which dissolves in water as K+ and ions to give an intensely pink to purple solution. Potassium permanganate is widely us ...
    , which is a convenient method for preparing
    oxygen Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), non ...
    in the laboratory: : : The oxygen produced from hydrogen peroxide and sodium hypochlorite is in the singlet state. Hydrogen peroxide also reduces silver oxide to
    silver Silver is a chemical element; it has Symbol (chemistry), symbol Ag () and atomic number 47. A soft, whitish-gray, lustrous transition metal, it exhibits the highest electrical conductivity, thermal conductivity, and reflectivity of any metal. ...
    : : Although usually a reductant, alkaline hydrogen peroxide converts Mn(II) to the dioxide: : In a related reaction,
    potassium permanganate Potassium permanganate is an inorganic compound with the chemical formula KMnO4. It is a purplish-black crystalline salt, which dissolves in water as K+ and ions to give an intensely pink to purple solution. Potassium permanganate is widely us ...
    is reduced to by ''acidic'' : :


    Organic reactions

    Hydrogen peroxide is frequently used as an
    oxidizing agent An oxidizing agent (also known as an oxidant, oxidizer, electron recipient, or electron acceptor) is a substance in a redox chemical reaction that gains or " accepts"/"receives" an electron from a (called the , , or ''electron donor''). In ot ...
    . Illustrative is oxidation of
    thioether In organic chemistry, a sulfide (British English sulphide) or thioether is an organosulfur functional group with the connectivity as shown on right. Like many other sulfur-containing compounds, Volatile organic compound, volatile sulfides have ...
    s to form sulfoxides, such as conversion of thioanisole to methyl phenyl sulfoxide: : Alkaline hydrogen peroxide is used for epoxidation of electron-deficient alkenes such as acrylic acid derivatives, and for the oxidation of alkylboranes to
    alcohol Alcohol may refer to: Common uses * Alcohol (chemistry), a class of compounds * Ethanol, one of several alcohols, commonly known as alcohol in everyday life ** Alcohol (drug), intoxicant found in alcoholic beverages ** Alcoholic beverage, an alco ...
    s, the second step of hydroboration-oxidation. It is also the principal reagent in the
    Dakin oxidation The Dakin oxidation (or Dakin reaction) is an organic chemistry, organic redox, redox reaction in which an ''arene substitution patterns, ortho''- or ''arene substitution patterns, para''-hydroxylated phenyl group, phenyl aldehyde (2-hydroxybe ...
    process.


    Precursor to other peroxide compounds

    Hydrogen peroxide is a weak acid, forming
    hydroperoxide Hydroperoxides or peroxols are Chemical compound, compounds of the form ROOH, where R stands for any group, typically Organic compound, organic, which contain the hydroperoxy functional group (). Hydroperoxide also refers to the hydroperoxide anio ...
    or
    peroxide In chemistry, peroxides are a group of Chemical compound, compounds with the structure , where the R's represent a radical (a portion of a complete molecule; not necessarily a free radical) and O's are single oxygen atoms. Oxygen atoms are joined ...
    salts In chemistry, a salt or ionic compound is a chemical compound consisting of an assembly of positively charged ions ( cations) and negatively charged ions (anions), which results in a compound with no net electric charge (electrically neutral). ...
    with many metals. It also converts metal oxides into the corresponding peroxides. For example, upon treatment with hydrogen peroxide,
    chromic acid Chromic acid is a chemical compound with the chemical formula . It is also a jargon for a solution formed by the addition of sulfuric acid to aqueous solutions of dichromate. It consists at least in part of chromium trioxide. The term "chromic ...
    ( and ) forms a blue peroxide .


    Biochemistry


    Production

    The aerobic oxidation of
    glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...
    in the presence of the enzyme glucose oxidase produces hydrogen peroxide. The conversion affords gluconolactone: :
    Superoxide dismutase Superoxide dismutase (SOD, ) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide () anion radical into normal molecular oxygen (O2) and hydrogen peroxide (). Superoxide is produced as a by-product of oxy ...
    s (SOD)s are
    enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
    s that promote the disproportionation of
    superoxide In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of t ...
    into
    oxygen Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), non ...
    and hydrogen peroxide. : :
    Peroxisome A peroxisome () is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen perox ...
    s are
    organelle In cell biology, an organelle is a specialized subunit, usually within a cell (biology), cell, that has a specific function. The name ''organelle'' comes from the idea that these structures are parts of cells, as Organ (anatomy), organs are to th ...
    s found in virtually all
    eukaryotic The eukaryotes ( ) constitute the Domain (biology), domain of Eukaryota or Eukarya, organisms whose Cell (biology), cells have a membrane-bound cell nucleus, nucleus. All animals, plants, Fungus, fungi, seaweeds, and many unicellular organisms ...
    cells. They are involved in the
    catabolism Catabolism () is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions. Catabolism breaks down large molecules (such as polysaccharides, lipid ...
    of very long chain fatty acids, branched chain fatty acids, D-amino acids, polyamines, and biosynthesis of plasmalogens and ether phospholipids, which are found in mammalian brains and lungs. They produce hydrogen peroxide in a process catalyzed by
    flavin adenine dinucleotide In biochemistry, flavin adenine dinucleotide (FAD) is a redox-active coenzyme associated with various proteins, which is involved with several enzymatic reactions in metabolism. A flavoprotein is a protein that contains a flavin group, which ma ...
    (FAD): :-> ce/chem> Hydrogen peroxide arises by the degradation of
    adenosine monophosphate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. It is an ester of phosphoric acid and the nucleoside adenosine. As a substituent it t ...
    , which yields
    hypoxanthine Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hyp ...
    . Hypoxanthine is then oxidatively catabolized first to xanthine and then to
    uric acid Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the Chemical formula, formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the meta ...
    , and the reaction is catalyzed by the enzyme xanthine oxidase:Nelson, David; Cox, Michael; Lehninger, Albert L. and Cox, Michael M
    Lehninger Biochemie
    p. 932, Springer, 2001, (in German)
    The degradation of guanosine monophosphate yields xanthine as an intermediate product which is then converted in the same way to uric acid with the formation of hydrogen peroxide.


    Consumption

    Catalase Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting ...
    , another peroxisomal enzyme, uses this to oxidize other substrates, including
    phenols In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (− O H) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, . Phenolic compounds ar ...
    ,
    formic acid Formic acid (), systematically named methanoic acid, is the simplest carboxylic acid. It has the chemical formula HCOOH and structure . This acid is an important intermediate in chemical synthesis and occurs naturally, most notably in some an ...
    ,
    formaldehyde Formaldehyde ( , ) (systematic name methanal) is an organic compound with the chemical formula and structure , more precisely . The compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde. It is stored as ...
    , and
    alcohol Alcohol may refer to: Common uses * Alcohol (chemistry), a class of compounds * Ethanol, one of several alcohols, commonly known as alcohol in everyday life ** Alcohol (drug), intoxicant found in alcoholic beverages ** Alcoholic beverage, an alco ...
    , by means of a peroxidation reaction: : thus eliminating the poisonous hydrogen peroxide in the process. This reaction is important in liver and kidney cells, where the peroxisomes neutralize various toxic substances that enter the blood. Some of the
    ethanol Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula . It is an Alcohol (chemistry), alcohol, with its formula also written as , or EtOH, where Et is the ps ...
    humans drink is oxidized to
    acetaldehyde Acetaldehyde (IUPAC systematic name ethanal) is an organic compound, organic chemical compound with the chemical formula, formula , sometimes abbreviated as . It is a colorless liquid or gas, boiling near room temperature. It is one of the most ...
    in this way. In addition, when excess accumulates in the cell, catalase converts it to through this reaction: : Glutathione peroxidase, a selenoenzyme, also catalyzes the disproportionation of hydrogen peroxide.


    Fenton reaction

    The reaction of and hydrogen peroxide is the basis of the Fenton reaction, which generates
    hydroxyl radical The hydroxyl radical, •HO, is the neutral form of the hydroxide ion (HO–). Hydroxyl radicals are highly reactive and consequently short-lived; however, they form an important part of radical chemistry. Most notably hydroxyl radicals are pr ...
    s, which are of significance in biology: : The Fenton reaction explains the toxicity of hydrogen peroxides because the hydroxyl radicals rapidly and irreversibly oxidize all organic compounds, including
    protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
    s, membrane lipids, and
    DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
    . Hydrogen peroxide is a significant source of oxidative DNA damage in living cells. DNA damage includes formation of
    8-Oxo-2'-deoxyguanosine 8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine. 8-Oxo-dG is one of the major products of DNA oxidation. Concentrations of 8-oxo-dG within a cell are a measurement of oxidative stress. In DNA Steady-state levels ...
    among many other altered bases, as well as strand breaks, inter-strand crosslinks, and deoxyribose damage. By interacting with Cl, hydrogen peroxide also leads to chlorinated DNA bases. Hydroxyl radicals readily damage vital cellular components, especially those of the
    mitochondria A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is us ...
    . The compound is a major factor implicated in the free-radical theory of aging, based on its ready conversion into a
    hydroxyl radical The hydroxyl radical, •HO, is the neutral form of the hydroxide ion (HO–). Hydroxyl radicals are highly reactive and consequently short-lived; however, they form an important part of radical chemistry. Most notably hydroxyl radicals are pr ...
    .


    Function

    Eggs of
    sea urchin Sea urchins or urchins () are echinoderms in the class (biology), class Echinoidea. About 950 species live on the seabed, inhabiting all oceans and depth zones from the intertidal zone to deep seas of . They typically have a globular body cove ...
    , shortly after fertilization by a sperm, produce hydrogen peroxide. It is then converted to
    hydroxyl radical The hydroxyl radical, •HO, is the neutral form of the hydroxide ion (HO–). Hydroxyl radicals are highly reactive and consequently short-lived; however, they form an important part of radical chemistry. Most notably hydroxyl radicals are pr ...
    s (HO•), which initiate radical polymerization, which surrounds the eggs with a protective layer of
    polymer A polymer () is a chemical substance, substance or material that consists of very large molecules, or macromolecules, that are constituted by many repeat unit, repeating subunits derived from one or more species of monomers. Due to their br ...
    . The bombardier beetle combines
    hydroquinone Hydroquinone, also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C6H4(OH)2. It has two hydroxyl groups bonded to a benzene ring in a ''para' ...
    and hydrogen peroxide, leading to a violent exothermic
    chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
    to produce boiling, foul-smelling liquid that partially becomes a gas ( flash evaporation) and is expelled through an outlet valve with a loud popping sound. As a proposed
    signaling molecule In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biol ...
    , hydrogen peroxide may regulate a wide variety of biological processes. At least one study has tried to link hydrogen peroxide production to cancer.


    Uses


    Bleaching

    About 60% of the world's production of hydrogen peroxide is used for pulp- and paper-bleaching. The second major industrial application is the manufacture of sodium percarbonate and
    sodium perborate Sodium perborate are chemical compounds with chemical formula (H2O)x. Commonly encountered salts are the anhydrous form (x = 0) and as a hydrate, hexahydrate (x = 6). These two species are sometimes called, respectively, "monohydrate" or PBS-1 a ...
    , which are used as mild bleaches in
    laundry Laundry is the washing of clothing and other textiles, and, more broadly, their drying and ironing as well. Laundry has been part of history since humans began to wear clothes, so the methods by which different cultures have dealt with this u ...
    detergent A detergent is a surfactant or a mixture of surfactants with Cleanliness, cleansing properties when in Concentration, dilute Solution (chemistry), solutions. There are a large variety of detergents. A common family is the alkylbenzene sulfonate ...
    s. A representative conversion is: : Sodium percarbonate, which is an adduct of
    sodium carbonate Sodium carbonate (also known as washing soda, soda ash, sal soda, and soda crystals) is the inorganic compound with the formula and its various hydrates. All forms are white, odourless, water-soluble salts that yield alkaline solutions in water ...
    and hydrogen peroxide, is the active ingredient in such laundry products as OxiClean and Tide laundry detergent. When dissolved in water, it releases hydrogen peroxide and sodium carbonate. By themselves these bleaching agents are only effective at wash temperatures of or above and so, often are used in conjunction with bleach activators, which facilitate cleaning at lower temperatures. Hydrogen peroxide has also been used as a flour bleaching agent and a tooth and bone whitening agent.


    Production of organic peroxy compounds

    It is used in the production of various
    organic peroxide In organic chemistry, organic peroxides are organic compounds containing the peroxide functional group (). If the R′ is hydrogen, the compounds are called hydroperoxides, which are discussed in that article. The O−O bond of peroxides easily b ...
    s with dibenzoyl peroxide being a high volume example. Peroxy acids, such as peracetic acid and ''meta''-chloroperoxybenzoic acid also are produced using hydrogen peroxide. Hydrogen peroxide has been used for creating
    organic peroxide In organic chemistry, organic peroxides are organic compounds containing the peroxide functional group (). If the R′ is hydrogen, the compounds are called hydroperoxides, which are discussed in that article. The O−O bond of peroxides easily b ...
    -based explosives, such as acetone peroxide. It is used as an initiator in polymerizations. Hydrogen peroxide reacts with certain di-
    ester In chemistry, an ester is a compound derived from an acid (either organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (R). These compounds contain a distin ...
    s, such as phenyl oxalate ester (cyalume), to produce chemiluminescence; this application is most commonly encountered in the form of glow sticks.


    Production of inorganic peroxides

    The reaction with borax leads to
    sodium perborate Sodium perborate are chemical compounds with chemical formula (H2O)x. Commonly encountered salts are the anhydrous form (x = 0) and as a hydrate, hexahydrate (x = 6). These two species are sometimes called, respectively, "monohydrate" or PBS-1 a ...
    , a bleach used in laundry detergents: :


    Sewage treatment

    Hydrogen peroxide is used in certain waste-water treatment processes to remove organic impurities. In advanced oxidation processing, the Fenton reaction gives the highly reactive
    hydroxyl radical The hydroxyl radical, •HO, is the neutral form of the hydroxide ion (HO–). Hydroxyl radicals are highly reactive and consequently short-lived; however, they form an important part of radical chemistry. Most notably hydroxyl radicals are pr ...
    (•OH). This degrades organic compounds, including those that are ordinarily robust, such as
    aromatic In organic chemistry, aromaticity is a chemical property describing the way in which a conjugated system, conjugated ring of unsaturated bonds, lone pairs, or empty orbitals exhibits a stabilization stronger than would be expected from conjugati ...
    or halogenated compounds. It can also oxidize
    sulfur Sulfur ( American spelling and the preferred IUPAC name) or sulphur ( Commonwealth spelling) is a chemical element; it has symbol S and atomic number 16. It is abundant, multivalent and nonmetallic. Under normal conditions, sulfur atoms ...
    -based compounds present in the waste; which is beneficial as it generally reduces their odour.


    Disinfectant

    Hydrogen peroxide may be used for the sterilization of various surfaces, including surgical instruments, and may be deployed as a vapour ( VHP) for room sterilization. demonstrates broad-spectrum efficacy against viruses, bacteria, yeasts, and bacterial spores. In general, greater activity is seen against
    Gram-positive In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. The Gram stain is ...
    than
    Gram-negative Gram-negative bacteria are bacteria that, unlike gram-positive bacteria, do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. Their defining characteristic is that their cell envelope consists ...
    bacteria; however, the presence of
    catalase Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting ...
    or other peroxidases in these organisms may increase tolerance in the presence of lower concentrations. Lower levels of concentration (3%) will work against most spores; higher concentrations (7 to 30%) and longer contact times will improve sporicidal activity. Hydrogen peroxide is seen as an environmentally safe alternative to
    chlorine Chlorine is a chemical element; it has Symbol (chemistry), symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between ...
    -based bleaches, as it degrades to form oxygen and water and it is
    generally recognized as safe Generally recognized as safe (GRAS) is a United States Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts under the conditions of its intended use. An ingredient with a GRAS d ...
    as an antimicrobial agent by the U.S.
    Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
    (FDA).


    Propellant

    High-concentration is referred to as "high-test peroxide" (HTP). It can be used as either a
    monopropellant Monopropellants are propellants consisting of chemicals that release energy through exothermic chemical decomposition. The molecular bond energy of the monopropellant is released usually through use of a catalyst. This can be contrasted with biprop ...
    (not mixed with fuel) or the oxidizer component of a bipropellant rocket. Use as a monopropellant takes advantage of the decomposition of 70–98% concentration hydrogen peroxide into steam and oxygen. The propellant is pumped into a reaction chamber, where a catalyst, usually a silver or platinum screen, triggers decomposition, producing steam at over , which is expelled through a
    nozzle A nozzle is a device designed to control the direction or characteristics of a fluid flow (specially to increase velocity) as it exits (or enters) an enclosed chamber or pipe (material), pipe. A nozzle is often a pipe or tube of varying cross ...
    , generating
    thrust Thrust is a reaction force described quantitatively by Newton's third law. When a system expels or accelerates mass in one direction, the accelerated mass will cause a force of equal magnitude but opposite direction to be applied to that ...
    . monopropellant produces a maximal
    specific impulse Specific impulse (usually abbreviated ) is a measure of how efficiently a reaction mass engine, such as a rocket engine, rocket using propellant or a jet engine using fuel, generates thrust. In general, this is a ratio of the ''Impulse (physics), ...
    (''I''sp) of 161 s (1.6 kN·s/kg). Peroxide was the first major monopropellant adopted for use in rocket applications.
    Hydrazine Hydrazine is an inorganic compound with the chemical formula . It is a simple pnictogen hydride, and is a colourless flammable liquid with an ammonia-like odour. Hydrazine is highly hazardous unless handled in solution as, for example, hydraz ...
    eventually replaced hydrogen peroxide monopropellant thruster applications primarily because of a 25% increase in the vacuum specific impulse. Hydrazine (toxic) and hydrogen peroxide (less toxic CGIH TLV 0.01 and 1 ppm respectively are the only two monopropellants (other than cold gases) to have been widely adopted and utilized for propulsion and power applications. The Bell Rocket Belt,
    reaction control system A reaction control system (RCS) is a spacecraft system that uses Thrusters (spacecraft), thrusters to provide Spacecraft attitude control, attitude control and translation (physics), translation. Alternatively, reaction wheels can be used for at ...
    s for X-1,
    X-15 The North American X-15 is a Hypersonic speed, hypersonic rocket-powered aircraft which was operated by the United States Air Force and the National Aeronautics and Space Administration (NASA) as part of the List of X-planes, X-plane series of ...
    ,
    Centaur A centaur ( ; ; ), occasionally hippocentaur, also called Ixionidae (), is a creature from Greek mythology with the upper body of a human and the lower body and legs of a horse that was said to live in the mountains of Thessaly. In one version o ...
    , Mercury, Little Joe, as well as the turbo-pump gas generators for X-1, X-15, Jupiter, Redstone and Viking used hydrogen peroxide as a monopropellant. The RD-107 engines (used from 1957 to present) in the R-7 series of rockets decompose hydrogen peroxide to power the turbopumps. In bipropellant applications, is decomposed to oxidize a burning fuel. Specific impulses as high as 350 s (3.5 kN·s/kg) can be achieved, depending on the fuel. Peroxide used as an oxidizer gives a somewhat lower ''I''sp than liquid oxygen but is dense, storable, and non-cryogenic and can be more easily used to drive gas turbines to give high pressures using an efficient ''closed cycle''. It may also be used for regenerative cooling of rocket engines. Peroxide was used very successfully as an oxidizer in World War II German rocket motors (e.g.,
    T-Stoff T-Stoff (; 'substance T') was a stabilised high test peroxide used in Nazi Germany, Germany during World War II. T-Stoff was specified to contain 80% (occasionally 85%) hydrogen peroxide (H2O2), remainder water, with traces (<0.1%) of stabiliser ...
    , containing oxyquinoline stabilizer, for both the Walter HWK 109-500 ''Starthilfe'' RATO externally podded monopropellant booster system and the Walter HWK 109-509 rocket motor series used for the Me 163B), most often used with
    C-Stoff C-Stoff (; "substance C") was a Redox, reductant used in bipropellant rocket fuels (as a fuel itself) developed by Hellmuth Walter Kommanditgesellschaft in Germany during World War II. It was developed for use with T-Stoff (a high-test peroxide) ...
    in a self-igniting hypergolic combination, and for the low-cost British Black Knight and Black Arrow launchers. Presently, HTP is used on ILR-33 AMBER and Nucleus suborbital rockets. In the 1940s and 1950s, the Hellmuth Walter KG–conceived
    turbine A turbine ( or ) (from the Greek , ''tyrbē'', or Latin ''turbo'', meaning vortex) is a rotary mechanical device that extracts energy from a fluid flow and converts it into useful work. The work produced can be used for generating electrical ...
    used hydrogen peroxide for use in
    submarine A submarine (often shortened to sub) is a watercraft capable of independent operation underwater. (It differs from a submersible, which has more limited underwater capability.) The term "submarine" is also sometimes used historically or infor ...
    s while submerged; it was found to be too noisy and require too much maintenance compared to diesel-electric power systems. Some
    torpedo A modern torpedo is an underwater ranged weapon launched above or below the water surface, self-propelled towards a target, with an explosive warhead designed to detonate either on contact with or in proximity to the target. Historically, such ...
    es used hydrogen peroxide as oxidizer or propellant. Operator error in the use of hydrogen peroxide torpedoes was named as possible causes for the sinking of HMS ''Sidon'' and the Russian submarine ''Kursk''. SAAB Underwater Systems is manufacturing the Torpedo 2000. This torpedo, used by the Swedish Navy, is powered by a piston engine propelled by HTP as an oxidizer and
    kerosene Kerosene, or paraffin, is a combustibility, combustible hydrocarbon liquid which is derived from petroleum. It is widely used as a fuel in Aviation fuel, aviation as well as households. Its name derives from the Greek (''kērós'') meaning " ...
    as a fuel in a bipropellant system.


    Household use

    Hydrogen peroxide has various domestic uses, primarily as a cleaning and disinfecting agent. ;Hair bleaching and coloring. Diluted (between 1.9% and 12%) mixed into a solution with
    aqueous ammonia Ammonia solution, also known as ammonia water, ammonium hydroxide, ammoniacal liquor, ammonia liquor, aqua ammonia, aqueous ammonia, or (inaccurately) ammonia, is a solution of ammonia in water. It can be denoted by the symbols NH3(aq). Although ...
    aniline(color molecule) and a coupler, has been used to color human
    hair Hair is a protein filament that grows from follicles found in the dermis. Hair is one of the defining characteristics of mammals. The human body, apart from areas of glabrous skin, is covered in follicles which produce thick terminal and ...
    . It can also be mixed with powder or cream bleach compounds, most notably potassium chloride. Bleaching hair follicles does not destroy or remove color molecule or melanocytes. Bleaching compounds work to drive wedges between color molecules or melanocyte's allowing more visible light to pass through the hair shaft. The chemical's bleaching property lends its name to the phrase " peroxide blonde". Hydrogen peroxide is also used for tooth whitening. It may be found in most whitening toothpastes. Hydrogen peroxide has shown positive results involving teeth lightness and chroma shade parameters. It works by oxidizing colored pigments onto the enamel where the shade of the tooth may become lighter. Hydrogen peroxide may be mixed with baking soda and salt to make a homemade toothpaste. ;Removal of blood stains Hydrogen peroxide reacts with blood as a bleaching agent, and so if a blood stain is fresh, or not too old, liberal application of hydrogen peroxide, if necessary in more than single application, will bleach the stain fully out. After about two minutes of the application, the blood should be firmly blotted out. ;Acne treatment Hydrogen peroxide may be used to treat
    acne Acne ( ), also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, ...
    , although benzoyl peroxide is a more common treatment. ;Oral cleaning agent The use of dilute hydrogen peroxide as an oral cleansing agent has been reviewed academically to determine its usefulness in treating gingivitis and plaque. Although there is a positive effect when compared with a placebo, it was concluded that
    chlorhexidine Chlorhexidine is a disinfectant and antiseptic which is used for skin disinfection before surgery and to disinfect surgical instruments. It is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and ...
    is a much more effective treatment.


    Niche uses

    ;Horticulture Some horticulturists and users of
    hydroponics Hydroponics is a type of horticulture and a subset of #Passive sub-irrigation, hydroculture which involves growing plants, usually crops or medicinal plants, without soil, by using water-based mineral Plant nutrition, nutrient Solution (chemi ...
    advocate the use of weak hydrogen peroxide solution in watering solutions. Its spontaneous decomposition releases oxygen that enhances a plant's root development and helps to treat
    root rot Root rot is a condition in which anoxic conditions in the soil or potting media around the roots of a plant cause them to rot. This occurs due to excessive standing water around the roots.-Hydroponics Root Rot: What is It, How To Treat It, How ...
    (cellular root death due to lack of oxygen) and a variety of other pests. For general watering concentrations, around 0.1% is in use. This can be increased up to one percent for antifungal actions. Tests show that plant foliage can safely tolerate concentrations up to 3%. ;Fishkeeping Hydrogen peroxide is used in
    aquaculture Aquaculture (less commonly spelled aquiculture), also known as aquafarming, is the controlled cultivation ("farming") of aquatic organisms such as fish, crustaceans, mollusks, algae and other organisms of value such as aquatic plants (e.g. Nelu ...
    for controlling mortality caused by various microbes. In 2019, the U.S. FDA approved it for control of ''Saprolegniasis'' in all coldwater finfish and all fingerling and adult coolwater and warmwater finfish, for control of external columnaris disease in warm-water finfish, and for control of '' Gyrodactylus'' spp. in freshwater-reared salmonids. Laboratory tests conducted by fish culturists have demonstrated that common household hydrogen peroxide may be used safely to provide oxygen for small fish. The hydrogen peroxide releases oxygen by decomposition when it is exposed to catalysts such as
    manganese dioxide Manganese dioxide is the inorganic compound with the formula . This blackish or brown solid occurs naturally as the mineral pyrolusite, which is the main ore of manganese and a component of manganese nodules. The principal use for is for dry-cel ...
    . ;Removing yellowing from aged plastics Hydrogen peroxide may be used in combination with a UV-light source to remove yellowing from white or light grey acrylonitrile butadiene styrene (ABS) plastics to partially or fully restore the original color. In the retrocomputing scene, this process is commonly referred to as retrobright.


    Safety

    Regulations vary, but low concentrations, such as 5%, are widely available and legal to buy for medical use. Most over-the-counter peroxide solutions are not suitable for ingestion. Higher concentrations may be considered hazardous and typically are accompanied by a safety data sheet (SDS). In high concentrations, hydrogen peroxide is an aggressive oxidizer and will corrode many materials, including human skin. In the presence of a
    reducing agent In chemistry, a reducing agent (also known as a reductant, reducer, or electron donor) is a chemical species that "donates" an electron to an (called the , , , or ). Examples of substances that are common reducing agents include hydrogen, carbon ...
    , high concentrations of will react violently. While concentrations up to 35% produce only "white" oxygen bubbles in the skin (and some biting pain) that disappear with the blood within 30–45 minutes, concentrations of 98% dissolve paper. However, concentrations as low as 3% can be dangerous for the eye because of oxygen evolution within the eye. High-concentration hydrogen peroxide streams, typically above 40%, should be considered hazardous due to concentrated hydrogen peroxide's meeting the definition of a DOT oxidizer according to U.S. regulations if released into the environment. The EPA Reportable Quantity (RQ) for D001 hazardous wastes is , or approximately , of concentrated hydrogen peroxide. Hydrogen peroxide should be stored in a cool, dry, well-ventilated area and away from any flammable or combustible substances. It should be stored in a container composed of non-reactive materials such as stainless steel or glass (other materials including some plastics and aluminium alloys may also be suitable). As it breaks down quickly when exposed to light, it should be stored in an opaque container, and pharmaceutical formulations typically come in brown bottles that block light. Hydrogen peroxide, either in pure or diluted form, may pose several risks, the main one being that it forms explosive mixtures upon contact with organic compounds.
    Distillation Distillation, also classical distillation, is the process of separating the component substances of a liquid mixture of two or more chemically discrete substances; the separation process is realized by way of the selective boiling of the mixt ...
    of hydrogen peroxide at normal pressures is highly dangerous. It is corrosive, especially when concentrated, but even domestic-strength solutions may cause irritation to the eyes,
    mucous membrane A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It ...
    s, and skin.For example, see an Swallowing hydrogen peroxide solutions is particularly dangerous, as decomposition in the stomach releases large quantities of gas (ten times the volume of a 3% solution), leading to internal bloating. Inhaling over 10% can cause severe pulmonary irritation.H2O2 toxicity and dangers
    Agency for Toxic Substances and Disease Registry website
    With a significant vapour pressure (1.2 kPa at 50 °C), hydrogen peroxide vapour is potentially hazardous. According to U.S. NIOSH, the immediately dangerous to life and health (IDLH) limit is only 75 ppm. The U.S.
    Occupational Safety and Health Administration The Occupational Safety and Health Administration (OSHA; ) is a regulatory agency of the United States Department of Labor that originally had federal visitorial powers to inspect and examine workplaces. The United States Congress established ...
    (OSHA) has established a permissible exposure limit of 1.0 ppm calculated as an 8-hour time-weighted average (29 CFR 1910.1000, Table Z-1). Hydrogen peroxide has been classified by the American Conference of Governmental Industrial Hygienists (ACGIH) as a "known animal carcinogen, with unknown relevance on humans". For workplaces where there is a risk of exposure to the hazardous concentrations of the vapours, continuous monitors for hydrogen peroxide should be used. Information on the hazards of hydrogen peroxide is available from OSHA and from the ATSDR.


    Wound healing

    Historically, hydrogen peroxide was used for disinfecting wounds, partly because of its low cost and prompt availability compared to other
    antiseptic An antiseptic ( and ) is an antimicrobial substance or compound that is applied to living tissue to reduce the possibility of sepsis, infection, or putrefaction. Antiseptics are generally distinguished from ''antibiotics'' by the latter's abil ...
    s. There is conflicting evidence on hydrogen peroxide's effect on wound healing. Some research finds benefit, while other research find delays and healing inhibition. Its use for home treatment of wounds is generally not recommended. 1.5–3% hydrogen peroxide is used as a disinfectant in dentistry, especially in endodotic treatments together with hypochlorite and chlorhexidine and 1–1.5% is also useful for treatment of inflammation of third molars (wisdom teeth).


    Use in alternative medicine

    Practitioners of
    alternative medicine Alternative medicine refers to practices that aim to achieve the healing effects of conventional medicine, but that typically lack biological plausibility, testability, repeatability, or supporting evidence of effectiveness. Such practices are ...
    have advocated the use of hydrogen peroxide for various conditions, including
    emphysema Emphysema is any air-filled enlargement in the body's tissues. Most commonly emphysema refers to the permanent enlargement of air spaces (alveoli) in the lungs, and is also known as pulmonary emphysema. Emphysema is a lower respiratory tract di ...
    ,
    influenza Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These sympto ...
    ,
    AIDS The HIV, human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a Preventive healthcare, pr ...
    , and in particular
    cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...
    . There is no evidence of effectiveness and in some cases it has proved fatal.Hydrogen Peroxide, 3%. 3. Hazards Identification
    Southeast Fisheries Science Center, daughter agency of
    NOAA The National Oceanic and Atmospheric Administration (NOAA ) is an American scientific and regulatory agency charged with forecasting weather, monitoring oceanic and atmospheric conditions, charting the seas, conducting deep-sea exploratio ...
    .
    Both the effectiveness and safety of hydrogen peroxide therapy is scientifically questionable. Hydrogen peroxide is produced by the immune system, but in a carefully controlled manner. Cells called phagocytes engulf pathogens and then use hydrogen peroxide to destroy them. The peroxide is toxic to both the cell and the pathogen and so is kept within a special compartment, called a
    phagosome In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs). A phagosome is formed by the fusion of the cel ...
    . Free hydrogen peroxide will damage any tissue it encounters via
    oxidative stress Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal ...
    , a process that also has been proposed as a cause of cancer. Claims that hydrogen peroxide therapy increases cellular levels of oxygen have not been supported. The quantities administered would be expected to provide very little additional oxygen compared to that available from normal respiration. It is also difficult to raise the level of oxygen around cancer cells within a tumour, as the blood supply tends to be poor, a situation known as tumor hypoxia. Large oral doses of hydrogen peroxide at a 3% concentration may cause irritation and blistering to the mouth, throat, and abdomen as well as abdominal pain, vomiting, and diarrhea. Ingestion of hydrogen peroxide at concentrations of 35% or higher has been implicated as the cause of numerous gas embolism events resulting in hospitalisation. In these cases, hyperbaric oxygen therapy was used to treat the embolisms. Intravenous injection of hydrogen peroxide has been linked to several deaths. The
    American Cancer Society The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''. History The society w ...
    states that "there is no scientific evidence that hydrogen peroxide is a safe, effective, or useful cancer treatment." Furthermore, the therapy is not approved by the U.S. FDA.


    Historical incidents

    * On 16 July 1934, in Kummersdorf, Germany, a propellant tank containing an experimental monopropellant mixture consisting of hydrogen peroxide and
    ethanol Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula . It is an Alcohol (chemistry), alcohol, with its formula also written as , or EtOH, where Et is the ps ...
    exploded during a test, killing three people. * During the
    Second World War World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...
    , doctors in German concentration camps experimented with the use of hydrogen peroxide injections in the killing of human subjects. * In December 1943, the pilot Josef Pöhs died after being exposed to the
    T-Stoff T-Stoff (; 'substance T') was a stabilised high test peroxide used in Nazi Germany, Germany during World War II. T-Stoff was specified to contain 80% (occasionally 85%) hydrogen peroxide (H2O2), remainder water, with traces (<0.1%) of stabiliser ...
    of his Messerschmitt Me 163. * In June 1955, Royal Navy submarine HMS ''Sidon'' sank after leaking high-test peroxide in a torpedo caused it to explode in its tube, killing twelve crew members; a member of the rescue party also succumbed. * In April 1992, an explosion occurred at the hydrogen peroxide plant at Jarrie in France, due to technical failure of the computerised control system and resulting in one fatality and wide destruction of the plant. * Several people received minor injuries after a hydrogen peroxide spill on board a
    Northwest Airlines Northwest Airlines (often abbreviated as NWA) was a major airline in the United States that operated from 1926 until it Delta Air Lines–Northwest Airlines merger, merged with Delta Air Lines in 2010. The merger made Delta the largest airline ...
    flight from
    Orlando, Florida Orlando ( ) is a city in and the county seat of Orange County, Florida, United States. The city proper had a population of 307,573 at the 2020 census, making it the fourth-most populous city in Florida behind Jacksonville, Florida, Jacksonville ...
    to
    Memphis, Tennessee Memphis is a city in Shelby County, Tennessee, United States, and its county seat. Situated along the Mississippi River, it had a population of 633,104 at the 2020 United States census, 2020 census, making it the List of municipalities in Tenne ...
    on 28 October 1998. * The Russian submarine K-141 ''Kursk'' sailed to perform an exercise of firing dummy torpedoes at the '' Pyotr Velikiy'', a ''Kirov''-class battlecruiser. On 12 August 2000, at 11:28 local time (07:28 UTC), there was an explosion while preparing to fire the torpedoes. The only credible report to date is that this was due to the failure and explosion of one of the ''Kursks hydrogen peroxide-fueled torpedoes. It is believed that HTP, a form of highly concentrated hydrogen peroxide used as propellant for the torpedo, seeped through its container, damaged either by rust or in the loading procedure on land where an incident involving one of the torpedoes accidentally touching ground went unreported. The vessel was lost with all hands. * On 15 August 2010, a spill of about of cleaning fluid occurred on the 54th floor of 1515 Broadway, in
    Times Square Times Square is a major commercial intersection, tourist destination, entertainment hub, and Neighborhoods in New York City, neighborhood in the Midtown Manhattan section of New York City. It is formed by the junction of Broadway (Manhattan), ...
    ,
    New York City New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive w ...
    . The spill, which a spokesperson for the
    New York City Fire Department The New York City Fire Department, officially the Fire Department of the City of New York (FDNY) is the full-service fire department of New York City, serving all Boroughs of New York City, five boroughs. The FDNY is responsible for providing Fi ...
    said was of hydrogen peroxide, shut down Broadway between West 42nd and West 48th streets as fire engines responded to the hazmat situation. There were no reported injuries.


    See also

    * FOX reagent, used to measure levels of hydrogen peroxide in biological systems * Hydrogen chalcogenide * Retrobright, a process using hydrogen peroxide to restore yellowed acrylonitrile butadiene styrene plastic * Bis(trimethylsilyl) peroxide, an aprotic substitute


    References

    Bibliography * * A great description of properties & chemistry of . * *


    External links


    Hydrogen Peroxide
    at ''
    The Periodic Table of Videos ''Periodic Videos'' (also known as ''The Periodic Table of Videos'') is a video project and YouTube channel on chemistry. It consists of a series of videos about chemical elements and the periodic table, with additional videos on other topics i ...
    '' (University of Nottingham)
    Material Safety Data Sheet







    Process flow sheet of Hydrogen Peroxide Production by anthrahydroquinone autoxidation

    Hydrogen Peroxide Handbook by Rocketdyne

    IR spectroscopic study J. Phys. Chem.

    Bleaching action of Hydrogen peroxide
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