The Fibronectin type III domain is an evolutionarily conserved
protein domain
In molecular biology, a protein domain is a region of a protein's Peptide, polypeptide chain that is self-stabilizing and that Protein folding, folds independently from the rest. Each domain forms a compact folded Protein tertiary structure, thre ...
that is widely found in animal proteins. The
fibronectin
Fibronectin is a high- molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as col ...
protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...
s long and possesses a
beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without
disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.
Human proteins containing this domain
ABI3BP;
ANKFN1;
ASTN2;
AXL;
BOC;
BZRAP1;
C20orf75;
CDON;
CHL1;
CMYA5;
CNTFR;
CNTN1;
CNTN2;
CNTN3;
CNTN4;
CNTN5;
CNTN6;
COL12A1;
COL14A1;
COL20A1;
COL7A1;
CRLF1;
CRLF3
Cytokine receptor-like factor 3 is a protein that in humans is encoded by the ''CRLF3'' gene.
Function
Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin rece ...
;
CSF2RB;
CSF3R
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the ''CSF3R'' gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimula ...
;
DCC DCC may refer to:
Biology
* Netrin receptor DCC, human receptor protein, and the gene encoding it
* Dosage compensation complex
Business
* Day Chocolate Company
* DCC plc, an Irish holding company
* Doppelmayr Cable Car, cable car company
* D ...
;
DSCAM;
DSCAML1;
EBI3;
EGFLAM;
EPHA1;
EPHA10;
EPHA2;
EPHA3;
EPHA4;
EPHA5;
EPHA6;
EPHA7;
EPHA8;
EPHB1;
EPHB2
Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene.
Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...
;
EPHB3;
EPHB4;
EPHB6;
EPOR;
FANK1;
FLRT1;
FLRT2;
FLRT3;
FN1;
FNDC1;
FNDC3A;
FNDC3B;
FNDC4;
FNDC5;
FNDC7;
FNDC8;
FSD1;
FSD1L;
FSD2;
GHR;
HCFC1;
HCFC2;
HUGO;
IFNGR2;
IGF1R;
IGSF22;
IGSF9;
IGSF9B;
IL4R;
IL11RA;
IL12B;
IL12RB1;
IL12RB2;
IL20RB;
IL23R;
IL27RA;
IL31RA;
IL6R;
IL6ST;
IL7R;
INSR;
INSRR;
ITGB4
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.
Function
Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Di ...
;
KAL1;
KALRN;
L1CAM;
LEPR;
LIFR;
LRFN2;
LRFN3;
LRFN4;
LRFN5;
LRIT1;
LRRN1;
LRRN3;
MERTK;
MID1;
MID2;
MPL;
MYBPC1;
MYBPC2;
MYBPC3;
MYBPH;
MYBPHL;
MYLK
Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the ''MYLK'' gene.
Function
This gene, a muscle member of the immunoglobulin superfamily, encodes a myosin ...
;
MYOM1;
MYOM2;
MYOM3;
NCAM1;
NCAM2;
NEO1;
NFASC;
NOPE;
NPHS1;
NRCAM;
OBSCN;
OBSL1;
OSMR;
PHYHIP;
PHYHIPL;
PRLR;
PRODH2;
PTPRB;
PTPRC
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the ''PTPRC'' gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocy ...
;
PTPRD;
PTPRF;
PTPRG;
PTPRH;
PTPRJ
Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the ''PTPRJ'' gene.
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signalin ...
;
PTPRK;
PTPRM;
PTPRO;
PTPRS;
PTPRT
Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene.
PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome tha ...
;
PTPRU;
PTPRZ1;
PTPsigma;
PUNC;
RIMBP2;
ROBO1
Roundabout homolog 1 is a protein that in humans is encoded by the ''ROBO1'' gene.
Function
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project ...
;
ROBO2;
ROBO3;
ROBO4;
ROS1;
SDK1;
SDK2;
SNED1;
SORL1;
SPEG;
TEK;
TIE1;
TNC;
TNN;
TNR;
TNXB;
TRIM36;
TRIM42;
TRIM46;
TRIM67;
TRIM9;
TTN;
TYRO3;
UMODL1;
USH2A;
VASN;
VWA1;
dJ34F7.1;
fmi;
See also
*
Monobodies are engineered (synthetic) antibody mimetics based on a fibronectin type III domain (specifically, the 10th FN3 domain of human fibronectin). Monobodies feature either diversified loops or diversified strands of a flat beta-sheet surface, which serve as interaction epitopes. Monobody binders have been selected a wide variety of target molecules, and have expanded beyond the potential range of binding interfaces observed in both natural and synthetic antibodies.
References
*
*
*
{{refend
Protein domains
Single-pass transmembrane proteins