The Fibronectin type III domain is an evolutionarily conserved

protein domain In molecular biology, a protein domain is a region of a protein's Peptide, polypeptide chain that is self-stabilizing and that Protein folding, folds independently from the rest. Each domain forms a compact folded Protein tertiary structure, thre ...

that is widely found in animal proteins. The

fibronectin Fibronectin is a high- molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as col ...

protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...

s long and possesses a

beta sandwich Beta-sandwich or β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one prote ...

structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.

Human proteins containing this domain

ABI3BP; ANKFN1; ASTN2; AXL; BOC; BZRAP1; C20orf75;

CDON Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the ''CDON'' gene. CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III ( FNIII) repeat family involved in m ...

;

CHL1 Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the ''CHL1'' gene. CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expre ...

; CMYA5; CNTFR;

CNTN1 Contactin 1 (CNTN1) is a protein which in humans is encoded by the ''CNTN1'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane p ...

; CNTN2; CNTN3;

CNTN4 Contactin-4 is a protein that in humans is encoded by the ''CNTN4'' gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that function ...

; CNTN5; CNTN6; COL12A1; COL14A1; COL20A1;

COL7A1 Collagen alpha-1(VII) chain is a protein that in humans is encoded by the ''COL7A1'' gene. It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epi ...

; CRLF1;

CRLF3 Cytokine receptor-like factor 3 is a protein that in humans is encoded by the ''CRLF3'' gene. Function Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin rece ...

; CSF2RB;

CSF3R The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the ''CSF3R'' gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimula ...

;

DCC DCC may refer to: Biology * Netrin receptor DCC, human receptor protein, and the gene encoding it * Dosage compensation complex Business * Day Chocolate Company * DCC plc, an Irish holding company * Doppelmayr Cable Car, cable car company * D ...

; DSCAM; DSCAML1;

EBI3 Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the ''EBI3'' gene. Function This gene was identified by the induction of its expression in B lymphocytes by Eps ...

; EGFLAM;

EPHA1 EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the ''EPHA1'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated ...

; EPHA10;

EPHA2 EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the ''EPHA2'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have be ...

;

EPHA3 EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the ''EPHA3'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been ...

;

EPHA4 EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the ''EPHA4'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicate ...

;

EPHA5 EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the ''EPHA5'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicate ...

;

EPHA6 Ephrin type-A receptor 6 is a protein that in humans is encoded by the ''EPHA6'' gene. EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer Brea ...

;

EPHA7 Ephrin type-A receptor 7 is a protein that in humans is encoded by the ''EPHA7'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating dev ...

;

EPHA8 Ephrin type-A receptor 8 is a protein that in humans is encoded by the ''EPHA8'' gene. Function This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implic ...

; EPHB1;

EPHB2 Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...

;

EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the ''EPHB3'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is ...

;

EPHB4 Ephrin type-B receptor 4 is a protein that in humans is encoded by the ''EPHB4'' gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and se ...

; EPHB6; EPOR; FANK1; FLRT1; FLRT2;

FLRT3 Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the ''FLRT3'' gene. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhe ...

; FN1; FNDC1; FNDC3A; FNDC3B; FNDC4;

FNDC5 Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris. Fibronec ...

; FNDC7; FNDC8; FSD1; FSD1L; FSD2; GHR;

HCFC1 Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a protein that in humans is encoded by the ''HCFC1'' gene. Structure HCF1 is a member of the highly conserved host cell factor family and encodes a protein wi ...

; HCFC2; HUGO;

IFNGR2 Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the ''IFNGR2'' gene. Function This gene (''IFNGR2'') encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-g ...

;

IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. ...

; IGSF22; IGSF9; IGSF9B; IL4R; IL11RA;

IL12B Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein subunit that in humans is encoded by the IL12B gene. IL-12B is ...

; IL12RB1; IL12RB2; IL20RB;

IL23R The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the ''IL23R'' gene. In complex with the interleukin-12 receptor β1 subunit ( IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The ''IL23R'' m ...

;

IL27RA Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene. Function In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly un ...

;

IL31RA Interleukin-31 receptor A is a protein that in humans is encoded by the ''IL31RA'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that ...

;

IL6R Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Function Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an import ...

; IL6ST; IL7R;

INSR The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose hom ...

; INSRR;

ITGB4 Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Function Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Di ...

;

KAL1 Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in ...

; KALRN;

L1CAM L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the ''L1CAM'' gene. This protein, of 200 to 220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neur ...

; LEPR;

LIFR LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. Function The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, and ...

; LRFN2; LRFN3; LRFN4; LRFN5; LRIT1; LRRN1; LRRN3; MERTK; MID1; MID2; MPL;

MYBPC1 Myosin-binding protein C, slow-type is a protein that in humans is encoded by the ''MYBPC1'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in ...

;

MYBPC2 Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each o ...

;

MYBPC3 ] The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the ''MYBPC3'' gene. This isoform is expressed exclusively in heart muscle during human and mouse development, and is distinct from those expressed in slow s ...

; MYBPH; MYBPHL;

MYLK Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the ''MYLK'' gene. Function This gene, a muscle member of the immunoglobulin superfamily, encodes a myosin ...

; MYOM1;

MYOM2 Myomesin-2, also known as M-protein is a protein that in humans is encoded by the ''MYOM2'' gene. M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins com ...

; MYOM3;

NCAM1 Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discover ...

; NCAM2;

NEO1 Neogenin is a protein that in humans is encoded by the ''NEO1'' gene. Interactions NEO1 has been shown to interact with PTK2 PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is ...

; NFASC; NOPE; NPHS1;

NRCAM Neuronal cell adhesion molecule is a protein that in humans is encoded by the ''NRCAM'' gene. Cell adhesion molecules Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other ce ...

; OBSCN;

OBSL1 Obscurin-like protein 1 is a protein that in humans is encoded by the ''OBSL1'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is ...

; OSMR; PHYHIP; PHYHIPL; PRLR; PRODH2;

PTPRB Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the ''PTPRB'' gene. Function VE-PTP is a member of the classical protein tyrosine phosphatase (PTP ...

;

PTPRC Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the ''PTPRC'' gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocy ...

;

PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the ''PTPRD'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signa ...

;

PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the ''PTPRF'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules t ...

; PTPRG; PTPRH;

PTPRJ Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the ''PTPRJ'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signalin ...

;

PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ...

;

PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ...

;

PTPRO Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the ''PTPRO'' gene. This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic sig ...

;

PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the ''PTPRS'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatas ...

;

PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene. PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome tha ...

;

PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene. Function The protein encoded by this gene is a member of the protein ...

; PTPRZ1; PTPsigma; PUNC; RIMBP2;

ROBO1 Roundabout homolog 1 is a protein that in humans is encoded by the ''ROBO1'' gene. Function Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project ...

; ROBO2; ROBO3; ROBO4;

ROS1 Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ''ROS1'' gene. Function This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase ins ...

; SDK1;

SDK2 Protein sidekick-2 is a protein that in humans is encoded by the ''SDK2'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transc ...

; SNED1;

SORL1 Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene. SORL1 (also known as SORLA, SORLA1, or LR11; SORLA or SORL1 are used, often interchangeably, for the protein product of the ...

; SPEG; TEK;

TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene. Function TIE1 is a cell surface protein expressed exclusively in endothelial cells, ...

; TNC; TNN; TNR;

TNXB Tenascin X (TN-X), also known as flexillin or hexabrachion-like protein, is a 450kDa glycoprotein, a member of the tenascin family, that is expressed in connective tissues. In humans it is encoded by the ''TNXB'' gene. The TN-X protein is expr ...

; TRIM36; TRIM42; TRIM46; TRIM67; TRIM9;

TTN ''ttn'' (''the total news'') was a 30 minute weekly Australian news program aimed at school-aged (9- to 14-year-old) children produced and broadcast by Network Ten from 2004 to 2008. It presented current issues and events in a way that could b ...

; TYRO3; UMODL1;

USH2A Usherin is a protein that in humans is encoded by the ''USH2A'' gene. This gene encodes the protein Usherin that contains laminin EGF motifs, a pentraxin domain, and many fibronectin type III motifs. The encoded basement membrane The baseme ...

; VASN; VWA1; dJ34F7.1; fmi;

References

* * * {{refend Protein domains Single-pass transmembrane proteins

Human proteins containing this domain

See also

References