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The Fibronectin type III domain is an evolutionarily conserved
protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...
that is widely found in animal proteins. The
fibronectin Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen ...
protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100
amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...
s long and possesses a
beta sandwich Beta-sandwich, β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one protein ...
structure. Of the three fibronectin-type domains, type III is the only one without
disulfide bonding In biochemistry, a disulfide (or disulphide in British English) refers to a functional group with the structure . The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups. In ...
present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.


Human proteins containing this domain

ABI3BP ABI family member 3 binding protein is a protein that in humans is encoded by the ABI3BP gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generat ...
; ANKFN1;
ASTN2 Automatic Switched Transport Network (ASTN) allows traffic paths to be set up through a switched network automatically. The term ASTN replaces the term ASON (Automatically Switched Optical Network) and is often used interchangeably with GMPLS (Ge ...
; AXL; BOC; BZRAP1;
C20orf75 C, or c, is the third letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''cee'' (pronounced ), plural ''cees''. History "C ...
;
CDON Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the ''CDON'' gene. CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III ( FNIII) repeat family involved in my ...
;
CHL1 Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the ''CHL1'' gene. CHL1 is a cell adhesion molecule Cell adhesion molecules (CAMs) are a subset of cell surface pr ...
; CMYA5;
CNTFR The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. ...
;
CNTN1 Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the ''CNTN1'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuron ...
;
CNTN2 Contactin-2 is a protein that in humans is encoded by the ''CNTN2'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein th ...
;
CNTN3 Contactin-3 is a protein that in humans is encoded by the ''CNTN3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ...
;
CNTN4 Contactin-4 is a protein that in humans is encoded by the ''CNTN4'' gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions ...
; CNTN5;
CNTN6 Contactin 6 is a protein in humans that is encoded by the CNTN6 gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol Glycosylphosphatidylinositol (), or glycophosphatidylino ...
;
COL12A1 Collagen alpha-1(XII) chain is a protein that in humans is encoded by the ''COL12A1'' gene. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen famil ...
;
COL14A1 Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the ''COL14A1'' gene. It likely plays a role in collagen binding and cell-cell adhesion Cell adhesion is the process by which cells interact and attach to neighbouring cel ...
; COL20A1;
COL7A1 Collagen alpha-1(VII) chain is a protein that in humans is encoded by the ''COL7A1'' gene. It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epide ...
;
CRLF1 Cytokine receptor-like factor 1 is a protein that in humans is encoded by the ''CRLF1'' gene. Function This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine f ...
;
CRLF3 Cytokine receptor-like factor 3 is a protein that in humans is encoded by the ''CRLF3'' gene. Model organisms Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called ''Crlf3tm1a(KOMP)Wtsi'' w ...
;
CSF2RB CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors: * GM-CSF receptor *IL-3 receptor The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit ...
;
CSF3R The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the ''CSF3R'' gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimula ...
; DCC; DSCAM;
DSCAML1 Down syndrome cell adhesion molecule like 1 is a protein in humans that is encoded by the DSCAML1 gene. See also * DSCAM, Down syndrome cell adhesion molecule * Fibronectin type III domain * Immunoglobulin superfamily References Exter ...
;
EBI3 Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the ''EBI3'' gene. Function This gene was identified by the induction of its expression in B lymphocytes by Epst ...
;
EGFLAM Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the ''EGFLAM'' gene. Pikachurin is a dystroglycan-interacting protein ...
; EPHA1; EPHA10; EPHA2;
EPHA3 EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the ''EPHA3'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been ...
;
EPHA4 EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the ''EPHA4'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated i ...
; EPHA5; EPHA6; EPHA7; EPHA8;
EPHB1 Ephrin type-B receptor 1 is a protein that in humans is encoded by the ''EPHB1'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their str ...
;
EPHB2 Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...
;
EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the ''EPHB3'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their struct ...
;
EPHB4 Ephrin type-B receptor 4 is a protein that in humans is encoded by the ''EPHB4'' gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and se ...
; EPHB6; EPOR; FANK1; FLRT1; FLRT2; FLRT3;
FN1 Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, ...
; FNDC1;
FNDC3A Fibronectin type-III domain-containing protein 3a is a protein that in humans is encoded by the ''FNDC3A'' gene. References Further reading

* * * * * * * * * {{gene-13-stub ...
; FNDC3B; FNDC4;
FNDC5 Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris. Fibronectin ...
; FNDC7; FNDC8; FSD1; FSD1L;
FSD2 FSD may refer to: Places * Faisalabad, Pakistan * Sioux Falls Regional Airport, in South Dakota, US (IATA code FSD) Education * Ferndale School District, Washington * Florida School for the Deaf, St. Augustine, Florida * Framwellgate School Durham ...
; GHR; HCFC1; HCFC2; HUGO; IFNGR2;
IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2 ...
; IGSF22; IGSF9; IGSF9B;
IL4R The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene. Function This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to ...
;
IL11RA Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit Int ...
;
IL12B Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein that in humans is encoded by the IL12B gene. IL-12B is a common ...
; IL12RB1;
IL12RB2 Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. ''IL12RB2'' orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this ...
;
IL20RB Interleukin 20 Receptor (biochemistry), receptor, beta subunit (IL20R2 or IL20RB) is a Protein subunit, subunit of the Interleukin-20 receptor, interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflamma ...
;
IL23R The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the ''IL23R'' gene. In complex with the interleukin-12 receptor β1 subunit ( IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The ''IL23R'' m ...
;
IL27RA Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotei ...
;
IL31RA Interleukin-31 receptor A is a protein that in humans is encoded by the ''IL31RA'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...
;
IL6R Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Function Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an importa ...
;
IL6ST Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor f ...
; IL7R;
INSR The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose hom ...
; INSRR;
ITGB4 Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Function Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Di ...
; KAL1;
KALRN Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the ''KALRN'' gene. Kaliri ...
;
L1CAM L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neurite ou ...
;
LEPR Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the ''LEPR'' gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 ...
;
LIFR LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. Function The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, a ...
; LRFN2; LRFN3;
LRFN4 Leucine rich repeat and fibronectin type III domain containing 4 is a protein that in humans is encoded by the ''LRFN4'' gene. See also *Fibronectin type III domain *Leucine rich repeat References Further reading

* {{gene-11 ...
; LRFN5; LRIT1;
LRRN1 Leucine-rich repeat neuronal protein 1 is a protein that in humans is encoded by the ''LRRN1'' gene. References Further reading

* * * * * * * * * {{gene-3-stub ...
;
LRRN3 Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a protein that in humans is encoded by the ''LRRN3'' gene. Gene The LRRN3 is located on human chromosome 7, at 7q31.1. It contains 6 distin ...
; MERTK;
MID1 MID1 is a protein that belongs to the Tripartite motif family (TRIM) and is also known as TRIM18. The ''MID1'' gene is located on the short arm of the X chromosome and loss-of-function mutations in this gene are causative of the X-linked form of a ...
;
MID2 Midline-2 is a protein that in humans is encoded by the ''MID2'' gene. Function The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and ...
; MPL; MYBPC1;
MYBPC2 Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each ...
;
MYBPC3 The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the ''MYBPC3'' gene. This isoform is expressed exclusively in heart muscle during human and mouse development, and is distinct from those expressed in slow skelet ...
; MYBPH; MYBPHL;
MYLK Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the ''MYLK'' gene. Function This gene, a muscle member of the immunoglobulin superfamily, encodes a myosi ...
; MYOM1;
MYOM2 Myomesin-2, also known as M-protein is a protein that in humans is encoded by the ''MYOM2'' gene. M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins com ...
; MYOM3;
NCAM1 Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discover ...
; NCAM2;
NEO1 Neogenin is a protein that in humans is encoded by the ''NEO1'' gene. Interactions NEO1 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organizati ...
;
NFASC Neurofascin is a protein that in humans is encoded by the ''NFASC'' gene. Function Neurofascin is an L1 family immunoglobulin cell adhesion molecule (see L1CAM) involved in axon subcellular targeting and synapse formation during neural develop ...
; NOPE;
NPHS1 Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is ...
; NRCAM;
OBSCN Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...
; OBSL1;
OSMR Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the ''OSMR'' gene. OSMR is a member of the type I cytokine receptor famil ...
;
PHYHIP Phytanoyl-CoA 2-hydroxylase interacting protein is a protein that in humans is encoded by the PHYHIP gene. References Further reading

* {{gene-8-stub ...
;
PHYHIPL Phytanoyl-CoA hydroxylase-interacting protein-like is an enzyme that in humans is encoded by the ''PHYHIPL'' gene. References Further reading

* * * * * * * * * {{gene-10-stub ...
; PRLR; PRODH2;
PTPRB Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the ''PTPRB'' gene. Function VE-PTP is a member of the classical protein tyrosine phosphatase (P ...
;
PTPRC Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the ''PTPRC'' gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leu ...
;
PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the ''PTPRD'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be sign ...
;
PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the ''PTPRF'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that ...
;
PTPRG Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the ''PTPRG'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules ...
;
PTPRH Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the ''PTPRH'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules th ...
;
PTPRJ Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the ''PTPRJ'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ...
;
PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ( ...
;
PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ...
; PTPRO;
PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the ''PTPRS'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phospha ...
;
PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene. PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that ...
;
PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene. Function The protein encoded by this gene is a member of the protein t ...
; PTPRZ1; PTPsigma; PUNC;
RIMBP2 RIMS binding protein 2 is a protein that in humans is encoded by the RIMBP2 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bi ...
;
ROBO1 Roundabout homolog 1 is a protein that in humans is encoded by the ''ROBO1'' gene. Function Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project t ...
; ROBO2; ROBO3;
ROBO4 Roundabout homolog 4 is a protein that in humans is encoded by the ''ROBO4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bir ...
;
ROS1 Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ''ROS1'' gene. Function This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase ins ...
;
SDK1 Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thir ...
;
SDK2 Protein sidekick-2 is a protein that in humans is encoded by the ''SDK2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth ...
; SNED1; SORL1; SPEG; TEK;
TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene. Function TIE1 is a cell surface protein expressed exclusively in endothelial cells, ...
; TNC; TNN; TNR;
TNXB A member of the tenascin family, tenascin X (TN-X) also known as flexillin or hexabrachion-like protein is a 450kDa glycoprotein that is expressed in connective tissues. TN-X possesses a modular structure composed, from the N- to the C-terminal p ...
; TRIM36; TRIM42; TRIM46; TRIM67;
TRIM9 Tripartite motif-containing protein 9 is a protein that in humans is encoded by the ''TRIM9'' gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, ...
; TTN;
TYRO3 Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the ''TYRO3'' gene. Interactions TYRO3 has been shown to interact with: * GAS6, and * PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme ...
; UMODL1;
USH2A Usherin is a protein that in humans is encoded by the ''USH2A'' gene. This gene encodes the protein Usherin that contains laminin EGF motifs, a pentraxin domain, and many fibronectin type III motifs. The encoded basement membrane-associated pr ...
; VASN; VWA1; dJ34F7.1; fmi;


See also

*
Monobodies Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold. Specifically, this class of binding proteins are built upon a diversified library of the 10th FN3 domain of human fibronecti ...
are engineered (synthetic) antibody mimetics based on a fibronectin type III domain (specifically, the 10th FN3 domain of human fibronectin). Monobodies feature either diversified loops or diversified strands of a flat beta-sheet surface, which serve as interaction epitopes. Monobody binders have been selected a wide variety of target molecules, and have expanded beyond the potential range of binding interfaces observed in both natural and synthetic antibodies.


References

* * * {{refend Protein domains Single-pass transmembrane proteins