Wyeth Pharmaceuticals Inc. was a

pharmaceutical company The pharmaceutical industry is a Medicine, medical industry that discovers, develops, produces, and markets pharmaceutical goods such as medications and medical devices. Medications are then administered to (or Self-medicate, self-administered b ...

until it was purchased by

Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...

in 2009. The company was founded in

Philadelphia, Pennsylvania Philadelphia ( ), colloquially referred to as Philly, is the List of municipalities in Pennsylvania, most populous city in the U.S. state of Pennsylvania and the List of United States cities by population, sixth-most populous city in the Unit ...

, in 1860 as John Wyeth and Brother. Its headquarters moved to Collegeville, Pennsylvania, and Madison, New Jersey, before its headquarters were consolidated with Pfizer's in

New York City New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive w ...

after the 2009 merger. Wyeth manufactured over-the-counter (OTC) drugs Robitussin and the

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

Advil Advil is a brand of pain reliever, pain-relieving medication, currently owned by Haleon, Haleon plc. The primary active ingredient in most Advil-branded products is ibuprofen, a non-steroidal anti-inflammatory drug, nonsteroidal anti-inflammato ...

(

ibuprofen Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes dysmenorrhea, painful menstrual periods, migraines, and rheumatoid arthritis. It can be taken oral administration, ...

) as well as prescription drugs Premarin and Effexor.

History

1860–1899

In 1860, pharmacists John (1834–1907) and Frank Wyeth opened a drugstore with a small research lab on Walnut Street in Philadelphia. In 1862, on the suggestion of doctors, they began to manufacture large quantities of commonly ordered medicines. They were successful, and in 1864 they began supplying medicines and beef extract to the Union army during the

Civil War A civil war is a war between organized groups within the same Sovereign state, state (or country). The aim of one side may be to take control of the country or a region, to achieve independence for a region, or to change government policies.J ...

. In 1872, Henry Bower, an employee of Wyeth, developed one of the first rotary compressed tablet machines in the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

. This enabled the mass production of medicines with unprecedented precision and speed. It was successful, and the Wyeth brothers won multiple awards at the Centennial Exhibition. In 1883, Wyeth opened its first international facility in

Montreal Montreal is the List of towns in Quebec, largest city in the Provinces and territories of Canada, province of Quebec, the List of the largest municipalities in Canada by population, second-largest in Canada, and the List of North American cit ...

, Canada, and began vaccine production. Six years later a fire destroyed the brothers' original Walnut Street store, and they sold the retail business and focused on mass production.

1900–1929

John Wyeth died in 1907 and his only son, Stuart, became the company's president. The Whitehall building in downtown

Manhattan Manhattan ( ) is the most densely populated and geographically smallest of the Boroughs of New York City, five boroughs of New York City. Coextensive with New York County, Manhattan is the County statistics of the United States#Smallest, larg ...

became the corporation's first headquarters. Global sales increased due to the sales of Wyeth's

Kolynos Kolynos is a line of oral care products created by Newell Sill Jenkins in 1908 and acquired by Colgate-Palmolive in 1995. The name is a combination of two Greek words, "κωλύω" & "νόσος", meaning "I am stopping" and "disease" respectively. ...

brand of toothpaste. In 1929, Stuart Wyeth died and left controlling interest to

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

1930–1949

In 1930, the Wyeth company purchased Anacin, a product for tension headaches which quickly became the company's flagship product. One year later, Harvard sold Wyeth to American Home Products for

US$ The United States dollar (Currency symbol, symbol: Dollar sign, $; ISO 4217, currency code: USD) is the official currency of the United States and International use of the U.S. dollar, several other countries. The Coinage Act of 1792 introdu ...

2.9 million. In 1935, Alvin G. Brush, a

Certified Public Accountant Certified Public Accountant (CPA) is the title of qualified accountants in numerous countries in the English-speaking world. It is generally equivalent to the title of chartered accountant in other English-speaking countries. In the United Stat ...

, became CEO of the organization and served for 30 years. Under Brush's leadership, 34 new companies were acquired in 15 years, including Chef Boyardee and the ''S.M.A. Corporation'', a pharmaceutical firm specializing in infant formulas. Wyeth also made its first licensing deal, acquiring an antibiotic for arthritis

vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...

research. In 1941, the US entered

World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

, and Wyeth shipped typical wartime drugs such as sulfa bacteriostatics,

blood plasma Blood plasma is a light Amber (color), amber-colored liquid component of blood in which blood cells are absent, but which contains Blood protein, proteins and other constituents of whole blood in Suspension (chemistry), suspension. It makes up ...

typhus Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposu ...

vaccine,

quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to ''Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg ...

, and atabrine tablets. Wyeth was later rewarded for its contribution to the war effort. During this time, Wyeth launched its

penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...

research facility with G. Raymond Rettew. In 1943, Wyeth purchased ''G. Washington Coffee Refining Company'', an

instant coffee Instant coffee is a beverage derived from brewed coffee beans that enables people to quickly prepare hot coffee by adding hot water or milk to coffee solids in powdered or crystallized form and stirring. The product was first invented in Inver ...

company created by early 20th century Belgian inventor

George Washington George Washington (, 1799) was a Founding Fathers of the United States, Founding Father and the first president of the United States, serving from 1789 to 1797. As commander of the Continental Army, Washington led Patriot (American Revoluti ...

. In 1943, Wyeth merged with ''Ayerst, McKenna and Harrison, Ltd.'' of Canada. With this merger came Premarin, the world's first conjugated

estrogen Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three ...

medicine, which was a flagship product for Wyeth until 2002, when preliminary results from the Women's Health Initiative linked it to a number of negative effects, including increased risk for breast cancer. Sales subsequently fell off worldwide. Wyeth was one of 22 companies selected by the government in 1944 to manufacture penicillin for the military, and later for the general public. In 1945, Wyeth acquired the Fort Dodge Serum Company, entering the animal health field.

1950–1969

In 1951, Wyeth launched Antabuse, a drug for the treatment of

alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...

, as well as the

antihistamine Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides ...

Phenergan. Ansolyen was launched the next year as a

high blood pressure Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms itself. It is, however, a major ri ...

medication. The

anticonvulsant Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatme ...

Mysoline was introduced in 1954. Other drugs introduced during this time include Isordil, a

vasodilator Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel wal ...

for treatment of angina, Dryvax, a freeze-dried smallpox vaccine, and Ovral, a

combined oral contraceptive pill The combined oral contraceptive pill (COCP), often referred to as the birth control pill or colloquially as "the pill", is a type of birth control that is designed to be Oral administration, taken orally by women. It is the oral form of combi ...

. Pharmaceuticals were generating an ever-increasing percentage of Wyeth's sales. Wyeth became a leading US vaccine producer after supplying

polio Poliomyelitis ( ), commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe ...

vaccine for Salk trials. The corporate headquarters were moved to Radnor, Pennsylvania, where they remained until 2003. William F. Laporte became the Chairman and President of AHP in 1965, and served until 1981. The

World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Gen ...

initiated the Global Smallpox Eradication Program in 1967, and approached Wyeth to develop a better injection system for

smallpox Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus '' Orthopoxvirus''. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (W ...

vaccines which could be used in the field. Wyeth waived

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

royalties on its innovative

bifurcated needle The bifurcated needle is a narrow steel rod, approximately long with two prongs at one end. It was designed to hold one dose of reconstituted freeze-dried smallpox vaccine between its prongs. Up to one hundred vaccinations can be given from one ...

, aiding in the delivery of over 200 million smallpox vaccines per year.

1970–1989

Wyeth's oral contraceptives became popular in the US. John W. Culligan, after becoming chairman and CEO in 1981, spun off less profitable lines and focused resources on consumer and prescription drugs. Wyeth made history in 1984 with the introduction of

, the first nonprescription

in America, as well as the most famous prescription-to- OTC switch in history. John R. Stafford became CEO and chairman in 1986. He completed the divestiture of non-core businesses such as household products, foods, candy ( Brach's), and medical devices (e.g., its Sherwood-Medical Company was sold to Tyco-Kendal in 1997). Wyeth and Ayerst merged to form Wyeth-Ayerst Laboratories, thus strengthening and consolidating Wyeth's pharmaceutical operations. In the late 1980s, Wyeth acquired the animal health businesses of Bristol-Myers and Parke-Davis. Wyeth also acquired A.H. Robins, makers of Robitussin, ChapStick, Dimetapp, and the Dalkon Shield merging it into its Whitehall unit to establish its Whitehall-Robins Division.

1990–1999

In 1990, Reckitt & Colman (now Reckitt Benckiser) acquired Boyle-Midway from American Home Products. After a dedication of the food business, the PAM trademark becomes part of American Home Foods. Premarin becomes the most prescribed drug in the US in 1993. Effexor ( venlafaxine HCl), the first serotonin-norepinephrine reuptake inhibitor (SNRI), is introduced for the treatment of

clinical depression Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Intro ...

and is later indicated for

generalized anxiety disorder Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry about events or activities. Worry often interferes with daily functioning. Individuals with GAD are often overly con ...

and

social anxiety disorder Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by sentiments of fear and anxiety in social situations, causing considerable distress and impairing ability to function in at least some asp ...

. In 1993, Wyeth founded the ''Women's Health Research Institute'', the only institute in the pharmaceutical industry entirely dedicated to research in women's health. The Institute conducted trials in menopausal issues,

endometriosis Endometriosis is a disease in which Tissue (biology), tissue similar to the endometrium, the lining of the uterus, grows in other places in the body, outside the uterus. It occurs in women and a limited number of other female mammals. Endomet ...

contraception Birth control, also known as contraception, anticonception, and fertility control, is the use of methods or devices to prevent pregnancy. Birth control has been used since ancient times, but effective and safe methods of birth control only be ...

, and more. In 1994, Wyeth acquired American Cyanamid and its subsidiary Lederle Laboratories. This acquisition brought the Lederle Praxis vaccines, new

research and development Research and development (R&D or R+D), known in some countries as OKB, experiment and design, is the set of innovative activities undertaken by corporations or governments in developing new services or products. R&D constitutes the first stage ...

capacity, and Centrum, the leading US multivitamin. Wyeth's sales topped

13 billion in 1995; two years later, Premarin became the company's first brand to reach

1 billion in sales. In 1995, Wyeth acquired the animal health division of Solvay, which was folded into Fort Dodge Animal Health. The acquisition gave Fort Dodge Animal Health strong market presence in Europe and Asia as well as expanding its product portfolio to include swine and poultry vaccines. In 1996, American Home Products spun off its food unit as International Home Foods. International Home Foods was purchased by ConAgra Foods in 2000. Wyeth also purchases full ownership of Genetics Institute, Inc. after acquiring a majority interest in 1992. In 1997, the U.S. Food and Drug Administration (FDA) requested that Wyeth withdraw its controversial diet drug fenfluramine from the market by after several reports of deaths and other health problems associated with the drug combination known as fen-phen occurred. In 1998, American Home Products was left at the altar by British pharma powerhouse SmithKline Beecham, who pulled the plug on the estimated $70 billion merger. The deal was reportedly killed in response to British regulators who feared losing jobs to a proposed US headquarters location. (SmithKline Beecham merged with fellow Brit Glaxo Wellcome in 1999 to form the world's leading drug company.) This was the start of a three-year losing streak in the mergers and acquisitions game for AHP. In 1999, another American Home Products merger fell through, this time a proposed $34 billion merger-of-equals with chemical and biotech manufacturer Monsanto Company. Though the companies issued a combined statement saying the breakup was mutual "because (the deal) was not in the best interests of shareholders," rumors circulated that AHP had canceled the deal due to issues in the soon-to-be-combined boardroom. (Monsanto announced in December 1999 that it would merge with Pharmacia & Upjohn instead; the new conglomerate eventually unloaded Monsanto again, before being bought themselves by

in 2003.)

2000–2009

* In 2000, American Home Products lost a

65 billion friendly takeover bid for rival drug company Warner-Lambert. After the merger announcement,

offered a competing hostile bid, primarily to save its joint venture with Warner over Lipitor (at the time the #1 prescription drug in the world). At one point talks were under way in which

Procter & Gamble The Procter & Gamble Company (P&G) is an American multinational consumer goods corporation headquartered in Cincinnati, Ohio. It was founded in 1837 by William Procter and James Gamble. It specializes in a wide range of personal health/con ...

would help by buying both companies in a wild three-way merger, a rumor which cost P&G a 10% drop in its stock price. Although both CEOs eventually toured the world to defend the deal to the company's shareholders, Pfizer won Warner-Lambert and formed the second largest drug company in the world, while AHP had to settle for a

1.8 billion poison-pill payment. This was at the time the biggest poison-pill payment in US history. * On May 17, 2000 the U.S. Food and Drug Administration approved Gemtuzumab Ozogamicin
Mylotarg®
Wyeth Laboratories, now part of

). The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.6) covalently attached to the cytotoxic antitumor antibioti
''calicheamicin''
(N-acetyl-γ-calicheamicin) via a bifunctional linker (4-(4-acetylphenoxy)butanoic acid). Gemtuzumab ozogamicin was developed in a collaboration between Wyeth-Ayerst Research and Celltech Chiroscience, using Celltech’s antibody-humanization technology and Wyeth-Ayerst’s calicheamicin-conjugation technology. The drug was approved on May 17, 2000 under the FDA's Accelerated Approval regulations, and was indicated for the treatment of patients with CD33-positive

Acute Myeloid Leukemia Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with haematopoiesis, normal blood cell production. Sympt ...

(AML) in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy. The approved dose was 9 mg/m i.v. over 4 h and repeated every 14 days. In 2010, after Pfizer acquired Wyeth Pharmaceuticals, gemtuzumab ozogamicin was voluntarily withdrawn from the market. In January 2017 Pfizer’s Biologics License Application (BLA; BLA761060) for gemtuzumab ozogamicin was accepted for filing by the FDA. A Marketing Authorization Application (MAA) for review by the

European Medicines Agency The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products. Prior to 2004, it was known as the European Agency for the Evaluation of Medicinal Products ...

(EMA) was validated in December 2016 and on September 1, 2017, the FDA (re)approved gemtuzumab ozogamicin. The (re-)approval included a lower recommended dose, a different schedule in combination with chemotherapy or on its own, and a new patient population. * On January 23, 2009, ''

The Wall Street Journal ''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...

'' reported that

was in talks to buy Wyeth at a cost of

68 billion. On January 25, Pfizer agreed to the purchase, a deal financed with cash, shares and loans. The deal was completed on October 15, 2009. The purchase was approved by the SEC and went into effect later in 2009, although vestiges of Wyeth remained for another year or two while effects of the merger were ironed out. * Robert Essner, the company's former CEO, was appointed in 2001. On September 27, 2007, the Wyeth Board of Directors elected Bernard Poussot President and Chief Executive Officer effective on January 1, 2008. * On March 11, 2002, American Home Products changed its name to Wyeth, having spun off unrelated businesses in order to focus on pharmaceuticals. * As part of the Women's Health Initiative sponsored by the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

, a large-scale clinical trial for

Hormone Replacement Therapy Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such ...

showed that long-term use of

progestin A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. A progestin is a '' synthetic'' progestogen. ...

and

may increase the risk of

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...

s, blood clots, and

breast cancer Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipp ...

. Following these results, Wyeth experienced a significant decline in its sales of Premarin, Prempro (conjugated equine

s) and related hormones, from over $2 billion in 2002 to just over $1 billion in 2006. The results from the study were significant enough that Wyeth terminated the trials early due to a fear that their participants may be at risk. * Wyeth, as a corporation, filed a 'citizens complaint' with the United States FDA on October 16, 2005, requesting that the US FDA take action against pharmacies who compound, manufacture, or sell unlicensed Bioidentical hormone replacement therapy (BHRT) drugs to their patients. Specifically, Wyeth asserted that the BHRT drugs are not licensed by the FDA according to section 505 of the Food, Drug and Cosmetic Act, misbranded and adulterated per sections 501 and 502 of 21 U.S.C. (paragraphs 351, 352, and 355). Drug manufacturers are required to demonstrate through clinical trials that marketed drugs are safe and efficacious, a process that BHRT drugs have not undergone. If honored, the request would require the same safety and efficacy data for those primarily engaged in

alternative medicine Alternative medicine refers to practices that aim to achieve the healing effects of conventional medicine, but that typically lack biological plausibility, testability, repeatability, or supporting evidence of effectiveness. Such practices are ...

. * The European Commissioner for Health and Consumer Protection blamed the presence of illegal steroids in the food supply on "fraudulent exchange and disposal of pharmaceutical waste". A Wyeth factory disposing of the byproducts from synthetic

progesterone Progesterone (; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the ma ...

manufacture was the source of the contamination. * In 2003 Wyeth reportedly contributed funds to a not-for-profit support group, The Meningitis Centre, which lobbied the

Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...

n Government to introduce universal immunisation against pneumococcal disease. Wyeth produced the only pneumococcal vaccine approved for young children in Australia. * During June 2009, an Arkansas federal judge granted public access to evidence that Wyeth Pharmaceuticals "ghostwrote" medical articles regarding its hormone therapy drug Prempro. Along with ''

The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...

'', PLoS Medicine, represented by the law firm Public Justice, had sought to intervene in a court case of women bringing an action in relation to Prempro and other hormone therapy drugs, in order to unseal papers that allegedly showed that Wyeth failed to disclose its role in preparing medical journal articles promoting Prempro and in recruiting academic authors to put their names on the articles for publication—that is that they practised ghost writing. * On October 15, 2009 Pfizer signed the final acquisition papers making Wyeth a wholly owned subsidiary of Pfizer, thus completing the

68 billion dollar deal.

2012–present

* In 2012,

Nestlé Nestlé S.A. ( ) is a Swiss multinational food and drink processing conglomerate corporation headquartered in Vevey, Switzerland. It has been the largest publicly held food company in the world, measured by revenue and other metrics, since 20 ...

bought the infant nutrition division of Pfizer and renamed it as Wyeth Nutrition. The Wyeth brand is still owned by Pfizer.

Subsidiaries

Wyeth Consumer Healthcare

''Wyeth Consumer Healthcare'' (formerly Whitehall-Robins Consumer Healthcare) operated throughout the world. The consumer healthcare division had sales of $2.5 billion in 2004 and was at the time the fifth largest over-the-counter health products company in the world.

Wyeth Pharmaceuticals

''Wyeth Pharmaceuticals'', formerly Wyeth-Ayerst Laboratories, is the original company founded by the Wyeth brothers, originally known as John Wyeth and Brother. They focused on the research, development, and marketing of prescription drugs. The pharmaceuticals division was further subdivided into five subdivisions: Wyeth Research, Prescription Products, Biotech, Vaccines, and Nutritionals.

Fort Dodge Animal Health

''Fort Dodge Animal Health'' was founded in 1912 by Daniel E. Baughman as "Fort Dodge Serum Company". The company was established in Fort Dodge, Iowa, to manufacture hog

cholera Cholera () is an infection of the small intestine by some Strain (biology), strains of the Bacteria, bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea last ...

serum. It became a division of American Home Products in 1945. It is a leading manufacturer of prescription and over-the-counter veterinary vaccines and pharmaceuticals. Its global headquarters are located in

Overland Park, Kansas Overland Park ( ) is the largest city in Johnson County, Kansas, United States, and the List of cities in Kansas#Highest population listing, second-most populous city in the state of Kansas. It is one of four principal city, principal cities in ...

. Innovative Fort Dodge products include West Nile-Innovator, Duramune Adult, CYDECTIN Pour-on, the Pyramid vaccine line, Quest Gel, and EtoGesic Tablets.

Products

Wyeth Consumer Healthcare Products (changed to Pfizer Consumer Healthcare, GSK Consumer Healthcare, and finally Haleon)

* Advil * Advil Allergy Sinus Caplets * Advil Allergy & Congestion Relief Tablets * Advil Caplets * Advil Cold & Sinus Caplets * Advil Cold & Sinus Liqui-Gels * Advil Congestion Relief * Advil Gelcaps * Advil Liqui-Gels * Advil PM Caplets * Advil PM Liqui-Gels * Advil Sodium Ibuprofen (Fast-Acting) * Alavert * Anadin * Anbesol * Caltrate * Centrum Advance * Centrum Kids * Centrum Silver/Select Advance * ChapStick * Clusivol OB * Clusivol Plus * Clusivol Power-C (defunct) * Children's Clusivol * Dimetapp * Dristan * Fibrosine * Incremin * Loviscol * Polymagma * Preparation H * Robitussin * Robikids * Robitol (now defunct) * Simeco * Stresstabs * Today

condom A condom is a sheath-shaped Barrier contraception, barrier device used during sexual intercourse to reduce the probability of pregnancy or a Sexually transmitted disease, sexually transmitted infection (STI). There are both external condo ...

s * Z-bec

Wyeth Pharmaceuticals Products

* Ativan (

lorazepam Lorazepam, sold under the brand name Ativan, Tavor among others, is a benzodiazepine medication. It is used to treat anxiety (including anxiety disorders), insomnia, severe agitation, active seizures including status epilepticus, alcoh ...

): a

benzodiazepine Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of central nervous system (CNS) depressant, depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed t ...

used to treat anxiety, insomnia, and certain seizures * Effexor/Effexor XR ( venlafaxine HCl): an SNRI for

Generalized Anxiety Disorder Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry about events or activities. Worry often interferes with daily functioning. Individuals with GAD are often overly con ...

, and

Social Anxiety Disorder Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by sentiments of fear and anxiety in social situations, causing considerable distress and impairing ability to function in at least some asp ...

* Enbrel ( etanercept): a drug approved for

Psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...

and various forms of

Rheumatoid Arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects synovial joint, joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and h ...

(co-marketed by Amgen) * Lybrel: A breakthrough birth control medication that went on the market in 2008, Wyeth put more into the advertising of this drug than any other medicine previously. * Premarin: (conjugated

tablets); Estrogen HRT for menopausal women * Premarin Vaginal Cream: (conjugated estrogens) indicated to treat vaginal dryness at menopause * Prevnar: vaccine to protect children from pneumococcal disease * Pristiq ( desvenlafaxine): a newly approved antidepressant for the treatment of major depressive disorder (MDD) * Protonix ( pantoprazole): a

proton pump A proton pump is an integral membrane protein pump that builds up a proton gradient across a biological membrane. Proton pumps catalyze the following reaction: : n one side of a biological membrane/sub> + energy n the other side of the m ...

inhibitor for treating dyspepsia, duodenal ulcers and Oesophagitis * Relistor ( methylnaltrexone): a newly approved drug for constipation induced by opioids (co-marketed with Progenics) * Surmontil ( trimipramine): a

tetracyclic antidepressant Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced in the 1970s. They are named after their tetracyclic chemical structure, containing four cyclic compound, rings of atoms, and are closely related to th ...

and the only psychotropic drug that shows no effect on REM sleep. * Torisel ( temsirolimus): a drug approved for the treatment of Renal Cell Carcinoma (a type of cancer). * Tygacil ( tigecycline): an

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

developed for treatment of intra-abdominal and skin / tissue infections caused by resistant pathogens such as MRSA * Xyntha (Antihemophilic Factor (Recombinant), Plasma/Albumin-Free): a new form of AHF, recently approved by the US FDA * Zosyn ( piperacillin/ tazobactam): another intravenous antibiotic used mainly in intensive care medicine. Also known as ''Tazocin'' in some countries.

Fort Dodge Animal Health Products

Barricade Barricade (from the French ''barrique'' - 'barrel') is any object or structure that creates a barrier or obstacle to control, block passage or force the flow of traffic in the desired direction. Adopted as a military term, a barricade denotes ...

* Biodectin Sheep Vaccine and wormer ( moxidectin) * Bursine-2/Bursine Plus/Bursine K Poultry Vaccines * Cefa-Lak/Cefa-Dri * CYDECTIN ( moxidectin) * Dicural * Duramune Dog Vaccines * Duvaxyn Horse Vaccines * EtoGesic Tablets * Ewegaurd Sheep Vaccine and wormer ( moxidectin) * Fel-O-Guard Cat Vaccines * Fel-O-Vax Cat Vaccines * Fluvac Innovator Horse Vaccine * GiardiaVax Dog Vaccine * Ketaset * LeptoVax Dog Vaccine * LymeVax Dog Vaccine * Nolvasan * PestVac Pig Vaccine * Pinnacle I.N. Horse Vaccine * Pneumobort Horse Vaccine * Polyflex * Poulvac Poultry Vaccines * Presponse Cattle Vaccines * ProHeart 6/ProHeart SR-12 ( moxidectin) Heartworm preventative * ProMeris for dogs and cats * Provac Poultry Vaccines * PYRAMID Cattle Vaccines * Quest/Equest Gel ( moxidectin) * Rabon Ear Tags for Cattle * Rabvac Rabies Vaccine for Dogs * Supona * Suvaxyn Pig Vaccines * Synanthic * SYNOVEX Implants * Telazol * ToDAY/ToMORROW * Torbugesic-SA * Triangle Cattle Vaccines * TriReo Poultry Vaccine * Vetdectin ( moxidectin) (New Zealand) * Weanerguard Sheep Vaccine and wormer ( moxidectin) * Websters Cattle, Sheep and Poultry Vaccines (Australia) * West Nile Innovator Horse Vaccine

Wyeth Nutrition Products

''Prenatal'' * Bonina ''Infant and Follow-on'' * S-26 * S-26 Gold * Bonna * Bonna Follow-up Formula (Formerly Bonamil) ''Toddler'' * Bonakid (Formerly Bonakid 1+) * S-26 Promil Gold (Formerly Progress Gold) * S-26 Promil (Formerly Progress & Promil Kid) * Ascenda ''Pre-school'' * Bonakid Pre-School * Promil (Formerly Promil Pre-School) * Promil Gold (Formerly Progress Pre-School Gold) * Ascenda Kid ''Special Feeder'' * S-26 Gold Comfortis HW * S-26 Gold CS * S-26 Gold HA * S-26 Gold LF * Bonna Low Lactose ''Former Milk Products'' * ProMama (Philippines) * Enercal Plus (Philippines) * Aqiva (Now Ascenda Kid) * Promil Aqiva (Now Ascenda) * Nursoy * S-26 Soy Gold * S-26 Lactose Free * Promil Lactose Free * S-26 LF Gold * Promil LF Gold * Bonakid School Age Choco Boost * S-26 Organic * S-26 Promil Organic * Promil Organic

Controversies

Rapamune

A "whistleblower suit" was filed against Wyeth in 2005 alleging that the company illegally marketed their drug Rapamune. Wyeth is targeted in the suit for off-label marketing, targeting specific doctors and medical facilities to increased sales of Rapamune, trying to get current transplant patients to change from their current transplant drugs to Rapamune and for specifically targeting African-Americans. According to the whistleblowers, Wyeth also provided doctors and hospitals with kickbacks to prescribe the drug in the form of grants, donations and other money. As of 2010 a US House of Representatives committee, led by Rep. Edolphus Towns was investigating Wyeth for these abuses.

Prempro

Wyeth was sued for its marketing of Prempro, a

hormone replacement therapy Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such ...

, which was implicated in the cancers of 14,000 patients. Wyeth was particularly criticised by observers for its use of 'ghostwriters' to put their names to research papers that Wyeth had paid a third party, DesignWrite, to prepare.Medical ghostwriters who build a brand , Comment is free , The Guardian
''The Guardian''

Diet-Drug: Dexfenfluramine (Phentermine/Fenfluramine, aka,"Fen-Phen")

The drug combination fenfluramine/phentermine, usually called "fen-phen," was an anti-obesity treatment. Fenfluramine was marketed by Wyeth as Pondimin, but was shown to cause potentially fatal pulmonary hypertension and heart valve problems. For more information refer to the article Fenfluramine/phentermine.

References

Harvard Business School Harvard Business School (HBS) is the graduate school, graduate business school of Harvard University, a Private university, private Ivy League research university. Located in Allston, Massachusetts, HBS owns Harvard Business Publishing, which p ...

Tygacil - tigecycline IV

Zosyn (tazobactam / piperacillin)

The Meningitis Centre

Effexor XR

Pristiq

ProMeris

Suvaxyn PCV-2

Gastro Club
* http://www.prevenar.co.uk/ {{Pharmaceutical companies of the United States Pfizer Companies established in 1860 Multinational companies Pharmaceutical companies based in New Jersey Companies based in Morris County, New Jersey Companies based in Rockland County, New York Madison, New Jersey Vaccine producers Companies formerly listed on the New York Stock Exchange