Acetryptine (
INN
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) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT),
is a
drug
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...
described as an
antihypertensive agent which was never marketed.
Structurally, acetryptine is a
substituted tryptamine
Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino (NH2) group via an ethy ...
, and is closely related to other substituted tryptamines like
serotonin (5-hydroxytryptamine).
It was developed in the early 1960s.
The
binding of acetryptine to
serotonin receptors does not seem to have been well-investigated, although it was assessed at the
5-HT1A and
5-HT1D receptors and found to bind to them with high
affinity
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.
The drug may also act as a
monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, esp ...
(MAOI); specifically, as an
inhibitor of
MAO-A
Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the ''MAOA'' gene. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, ...
.
See also
*
5-Benzyloxytryptamine
5-Benzyloxytryptamine (5-BT), is a tryptamine derivative which acts as an agonist at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors, and an antagonist of TRPM8.
Legality
5-Benzyloxytryptamine is illegal in Singapore.
See also
* 5-Carboxa ...
*
5-Carboxamidotryptamine
5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.
5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well a ...
*
5-Ethoxy-DMT
5-Ethoxy-DMT (5-ethoxy-''N'',''N''-dimethyltryptamine, 5-EtO-DMT, ''O''-ethylbufotenine) is a tryptamine derivative which has been previously synthesized as a chemical intermediate, but has not been studied to determine its pharmacology.
The w ...
*
5-Methoxytryptamine
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine chemical derivative, derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynth ...
*
5-(Nonyloxy)tryptamine
5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT1B, with highest activity ...
*
Azepindole
Azepindole (McN-2453) is a tricyclic chemical compound, compound with antidepressant and antihypertensive effects that was developed in the late 1960s but was never marketed.
See also
* Tricyclic antidepressant
References
Tricycli ...
*
Indorenate
Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with som ...
*
Metralindole
Metralindole (Inkazan) is a reversible inhibitor of monoamine oxidase A (RIMA) which was investigated in Russia as a potential antidepressant. It is structurally and pharmacologically
Pharmacology is a branch of medicine, biology and pha ...
*
Pargyline
Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug ( IC50 for MAO-A is 0.01152 μmol/L and for MAO-B is 0.00820 μmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an ant ...
*
Pirlindole
Pirlindole (Lifril, Pyrazidol) is mainly a reversible inhibitor of monoamine oxidase A (RIMA) and secondly a SNRI which was developed and is used in Russia as an antidepressant. It is structurally and pharmacologically related to metralindole. S ...
*
Sumatriptan
Sumatriptan, sold commonly under brand names Imitrex and Treximet among others, is a medication used to treat migraine headaches and cluster headaches. It is taken orally, intranasally, or by subcutaneous injection. Therapeutic effects genera ...
*
Tetrindole
Tetrindole was a drug candidate that functions by reversibly inhibiting monoamine oxidase A; it was first synthesized in Moscow in the early 1990s. Tetrindole is similar in its chemical structure to pirlindole (Pyrazidol), and metralindole.
...
References
Antihypertensive agents
Serotonin receptor agonists
Tryptamines
{{antihypertensive-stub