2022 Houston Astros

The 2022 Houston Astros season was the 61st season for the Major League Baseball (MLB) franchise located in Houston, Texas, their 58th as the Astros, 10th in both the American League (AL) and AL West division, and 23rd at Minute Maid Park. The Astros, who entered the season as both the defending AL and AL West champions, looked to avenge their 2021 World Series loss to the Atlanta Braves.

The collective bargaining agreement (CBA) between MLB and the MLB Players Association (MLBPA) expired on December 1, 2021. With no new agreement in place, Commissioner of Baseball Rob Manfred announced a lockout of players the following day. On March 10, 2022, MLB and MLBPA agreed to a new CBA, thus ending the lockout. Opening Day, originally scheduled for March 31, instead took place on April 7, and a full 162-game season was played.

Behind Framber Valdez' first Opening Day start, the Astros won for the tenth straight year, which set a modern-day major league record for most consecutive Opening Day victories. Manager Dusty Baker reached 2,000 career wins on May 3 with a 4–0 win over the Seattle Mariners, becoming the 12th manager to reach the milestone. Two Astros pitchers, Luis García and Phil Maton, recorded an immaculate inning on June 15, 2022, the first occurrence in major league history of more than one immaculate inning pitched on the same day. On June 25, three Astros pitchers— Cristian Javier, Héctor Neris and Ryan Pressly—combined to no-hit the New York Yankees for the 14th no-hitter in team history. The following day, the hitless streak reached innings via José Urquidy's hitless innings, tying an expansion era record..

The Astros secured a sixth consecutive playoff berth following a 5–0 win against the Oakland Athletics. On September 19, they clinched their fifth AL West title in the last six seasons following a 4–0 win against the Tampa Bay Rays. With a 106–56 regular season record, the win total represented the second-highest total to date in franchise history—trailing only the 2019 club with 107—and the fifth time the Astros reached at least 100. Their AL West title was the 12th division title in franchise history, seventh playoff berth over the previous eight seasons, and 16th playoff appearance overall.

Houston swept Seattle in the American League Division Series (ALDS) to reach the American League Championship Series (ALCS) for a sixth straight season, in doing so becoming the first team in major league history to win a postseason series in six consecutive seasons. They swept the New York Yankees in the ALCS for their fourth AL pennant and fifth pennant overall. The Astros advanced to the World Series and faced the Philadelphia Phillies. In Game 4, Javier, Bryan Abreu, Rafael Montero, and Pressly all combined for another no-hitter, just the second in World Series history. On November 5, they beat the Phillies 4–1 in Game 6 at Minute Maid Park to win their second championship and first since 2017. The 2022 Astros became just the third team after the 1995 Atlanta Braves and the 2019 Washington Nationals to sweep the LCS since the best-of-seven-game format was introduced and subsequently win the World Series. The momentum for this World Series run resulted largely from a historic bullpen performance which surrendered just five total earned runs, rookie shortstop Jeremy Peña, who claimed both ALCS and World Series Most Valuable Player (MVP) honors, and Yordan Alvarez, who connected for go-ahead home runs in three of the Astros’ eleven postseason victories. In his 25th season, Dusty Baker earned his first championship as a manager. The Astros became the first team to have a winning percentage of .622 (or better) in a six-season span (2017–2022) with multiple World Series titles since the 1953–1958 New York Yankees, and they became the sixth team since 1960 to win the World Series after losing it the previous year. Several pundits have posited the 2022 Astros as one of the most dominant teams in MLB history, owing largely to the club's immense pitching success throughout the entire regular season and postseason.

Offseason

Summary of Astros' offseason

The Houston Astros entered the 2022 MLB season as runners-up in the 2021 World Series championship, falling to the Atlanta Braves in six games. It was the Astros' third World Series appearance in five years, including a route to their fifth consecutive American League (AL) Championship Series. They had won the AL West division with 95–67 record, their fourth division championship in five seasons.

Personnel

On November 3, 2021, the day following the ending of the World Series, seven Astros were declared free agents, including Carlos Correa, Yimi García, Marwin González, Kendall Graveman, Zack Greinke, Brooks Raley, and Justin Verlander.

Pitching coach Brent Strom announced on November 2 that he was leaving the organization and would contemplate retiring from professional baseball. Heralded as an essential architect of an era of increasingly-dominant Astros pitching, the 73 year-old rejoined the Astros in 2014. Ably blending his experience and teaching with analytics, he coached Dallas Keuchel and Verlander in their Cy Young-winning seasons (2015 and 2019, respectively) and was credited with assisting Gerrit Cole and Charlie Morton in elevating their own success. Club owner and chairman Jim Crane announced on November 5 that the Astros re-signed manager Dusty Baker for the 2022 season, to return for a third season with the club. Through the 2021 season, Baker had won 1,987 games in 24 seasons over his managerial career.

Former manager Bill Virdon died at age 90 on November 23, 2021, and was survived by his wife of 70 years, Shirley. He was the Astros' franchise leader in wins by a manager, and guided them to their first playoff berth in 1980, when they fell one victory short of advancing to the World Series. He managed the Astros for eight seasons, from 1975 to 1982, and also led the New York Yankees, Pittsburgh Pirates, and Montreal Expos. A former major league outfielder, Virdon hit .404 against the legendary Sandy Koufax, the highest average allowed to a single hitter by the Hall of Famer during his career.

Uniform addition

To celebrate the 60th anniversary of Major League Baseball in Houston, the Astros unveiled commemorative shield patches for their New Era on-field caps and on the sleeve of the uniforms to be worn throughout the 2022 season. Displaying the number 60 prominently within an orange home plate-shaped shield, it was outlined with a navy blue border flanked by white piping on the outside of the border, and ensconced within the nadir of the shield, the Astros star-H logo. The outline of the state of Texas was suspended within the zero, the Colt .45 logo with "1962" on the bottom left side, and the current Astros wordmark logo and "2022" on the bottom right. The club would celebrate its 60 years in Houston throughout the season, including special commemorations Flashback Friday games.

Negotiation of collective bargaining agreement

Lockout

On December 1, 2021, the collective bargaining agreement (CBA) between the league and the Major League Baseball Players Association (MLBPA) expired, with no substantial, new agreement being materialized. Thus, the team owners voted unanimously to lockout the players, stopping all free agency and trades. On December 2, 2021, Commissioner of Baseball Rob Manfred announced that the league had instituted the lockout. On March 10, 2022, the MLB and MLBPA agreed to a new collective bargaining agreement, thus ending the lockout. Spring training games began on March 17. Opening Day, originally scheduled for March 31, would instead take place on April 7. Although MLB previously announced that series would be cancelled due to the lockout, the new agreement provided for a full, 162-game season, with any games cancelled games to be made up via doubleheaders.

Rule changes

Pursuant to the new CBA, several new rules were instituted for the 2022 season. The National League adopted the designated hitter full-time, a draft lottery was implemented, postseason eligibility was expanded from ten teams to twelve, and advertising patches appeared on player uniforms and helmets for the first time.

Spring training

Two players continued recovery from injuries sustained in the 2021 American League Division Series (ALDS) and missed the start of the regular season with estimated return dates uncertain. Starting pitcher Lance McCullers Jr. (right forearm strain) was still unable to throw in spring training. Jake Meyers, who torn the labrum in his left shoulder, underwent surgery following the conclusion of the World Series. Forrest Whitley, on the Astros' 40-man roster, was recovering from Tommy John surgery as of the start of the 2022 season.

On March 30, the Astros named Framber Valdez their Opening Day starter, scheduled on April 7, 2022, versus the Los Angeles Angels. Justin Verlander, who had previously handled the duties, was technically available. Due to the shortened spring training and his rehabilitation from Tommy John surgery, he was instead scheduled to make his first start of the season on April 9.

The Astros and closer Ryan Pressly agreed to terms on a new contract extension on April 5, worth $30 million guaranteed. A two-year contract, it covered the 2023 and 2024 seasons, with an option for 2025.

Regular season

Opening Day lineup

April

Opening Weekend series, April 7–10 at Los Angeles Angels: Houston won series, 3–1

On April 7, Astros left-handed pitcher Framber Valdez made his first career Opening Day start at Angel Stadium, opposite Los Angeles Angels two-way star Shohei Ohtani, the reigning American League (AL) Most Valuable Player (MVP). Rookie Jeremy Peña, making his major league debut, replaced at shortstop longtime franchise cornerstone Carlos Correa, who had departed via free agency. Valdez carried a shutout and had retired 15 consecutive batters until he pitched to Mike Trout in the bottom of the seventh inning. He reached on a throwing error by Peña, but Anthony Rendon grounded into a double play to deny the threat. Valdez, relying on his sinker in 50 percent of the pitches, got nine total ground ball outs. He recorded scoreless innings pitched, while Ohtani allowed one run over innings. Alex Bregman and Yordan Alvarez hit back-to-back home runs versus relief pitcher Ryan Tepera in the eighth inning. The Astros prevailed, 3–1, allowing Valdez to win his first start on Opening Day, and giving the club a record-tying 10th consecutive Opening Day win. The Boston Beaneaters first accomplished the feat from 1887 to 1896.

The Astros won the second game of the season, 13–6, aided by Peña's first major league home run. Batting versus Mike Mayers in the seventh inning, he hit it 423 feet to left field while his parents, Cecilia and former major league second baseman Gerónimo Peña, were interviewed by Heidi Watney on Apple TV+. The home run ignited an eight-run inning. Peña totaled three hits for the day—including his first in the major leagues in the second inning. Right fielder Kyle Tucker homered twice, and Jose Altuve, Aledmys Díaz and Alex Bregman each homered as well.

Ace Justin Verlander made his first start since July 24, 2020, on April 9 versus Los Angeles. He completed five innings, allowed three hits–yielding a home run to Jared Walsh–and struck out seven. Walsh's home provided all the offense in the game as the Angels handed the Astros their first defeat of the season in a 2–0 score.

In the April 10 game versus Los Angeles, starting pitcher José Urquidy debuted for the season with five solid innings that helped Houston hold on to a 2–1 lead. Four relievers hurled one scoreless inning apiece. Over his first four games, Peña collected six hits in 16 at bats.

On April 11, 2022, third baseman Alex Bregman was named AL Player of the Week. Over the four games comprising MLB's Opening Weekend, he batted .429 (6-for-14) with two home runs, six RBI and a 1.286 OPS.

;Release of City Connect jerseys

On April 10, the Astros announced the release of their Nike MLB City Connect jerseys to debut on April 20, 2022, and to be worn each Monday home game for the rest of the season. The theme of the uniform draws heavily on the city of Houston's connection with NASA, space and space travel and being home to the Johnson Space Center. The nickname for the city, "Space City," was featured prominently in NASA-inspired orange worm lettering across the chest on an all-navy blue uniform. The sleeve featured a mission patch with the flag of Texas with the Houston Astros star-H logo superimposed on the star, and one of each of Houston's four area codes adjacent to the flag's corners. The right pant leg featured the unconventional placement of each player's uniform number.

April 12–13 at Arizona Diamondbacks: Houston split series with ARI, 1–1

At Chase Field on April 12, José Siri's home run in the fifth inning versus Arizona Diamondbacks starter Madison Bumgarner traveled a Statcast-projected 456 feet onto the left-center-field concourse with an exit velocity of 109.7 mph, his second-hardest hit in 24 big league games. Siri singled versus Mark Melancon into right center field in the ninth inning to spark a ninth-inning rally. Altuve then walked, and Michael Brantley followed with single into left field to score Siri for the game-winning run with a final score of 2–1. Reliever Héctor Neris, a free agent acquisition, struck out two in a perfect eighth inning to earn in his first win in an Astros uniform. The following game, Arizona and Houston combined for to strand 28 baserunners while batting 1-for-19 with runners on base. Houston pitching walked nine Diamondbacks and hit another three. Closer Ryan Pressly, pitching in back-to-back contests for the first time on the season, issued two walks in the tenth before Ketel Marte lifted a sacrifice fly to score Seth Beer for the game-winning run.

April 15–17 at Seattle Mariners. The Astros' pitching staff had entered this game with a major league-leading 1.69 earned run average (ERA), but the Seattle Mariners won 11–1 at T-Mobile Park as the Astros' offense continued to struggle. Starter Jake Odorizzi allowed four earned runs in innings, unable to command his fastball consistently nor find the feel for his secondary pitches. The lineup collected five total hits and Altuve and Tucker both were 0-for-4 and a combined 6-for-51 to start the season. Houston had scored five runs in their previous 28 innings.

The Astros placed Alvarez on the injured list on April 15 for "health and safety protocols," although manager Dusty Baker noted that he had not tested positive for COVID-19, but that "he's still feeling under the weather" since missing both games versus Arizona. Joe Perez was recalled from the Corpus Christi Hooks to take Alvarez' place on the roster. On April 16, Verlander shut out the Mariners for eight innings on his way to his first win of the season and first since Opening Day of 2020. He struck out eight, walked none, and permitted no runner to advance past first base in a 4–0 score. He also become the 138th pitcher to pass the 3,000 innings pitched threshold. Catcher Martín Maldonado hit his first home run of the season, scoring Jeremy Peña in the fifth inning. Due to a case of knee inflammation, Ryan Pressley was placed on the 10-day injured list on April 16.

After a hamstring injury to Altuve, the Astros called up first baseman J. J. Matijevic from the Sugar Land Space Cowboys. He made his major league debut on April 22 versus the Toronto Blue Jays, as a pinch hitter the ninth inning of a 4–3 loss, striking out in his lone at bat.

Having lost four games in a row going into the April 24 game, Peña hit his first career walk-off home run in the bottom of the 10th inning versus the Blue Jays, leading to an 8–7 victory.

April 25–28, at Texas Rangers: Houston won series, 3–1

On April 25, the Rangers won the opener to hand the Astros their fifth defeat in six games, after Adolis García's bases-clearing double in the seventh inning rallied Texas to a 6–2 win. Yordan Alvarez homered for the Astros, Kyle Tucker hit a two-run single, and starter Framber Valdez allowed one unearned run over six innings. Jake Odorizzi (1–2) started and won on April 26, ending a 10-game winless streak spanning since last August. He allowed one hit and two total baserunners. Tucker homered and drove in three runners. On April 27, Cristian Javier won his season starting debut; in five innings, he allowed two runs, four hits, and two walks. Tucker hit a three-run double in the fifth inning to score the decisive runs for a 4–3 final score. Matijevic received his first career start in the major leagues, manning first base on April 27. On Auril 28, Rangers starter Martín Pérez took a perfect game into the seventh inning until a leadoff double by Chas McCormick. Tucker, pinch hitting in the eighth inning, again hit a home run that provided the margin of victory for the Astros, 3–2.

May

The Astros finished the month of April with a record of 11–10. They began May with a loss to the Toronto Blue Jays to lose both series matchups with them. The next day, they faced the Seattle Mariners for three games with Jake Odorizzi, Cristian Javier and Justin Verlander pitching as starters. They proceeded to sweep the Mariners in convincing fashion, outscoring them 14-2 while not allowing a run for 23 innings. The Astros' defeat of the Martiners by the score of 4–0 on May 3 was also the 2,000th win of manager Dusty Baker's career, making him the 12th manager to reach the milestone, and first African American.

May 5–8 vs Detroit Tigers: Houston won series, 4–0

Next was the Tigers, with Urquidy, Luis García, Framber Valdez, and Jake Odorizzi on the mound for the Astros. It was a tightly contested series that saw three games end with a 3–2 score before the final saw a 5–0 rout, and Houston won each one. On May 6, García matched a career-high with nine strikeouts over seven innings and allowed two hits and one earned run. Chas McCormick and Martín Maldonado hit back-to-back home runs in the second inning; Maldonado's home run provided the eventual decisive run in a 3–2 Astros win. On May 8, Aledmys Díaz hit a grand slam, and Odorizzi hurled five innings of one-hit ball to defeat the Tigers, 5–0, complete a sweep and a 7–0 homestand.

The Astros next traveled to Minnesota to face the Twins (missing newly acquired free agent Carlos Correa due to injury). Verlander started the first game and allowed just one hit in eight innings as Houston prevailed, 5–0. He suppressed any hits until reaching one out in the eighth inning, when Gio Urshela singled to right field to end the right-hander's fourth career no-hit bid.

Urquidy started the second game versus the Twins, but rain limited him to three innings pitched as the game was not completed until the next afternoon, which saw four relievers used by Houston in a 11–3 win. Garcia then started the final game of the three-game set and stuck out nine batters (tying a career high) in five innings for a 5–0 win. It was the tenth victory in a row for Houston and the seventh time since 2010 that Houston had a ten-game winning streak in the regular season, most for all teams in that span. A 6–1 win versus Washington Nationals at Nationals Park on May 13 extended the winning streak to 11 games, led by Valdez' innings and one run allowed. The Astros' pitching staff as a whole had allowed 10 earned runs in 99 innings (0.91 ERA) during the streak. The Astros scored five runs in the first inning, including Yuli Gurriel's first home run of the season. The 2,009th win of Baker's career moved him past Leo Durocher for sole possession of 10th place in MLB history.

The Astros acquired infielder Mauricio Dubón from the San Francisco Giants for catcher Michael Papierski on May 14. Dubón is the second Honduran to play for the Astros; center fielder Gerald Young was the first.

A 13–6 loss to the Nationals on May 14 ended the winning streak. Until that loss, the Astros pitching staff led MLB with a 2.68 ERA; after this game, their ERA had risen to 3.00.

On May 17, the Astros tied the rare major league record of five home runs in one inning. Facing the Boston Red Sox, Yordan Alvarez, Kyle Tucker, Jeremy Peña, Michael Brantley, and Yuli Gurriel all hit home runs off Nathan Eovaldi in the second inning as the Astros rolled to a 13–4 victory; Tucker also hit a grand slam in the fourth inning to tie his career best for runs batted in (RBI) with six. On May 19 in a 5–1 win over the Texas Rangers, Altuve doubled for the 344th time in his career to pass César Cedeño for fourth place in franchise history.

May 19–22 vs Texas Rangers: Houston won series, 3–1

Framber Valdez tied his season-high with seven strikeouts over seven innings versus the Rangers on May 19, allowing one run on six hits to lead a 5–1 win. Jose Altuve collected a season-high four hits, and Martín Maldonado's bases loaded double in the eighth inning provided insurance runs.

May 30–June 1 at Oakland Athletics: Houston won series, 3–0

Valdez achieved the first complete game of the season for the Astros, and first of his career lasting nine innings or more, on May 30 versus the A's at Oakland Coliseum. He allowed two total hits in a 5–1 Astros win. The last Astros pitcher to author a nine-inning complete game was Zack Greinke on June 4, 2021, versus Toronto. Alvarez homered twice, and Altuve also homered. On May 31, Chas McCormick hit a tie-breaking home run in the eighth inning versus starter Frankie Montas that resulted in a 3–1 Astros win. Entering the game in a 2-for-23 slump, McCormick also hit an RBI single in the fifth inning among three total hits.

June

The Astros won their fourth game in row on June 1. Justin Verlander took a no-hitter into the seventh inning, and Yordan Alvarez emptied the bases with a go-ahead double in the ninth as the Houston Astros defeated the Oakland Athletics, 5–4, to complete a three-game sweep. Elvis Andrus hit an RBI double to end Verlander's no-hit bit, tying the game at 1, and Christian Bethancourt succeeded with a two-run home run. Houston answered with four ninth inning runs, including a bases loaded double by Alvarez. Verlander received a no-decision and Bryan Abreu (3–0) produced a scoreless eighth inning. In the ninth, Andrus realized a second RBI double of the game to close the gap to one for the A's, but Ryan Pressly induced a groundout from Bethancourt that stranded the tying run at second base for his 10th save.

On June 2, the Astros agreed to a six-year contract extension with Alvarez worth $115 million; the deal bought out three remaining free-agent years that would keep him on the team until the 2028 season.

June 3–5 at Kansas City Royals: Houston won series, 2–1

On June 3, Yordan Alvarez, Aledmys Díaz and Martín Maldonado all homered to lead a 10–3 defeat of the Kansas City Royals for the Astros' fifth consecutive win. Alvarez added a pair of singles for his fifth straight multi-hit game. Díaz, who initiated the scoring with a two-run home in the second inning, also added two singles for his first three-hit effort of the season. Maldonado and Alvarez both hit two-run home runs in the fifth off Brady Singer (2–1), who surrendered eight hits and seven runs in five innings.

Salvador Pérez hit a two-run home versus Luis García (3–4) on June 4 to break a scoreless tie in the sixth and lead a 6–0 shutout of Houston. The Royals ended a five-game losing streak. Michael Brantley collected two of the Astros' five hits, who were shutout for the fifth time of the season.

On June 5, Alvarez hit his 16th home run and Valdez won his fifth consecutive start to close out the series with a 7–4 victory over the Royals. The home run, among three hits, traveled to right field, and extended a hitting streak to seven games. He hit .556 (15-for-27) in that span, including six multi-hit games. Valdez allowed four hits, three walks and two runs over six innings, and struck out five. He turned in a 2.11 ERA over his last six starts (10 earned runs in innings). Closer Ryan Pressly was ejected in the ninth inning after throwing inside to Michael A. Taylor of the Royals.

For the week of May 30 to June 5, Alvarez batted .565/.630/1.217 with two walks, four home runs, eight RBI, and one strikeout in six games. He was named AL Player of the Week for the first time in his career on June 6.

June 6–8 vs Seattle Mariners: Seattle won series, 2–1

Astros reliever Héctor Neris dinged Mariners slugger Ty France in the back, and players and coaches from both sides began shouting at each other.
Seattle manager Scott Servais rushed toward home plate and induced his team into a melee. The Astros met then, and both sides shoved and shouted — except for the 21-year-old rookie Julio Rodríguez, who wrapped up Neris and pulled him away from the scuffle. Rodríguez hit a two-run home run in the ninth moments after his manager was ejected as Seattle won the opener, 7–4. Justin Verlander (7–2) delivered 12 strikeouts over seven dominant innings on June 7 and Yordan Alvarez hit a two-run home run to lead a 4–1 Astros win.

Due to left elbow discomfort, the Astros placed left-handed reliever Parker Mushinski on the 15-day IL on June 7 and recalled Brandon Bielak from Sugar Land to replace him on the roster.

On June 8, starter José Urquidy (5–3) walked a career-high four batters and allowed seven hits and five runs–including home runs to Cal Raleigh and Ty France–over innings. Seattle won, 6–3, for their first series win in Houston since 2018. Alvarez tallied three hits and two RBI for Houston.

June 13–15, at Texas Rangers: Houston won series, 2–1

Utility player Aledmys Díaz assumed duties as starting shortstop after rookie Jeremy Peña sustained a left thumb injury versus the Texas Rangers on June 13 and was placed on the injured list. At the time, Peña had batted .277 with six stolen bases; he led all MLB rookies with nine home runs, and led AL rookies in runs scored (27) and RBI (27).

On June 15, 2022, Luis Garcia and Phil Maton each pitched a immaculate inning versus the Rangers at Globe Life Field, striking out the same trio of Nathaniel Lowe, Ezequiel Durán, and Brad Miller in the second and seventh inning, respectively. This was the first time a major league game has seen at least two immaculate innings pitched, first by two teammates, and the first occurrence of more than one immaculate inning pitched on the same date in the major leagues. Martín Maldonado, the catcher for each of Houston's strikeouts – 14 in all – doubled and homered to help lead an offensive surge in a 9–2 Astros win. The immaculate innings were the eighth and ninth such occurrences in team history.

The Astros claimed outfielder Dillon Thomas off waivers from the Los Angeles Angels on June 15 and transferred center fielder Jake Meyers to the 60-day injured list. At the time, the team did not have a healthy position player available who was on the inactive 40-man roster.

Pitcher Forrest Whitley, once the top prospect in baseball, began a rehabilitation assignment on June 16 with the Florida Complex League (FCL) Astros. He delivered 38 pitches across two innings, allowed three runs and averaged on his fastball versus the FCL Nationals. It was his first competition in professional baseball since September 2, 2019.

June 17–19, vs Chicago White Sox: Houston won series, 2–1

The Astros scored 10 runs in the sixth inning of a 13–3 win versus the Chicago White Sox on June 17, 2022, accounting for their highest-scoring frame since May 29, 2017. The Astros batted 14 times in the sixth as Michael Brantley, Yordan Alvarez and Kyle Tucker each homered. Brantley's home run was a grand slam versus reliever Matt Foster, who had struck out the previous two batters with the bases loaded. Tucker extended a career-high hitting streak to 15 games. Alex Bregman and Yuli Gurriel, both mired in season-long slumps, added big contributions. Bregman (.214 batting average and .694 OPS entering the game) was 1-for-3 with a home run and two walks, and Gurriel (.218 average) was 3-for3 with a home run and two runs scored. On June 18, the White Sox defeated the Astros, 7–0, as they forced Verlander out after innings and a season-high seven runs allowed, his shortest outing of the season. In the June 18 game, both Alvarez and Díaz left due to injury. Díaz left due to left shoulder discomfort in the fifth inning, and Alvarez injured himself while batting in the seventh inning. J. J. Matijevic, starting as the designated hitter, achieved his first major league hit—a home run—on June 19 versus Chicago White Sox starter Michael Kopech in the fourth inning, landing in the Crawford Box seats at Minute Maid Park, in a 4–3 Astros win. Mauricio Dubón started as the shortstop and hit his first home run in an Astros uniform.

June 21–22, vs New York Mets: Houston won series, 2–0

The New York Mets visited the Astros at Minute Maid Park on June 21–22 for a two-game set and the first of nine consecutive versus both New York clubs. On June 21, José Urquidy started for the Astros, recording six innings and reaching a career-high 104 pitches thrown as Houston prevailed, 8–3. He struck out Eduardo Escobar and J. D. Davis with the bases loaded to end the fourth inning. Jose Altuve hit a solo home run for the Astros. Entering the contest, the Mets had scored 5.04 runs per game, the highest in the National League. Alvarez homered three times during the Astros sweep of a two-game set versus the Mets. His 1.064 on-base plus slugging percentage (OPS) at the end of the second game led the major leagues, while his 21 home runs were tied with Mike Trout for second place. Bregman also homered in the second game, decided by a 5–3 score.

June 23–26, at New York Yankees: Houston split series with NYY, 2–2

In the Bronx, the Yankees defeated the Astros, 7–6, on June 23, scoring four runs in the bottom of the ninth inning, capped by Aaron Judge's walk-off single. In the first inning, the Astros' Alex Bregman and the Yankees' Giancarlo Stanton each exchanged three-run home runs. Alvarez followed with another three-run home run in the third inning versus Yankees starter Jameson Taillon. Entering the bottom of the ninth inning, the Astros led, 6–3. Aaron Hicks hit a three-run home run versus closer Ryan Pressly to tie it before Judge delivered the decisive hit.

On June 24, the Astros ended a Yankees' 15-home game winning streak, by a 3–1 score, behind Verlander's seven inning, one run performance. He allowed four hits and delivered nine of his 20 hardest-thrown fastballs on the season to date, averaging , up from on his incoming season average. The lone Yankees run was a Stanton home run in the bottom of the sixth inning. Kyle Tucker hit a three-run home run in the top of the sixth inning to supply the Astros' offense. The Yankees drew a crowd of 47,528, to date a season-high.

The Astros activated Meyers from the 60-day injured list on June 24. To make room for him on both the active and 40-man rosters, the club optioned José Siri to Sugar Land, and designated Dillon Thomas for assignment.

The Astros combined to no-hit the Yankees on June 25, a 3–0 win led by starter Cristian Javier's seven innings. He set career highs with 13 strikeouts and 115 pitches. Héctor Neris pitched the eighth inning, and Pressly closed out the ninth for his 15th save. It was the 14th no-hitter in Astros history, third combined no-hitter, and first no-hitter in the Bronx since June 11, 2003, an effort secured by six Houston pitchers. The Yankees' starting lineup featured two former Astros: Javier's counterpart Gerrit Cole, and at shortstop was Marwin González. Matijevic homered in the seventh inning for the Astros' first run, Altuve homered in the eighth, and Gurriel hit a pinch-hit RBI single in the ninth inning. The Astros are the only team to no-hit the Yankees at home since 1958. Martin Maldonado became the first player to catch more than one combined no-hitter in the major leagues; the previous combined no-hitter he had caught was for Houston on August 3, 2019.

The Astros activated SS Jeremy Peña (left thumb) from the injured list prior to the June 26 game. He doubled and scored on a Mauricio Dubón single and took away a hit from DJ LeMahieu in his first game back. Optioned to AAA was Chas McCormick.

In the series finale on June 26, Jose Altuve led the game off with a home run on the first pitch from Nestor Cortés for his seventh leadoff home run, tying him with ex-teammate George Springer for the league lead. Starting pitcher José Urquidy continued Houston's mastery, going to eight outs from a second consecutive no-hitter before Stanton hit a solo home run with one in the seventh. Urquidy left with the Astros leading, 3–1. Having pitched consecutive hitless innings, the Astros staff tied an expansion-era record (since 1961) with the 1981 Astros versus the 1981 Dodgers lineup. In the eighth inning, LeMahieu homered versus Phil Maton to tie the game at three. In the top of the tenth inning, two Yankees miscues presented a big opportunity for the Astros. Catcher Jose Trevino's throw to second base to pick Jason Castro off found the base empty; he instead was on the move and stole third base. Shortstop Isiah Kiner-Falefa misplayed an Altuve ground ball to allow him on base. Michael King then walked Alex Bregman. However, the Astros could not capitalize as King (5–1) stranded the bases loaded. Judge walked off the Astros for the second time in four days, hitting the game-winning three-run home run in the bottom of the tenth inning versus Seth Martinez (0–1) for a 6–3 final score. Before the home run, Martinez had forged a -inning scoreless streak, second in the AL only to teammate Ryne Stanek's innings.

Despite earning a split, the Yankees did not lead for a single inning in the four-game series against the Astros. An average of 45,176 fans attended per game, the highest for a series at Yankee Stadium since 45,675 when Cleveland visited in 2019.

June 28–29, at New York Mets: Houston won series, 2–0

At Citi Field in Queens, New York, Kyle Tucker hit a three-run homer in the first inning to back Framber Valdez' eight shutout innings as Houston prevailed, 9–1. Yordan Alvarez hit his 23rd home run among three total hits and two walks. Yuli Gurriel also homered and Alex Bregman had three hits. Tucker led off the fourth inning with 12-pitch walk, then stole his 14th base, and scored on a Jake Meyers single. Valdez allowed six hits, struck out four and induced 12 ground ball outs. Astros right-hander Enoli Paredes, pitching the ninth inning for his first outing of the year with Houston, gave up the shoutout. He was assisted by a stellar catch from left fielder Chas McCormick, who snagged a foul pop-up over the railing in foul territory from Eduardo Escobar. Paredes then walked James McCann with two outs and the bases loaded. Mets starter Carlos Carrasco struggled in a second straight start versus Houston, allowing six runs, six hits, and three walks in innings. Michael Brantley was placed on the 10-day injured list for right shoulder discomfort; McCormick and Paredes were recalled from Sugar Land.

Justin Verlander was the starting pitcher and Jason Castro the starting catcher for the finale against the Mets on June 29. The Astros hurled a shutout, winning 2–0, with Verlander (10–3) tallying eight of the innings and Pressly closing out the ninth inning for his 16th save. Verlander became the first pitcher in 2022 to reach double-figures in wins and turned in the fourth-lowest ERA (2.03) in the sport. In the eighth inning, Peña collided Alvarez while running for a Dominic Smith shallow fly ball; both men left the game. Alvarez laid on the ground for several moments before being carted off the field. The game remained scoreless until the ninth inning. In the top of the ninth inning, Castro, facing reliever Drew Smith, hit his first home run of the season with Gurriel on base to put the Astros ahead, 2–0.

June 30, vs New York Yankees: Houston won series, 1–0

The Astros got ahead of the Yankees early at Minute Maid Park after a two-run double from Alex Bregman. Luis García (6–5) hurled innings for the Astros, allowing three hits and one run with six strikeouts. Jake Meyers doubled to lead off the bottom half of the third inning. Aledmys Díaz and Kyle Tucker drew consecutive walks with two outs, loading the bases. Bregman's double scored Meyers and Díaz and Tucker reached third. With Yuli Gurriel batting, Yankees starter Luis Severino removed his PitchCom device and held the speaker to his ear, apparently unable to hear Jose Trevino's signals. Tucker, noting that Severino was distracted, raced toward home plate. Still holding the PitchCom device in his right hand, and ballcap in his left, Severino maneuvered to free his right hand and threw to Trevino, who narrowly tagged Tucker out to end the inning. Anthony Rizzo hit a solo home run for the Yankees in the sixth inning, but the Astros held on to win, 2–1.

Alvarez named Player of the Month. Yordan Alvarez won the American League (AL) Player of the Month Award for June, his first (previously, he had won three AL Rookie of the Month Awards in 2019). Over 23 games, he batted .418/.510/.835/1.346, garnering four doubles, one triple, nine home runs, and 28 RBI. He led the league in batting, on-base percentage, slugging percentage, on-base plus slugging percentage (OPS), and RBI, and ranked fourth the in the AL in home runs. He posted an equal number of bases on balls (BB) and strikeouts (SO)—13.

July

Following a left knee injury to Jason Castro, the Astros selected the contract of catcher Korey Lee from AAA Sugar Land on July 1, 2022, and promoted him to the major league roster that day. Castro was placed on the 10-day IL.

July 1–3 vs Los Angeles Angels: Houston won series, 3–0

Cristian Javier, making his first start since the combined no-hitter, threw seven innings and allowed one run on one hit, striking out 14 in an 8–1 Astros win. A home run to Shohei Ohtani in the first inning was the only baserunner that Javier (6–3) allowed aboard. The 14 strikeouts established another new career high, and the 27 counting those from the previous start made Javier the only pitcher in the modern era to achieve that number of strikeouts in a span of two starts while allowing one or fewer hits. He was the fourth pitcher in franchise history to attain 13 or more strikeouts in consecutive starts, and the first since Gerrit Cole in 2019. In the sixth inning, Chas McCormick made a key leaping catch in front of the left field wall to rob Andrew Velazquez of a hit. Yuli Gurriel, McCormick, and Jake Meyers all homered off Michael Lorenzen (6–6) to harangue him eight runs within the first three innings.

The Astros scored six runs in the third inning. Tyler Wade's throwing error allowed leadoff hitter Jeremy Peña to reach base, Kyle Tucker singled and Alex Bregman hit a sacrifice fly to score Peña and make it 3–1. Gurriel walked, J. J. Matijevic hit a double, Meyers singled home Tucker, and McCormick homered, extending the lead to 8–1.

Peña returned after missing the previous contest versus the Yankees following the outfield collision with Alvarez on June 29, who remained out of play on July 1. Lee made his major league debut in the eighth inning as a pinch hitter for Martín Maldonado and was retired to on popup.

On July 2, catcher Martín Maldonado, second baseman Jose Altuve, and starter José Urquidy led a 9–1 rout of Los Angeles as Houston delivered their 50th win of the season. Maldonado homered twice, Altuve homered, doubled twice, and stole a base, and Urquidy (7–3) allowed one run on two hits while striking out eight over six innings. Kyle Tucker and Chas McCormick also homered for Houston. The fifth straight win for the Astros, it was also the fifth consecutive contest in which they allowed one run or fewer. In the fourth inning, Maldonado and Altuve struck back-to-back home runs. Alvarez returned as the designated hitter after missing two games due to the collision in the outfield, going 0-for-4 with a walk.

The Astros concluded the series with Los Angeles establishing a number of records and personal bests on the way to a 4–2 win, led by Peña, Framber Valdez, and Altuve. Peña produced both his first career four-hit and multi-homer game, as well as the rookie's second career walk-off home run. With a 2-all score, two outs, and Altuve aboard in the bottom of the ninth, Peña homered off Ryan Tepera (1–2). Altuve appeared in his 1,500th career game and forged three hits. Valdez produced his 13th consecutive quality start, while reaching a career-high with 13 strikeouts, among five walks. Twelve consecutive outs Valdez produced were via strikeout, supplanting the franchise record of nine previously accomplished by Don Wilson, Randy Johnson, and Gerrit Cole (twice). Further, the Astros struck out a franchise record 20 batters over a nine-inning game. Héctor Neris struck out two in the seventh, Rafael Montero two in the eighth, and Ryan Pressly (2–2) retired the side on strikeouts in the ninth. Per STATS, the Astros become the first team in major league history to record 48 strikeouts over a three-game series without playing extra innings.

July 4–7 vs Kansas City Royals: Houston won series, 3–1

Jake Odorizzi was activated from the injured list on July 4 after missing 42 games to start against the Kansas City Royals. As they had one off day prior to the All-Star break starting July 18, the Astros shifted to a 6-man starting rotation. Enoli Paredes was optioned to make room for Odorizzi.

Despite having won only once in just 12 times when their opponents scored first, the Astros made their biggest comeback of the season. After trailing by five runs in opener versus the Royals, Alvarez provided a second consecutive walk-off. Starting pitcher Jake Odorizzi struggled with command, unable to get ahead of hitters, to induce swings and misses, or weak contact. The Astros found themselves in a 5–0 deficit after three innings. MJ Melendez homered twice for Kansa City, including once versus Odorizzi, whose afternoon concluded after four innings and 90 pitches. Houston starters had yielded a 0.67 ERA and the staff 10 earned runs overall in the previous ten contests. The Astros scored once each in the fourth, fifth and seventh innings. In the eighth, Royals reliever Amir Garrett walked two of three batters he faced before both runners scored on a Kyle Tucker single to center field. Taylor Clarke then relieved Garrett, who yielded a slowly-hit ground ball to Yuli Gurriel that snuck through the Kansas City infield to score Tucker and tie the game at 6. Alvarez launched a fastball from Scott Barlow for a solo home run in the bottom of the ninth inning, giving the Astros a 7–6 victory.

On July 5, the Astros won their eighth consecutive contest, 9–7. Former Astros standout Zack Greinke, now pitching for the Royals, was honored with a video tribute before the game. Astros batters got ten hits and six runs over five innings against him, including home runs from Bregman and Peña in the fifth inning. Aledmys Díaz got three hits and a two-run home run off reliever Jackson Kowar. Alvarez turned his first career double play and hit his 25th home run. Entering the eighth inning, Houston held an 8–5 lead. The Astros infield appeared to have turned a routine double play, but the Royals challenged, contending that Jose Altuve failed to touch second base to eliminate the lead runner and his throw to first was late. After review, the call on both outs was overturned, and the Royals were then positioned with runners on first and second with no outs. After Houston reliever Bryan Abreu walked home a run, he was removed in favor of Phil Maton, which resulted in Nicky Lopez hitting a fly ball to Alvarez in left field. Alvarez rifled the ball home to Maldonado on a carom, who applied the tag to Hunter Dozier racing for home in time for the out. Rafael Montero pitched the ninth for his sixth save.

The Royals homered three times off Cristian Javier (6–4) on July 6 en route to 7–4 win to terminate the Astros' eight-game winning streak. Whit Merrifield, the leadoff hitter, homered on the third pitch of the game, and Hunter Dozier and Emmanuel Rivera also connected versus Javier. It was his first loss since June 6 and the three home runs allowed tied a career high. In the sixth inning, Díaz homered in a second straight game for Houston.

The Astros concluded the mathematical first half of their season with a 53–28 record, including 26–12 at home.

Houston won the final game of the series versus Kansas City, 5–2, behind Justin Verlander's (11–3) six innings and two runs, pushing further his AL-leading win total. Martín Maldonado led the offense with a double among three total hits and one walk, Altuve (17) and Alvarez (26) both homered, and Altuve drive n three including Maldonado after his double. Verlander, who allowed seven hits and one earned run over six innings, struck out eight. Continuing an impressing return from Tommy John surgery, his ERA to shrunk to 2.00; his ERA, opponent average (.190) and WHIP (0.97) all ranked second in the AL. Dusty Baker (2,041) took over sole possession of ninth place in wins among managers, passing Walter Alston.

July 8–10 at Oakland Athletics: Houston won series, 2–1

With MLB All-Star starters announced, Altuve was named starter at second base for the American League. It was his eight selection overall, and fifth as a starter, both franchise records. He led AL second basemen in on-base percentage (.368), slugging percentage (.539) OPS (.907) and home runs (17). Craig Biggio (seven) previously held the record for most appearances. Dusty Baker, by rule of having been manager of the Astros in the 2021 World Series, was named manager of the American League.

On July 8, José Urquidy started the series opener versus Oakland and reached a career high eight innings in an 8–3 win. Urquidy (8–3) was charged with all three runs, and, over his last 27 innings, had allowed six to score to lower his ERA from 4.99 to 4.08. Alex Bregman and Martín Maldonado both homered for Houston, Yuli Gurriel stroked three base hits and every starter in the lineup mustered at least one hit for 14 total hits. A's starter Paul Blackburn (6–4) retired the first 10 Astros batters allowing consecutive one-out doubles to Díaz and Alvarez.

Limited to four hits on July 9 for the fourth consecutive game, Oakland held on to defeat Houston, 3–2, largely behind a solid effort from left-handed starter Zach Logue. Logue held the Astros to two hits over his five innings, including retiring the final ten batters he faced. Framber Valdez (8–4), who last hurled a complete game versus Oakland on May 30, repeated the effort, this time on the losing end for Houston. He matched Sandy Alcántara of the Marlins as the only pitchers to have tossed two complete games for the season thus far in the major leagues.

Four more Astros were named to the All-Star team per MLB's unveiling of the reserves and pitching staffs on July 10. Verlander received his ninth overall selection, and the trio of Alvarez, Tucker, and Valdez were named for the first time. Alvarez was leading the major leagues in OPS (1.058) and third in home runs (26). Valdez put together a stellar first half with an ERA (2.64) second on the Astros' staff to only Verlander (2.00). Tucker batted .259 with 16 home runs, ranked fourth in the AL in RBI (58) and tied for fifth in steals (14). He garnered 10 Defensive Runs Saved, per Fangraphs, tied with Brett Phillips for the lead among AL outfielders. Per STATS, LLC, Verlander became the first pitcher in history to have reached or exceeded the following as of an All-Star break: 2.00 ERA, 12 wins, .800 winning percentage, .200 batting average against, 0.900 WHIP, and a strikeout-to-walk ratio of 5.00.

Due to lingering right hand inflammation, the Astros placed Yordan Alvarez on the 10-day injured list. Stemming from an injury that occurred while swinging versus the White Sox on June 18, he subsequently missed time but the condition had become “progressively worse,” commented manager Dusty Baker. It precluded him from participating in the All-Star Game. The Astros called up José Siri from AAA Sugar Land to take Alvarez' place on the active roster.

Starting pitcher Jake Odorizzi delivered seven stellar innings on July 10, Korey Lee achieved his first three major league hits and RBI, and Kyle Tucker hit his 17th home run as Houston cruised to a 6–1 win. It was their 11th win in 13 games. In the fifth inning, Lee hit a soft single through the infield to score Jake Meyers for his first hit and RBI. Lee added a two-run double in the seventh and singled to lead off the ninth. Odorizzi (4–2) threw seven scoreless innings and struck out a season-high seven.

July 12–14 at Los Angeles Angels: Houston won series, 2–1

On July 12, Kyle Tucker hit a tie-breaking RBI double in the ninth inning to deliver a 6–5 win. The win gave the Astros four wins in five games, and 21 of 27, moving the club to a season-high 28 games above .500 at 57–29. Aledmys Díaz hit an early two-run home run and Alex Bregman and Altuve hit RBI singles. In spite of Luis García's six scoreless innings, the bullpen and defense allowed four to score in the seventh, with Phil Maton being charged four unearened runs. Hector Neris (2–3) navigated the eighth, and Ryan Pressly closed it for his 19th save. García's one hit allowed was a career-best through his first 45 major league starts. His sixth quality start of the season, it was the 17th consecutive produced on the road by Houston pitching. Per an AT&T SportsNet broadcast, the quality start extended the longest streak franchise history, exceeding the 1972 club (14).

The Angels won on July 13, 7–1, largely behind the effort of Shohei Ohtani, who hurled six strong innings and hit a two-run triple. Winning his sixth straight start (9–4), Ohtani struck out 12. Cristian Javier lasted just innings, allowing three runs with 10 strikeouts. It was the first double-digit strikeout effort with less than four innings completed by a starting pitcher since Cleveland's Danny Salazar in 2014. Combining for 32 strikeouts, Houston (15) and Los Angeles (17) set an American League record.

In the first inning on July 14, Jose Altuve left the game after being hit by the first pitch from Reid Detmers. The next three Houston batters also reached base, who took a 2–0 lead on a Kyle Tucker single. In the tenth inning, Jeremy Peña's single scored automatic runner Korey Lee for a 3–2 score. Ryan Pressley (3–2), who pitched both the ninth and tenth innings, struck out Brandon Marsh with the tying run on third base in the tenth to end the contest.

July 15–17 vs Oakland Athletics: Oakland won series, 2–1

A three-run home run from Skye Bolt and Cole Irvin's (4–7) six sharp innings helped lead a 5–1 Oakland win over Houston in the series opener. José Urquidy (8–4), who had won three straight decisions, took the loss. He allowed six hits and three runs, striking out nine over innings. Offensively, the Astros connected for four hits, and were held hitless until Alex Bregman singled with two outs in the fourth.

On July 16, Houston won, 5–0, behind Verlander's six scoreless innings and one inning each from Phil Maton, Héctor Neris, and Bryan Abreu. Martín Maldonado hit a grand slam, and Jose Altuve, starting at designated hitter after missing one game, stroked a single. With two outs in the second inning, Yuli Gurriel and Jake Meyers hit consecutive singles before Chas McCormick walked to load the bases, and Maldonado followed with his drive versus rookie Jared Koenig (1–3). Verlander (12–5) upped his major league-league leading win total while dropping his ERA to 1.89, which ranked third in the major leagues. His 10 strikeouts pushed his career total to 3,121, moving him to 14th all time, passing Curt Schilling (3,116) and Bob Gibson (3,117).

Stephen Vogt hit a tie-breaking single in the eighth inning to lead 4–3 win versus the Astros on July 17. Tucker and Peña homered for Houston, who finished their All-Star break first half at 59–32, the second-best record in the AL. Pressly, who struck out the side in the ninth inning, tied the Astros' franchise record with 27 consecutive batters retired first achieved by Dave Giusti in 1965. Pressly's streak occurred over eight straight outings.

July 21 vs New York Yankees ×2: Houston won series, 2–0

On July 21, the Astros activated Yordan Alvarez and Parker Mushinski from the 10- and 15-day injured lists, respectively, moved Ryan Pressly to the paternity list, and optioned José Siri to Sugar Land.

The New York Yankees visited the Astros for a July 21 doubleheader, just the third played at the domed Minute Maid Park since it opened in 2000. The doubleheader games were makeup games for part of the June 30 series that was postponed as a consequence of the lockout. In the bottom of the ninth inning of the first game, pinch hitter J. J. Matijevic hit a walk-off infield single with the bases loaded to score Alex Bregman for a 3–2 win. Cristian Javier, on the mound against New York since starting the combined no-hitter on June 25, tied his season high with four walks allowed with one run over five innings. Yordan Alvarez returned to the starting lineup in the second game, greeting Domingo Germán (0–1), who made his season debut, with a home run in the first inning. The next hitter, Alex Bregman, also homered as the two sluggers combined for five RBI. The Astros won, 7–5, to sweep the doubleheader and win the season series, 5–2. Per ESPN Stats and Info, the Yankees hit .151 (33-for-229) in the seven games versus Astros pitching, the lowest mark in franchise history with at least five games played against one opponent in a single season. New York had the best record in baseball and were on pace to win 110 games.

July 22–24 at Seattle Mariners: Houston won series, 3–0

The Houston Astros opened a series at T-Mobile Park by snapping the Mariners' 14-game winning streak, and Jose Altuve, Yordan Alvarez, Martín Maldonado all homered in a 5–2 score. It was one win short of the longest in Mariners' franchise history, accomplished during their historic 2001 campaign. Starter José Urquidy (9–4), who allowed one run on four hits over six innings, had previously been batted around for 27 hits and 15 earned runs in 13 innings opposing Seattle for a 10.38 ERA. Entering the eight with the bases loaded and tying run aboard, Ryne Stanek closed out the inning and extended a personal scoreless inning streak to 27. A season-high 45,290 fans were in attendance. Justin Verlander became the majors' first 13-game winner on July 23 behind seven innings of one-run ball to lead a 3–1 win, winning his fifth start in a row, while lowering his ERA to 1.86, second in the majors to Tampa Bay's Shane McClanahan (1.71). Both Yuli Gurriel and Kyle Tucker hit RBI doubles in the fourth inning. Bryan Abreu finished off the last three outs for his first save on the season. In the final game of the series, Altuve and Jeremy Peña led off the game with back-to-back home runs versus Robbie Ray (8–7), leading to an 8–5 victory. It was Altuve's major-league leading eighth leadoff home run. Martín Maldonado drove in three on two hits, and Framber Valdez (9–4) carried a shutout into the seventh inning. Ryan Pressly retired three batters faced in the ninth to establish a new Houston club record among relievers for consecutive batters retired, at 30.

July 25–27 at Oakland Athletics: Oakland won series, 3–0

Former Astro Tony Kemp homered versus Jake Odorizzi (4–3) as Adam Oller (1–3) earned his first major league win in a 7–5 Oakland victory on July 25. Odorizzi, 4–0 in seven previous starts, yielded the home run to Kemp in the third inning while a blister on his pitching hand began to develop. Jeremy Peña homered in the first inning for Houston, who had won five in a row in the since the All-Star break, and were an AL-leading 28–10 since June 12. Chad Pinder hit his second grand slam in two weeks as the A's held on to defeat the Astros, 5–3, on July 26. Kyle Tucker hit his 19th home run and Yordan Alvarez collected two hits for the Astros. The A's also won the series' final game on July 27, 4–2, for their first sweep of the season. Alvarez hit his 29th home of the season. Tony Kemp tallied another strong game, collecting three hits and one RBI. The sweep upped the A's AL-worst record to 38–63 but they had won six of eight versus the AL West-leading Astros (64–35).

July 28–31 vs Seattle Mariners: Houston won series, 3–1

Alex Bregman connected for a two-run home run and added an RBI double in the eighth inning to help lead Houston to a 4–2 win versus the Mariners on July 28. Rafael Montero (4–1) recorded four perfect outs and Ryan Pressly architected a scoreless ninth for a 21st save in 24 chances. Pressly retired the first two batters before J. P. Crawford singled to reach 32 consecutive hitters retired, a streak that tied Justin Verlander (2019) for most in Astros history among all pitchers. Verlander (14–3) took one-run ball into the eighth inning on July 29 en route to an 11–1 win over Seattle. Yuli Gurriel and Yordan Alvarez stroked consecutive singles in the fourth before Bregman hit a two-run double for a 4–0 lead to chase Mariners starter Robbie Ray (8–8). Aledmys Díaz homered twice, and Alvarez and Mauricio Dubón also homered. The 240th win of Verlander's career, it moved him into a tie with Frank Tanana for 56th all-time. Alvarez, who was 3-for-3, established a team record by reaching 30 home runs in the fewest appearances, doing so in his 84th game of the season.

Former Astro Abraham Toro delivered a pinch-hit two-run single in the ninth inning on July 30 versus Pressly (3–3) to rally Seattle to a 5–4 victory. It was Pressly's first blown save since June 23 versus New York, and fourth in 25 chances in 2022. Díaz again homered, finishing 3-for-3 with two RBI and one walk. Framber Valdez allowed three runs on five hits, walked one and struck out seven over seven innings. It was his majors-leading 18th quality start, and 17th consecutive, the second-most in Astros history. On July 31, Yordan Alvarez delivered a single to drive in Jose Altuve in the bottom of the tenth for the 3−2, game-winning run. Jake Odorizzi delivered seven shutout innings for a game score of 79, allowing just two hits and one walk while establishing a season-high of eight strikeouts. In the first inning, Altuve stole home on a double steal as Gurriel took second for the Astros' first run, and Kyle Tucker singled home Gurriel for the second run.

August

Trade deadline transactions

On August 1, the Astros acquired Baltimore Orioles first baseman and outfielder Trey Mancini in a trhee-team trade that also involved the Tampa Bay Rays, from whom they received pitcher Jayden Murray. Baltimore received Seth Johnson from Tampa Bay, and pitcher Chayce McDermott from the Astros. Houston sent outfielder José Siri to Tampa Bay . Houston also traded on August 1 minor league players Enmanuel Valdez and Wilyer Abreu to the Boston Red Sox to acquire catcher Christian Vázquez.

August 1–3 vs Boston Red Sox: Boston won series, 2–1

Jarren Duran homered and collected three runs batted in (RBI) on August 1 to lead a 3–2 Red Sox win. Nate Eovaldi (5–3) rebounded from a loss versus Houston on May 17, in which he allowed a record-tying five home runs in one inning. He recorded innings, allowing no earned runs and four hits with six strikeouts. The Astros acquired Red Sox catcher Christian Vázquez during this game's pregame phase. On August 2, Rafael Devers homered in a return from the injured list to power the Red Sox to a 2–1 win. Starter Cristian Javier (6–7) worked six innings, yielding four hits and two runs and striking out seven, in his fourth straight loss. New acquisitions Vázquez and Trey Mancini both made their Astros debuts as pinch hitters in ninth inning. Catcher Jason Castro had surgery on the left knee and was ruled out for the remainder of the season. Trey Mancini went deep for his first hit as an Astro on August 3 to help lead a 6–1 win. José Urquidy (10–4) spun 7 scoreless innings, delivered a game score of 83 and tied his career high of 10 strikeouts. Reliever Will Smith, making his Astros debut, allowed a solo home run in an otherwise clean ninth inning. Vázquez made his first start as catcher for Houston. Jose Altuve, who crafted the 34th four-hit game of his career, tied Craig Biggio for most in team history.

August 4–7 at Cleveland Guardians: Houston split series with CLE, 2–2

On August 4, Justin Verlander (15–3) pitched six scoreless innings to increase an MLB-leading win total, and Chas McCormick and Martín Maldonado both homered with three RBI as Houston took the opener in Cleveland, 6–0. Mancini homered twice on August 5, including his first career grand slam, and drove in five runs to lead a 9–3 win over the Guardians. Jose Altuve added three hits, a double, and an RBI for Houston. On August 6, Cal Quantrill (8–5) tossed six scoreless innings to remain undefeated at Progressive Field (11–0 in 26 career starts) as the Guardians breezed past the Astros, 4–1. Aledmys Díaz started at shortstop and doubled twice, driving in Houston's lone run in the ninth. On August 7, Triston McKenzie (8~8, game score 85) tossed eight scoreless innings and catcher Luke Maile hit his first home run since May 20, 2019, as the Guardians handed Houston their 7th shutout loss of the season, 1~0. Cristian Javier (6~8, game score 60) lost a fifth straight decision for the Astros, going six innings while allowing six hits, allowing the solo home run to Maile, and striking out four.

August 9–11 vs Texas Rangers: Houston won series, 2–1

The Astros halted Martín Pérez' nine-game winning streak (9–3), tagging him for seven runs, including a game-tying grand slam from Aledmys Díaz, helping to result in a 7–5 win on August 9. José Urquidy (11–4) earned a third consecutive win in spite of allowing five runs and a season-tying high of three home runs. Leody Taveras hit a bases-clearing double in the tenth inning on August 10 versus Phil Maton (0–2) to lead an 8–4 Rangers victory. Kyle Tucker and Yordan Alvarez both hit solo home runs for Houston. On August 11, Framber Valdez (11–4) notched a major-league leading 19th consecutive quality start, and second-longest in franchise history to lead a 7–3 victory over Texas. Alex Bregman and Martín Maldonado homered and drove in three runs each, and Yuli Gurriel broke an 0-for-12 slump with three hits to tie his season high.

August 12–14 vs Oakland Athletics: Houston won series, 3–0

Outfielder Michael Brantley was ruled out for the rest of the season on August 12, having undergone right shoulder surgery. In the midst of another excellent season, his .370 on-base percentage ranked second on the team at the time of the surgery.

Kyle Tucker hit a grand slam versus reliever Sam Moll (1–2) in a six-run fifth inning on August 12 versus Oakland to rally Houston from a 2–0 deficit, catalyzing in a 7–5 Astros win. Starter Luis García (9–8) hurled six innings with six strikeouts, allowing four runs on eight hits. He snapped a three-game losing streak after the Astros' lineup had scored three runs or fewer in each of those starts. Reliever Héctor Neris threw a scoreless ninth for his second save. On August 13, Lance McCullers Jr. made his season debut and earned the win versus the A's (1–0, game score 69). He hurled six shutout innings, allowed two hits, walked four, and struck out five. Alex Bregman homered, Trey Mancini collected three hits, and Tucker and Chas McCormick both stroked an RBI triple for Houston.

Astros Hall of Fame induction. On August 13, former outfielder Terry Puhl and former executive Tal Smith were inducted into the Astros Hall of Fame during a pregame ceremony.

Uvalde shooting victims honored. Prior to the August 14 game versus Oakland, the Astros chartered 10 buses to transport approximately 500 family members and friends of the victimes of the Robb Elementary School shooting on May 24, 2022, in Uvalde, Texas. In a pregame event, the group met with Dusty Baker, Jose Altuve, Bregman and McCullers, who each spoke and answered questions. The Astros also distributed 2,500 additional free tickets to residents of Ulvade and held fundraisers where all proceeds went to those affected by the shooting. During the game, Astros starter Cristian Javier hurled six shutout innings, allowing one hit and three walks while striking out six, as the Astros prevailed, 5–3. Over his previous six outings, Javier had gone 0–5 with a 4.40 ERA. Bregman hit a two-run home run in the first inning for the second consecutive day, and Altuve added two RBI. Christian Vázquez produced his first three-hit game as an Astro.

August 15–18 at Chicago White Sox: Houston split series with CHI, 2–2

On August 15, the White Sox defeated Houston 4–2 largely behind a masterful effort by starter Johnny Cueto. A four-run eighth inning sunk Houston predicated on a rare collapse by Houston reliever Rafael Montero (4–2), charged three of the runs without having recorded an out. Astros starter José Urquidy threw hitless innings and was removed after A. J. Pollock got the first hit for Chicago. On August 16, the Astros ended a record 14 consecutive starts of one run or fewer allowed by Dylan Cease, who yielded three runs in five innings. Gavin Sheets hit a game-tying two-run double off Justin Verlander in the seventh inning. Yoán Moncada drove in the go-ahead run in the eighth for the second consecutive night, this time versus Héctor Neris (4–4). Chicago won, 4–3. The Astros won 3–2 on August 17 after having blown late-inning leads the prior two games. Framber Valdez (12–4) delivered seven innings of two-run ball for his 20th consecutive quality start on August 17, tying Mike Scott's club record established during his Cy Young-winning season in 1986. Yordan Alvarez led the way offensively, scoring a run and driving in another. The Astros concluded their season series with Chicago winning 21–5, spearheaded by Alex Bregman's two home runs, two doubles and six RBI. The 21 runs tied for second-most in franchise history. Bregman, Kyle Tucker, and Christian Vázquez each tied their career high with four hits. Chas McCormick, who tallied five RBI, and Trey Mancini, also homered for Houston. The Astros totaled 25 hits, tying the franchise record.

August 19–21 at Atlanta Braves: Atlanta won series, 2–1

The Astros dropped the first game of a rematch of the 2021 World Series, 6–2, to the Atlanta Braves at Truist Park. Slugger Yordan Alvarez left in the fifth inning due to an episode of shortness of breath and his replacement, Mauricio Dubón, exited an inning later after crashing into the outfield wall while tracking a Dansby Swanson fly ball. On August 20, Cristian Javier hurled six innings of two-hit and one-run ball with eight strikeouts for a game score of 71. Jeremy Peña hit a first-inning home run and drove in the go-ahead run in the top of the 11th inning. The Braves won in the bottom of the 11th, 5–4.

On August 20, the Astros selected infielder David Hensley's contract to promote him to the major leagues.

Former Astro Charlie Morton struck out 11 on August 21, just the third starter in 2022 to strike out double-figures in Astros hitters, following Shohei Ohtani and Kevin Gausman. Astros starter José Urquidy (12–4) allowed two runs over seven solid innings, striking out six, as Houston won the finale, 5–4. The Astros had won 15 of his last 20 starts, and over his last 11, Urquidy was 7–1 with a 2.48 ERA. Alvarez returned to play after a one-game absence, collecting two hits and an RBI, and scored the go-ahead run in the eighth when Kyle Tucker singled.

August 23–25 vs Minnesota Twins: Houston won series, 3–0

On August 23, Justin Verlander left a no-hitter intact after six innings with 10 strikeouts on the way to extending a major-league leading 16 wins to lead a 4–2 victory over Minnesota. Ryne Stanek allowed the first hit to former Astro Carlos Correa in the top of the seventh, who received a warm and lengthy ovation from the Houston crowd in a return during his first at bat. It was Verlandfer's second no-hit try versus the Twins on the season; in May, he lost a no-hit bid after eight innings. Alex Bregman's home run provided insurance for a 4–0 lead. Yordan Alvarez collected a single in front his family, who had just left Cuba and saw him play professionally for the first time. Framber Valdez (13–4) authored a new franchise record 21st-consecutive quality start on August 24 versus the Twins, allowing two hits and one run in seven innings and getting eight strikeouts to lead a 5–3 Astros win. On August 25, the Astros defeated the Twins 6–3 with a solid outing by Luis García, who gave up 3 runs in 5 innings while striking out five Twins batters. On the other side of the ball, Trey Mancini hit a 3 run homer which ended up being the difference in the game as Twins starter Chris Archer allowed 5 runs in 4 innings. The Astros swept not only this series from Minnesota but also swept the season series outright.

August 26–28 vs Baltimore Orioles: Baltimore won series, 2–1

On August 26, Orioles rookie starter Kyle Bradish (2–5) allowed just two hits over eight brilliant innings to lead an Orioles' shutout of the Astros, 2–0. A two-run home run in the sixth inning by catcher Ramón Urías provided all the offense in the contest, who hit it off Cristian Javier. Astros starter Lance McCullers Jr. allowed a season-high four bases on ball while pitching five shoutout innings. Javier (7–9), making his first relief appearance since April, hurled three total innings and struck out four. On August 27, the Orioles again leveraged a sharp pitching performance from a young starter for a 3–1 win. Dean Kremer (6–4) allowed four hits in a career-high innings, and Anthony Santander and Austin Hays both homered for the Orioles. For the Astros, Kyle Tucker went hitless to end a career-best 17-game hitting streak, and David Hensley made his major league debut, starting at shortstop and going 0-for-3. Justin Verlander started the series finale, leaving after three scoreless innings and six strikeouts due to right calf discomfort. The bullpen took over, and Houston won the finale, 3–1. Verlander's shortest outing of his season, it broke a string of a club-record 41 of at least five innings each by Astros' starting pitching. Seth Martinez took over for Verlander, and Bryan Abreu, Ryne Stanek (2–1) and Héctor Neris followed. In the bottom of the third, Hensley doubled off Orioles' starter Austin Voth for his first major league hit. The game remained scoreless until Yuli Gurriel's two-run groundball single in the seventh inning. Tucker doubled twice, and Alex Bregman walked twice, scored twice, and homered in the eighth inning (20). Rafael Montero allowed one run on three hits striking out Rougned Odor for the final out and securing the save (9). Mauricio Dubón, starting in center field, collected one single and two outfield assists, rifling out both Robinson Chirinos and Jorge Mateo at third base.

August 30–31 at Texas Rangers: Houston won series, 2–0

Framber Valdez hurled eight innings and allowed two runs in a 4–2 win versus Texas in the opener for his 22nd consecutive quality start—among left-handers, it was both the most consecutive in major league history and highest total in one season, and second-most consecutive among all pitchers. It was the fourth-most overall in one season, tying Hall of Famer Bob Gibson (1968) and Chris Carpenter (2005) behind Jacob deGrom (24 consecutive in 2018). Jose Altuve doubled twice, walked twice, scored twice and drove in two runs lead a 5–3 win over Texas on August 31. Astros right-hander Cristian Javier (8–9) started and worked five innings, allowing three runs and struck out seven. Rafael Montero closed out the ninth for his tenth save, the first time he had recorded double figures in saves in a season.

Bregman named Player of the Month. Entering the month of August with a .773 OPS, Alex Bregman batted 362/.452/.681 with nine doubles, seven home runs, 22 RBI, 17 walks and 27 runs scored over 27 games. It was his third career monthly award, which he had last won in August 2019.

September

The Astros promoted prospects Hunter Brown and Yainer Díaz from Sugar Land to the major league roster for the first time on September 1.

September 2–4 at Los Angeles Angels: Houston won series, 2–1

In the series opener versus Los Angeles, starter Lance McCullers Jr. (2–1) went innings to continue an impressive comeback, allowing two runs, six hits, four walks and striking out seven as Houston won, 4–2. Yainer Díaz made his major league debut, starting as the designated hitter. He was 0-for-3 with a bases loaded walk for his first RBI. Astro starter Luis García (seven innings, seven strikeouts) matched the Angels' Shohei Ohtani (eight innings, five strikeouts) frame-for-frame with one run allowed apiece on September 3. Los Angeles won 2–1 in the bottom of the 12th after Matt Duffy's bloop single drove home automatic runner Taylor Ward. Center fielder Mauricio Dubón raced to catch Duffy's hit but replay showed the ball had dropped just inches from his reach. Ohtani became the 10th-fastest to reach 400 strikeouts. The Astros took the finale on September 4, winning 9–1 on Jose Altuve going 3-for4 with a home run, double, and three RBI. José Urquidy (13–5) delivered seven sterling shutout innings with eight strikeouts and four hits allowed.

September 5–7 vs Texas Rangers: Houston won series, 2–1

All-time franchise record at .500. With a 1–0 win over the Rangers on September 5, the Astros raised their all-time franchise win-loss record to .500 at 4,812–4,812, for the first time since in May 14, 2006 (3,519–3,519). Thus far, the Astros had ended a total of 25 games above .500 since they began play in 1962.

On September 5, Hunter Brown (1–0) started and won a sensational major league debut, hurling the first six innings of a 1–0 shutout of the Texas Rangers. He allowed three hits, one walk and struck out five to outduel Rangers All-Star Martín Pérez. Brown retired the first eight batters, including striking out the first two of the game, Marcus Semien and Corey Seager, for his first career strikeouts. Martín Maldonado, who caught the entire game, singled home Trey Mancini in the second inning for the game's only run. On September 6, Framber Valdez delivered a 23rd consecutive quality start, but Seager scored the go-ahead run in the seventh on a wild pitch from Valdez (14–5) on the way to a 4–3 Rangers win. The Astros committed three errors and were 1-for-11 with runners in scoring position. On September 7, Jose Altuve scored on a wild pitch with two outs and bases loaded in the bottom of the tenth for the winning run (4–3). Héctor Neris pitched the tenth for the Astros to earn the win (5–4).

September 9–11 vs Los Angeles Angels: Houston won series, 2–1

On September 9, center fielder Chas McCormick homered and drove in three runs to lead the Astros to a 4–3 win, backing Lance McCullers Jr. (3–1) in his longest outing of the season with seven innings. Closer Ryan Pressly, in a return from the injured list, allowed a solo home run in the ninth inning to Taylor Ward before ending the game to earn his 26th save. Mike Trout homered for a sixth game in a row on September 10 as the Angels handed the Astros a 6–1 loss. Astros starter José Urquidy (13-6) was ambushed for a career high-tying six runs with ten hits over five innings. Five Astros home runs powered 12–3 win in the series finale on September 11, including from Dubón (5), Alex Bregman (21), Mancini (17), Yordan Alvarez (32), and Kyle Tucker (25). Bregman's home run was his fourth career grand slam to give the Astros the lead for good. Alvarez reached base four times total. Jose Altuve collected three hits and two runs scored for his 12th three-hit game of the season. Starter Luis García (12–8) won after allowing three runs on eight hits and in five innings on 88 pitches, striking out four.

September 12–14 at Detroit Tigers: Houston won series, 3–0

Valdez (15–5) tossed his first career shutout, a 7–0 win versus Detroit on September 12 while tying Jacob deGrom for an in-season record 24 consecutive quality starts (2018). In his second start of the season, Brown made his road debut in his hometown of Detroit, leading a 6–3 defeat of the Tigers. He allowed two runs on five hits in front of friends and family. His alma mater of Wayne State is one mile from Comerica Park. Yordan Alvarez homered and doubled, scoring three runs to power Houston's offense. Houston won 2–1 on September 14 largely between Cristian Javier's six scoreless innings to sweep both the series and season series (7–0) from Detroit. Javier (9–9) allowed two hits and no walks while striking out eight. Kyle Tucker homered leading off the fourth inning and Alex Bregman hit a sacrifice fly the following inning. It was Houston's first sweep of Detroit in a season series since moving to the American League in 2013.

September 15–18 vs Oakland Athletics: Houston won series, 3–1

McCullers hurled six innings on September 15 versus Oakland, issuing four walks, two hits, and two runs as he struck out 11, his most since July 29, 2018. Aledmys Díaz, just activated since the series in Detroit, homered (11) into the Crawford Boxes in the seventh inning to break a 2–2 tie. Seth Martinez (1–1) worked a scoreless seventh to earn his first major league win.

Astros clinch playoff berth on Alvarez' 3-home run game. On September 16, Yordan Alvarez and Justin Verlander led the Astros to a 5–0 victory over the A's to secure a sixth consecutive postseason berth. Alvarez, with a 4-hit performance, hit three home runs in consecutive at bats off A's starter Adrián Martínez. Meanwhile, Verlander (17–3) hurled five hitless innings in a return from a calf injury sustained on August 28, walked one, and struck out nine. He extended a season-long winning streak to nine games while lowering his major league-leading ERA to 1.78. Alvarez hit one home run each hit in the first, third and fifth innings versus Martínez, making him the first Astros player to hit three off one pitcher in the same game.

Valdez' in-season quality start record. In the series finale and last meeting with Oakland for the season, Valdez allowed two runs over six innings for a 25th consecutive quality start, surpassing deGrom's in-season record, as Houston won 11–2. Alvarez and Maldonado each drove in four runs; Maldonado also scored four runs in a game for the first time in his career.

Alvarez earned the AL Player of the Week Award for the week ended September 18. He totaled a .520 average (13-for-25), .556 OBP, 1.280 slugging percentage, 10 runs scored, 10 RBI, four doubles and five home runs.

September 19–21 at Tampa Bay Rays: Houston won series, 3–0

Astros clinch AL West division title. The Astros clinched a fifth AL West division title over the last six season with a 4–0 victory over Tampa Bay in the two clubs' first meeting of the season on September 19. The win also granted Houston a bye through the American League Wild Card Series into the American League Division Series. Luis García (13–8) started the first five innings and won the combined shutout, followed by Brown (three innings) and Neris (one). Jose Altuve hit a leadoff home run (25) and Alex Bregman drive in two runs.

On September 20, Kyle Tucker reached 100 RBI for the first time in his career as the Astros won, 5–0. Yainer Díaz doubled in eighth inning off Javy Guerra for his first major league hit. Starter Cristian Javier did not allow any hits until the fifth inning, the only hit given up in five innings. Astros pitching hurled their 17th shutout of the season and extended a scoreless inning streak to 21. Tampa natives Lance McCullers Jr. and Kyle Tucker led the Astros to a 5–2 win for the series sweep on September 21, the first-ever at Tropicana Field for the Astros. McCullers allowed both runs over seven strong innings to earn the win, and Tucker hit the go-ahead home run in the eighth inning. The Astros' scoreless innings pitched streak reached 26 innings, their longest since a 28-inning streak in 2012.

September 22–25 at Baltimore Orioles: Houston split series with BAL, 2–2

On September 22 and 23, the Astros were shut out in consecutive games for the first time all season, led by brilliant performances from Baltimore starters Dean Kremer and Kyle Bradish for a second-consecutive turn against Houston.

Astros' 100th win is milestone for Baker. On September 24, Houston rallied from a 9–7 deficit in the ninth inning to mount an 11–10 win. Kyle Tucker two-out RBI double the score and Yuli Gurriel followed with a single versus Baltimore closer Félix Bautista (4–4), The Astros' 100th win of the season made manager Dusty Baker one of four in major league history to win the same number in both leagues, joining Sparky Anderson, Tony La Russa and Whitey Herzog.

Cristian Javier retired the first 13 Orioles faced on September 25, allowing one total hit and baserunner over six innings while striking eight for a game score of 78. Cristian Vázquez drove in three runs in extra innings, including a bases-loaded single to cap a four-run 11th inning as Houston won, 6–3.

September 27–28 vs Arizona Diamondbacks: Houston split series with ARI, 1–1

On September 27, Jose Altuve hit two of the Astros' five home runs as Houston won the opener of a two-game set, 10–2. David Hensley hit his first major league home run in the sixth inning versus Ian Kennedy. Former Astros pitching coach Brent Strom returned to Minute Maid Park in game action as a visitor for the first time since resigning his post with the club after the 2021 World Series. The Diamondbacks won the season series finale 5–2 on September 28 with a three-run rally in the tenth inning capped by Christian Walker's two-run single versus Will Smith (0–3). Chas McCormick hit a two-run home in the fifth inning to account for Houston's scoring.

September 30–October 2 vs Tampa Bay Rays: Houston won series, 2–1

In spite of a 7–3 loss to the Rays on September 30, the Astros clinched home-field advantage through the AL Championship Series following a Yankees' 2–1 loss to the Orioles. It was second time Houston secured the top AL playoff seed in franchise history, and third overall, to join the 1980 (NL) and the 2019 (AL) clubs with this distinction. Framber Valdez (16–6) allowed six runs to tie his season high, and 12 runs over his previous innings.

October

Cristian Javier threw six shutout innings on October 1 and Jake Meyers collected two hits in his return from Sugar Land as the Astros won against the Rays, 2–1. Javier (11–9) increased his scoreless streak to innings, the longest active in the major leagues. It was the 103rd win for the Astros, tying the 2018 team for second-most in franchise history, which trailed only the 107 piled on by the 2019 club.
The Astros won again on October 2 versus Tampa Bay, 3–1, securing a new second-best franchise leader at 104 wins. Rookie shortstop Jeremy Peña and starter Luis García led the way, with Peña collecting his eighth three-hit game of the season and driving in all three runs, and García (15–8) establishing a new career-high in wins with one run allowed over six innings. The Astros improved to an incredible 41–6 with Peña batting second in the lineup.

October 3–5 vs Philadelphia Phillies: Houston won series, 2–1

1,000 wins at Minute Maid Park. On October 4, Houston pitching, started by Verlander, took a no-hitter into the ninth inning while the Astros cruised to a 10–0 win over Philadelphia. Jeremy Pena, Kyle Tucker, and Martin Maldonado each homered in the first inning and the Astros piled on five runs in the opening frame before making their first out. Verlander worked the first five innings, Hunter Brown hurled innings and Hector Neris converted two perfect outs. In the top of the ninth, former Astro Garrett Stubbs hit a leadoff single off lefty Will Smith to break up the no-hitter. Verlander (18–4), who struck out 10 batters, collected eight consecutive strikeouts to establish a personal best while tying a franchise record set by Jim Deshaies in 1986. Their 105th win of the season, it moved the 2022 Astros club into sole possession of second place in franchise history behind the 2019 team (107) for most wins in a season. It was also the 1,000th win for the Astros at Minute Maid Park, which opened in 2000.

In the regular season finale, Framber Valdez led a 3–2 win over Philadelphia with 10 strikeouts over five shutout innings. Houston, who won the fourth of their final five games, opened the scoring when Mauricio Dubón doubled home Chas McCormick in the third inning. Christian Vazquez hit a solo home run, hsi first as an Astro, and Yordan Alvarez also drove in a run. Ryne Stanek pitched a clean seventh to lower his ERA to 1.16, setting a franchise record that eclipsed Will Harris' 1.50 ERA set in 2019.

Regular season accomplishments

With a 106-win season in 2022, the Astros became the first major league team to reach 100 wins four times in a six-year span. Over the previous fifty seasons, they had tallied five 100-win seasons, tying the Los Angeles Dodgers and trailing only the Atlanta Braves (7) and New York Yankees (10).

The following accomplishments were rate-statistic qualifying records for a 162-game season, and in second place inclusive of all qualifying seasons:

* Astros pitching registered a 2.90 earned run average (ERA), a franchise record over a 162-game season, Only the 1981 club posted a lower ERA, at 2.66, over an entire season, which was shortened to 110 games due to the players’ strike. Maldonado was recognized with the 2022 Darryl Kile Award due in large part to his work handling the pitching staff.
* Justin Verlander recorded a 1.75 ERA, also winning the AL ERA title, trailing only Nolan Ryan, who, with a 1.69 ERA, won the 1981 NL ERA title.
* Yordan Alvarez produced a 187 adjusted OPS+, the second-highest in club history in a qualified season, trailing Bagwell's 213 OPS+ in the strike-shortened 1994 season.

The Astros' bullpen led the major leagues with a 2.80 ERA. Left-handed batters produced a .595 OPS against the bullpen, the lowest figure in the major leagues, in spite of the Astros having the second-fewest lefty–lefty matchups in the major leagues. The Astros' right-handed relievers limited left-handed batters to .206/.278/.308 slash; the .308 SLG was the lowest in major league baseball in such matchups.

Ryne Stanek recorded an ERA of 1.16, setting a franchise record for relief pitchers that eclipsed Will Harris' 1.50 ERA achieved in 2019.

Kyle Tucker joined Bagwell (1997 and 1999) as the only players in Astros history to have reached 30 home runs, 100 RBI, and 25 stolen bases in the same season.

Ryan Pressly recorded a career-high 33 saves, totaling 76 in an Astros uniform, which tied him with Fred Gladding for fourth place. The only hurlers with more saves as an Astro were Billy Wagner (225), Dave Smith (199) and Brad Lidge (123).

Major League Baseball awards nominees (finalists):
* Hank Aaron Award (×2): Altuve, Alvarez
* Gold Glove Award (×2): Peña (SS), Tucker (OF)
* Silver Slugger Award (×5): Altuve (2B), Alvarez (DH), Bregman (3B), Maldonado (C), Tucker (RF)

Baseball Writers' Association of America (BBWAA) awards finalists:
* AL Cy Young Award: Verlander
* AL MVP: Alvarez

Regular season standings

American League West

American League Wild Card

Record vs. opponents

Regular season game log

, - style="background:#bfb;"
, 1 , , April 7 , , @ Angels , , 3–1 , , Valdez (1–0) , , Ohtani (0–1) , , Pressly (1) , , 44,723 , , 1–0 ,
W1
, - style="background:#bfb;"
, 2 , , April 8 , , @ Angels , , 13–6 , , Montero (1–0) , , Ortega (0–1) , , — , , 42,719 , , 2–0 ,
W2
, - style="background:#fcc;"
, 3 , , April 9 , , @ Angels , , 0–2 , , Syndergaard (1–0) , , Verlander (0–1) , , Iglesias (1) , , 36,139 , , 2–1 ,
L1
, - style="background:#bfb;"
, 4 , , April 10 , , @ Angels , , 4–1 , , Urquidy (1–0) , , Suárez (0–1) , , Pressly (2) , , 41,253 , , 3–1 ,
W1
, - style="background:#bfb;"
, 5 , , April 12 , , @ Diamondbacks , , 2–1 , , Neris (1–0) , , Melancon (0–1) , , Pressly (3) , , 17,674 , , 4–1 ,
W2
, - style="background:#fcc;"
, 6 , , April 13 , , @ Diamondbacks , , 2–3 , , Pérez (1–1) , , Pressly (0–1) , , — , , 10,841 , , 4–2 ,
L1
, - style="background:#fcc;"
, 7 , , April 15 , , @ Mariners , , 1–11 , , Gonzales (1–1) , , Odorizzi (0–1) , , — , , 45,023 , , 4–3 ,
L2
, - style="background:#bfb;"
, 8 , , April 16 , , @ Mariners , , 4–0 , , Verlander (1–1) , , Flexen (0–2) , , — , , 38,504 , , 5–3 ,
W1
, - style="background:#fcc;"
, 9 , , April 17 , , @ Mariners , , 2–7 , , Brash (1–1) , , Urquidy (1–1) , , — , , 26,583 , , 5–4 ,
L1
, - style="background:#bfb;"
, 10 , , April 18 , , Angels , , 8–3 , , García (1–0) , , Lorenzen (1–1) , , — , , 42,646 , , 6–4 ,
W1
, - style="background:#fcc;"
, 11 , , April 19 , , Angels , , 2–7 , , Ortega (1–1) , , Valdez (1–1) , , — , , 30,212 , , 6–5 ,
L1
, - style="background:#fcc;"
, 12 , , April 20 , , Angels , , 0–6 , , Ohtani (1–2) , , Odorizzi (0–2) , , — , , 29,049 , , 6–6 ,
L2
, - style="background:#fcc;"
, 13 , , April 22 , , Blue Jays , , 3–4 , , Mayza (1–0) , , Neris (1–1) , , Romano (8) , , 36,757 , , 6–7 ,
L3
, - style="background:#fcc;"
, 14 , , April 23 , , Blue Jays , , 2–3 , , Manoah (3–0) , , Taylor (0–1) , , Cimber (1) , , 36,075 , , 6–8 ,
L4
, - style="background:#bfb;"
, 15 , , April 24 , , Blue Jays , , 8–7 , , Taylor (1–1) , , Romano (0–1) , , — , , 39,534 , , 7–8 ,
W1
, - style="background:#fcc;"
, 16 , , April 25 , , @ Rangers , , 2–6 , , Moore (1–0) , , Maton (0–1) , , — , , 17,420 , , 7–9 ,
L1
, - style="background:#bfb;"
, 17 , , April 26 , , @ Rangers , , 5–1 , , Odorizzi (1–2) , , Hearn (0–2) , , — , , 16,469 , , 8–9 ,
W1
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, 18 , , April 27 , , @ Rangers , , 4–3 , , Javier (1–0) , , Martin (0–2) , , Stanek (1) , , 20,399 , , 9–9 ,
W2
, - style="background:#bfb;" 2
, 19 , , April 28 , , @ Rangers , , 3–2 , , Verlander (2–1) , , Bush (0–1) , , Montero (1) , , 19,484 , , 10–9 ,
W3
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, 20 , , April 29 , , @ Blue Jays , , 11–7 , , Urquidy (2–1) , , Thornton (0–2) , , — , , 35,066 , , 11–9 ,
W4
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, 21 , , April 30 , , @ Blue Jays , , 1–2 , , Berríos (2–0) , , García (1–1) , , Romano (10) , , 40,732 , , 11–10 ,
L1
, -

, - style="background:#fcc;"
, 22 , , May 1 , , @ Blue Jays , , 2–3 , , Gausman (2–1) , , Valdez (1–2) , , Romano (11) , , 31,802 , , 11–11 ,
L2
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, 23 , , May 2 , , Mariners , , 3–0 , , Odorizzi (2–2) , , Gonzales (1–3) , , Montero (2) , , 27,321 , , 12–11 ,
W1
, - style="background:#bfb;"
, 24 , , May 3 , , Mariners , , 4–0 , , Javier (2–0) , , Flexen (1–4) , , — , , 23,796 , , 13–11 ,
W2
, - style="background:#bfb;"
, 25 , , May 4 , , Mariners , , 7–2 , , Verlander (3–1) , , Brash (1–3) , , — , , 24,110 , , 14–11 ,
W3
, - style="background:#bfb;"
, 26 , , May 5 , , Tigers , , 3–2 , , Pressly (1–1) , , Soto (1–2) , , — , , 24,116 , , 15–11 ,
W4
, - style="background:#bfb;"
, 27 , , May 6 , , Tigers , , 3–2 , , García (2–1) , , Brieske (0–2) , , Montero (3) , , 38,020 , , 16–11 ,
W5
, - style="background:#bfb;"
, 28 , , May 7 , , Tigers , , 3–2 , , Abreu (1–0) , , Fulmer (1–1) , , Pressly (4) , , 34,109 , , 17–11 ,
W6
, - style="background:#bfb;"
, 29 , , May 8 , , Tigers , , 5–0 , , Odorizzi (3–2) , , Hutchison (0–3) , , — , , 36,934 , , 18–11 ,
W7
, - style="background:#bfb;"
, 30 , , May 10 , , @ Twins , , 5–0 , , Verlander (4–1) , , Ryan (3–2) , , — , , 16,156 , , 19–11 ,
W8
, - style="background:#bbb;"
, — , , May 11 , , @ Twins , , colspan=7, SUSPENDED, RAIN; resuming on MAY 12
, - style="background:#bfb;"
, 31 , , May 12 , , @ Twins , , 11–3 , , Abreu (2–0) , , Archer (0–1) , , — , , , , 20–11 ,
W9
, - style="background:#bfb;"
, 32 , , May 12 , , @ Twins , , 5–0 , , García (3–1) , , Winder (2–1) , , — , , 16,918 , , 21–11 ,
W10
, - style="background:#bfb;"
, 33 , , May 13 , , @ Nationals , , 6–1 , , Valdez (2–2) , , Gray (4–3) , , — , , 18,433 , , 22–11 ,
W11
, - style="background:#fcc;"
, 34 , , May 14 , , @ Nationals , , 6–13 , , Rogers (2–2) , , Javier (2–1) , , — , , 22,949 , , 22–12 ,
L1
, - style="background:#bfb;"
, 35 , , May 15 , , @ Nationals , , 8–0 , , Verlander (5–1) , , Corbin (0–6) , , — , , 25,915 , , 23–12 ,
W1
, - style="background:#fcc;"
, 36 , , May 16 , , @ Red Sox , , 3–6 , , Strahm (2–1) , , Neris (1–2) , , Robles (2) , , 29,706 , , 23–13 ,
L1
, - style="background:#bfb;"
, 37 , , May 17 , , @ Red Sox , , 13–4 , , Urquidy (3–1) , , Eovaldi (1–2) , , — , , 27,328 , , 24–13 ,
W1
, - style="background:#fcc;"
, 38 , , May 18 , , @ Red Sox , , 1–5 , , Pivetta (2–4) , , García (3–2) , , — , , 31,717 , , 24–14 ,
L1
, - style="background:#bfb;"
, 39 , , May 19 , , Rangers , , 5–1 , , Valdez (3–2) , , Otto (1–2) , , — , , 34,593 , , 25–14 ,
W1
, - style="background:#fcc;"
, 40 , , May 20 , , Rangers , , 0–3 , , Pérez (3–2) , , Javier (2–2) , , — , , 35,294 , , 25–15 ,
L1
, - style="background:#bfb;"
, 41 , , May 21 , , Rangers , , 2–1 , , Verlander (6–1) , , Gray (1–2) , , Pressly (5) , , 37,187 , , 26–15 ,
W1
, - style="background:#bfb;"
, 42 , , May 22 , , Rangers , , 5–2 , , Urquidy (4–1) , , Hearn (2–3) , , Pressly (6) , , 38,745 , , 27–15 ,
W2
, - style="background:#fcc;"
, 43 , , May 23 , , Guardians , , 1–6 , , McKenzie (3–3) , , García (3–3) , , — , , 28,284 , , 27–16 ,
L1
, - style="background:#bfb;"
, 44 , , May 24 , , Guardians , , 7–3 , , Valdez (4–2) , , Plesac (1–4) , , — , , 26,621 , , 28–16 ,
W1
, - style="background:#bfb;"
, 45 , , May 25 , , Guardians , , 2–1 , , Javier (3–2) , , Quantrill (1–3) , , Pressly (7) , , 25,412 , , 29–16 ,
W2
, - style="background:#fcc;"
, 46 , , May 27 , , @ Mariners , , 1–6 , , Flexen (2–6) , , Verlander (6–2) , , — , , 26,017 , , 29–17 ,
L1
, - style="background:#fcc;"
, 47 , , May 28 , , @ Mariners , , 0–6 , , Gilbert (5–2) , , Urquidy (4–2) , , — , , 24,007 , , 29–18 ,
L2
, - style="background:#bfb;"
, 48 , , May 29 , , @ Mariners , , 2–1 , , Montero (2–0) , , Gonzales (3–5) , , Pressly (8) , , 28,986 , , 30–18 ,
W1
, - style="background:#bfb;"
, 49 , , May 30 , , @ Athletics , , 5–1 , , Valdez (5–2) , , Blackburn (5–1) , , — , , 8,753 , , 31–18 ,
W2
, - style="background:#bfb;"
, 50 , , May 31 , , @ Athletics , , 3–1 , , Montero (3–0) , , Montas (2–5) , , Pressly (9) , , 3,469 , , 32–18 ,
W3
, -

, - style="background:#bfb;"
, 51 , , June 1 , , @ Athletics , , 5–4 , , Abreu (3–0) , , Jiménez (2–3) , , Pressly (10) , , 5,189 , , 33–18 ,
W4
, - style="background:#bfb;"
, 52 , , June 3 , , @ Royals , , 10–3 , , Urquidy (5–2) , , Singer (2–1) , , — , , 22,516 , , 34–18 ,
W5
, - style="background:#fcc;"
, 53 , , June 4 , , @ Royals , , 0–6 , , Snider (4–2) , , García (3–4) , , — , , 14,663 , , 34–19 ,
L1
, - style="background:#bfb;"
, 54 , , June 5 , , @ Royals , , 7–4 , , Valdez (6–2) , , Heasley (0–3) , , Montero (4) , , 12,776 , , 35–19 ,
W1
, - style="background:#fcc;"
, 55 , , June 6 , , Mariners , , 4–7 , , Ray (5–6) , , Javier (3–3) , , Castillo (3) , , 27,521 , , 35–20 ,
L1
, - style="background:#bfb;"
, 56 , , June 7 , , Mariners , , 4–1 , , Verlander (7–2) , , Flexen (2–7) , , Pressly (11) , , 30,583 , , 36–20 ,
W1
, - style="background:#fcc;"
, 57 , , June 8 , , Mariners , , 3–6 , , Gilbert (6–2) , , Urquidy (5–3) , , Castillo (4) , , 23,752 , , 36–21 ,
L1
, - style="background:#fcc;"
, 58 , , June 10 , , Marlins , , 4–7 , , Sulser (1–3) , , García (3–5) , , Scott (4) , , 34,163 , , 36–22 ,
L2
, - style="background:#fcc;"
, 59 , , June 11 , , Marlins , , 1–5 , , Garrett (1–1) , , Valdez (6–3) , , — , , 31,379 , , 36–23 ,
L3
, - style="background:#bfb;"
, 60 , , June 12 , , Marlins , , 9–4 , , Verlander (8–2) , , Cabrera (2–1) , , — , , 29,341 , , 37–23 ,
W1
, - style="background:#fcc;"
, 61 , , June 13 , , @ Rangers , , 3–5 , , Burke (4–1) , , Neris (1–3) , , Moore (1) , , 29,805 , , 37–24 ,
L1
, - style="background:#bfb;"
, 62 , , June 14 , , @ Rangers , , 4–3 , , Abreu (4–0) , , King (1–3) , , Pressly (12) , , 29,370 , , 38–24 ,
W1
, - style="background:#bfb;"
, 63 , , June 15 , , @ Rangers , , 9–2 , , García (4–5) , , Miller (0–1) , , — , , 24,992 , , 39–24 ,
W2
, - style="background:#bfb;"
, 64 , , June 17 , , White Sox , , 13–3 , , Valdez (7–3) , , Giolito (4–3) , , — , , 35,467 , , 40–24 ,
W3
, - style="background:#fcc;"
, 65 , , June 18 , , White Sox , , 0–7 , , Cueto (1–3) , , Verlander (8–3) , , — , , 36,747 , , 40–25 ,
L1
, - style="background:#bfb;"
, 66 , , June 19 , , White Sox , , 4–3 , , Javier (4–3) , , Kopech (2–3) , , Pressly (13) , , 37,709 , , 41–25 ,
W1
, - style="background:#bfb;"
, 67 , , June 21 , , Mets , , 8–2 , , Urquidy (6–3) , , Williams (1–4) , , — , , 35,140 , , 42–25 ,
W2
, - style="background:#bfb;"
, 68 , , June 22 , , Mets , , 5–3 , , García (5–5) , , Carrasco (8–3) , , Pressly (14) , , 35,450 , , 43–25 ,
W3
, - style="background:#fcc;"
, 69 , , June 23 , , @ Yankees , , 6–7 , , Castro (4–0) , , Pressly (1–2) , , — , , 44,071 , , 43–26 ,
L1
, - style="background:#bfb;"
, 70 , , June 24 , , @ Yankees , , 3–1 , , Verlander (9–3) , , Severino (4–2) , , Montero (5) , , 47,528 , , 44–26 ,
W1
, - style="background:#bfb;"
, 71 , , June 25 , , @ Yankees , , 3–0 , , Javier (5–3) , , Cole (6–2) , , Pressly (15) , , 45,076 , , 45–26 ,
W2
, - style="background:#fcc;"
, 72 , , June 26 , , @ Yankees , , 3–6 , , King (5–1) , , Martinez (0–1) , , — , , 44,028 , , 45–27 ,
L1
, - style="background:#bfb;"
, 73 , , June 28 , , @ Mets , , 9–1 , , Valdez (8–3) , , Carrasco (8–4) , , — , , 36,673 , , 46–27 ,
W1
, - style="background:#bfb;"
, 74 , , June 29 , , @ Mets , , 2–0 , , Verlander (10–3) , , Smith (1–2) , , Pressly (16) , , 29,230 , , 47–27 ,
W2
, - style="background:#bfb;"
, 75 , , June 30 , , Yankees , , 2–1 , , García (6–5) , , Severino (4–3) , , Pressly (17) , , 40,674 , , 48–27 ,
W3
, -

, - style="background:#bfb;"
, 76 , , July 1 , , Angels , , 8–1 , , Javier (6–3) , , Lorenzen (6–6) , , — , , 36,420 , , 49–27 ,
W4
, - style="background:#bfb;"
, 77 , , July 2 , , Angels , , 9–1 , , Urquidy (7–3) , , Sandoval (3–3) , , — , , 35,332 , , 50–27 ,
W5
, - style="background:#bfb;"
, 78 , , July 3 , , Angels , , 4–2 , , Pressly (2–2) , , Tepera (1–2) , , — , , 36,048 , , 51–27 ,
W6
, - style="background:#bfb;"
, 79 , , July 4 , , Royals , , 7–6 , , Stanek (1–0) , , Barlow (2–2) , , — , , 33,936 , , 52–27 ,
W7
, - style="background:#bfb;"
, 80 , , July 5 , , Royals , , 9–7 , , García (7–5) , , Greinke (2–5) , , Montero (6) , , 28,762 , , 53–27 ,
W8
, - style="background:#fcc;"
, 81 , , July 6 , , Royals , , 4–7 , , Keller (4–9) , , Javier (6–4) , , Barlow (13) , , 26,534 , , 53–28 ,
L1
, - style="background:#bfb;"
, 82 , , July 7 , , Royals , , 5–2 , , Verlander (11–3) , , Bubic (1–6) , , Pressly (18) , , 36,067 , , 54–28 ,
W1
, - style="background:#bfb;"
, 83 , , July 8 , , @ Athletics , , 8–3 , , Urquidy (8–3) , , Blackburn (6–4) , , — , , 6,012 , , 55–28 ,
W2
, - style="background:#fcc;"
, 84 , , July 9 , , @ Athletics , , 2–3 , , Logue (3–4) , , Valdez (8–4) , , Trivino (7) , , 10,058 , , 55–29 ,
L1
, - style="background:#bfb;"
, 85 , , July 10 , , @ Athletics , , 6–1 , , Odorizzi (4–2) , , Irvin (3–7) , , — , , 10,195 , , 56–29 ,
W1
, - style="background:#bfb;"
, 86 , , July 12 , , @ Angels , , 6–5 , , Neris (2–3) , , Iglesias (2–6) , , Pressly (19) , , 27,180 , , 57–29 ,
W2
, - style="background:#fcc;"
, 87 , , July 13 , , @ Angels , , 1–7 , , Ohtani (9–4) , , Javier (6–5) , , — , , 27,803 , , 57–30 ,
L1
, - style="background:#bfb;"
, 88 , , July 14 , , @ Angels , , 3–2 , , Pressly (3–2) , , Loup (0–3) , , — , , 34,496 , , 58–30 ,
W1
, - style="background:#fcc;"
, 89 , , July 15 , , Athletics , , 1–5 , , Irvin (4–7) , , Urquidy (8–4) , , — , , 39,434 , , 58–31 ,
L1
, - style="background:#bfb;"
, 90 , , July 16 , , Athletics , , 5–0 , , Verlander (12–3) , , Koenig (1–3) , , — , , 39,125 , , 59–31 ,
W1
, - style="background:#fcc;"
, 91 , , July 17 , , Athletics , , 3–4 , , Puk (2–1) , , Montero (3–1) , , Trivino (8) , , 34,534 , , 59–32 ,
L1
, - style="background:#bbcaff"
, – , , July 19 , , 92nd All-Star Game , , AL 3–2 NL , , Valdez (1–0) , , Gonsolin (0–1) , , Clase (1) , , 52,518 , , N/A ,
N/A
, - style="background:#bfb;"
, 92 , , July 21 , , Yankees , , 3–2 , , Neris (3–3) , , King (6–3) , , — , , 36,225 , , 60–32 ,
W1
, - style="background:#bfb;"
, 93 , , July 21 , , Yankees , , 7–5 , , García (8–5) , , Germán (0–1) , , Montero (7) , , 39,342 , , 61–32 ,
W2
, - style="background:#bfb;"
, 94 , , July 22 , , @ Mariners , , 5–2 , , Urquidy (9–4) , , Gonzales (5–10) , , Neris (1) , , 45,290 , , 62–32 ,
W3
, - style="background:#bfb;"
, 95 , , July 23 , , @ Mariners , , 3–1 , , Verlander (13–3) , , Gilbert (10–4) , , Abreu (1) , , 43,197 , , 63–32 ,
W4
, - style="background:#bfb;"
, 96 , , July 24 , , @ Mariners , , 8–5 , , Valdez (9–4) , , Ray (8–7) , , Pressly (20) , , 34,827 , , 64–32 ,
W5
, - style="background:#fcc;"
, 97 , , July 25 , , @ Athletics , , 5–7 , , Oller (1–3) , , Odorizzi (4–3) , , Trivino (9) , , 4,105 , , 64–33 ,
L1
, - style="background:#fcc;"
, 98 , , July 26 , , @ Athletics , , 3–5 , , Montas (4–9) , , García (8–6) , , Trivino (10) , , 5,130 , , 64–34 ,
L2
, - style="background:#fcc;"
, 99 , , July 27 , , @ Athletics , , 2–4 , , Irvin (6–7) , , Javier (6–6) , , Puk (2) , , 9,367 , , 64–35 ,
L3
, - style="background:#bfb;"
, 100 , , July 28 , , Mariners , , 4–2 , , Montero (4–1) , , Muñoz (1–4) , , Pressly (21) , , 29,799 , , 65–35 ,
W1
, - style="background:#bfb;"
, 101 , , July 29 , , Mariners , , 11–1 , , Verlander (14–3) , , Ray (8–8) , , — , , 38,497 , , 66–35 ,
W2
, - style="background:#fcc;"
, 102 , , July 30 , , Mariners , , 4–5 , , Swanson (2–0) , , Pressly (3–3) , , Sewald (13) , , 37,385 , , 66–36 ,
L1
, - style="background:#bfb;"
, 103 , , July 31 , , Mariners , , 3–2 , , Neris (4–3) , , Bernardino (0–1) , , — , , 35,773 , , 67–36 ,
W1
, -

, - style="background:#fcc;"
, 104 , , August 1 , , Red Sox , , 2–3 , , Eovaldi (5–3) , , García (8–7) , , Houck (7) , , 35,185 , , 67–37 ,
L1
, - style="background:#fcc;"
, 105 , , August 2 , , Red Sox , , 1–2 , , Crawford (3–3) , , Javier (6–7) , , Houck (8) , , 31,229 , , 67–38 ,
L2
, - style="background:#bfb;"
, 106 , , August 3 , , Red Sox , , 6–1 , , Urquidy (10–4) , , Hill (4–5) , , — , , 32,295 , , 68–38 ,
W1
, - style="background:#bfb;"
, 107 , , August 4 , , @ Guardians , , 6–0 , , Verlander (15–3) , , Plesac (2–10) , , — , , 16,808 , , 69–38 ,
W2
, - style="background:#bfb;"
, 108 , , August 5 , , @ Guardians , , 9–3 , , Valdez (10–4) , , Gaddis (0–1) , , — , , 24,712 , , 70–38 ,
W3
, - style="background:#fcc;"
, 109 , , August 6 , , @ Guardians , , 1–4 , , Quantrill (8–5) , , García (8–8) , , — , , 25,327 , , 70–39 ,
L1
, - style="background:#fcc;"
, 110 , , August 7 , , @ Guardians , , 0–1 , , McKenzie (8–8) , , Javier (6–8) , , Clase (24) , , 22,688 , , 70–40 ,
L2
, - style="background:#bfb;"
, 111 , , August 9 , , Rangers , , 7–5 , , Urquidy (11–4) , , Pérez (9–3) , , Pressly (22) , , 30,629 , , 71–40 ,
W1
, - style="background:#fcc;"
, 112 , , August 10 , , Rangers , , 4–8 , , Hearn (5–6) , , Maton (0–2) , , — , , 26,670 , , 71–41 ,
L1
, - style="background:#bfb;"
, 113 , , August 11 , , Rangers , , 7–3 , , Valdez (11–4) , , Ragans (0–1) , , — , , 30,872 , , 72–41 ,
W1
, - style="background:#bfb;"
, 114 , , August 12 , , Athletics , , 7–5 , , García (9–8) , , Moll (1–2) , , Neris (2) , , 31,230 , , 73–41 ,
W2
, - style="background:#bfb;"
, 115 , , August 13 , , Athletics , , 8–0 , , McCullers Jr. (1–0) , , Logue (3–6) , , — , , 34,078 , , 74–41 ,
W3
, - style="background:#bfb;"
, 116 , , August 14 , , Athletics , , 6–3 , , Javier (7–8) , , Irvin (6–10) , , Pressly (23) , , 38,906 , , 75–41 ,
W4
, - style="background:#fcc;"
, 117 , , August 15 , , @ White Sox , , 2–4 , , Cueto (5–5) , , Montero (4–2) , , Hendriks (26) , , 18,205 , , 75–42 ,
L1
, - style="background:#fcc;"
, 118 , , August 16 , , @ White Sox , , 3–4 , , Lambert (1–2) , , Neris (4–4) , , Hendriks (27) , , 23,476 , , 75–43 ,
L2
, - style="background:#bfb;"
, 119 , , August 17 , , @ White Sox , , 3–2 , , Valdez (12–4) , , Kopech (4–9) , , Pressly (24) , , 24,671 , , 76–43 ,
W1
, - style="background:#bfb;"
, 120 , , August 18 , , @ White Sox , , 21–5 , , García (10–8) , , Giolito (9–7) , , — , , 24,407 , , 77–43 ,
W2
, - style="background:#fcc;"
, 121 , , August 19 , , @ Braves , , 2–6 , , Wright (15–5) , , McCullers Jr. (1–1) , , — , , 42,837 , , 77–44 ,
L1
, - style="background:#fcc;"
, 122 , , August 20 , , @ Braves , , 4–5 , , Stephens (2–2) , , Stanek (1–1) , , — , , 42,893 , , 77–45 ,
L2
, - style="background:#bfb;"
, 123 , , August 21 , , @ Braves , , 5–4 , , Urquidy (12–4) , , Lee (3–1) , , Pressly (25) , , 42,531 , , 78–45 ,
W1
, - style="background:#bfb;"
, 124 , , August 23 , , Twins , , 4–2 , , Verlander (16–3) , , Sanchez (3–4) , , Abreu (2) , , 32,639 , , 79–45 ,
W2
, - style="background:#bfb;"
, 125 , , August 24 , , Twins , , 5–3 , , Valdez (13–4) , , Bundy (7–6) , , — , , 27,070 , , 80–45 ,
W3
, - style="background:#bfb;"
, 126 , , August 25 , , Twins , , 6–3 , , García (11–8) , , Archer (2–7) , , Montero (8) , , 33,320 , , 81–45 ,
W4
, - style="background:#fcc;"
, 127 , , August 26 , , Orioles , , 0–2 , , Bradish (2–5) , , Javier (7–9) , , Tate (3) , , 31,035 , , 81–46 ,
L1
, - style="background:#fcc;"
, 128 , , August 27 , , Orioles , , 1–3 , , Kremer (6–4) , , Urquidy (12–5) , , Bautista (10) , , 34,526 , , 81–47 ,
L2
, - style="background:#bfb;"
, 129 , , August 28 , , Orioles , , 3–1 , , Stanek (2–1) , , Voth (4–2) , , Montero (9) , , 31,559 , , 82–47 ,
W1
, - style="background:#bfb;"
, 130 , , August 30 , , @ Rangers , , 4–2 , , Valdez (14–4) , , Dunning (3–7) , , Neris (3) , , 25,566 , , 83–47 ,
W2
, - style="background:#bfb;"
, 131 , , August 31 , , @ Rangers , , 5–3 , , Javier (8–9) , , Pérez (10–5) , , Montero (10) , , 19,607 , , 84–47 ,
W3
, -

, - style="background:#bfb;"
, 132 , , September 2 , , @ Angels , , 4–2 , , McCullers Jr. (2–1) , , Detmers (5–5) , , Montero (11) , , 22,464 , , 85–47 ,
W4
, - style="background:#fcc;"
, 133 , , September 3 , , @ Angels , , 1–2 , , Tepera (3–2) , , Smith (0–2) , , — , , 38,244 , , 85–48 ,
L1
, - style="background:#bfb;"
, 134 , , September 4 , , @ Angels , , 9–1 , , Urquidy (13–5) , , Davidson (2–5) , , — , , 28,179 , , 86–48 ,
W1
, - style="background:#bfb;"
, 135 , , September 5 , , Rangers , , 1–0 , , Brown (1–0) , , Pérez (10–6) , , Montero (12) , , 35,162 , , 87–48 ,
W2
, - style="background:#fcc;"
, 136 , , September 6 , , Rangers , , 3–4 , , Hearn (6–7) , , Valdez (14–5) , , Leclerc (3) , , 26,803 , , 87–49 ,
L1
, - style="background:#bfb;"
, 137 , , September 7 , , Rangers , , 4–3 , , Neris (5–4) , , Hernández (1–2) , , — , , 26,239 , , 88–49 ,
W1
, - style="background:#bfb;"
, 138 , , September 9 , , Angels , , 4–3 , , McCullers Jr. (3–1) , , Wantz (2–1) , , Pressly (26) , , 33,509 , , 89–49 ,
W2
, - style="background:#fcc;"
, 139 , , September 10 , , Angels , , 1–6 , , Ohtani (12–8) , , Urquidy (13–6) , , — , , 38,533 , , 89–50 ,
L1
, - style="background:#bfb;"
, 140 , , September 11 , , Angels , , 12–4 , , García (12–8) , , Davidson (2–6) , , — , , 32,901 , , 90–50 ,
W1
, - style="background:#bfb;"
, 141 , , September 12 , , @ Tigers , , 7–0 , , Valdez (15–5) , , Rodríguez (3–5) , , — , , 13,054 , , 91–50 ,
W2
, - style="background:#bfb;"
, 142 , , September 13 , , @ Tigers , , 6–3 , , Brown (2–0) , , Hutchison (2–8) , , Pressly (27) , , 13,820 , , 92–50 ,
W3
, - style="background:#bfb;"
, 143 , , September 14 , , @ Tigers , , 2–1 , , Javier (9–9) , , Wentz (1–2) , , Pressly (28) , , 13,947 , , 93–50 ,
W4
, - style="background:#bfb;"
, 144 , , September 15 , , Athletics , , 5–2 , , Martinez (1–1) , , Payamps (3–6) , , Montero (13) , , 26,543 , , 94–50 ,
W5
, - style="background:#039;"
, 145 , , September 16 , , Athletics , , 5–0 , , Verlander (17–3) , , Martínez (4–5) , , — , , 33,850 , , 95–50 ,
W6">W6
, - style="background:#fcc;"
, 146 , , September 17 , , Athletics , , 5–8 , , Irvin (9–11) , , Urquidy (13–7) , , Acevedo (2) , , 33,419 , , 95–51 ,
L1
, - style="background:#bfb;"
, 147 , , September 18 , , Athletics , , 11–2 , , Valdez (16–5) , , Waldichuk (0–2) , , — , , 30,375 , , 96–51 ,
W1
, - style="background:#090;"
, 148 , , September 19 , , @ Rays , , 4–0 , , García (13–8) , , Rasmussen (10–6) , , — , , 10,390 , , 97–51 ,
W2">W2
, - style="background:#bfb;"
, 149 , , September 20 , , @ Rays , , 5–0 , , Javier (10–9) , , McClanahan (12–6) , , Pressly (29) , , 8,992 , , 98–51 ,
W3
, - style="background:#bfb;"
, 150 , , September 21 , , @ Rays , , 5–2 , , McCullers Jr. (4–1) , , Raley (1–2) , , Pressly (30) , , 9,293 , , 99–51 ,
W4
, - style="background:#fcc;"
, 151 , , September 22 , , @ Orioles , , 0–2 , , Bradish (4–7) , , Verlander (17–4) , , Bautista (15) , , 16,417 , , 99–52 ,
L1
, - style="background:#fcc;"
, 152 , , September 23 , , @ Orioles , , 0–6 , , Kremer (8–5) , , Urquidy (13–8) , , — , , 22,833 , , 99–53 ,
L2
, - style="background:#bfb;"
, 153 , , September 24 , , @ Orioles , , 11–10 , , Montero (5–2) , , Bautista (4–4) , , Pressly (31) , , 22,546 , , 100–53 ,
W1
, - style="background:#bfb;"
, 154 , , September 25 , , @ Orioles , , 6–3 , , Neris (6–4) , , Akin (3–3) , , — , , 24,449 , , 101–53 ,
W2
, - style="background:#bfb;"
, 155 , , September 27 , , Diamondbacks , , 10–2 , , García (14–8) , , Davies (2–5) , , — , , 37,480 , , 102–53 ,
W3
, - style="background:#fcc;"
, 156 , , September 28 , , Diamondbacks , , 2–5 , , Moronta (2–1) , , Smith (0–3) , , Melancon (18) , , 35,670 , , 102–54 ,
L1
, - style="background:#fcc;"
, 157 , , September 30 , , Rays , , 3–7 , , Rasmussen

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