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Photoacoustic Imaging
Photoacoustic imaging or optoacoustic imaging is a biomedical imaging modality based on the photoacoustic effect. Non-ionizing laser pulses are delivered into biological tissues and part of the energy will be absorbed and converted into heat, leading to transient thermoelastic expansion and thus wideband (i.e., megahertz-order bandwidth) ultrasonic emission. The generated ultrasonic waves are detected by ultrasonic transducers and then analyzed to produce images. It is known that optical absorption is closely associated with physiological properties, such as hemoglobin concentration and oxygen saturation. As a result, the magnitude of the ultrasonic emission (i.e. photoacoustic signal), which is proportional to the local energy deposition, reveals physiologically specific optical absorption contrast. 2D or 3D images of the targeted areas can then be formed. Biomedical imaging The optical absorption in biological tissues can be due to endogenous molecules such as hemoglobin or ...
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Photoacoustic Effect
The photoacoustic effect or optoacoustic effect is the formation of sound waves following light absorption in a material sample. In order to obtain this effect the light intensity must vary, either periodically (''modulated light'') or as a single flash (''pulsed light'').Rosencwaig, A. (1980''Photoacoustics and photoacoustic spectroscopy'' Chemical Analysis: a Series of Monographs on Analytical Chemistry and Its Applications, Vol. 57. New York:John Wiley & Sons, . The photoacoustic effect is quantified by measuring the formed sound (pressure changes) with appropriate detectors, such as microphones or piezoelectric sensors. The time variation of the electric output (current or voltage) from these detectors is the photoacoustic signal. These measurements are useful to determine certain properties of the studied sample. For example, in photoacoustic spectroscopy, the photoacoustic signal is used to obtain the actual absorption of light in either opaque or transparent objects. It is ...
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Optical Coherence Tomography
Optical coherence tomography (OCT) is a high-resolution imaging technique with most of its applications in medicine and biology. OCT uses coherent near-infrared light to obtain micrometer-level depth resolved images of biological tissue or other scattering media. It uses interferometry techniques to detect the amplitude and time-of-flight of reflected light. OCT uses transverse sample scanning of the light beam to obtain two- and three-dimensional images. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging (in vitro) was published by a team from MIT and Harvard Medical School in a 1991 article in the journal ''Science (journal), Science''. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrat ...
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Deep Learning In Photoacoustic Imaging
Photoacoustic imaging (PA) is based on the photoacoustic effect, in which optical absorption causes a rise in temperature, which causes a subsequent rise in pressure via thermo-elastic expansion. This pressure rise propagates through the tissue and is sensed via ultrasonic transducers. Due to the proportionality between the optical absorption, the rise in temperature, and the rise in pressure, the ultrasound pressure wave signal can be used to quantify the original optical energy deposition within the tissue. Photoacoustic imaging has applications of deep learning in both photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM). PACT utilizes wide-field optical excitation and an array of unfocused ultrasound transducers. Similar to other computed tomography methods, the sample is imaged at multiple view angles, which are then used to perform an inverse reconstruction algorithm based on the detection geometry (typically through universal backprojection, modifie ...
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Gold Nanocage
Gold nanocages (AuNCs) are gold nanoparticles of size 20–500 nm with a hollow cubic structure and porous walls. They can be synthesized by reacting silver nanoparticles with chloroauric acid (hydrogen, HGold, Auchlorine, Cl4) in boiling water. Gold nanocages have been suggested for use in drug delivery, photothermal therapy, and as contrast agents. Origin and development Gold nanocages were first created in 2002 by a group at Washington University, Saint Louis, led by Younan Xia. He developed the idea for the synthesis when he was teaching Galvanic corrosion, galvanic replacement in a general chemistry course at the same time as a method for silver nanocube creation via polyol reduction was being developed. Since the invention of AuNCs, research has focused on the development of alternative synthesis strategies for more precise tuning of nanocage structure and properties. Another significant area of nanocage development has been the investigation of their potential applic ...
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Canvas
Canvas is an extremely durable Plain weave, plain-woven Cloth, fabric used for making sails, tents, Tent#Marquees and larger tents, marquees, backpacks, Shelter (building), shelters, as a Support (art), support for oil painting and for other items for which sturdiness is required, as well as in such fashion objects as handbags, electronic device cases, and shoes. It is popularly used by artists as a painting surface, typically stretched across a wooden frame. Although historically made from hemp, modern canvas is usually made of cotton, linen, or sometimes polyvinyl chloride (PVC). It differs from other heavy cotton fabrics, such as denim, in being plain weave rather than Twill, twill weave. Canvas comes in two basic types: plain and Cotton duck, duck. The threads in duck canvas are more tightly woven. The term ''duck'' comes from the Dutch language, Dutch word for cloth, ''doek''. In the United States, canvas is classified in two ways: by weight (ounces per square yard) and by ...
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Oil Painting
Oil painting is a painting method involving the procedure of painting with pigments combined with a drying oil as the Binder (material), binder. It has been the most common technique for artistic painting on canvas, wood panel, or oil on copper, copper for several centuries. The advantages of oil for painting images include "greater flexibility, richer and denser color, the use of layers, and a wider range from light to dark". The oldest known oil paintings were created by Buddhism, Buddhist artists in Afghanistan, and date back to the 7th century AD. Oil paint was later developed by Europeans for painting statues and woodwork from at least the 12th century, but its common use for painted images began with Early Netherlandish painting in Northern Europe, and by the height of the Renaissance, oil painting techniques had almost completely replaced the use of egg tempera paints for panel paintings in most of Europe, though not for Orthodox icons or wall paintings, where tempera a ...
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Painting
Painting is a Visual arts, visual art, which is characterized by the practice of applying paint, pigment, color or other medium to a solid surface (called "matrix" or "Support (art), support"). The medium is commonly applied to the base with a brush. Other implements, such as palette knives, sponges, airbrushes, the artist's fingers, or even a dripping technique that uses gravity may be used. One who produces paintings is called a painter. In art, the term "painting" describes both the act and the result of the action (the final work is called "a painting"). The support for paintings includes such surfaces as walls, paper, canvas, wood, glass, lacquer, pottery, leaf, copper and concrete, and the painting may incorporate other materials, in single or multiple form, including sand, clay, paper, cardboard, newspaper, plaster, gold leaf, and even entire objects. Painting is an important form of visual arts, visual art, bringing in elements such as drawing, Composition (visual art ...
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Work Of Art
A work of art, artwork, art piece, piece of art or art object is an artistic creation of aesthetic value. Except for "work of art", which may be used of any work regarded as art in its widest sense, including works from literature and music, these terms apply principally to tangible, physical forms of visual art: *An example of fine art, such as a painting or sculpture. *Objects in the decorative arts or applied arts that have been designed for aesthetic appeal, as well as any functional purpose, such as a piece of jewellery, many ceramics and much folk art. *An object created for principally or entirely functional, religious or other non-aesthetic reasons which has come to be appreciated as art (often later, or by cultural outsiders). *A non-ephemeral photograph or film. *A work of installation art or conceptual art. Used more broadly, the term is less commonly applied to: *A fine work of architecture or landscape design *A production of live performance, such ...
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Chromophore
A chromophore is the part of a molecule responsible for its color. The word is derived . The color that is seen by our eyes is that of the light not Absorption (electromagnetic radiation), absorbed by the reflecting object within a certain wavelength spectrum of visible spectrum, visible light. The chromophore is a region in the molecule where the energy difference between two separate molecular orbitals falls within the range of the visible spectrum (or in informal contexts, the spectrum under scrutiny). Visible light that hits the chromophore can thus be absorbed by exciting an electron from its ground state into an excited state. In biological molecules that serve to capture or detect light energy, the chromophore is the Moiety (chemistry), moiety that causes a conformational change in the molecule when hit by light. Conjugated pi-bond system chromophores Just like how two adjacent p-orbitals in a molecule will form a pi-bond, three or more adjacent p-orbitals in a molec ...
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Sound Pressure
Sound pressure or acoustic pressure is the local pressure deviation from the ambient (average or equilibrium) atmospheric pressure, caused by a sound wave. In air, sound pressure can be measured using a microphone, and in water with a hydrophone. The SI unit of sound pressure is the pascal (Pa). Mathematical definition A sound wave in a transmission medium causes a deviation (sound pressure, a ''dynamic'' pressure) in the local ambient pressure, a ''static'' pressure. Sound pressure, denoted ''p'', is defined by p_\text = p_\text + p, where * ''p''total is the total pressure, * ''p''stat is the static pressure. Sound measurements Sound intensity In a sound wave, the complementary variable to sound pressure is the particle velocity. Together, they determine the sound intensity of the wave. ''Sound intensity'', denoted I and measured in W· m−2 in SI units, is defined by \mathbf I = p \mathbf v, where * ''p'' is the sound pressure, * v is the particle velocity. Acous ...
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Photoacoustic Microscopy
Photoacoustic microscopy is an imaging method based on the photoacoustic effect and is a subset of photoacoustic tomography. Photoacoustic microscopy takes advantage of the local temperature rise that occurs as a result of light absorption in tissue. Using a nanosecond pulsed laser beam, tissues undergo thermoelastic expansion, resulting in the release of a wide-band acoustic wave that can be detected using a high-frequency ultrasound transducer. Since ultrasonic scattering in tissue is weaker than optical scattering, photoacoustic microscopy is capable of achieving high-resolution images at greater depths than conventional microscopy methods. Furthermore, photoacoustic microscopy is especially useful in the field of biomedical imaging due to its scalability. By adjusting the optical and acoustic foci, lateral resolution may be optimized for the desired imaging depth. Photoacoustic signal The goal of photoacoustic microscopy is to find the local pressure rise p_0, which can be use ...
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Voxel
In computing, a voxel is a representation of a value on a three-dimensional regular grid, akin to the two-dimensional pixel. Voxels are frequently used in the Data visualization, visualization and analysis of medical imaging, medical and scientific data (e.g. geographic information systems (GIS)). Voxels also have technical and artistic applications in video games, largely originating with surface rendering in ''Outcast (video game), Outcast'' (1999). ''Minecraft'' (2011) makes use of an entirely voxelated world to allow for a fully destructable and constructable environment. Voxel art, of the sort used in ''Minecraft'' and elsewhere, is a style and format of 3D art analogous to pixel art. As with pixels in a 2D bitmap, voxels themselves do not typically have their position (i.e. coordinates) explicitly encoded with their values. Instead, Rendering (computer graphics), rendering systems infer the position of a voxel based upon its position relative to other voxels (i.e., its pos ...
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