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Myricetin
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Reported average intake of myricetin per day varies depending on diet, but has been shown in the Netherlands to average 23 mg/day. Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). Myricetin can alternatively be produced directly ...
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Ampelopsin
Ampelopsin, also known as dihydromyricetin and DHM, when used as an herbal medicine, is a flavanonol, a type of flavonoid. It is extracted from the Japanese raisin tree and found in '' Ampelopsis'' species ''japonica'', ''megalophylla'', and ''grossedentata''; ''Cercidiphyllum japonicum''; '' Hovenia dulcis''; '' Rhododendron cinnabarinum''; some ''Pinus'' species; and some ''Cedrus'' species, as well as in '' Salix sachalinensis''. '' Hovenia dulcis'' has been used in traditional Japanese, Chinese, and Korean medicines to treat fever, parasitic infection, as a laxative, and a treatment of liver diseases, and as a hangover treatment. Methods have been developed to extract ampelopsin on a larger scale, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used. Research Research suggests that DHM protects against DOX-induced cardiotoxicity by inhibiting ...
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Laricitrin
Laricitrin is an ''O''-methylated flavonol, a type of flavonoid. It is found in red grape (absent in white grape) and in '' Vaccinium uliginosum'' (bog bilberries). It is one of the phenolic compounds present in wine. Metabolism Laricitrin is formed from myricetin Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine. Myricetin is stru ... by the action of the enzyme myricetin O-methyltransferase. It is further methylated by laricitrin 5'-O-methyltransferase into syringetin. Glycosides * Laricitrin 3-O-galactoside, found in grape * Laricitrin 3-glucoside found in '' Larix sibirica'' * Laricitrin 3,5’-di-O-β-glucopyranoside, found in '' Medicago littoralis''
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Syringetin
Syringetin is an ''O''-methylated flavonol, a type of flavonoid. It is found in red grape (absent in white grape), in '' Lysimachia congestiflora'' and in '' Vaccinium uliginosum'' (bog bilberries). It is one of the phenolic compounds present in wine. It induces human osteoblast differentiation through bone morphogenetic protein-2/ extracellular signal-regulated kinase 1/2 pathway. Metabolism Syringetin is formed from laricitrin by the action of the enzyme laricitrin 5′-''O''-methyltransferase ( myricetin ''O''-methyltransferase). Glycosides * Syringetin-3-''O''-galactoside * Syringetin-3-''O''-glucoside * Syringetin 3-rhamnoside (CAS number 93126-00-2) * Syringetin-3-''O''-rutinoside found in ''Larix sibirica'' * Syringetin 3-''O''-(6′′-acetyl)-β-glucopyranoside found in ''Picea abies ''Picea abies'', the Norway spruce or European spruce, is a species of spruce native to Northern Europe, Northern, Central Europe, Central and Eastern Europe. It has branchlets ...
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Fisetin
Fisetin (7,3′,4′- flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It occurs in many plants where it serves as a yellow pigment A pigment is a powder used to add or alter color or change visual appearance. Pigments are completely or nearly solubility, insoluble and reactivity (chemistry), chemically unreactive in water or another medium; in contrast, dyes are colored sub .... It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. Its chemical formula was first described by Austrian chemist Josef Herzig in 1891. Sources Fisetin is a flavonoid synthesized by many plants such as the trees and shrubs of Fabaceae, acacias '' Acacia greggii'', and '' Acacia berlandieri'', parrot tree ('' Butea frondosa''), honey locust ('' Gleditsia triacanthos''), members of the family Anacardiaceae such as the '' Quebracho colorado'', and species of the genus '' Rhus'', which contains the sumacs. Along wit ...
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Blackcurrant
The blackcurrant (''Ribes nigrum''), also known as black currant or cassis, is a deciduous shrub in the family Grossulariaceae grown for its edible berries. It is native to temperate parts of central and northern Europe and northern Asia, where it prefers damp fertile soils. It is widely cultivated both commercially and domestically. It is winter hardy, but cold weather at flowering time during the spring may reduce the size of the crop. Bunches of small, glossy black fruit develop along the stems in the summer and can be harvested by hand or by machine. The raw fruit is particularly rich in vitamin C and polyphenols. Blackcurrants can be eaten raw but are usually cooked in sweet or savoury dishes. They are used to make jams, preserves, and syrups and are grown commercially for the juice market. The fruit is also used to make alcoholic beverages and dyes. Description ''Ribes nigrum'' is a medium-sized shrub, growing to . The leaves are alternate, simple, broad and lon ...
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Empetrum Nigrum
''Empetrum nigrum'', crowberry, black crowberry, mossberry, or, in western Alaska, Labrador, etc., blackberry, is a flowering plant species in the heather family Ericaceae with a near circumboreal distribution in the Northern Hemisphere. Description ''Empetrum nigrum'' is a low growing, evergreen shrub with a creeping habit. The leaves are long, arranged alternately along the stem. The stems are red when young and then fade to brown. It blooms between May and June. It is usually dioecious. The flowers are small and not very noticeable, with greenish-pink sepals that turn reddish purple. The round fruits are drupes, wide, usually black or purplish-black but occasionally red. Its fruit persists for an average of 92.7 days, and bears an average of 7.8 seeds per fruit. Fruits average 86.5% water, and their dry weight includes 14.4% carbohydrates and 12.2% lipids, which is possibly the highest lipid content of any fleshy fruit in Europe. Subspecies * ''Empetrum nigrum'' subs ...
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Vaccinium Virgatum
''Vaccinium virgatum'' (commonly known as rabbit-eye blueberry, smallflower blueberry or southern black blueberry) is a species of blueberry native to the Southeastern United States, from North Carolina south to Florida and west to Texas. Description ''Vaccinium virgatum'' is a deciduous shrub growing to 3 to 6 feet tall and with up to a 3-foot spread. The leaves are spirally arranged, oblate to narrow elliptic, 3 inches long and start red-bronze in the spring only to develop into a dark-green. The flowers are white, bell-shaped, 5 mm long. The fruit is a berry 5 mm diameter, dark blue to black, bloomed pale blue-gray by a thin wax coating. Cytology is 2n = 72. Pollination ''Vaccinium virgatum'' is self-infertile, and must have two or more varieties to pollenize each other. Honeybees are inefficient pollinators, and carpenter bees frequently cut the corollas to rob nectar without pollinating the flowers. ''V. virgatum'' does best when pollinated by buzz pollinat ...
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Sweet Potato
The sweet potato or sweetpotato (''Ipomoea batatas'') is a dicotyledonous plant in the morning glory family, Convolvulaceae. Its sizeable, starchy, sweet-tasting tuberous roots are used as a root vegetable, which is a staple food in parts of the world. Cultivars of the sweet potato have been bred to bear tubers with flesh and skin of various colors. Moreover, the young shoots and leaves are occasionally eaten as greens. The sweet potato and the potato are in the order Solanales, making them distant relatives. Although darker sweet potatoes are often known as "yams" in parts of North America, they are even more distant from actual yams, which are monocots in the order Dioscoreales. The sweet potato is native to the tropical regions of South America in what is present-day Ecuador. Of the approximately 50 genera and more than 1,000 species of Convolvulaceae, ''I. batatas'' is the only crop plant of major importance—some others are used locally (e.g., ''I. aquatica'' "ka ...
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Antioxidants
Antioxidants are Chemical compound, compounds that inhibit Redox, oxidation, a chemical reaction that can produce Radical (chemistry), free radicals. Autoxidation leads to degradation of organic compounds, including living matter. Antioxidants are frequently added to industrial products, such as polymers, fuels, and lubricants, to extend their usable lifetimes. Foods are also treated with antioxidants to prevent Food spoilage, spoilage, in particular the rancidification of Vegetable oil, oils and fats. In Cell (biology), cells, antioxidants such as glutathione, mycothiol, or bacillithiol, and enzyme systems like superoxide dismutase, inhibit damage from oxidative stress. Known diet (nutrition), dietary antioxidants are vitamins vitamin A, A, vitamin C, C, and vitamin E, E, but the term has also been applied to various compounds that exhibit antioxidant properties in vitro, having little evidence for antioxidant properties in vivo. Dietary supplements marketed as antioxidants hav ...
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Flavonoid
Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a Heterocyclic compound, heterocyclic ring (C, the ring containing the embedded oxygen). This carbon structure can be abbreviated C6-C3-C6. According to the IUPAC nomenclature, they can be classified into: *flavonoids or bioflavonoids *isoflavonoids, derived from 3-phenylchromone, chromen-4-one (3-phenyl-1,4-benzopyran, benzopyrone) structure *neoflavonoids, derived from 4-phenylcoumarin (4-phenyl-1,2-benzopyran, benzopyrone) structure The three flavonoid classes above are all ketone-containing compounds and as such, anthoxanthins (flavones and flavonols). This class was the first to be termed bioflavonoids. The terms flavonoid and bioflavo ...
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Cranberry
Cranberries are a group of evergreen dwarf shrubs or trailing vines in the subgenus ''Oxycoccus'' of the genus ''Vaccinium''. Cranberries are low, creeping shrubs or vines up to long and in height; they have slender stems that are not thickly woody and have small evergreen leaves. The flowers are dark pink. The fruit is a berry (botany), berry that is larger than the leaves of the plant; it is initially light green, turning red when ripe. It is edible, but has an acidic taste. In Britain, ''cranberry'' may refer to the native species ''Vaccinium oxycoccos'', while in North America, ''cranberry'' may refer to ''Vaccinium macrocarpon''. ''Vaccinium oxycoccos'' is cultivated in central and northern Europe, while ''V. macrocarpon'' is cultivated throughout the northern United States, Canada and Chile. In some methods of classification, ''Oxycoccus'' is regarded as a genus in its own right. Cranberries can be found in acidic bogs throughout the cooler regions of the North ...
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Reactive Oxygen Species
In chemistry and biology, reactive oxygen species (ROS) are highly Reactivity (chemistry), reactive chemicals formed from diatomic oxygen (), water, and hydrogen peroxide. Some prominent ROS are hydroperoxide (H2O2), superoxide (O2−), hydroxyl radical (OH.), and singlet oxygen(1O2). ROS are pervasive because they are readily produced from O2, which is abundant. ROS are important in many ways, both beneficial and otherwise. ROS function as signals, that turn on and off biological functions. They are intermediates in the redox behavior of O2, which is central to fuel cells. ROS are central to the photodegradation of organic pollutants in the atmosphere. Most often however, ROS are discussed in a biological context, ranging from their effects on aging and their role in causing dangerous genetic mutations. Inventory of ROS ROS are not uniformly defined. All sources include superoxide, singlet oxygen, and hydroxyl radical. Hydrogen peroxide is not nearly as reactive as these s ...
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