|
RU-27849
RU-27849 is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship (SAR) studies of LSD. It shows affinity for serotonin receptors, including for the serotonin 5-HT1, 5-HT1A, and 5-HT2 receptors ( = 267–520nM, 325–326nM, and 1,964–2,900nM, respectively). RU-27849's affinities for serotonin receptors are similar to but lower than those of tryptamine and dimethyltryptamine (DMT). It shows very weak affinity for dopamine receptors and weak associated activity. The 6-methoxy derivative of RU-27849, which is to RU-27849 as 5-methoxytryptamine is to tryptamine, appears to have much higher affinity for serotonin receptors than RU-27849 itself ( ≈ 50nM). A number of other derivatives also exist, including FHATHBIN (6-hydroxy), RU-28306 (''N'',''N''-dimethyl), RU-28251 (''N'',''N''-dipropyl), Bay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simplified/partial LSD Analogue
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergolines
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ... and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenethylamines
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative (chemistry), derivative compounds of phenethylamine which can be formed by replacing, or substitution reaction, substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens. Structural classification The structural formula of any substituted phenethylamine contains a phenyl group, phenyl ring that is joined to an amino group, amino (NH) group via a two-carbon substituent, sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen atom, hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a moiety (chemistry), specific group of at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Alkyltryptamines
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5252
CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent bond between the 10 and 11 positions of the ergoline ring system (chemistry), ring system has been broken to conformational constraint, unconstrain the chemical structure, structure. The drug produces specific LSD-like behavioral changes in guinea pigs but with only about 1/48th the potency (pharmacology), potency of LSD. It also causes seizures at slightly higher doses than those that cause LSD-like effects. CT-5252 was first described in the scientific literature in 1969. The structural analog, analogue of CT-5252 with an ''N'',''N''-diethyl-carboxamide moiety (chemistry), moiety on the tetrahydropyridine ring (chemistry), ring instead of the carboxylate functional group, group (i.e., more analogous to LSD) has also been assessed and descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-DEAOP-NMT
''N''-(3-Diethylamino-3-oxopropyl)-''N''-methyltryptamine (''N''-DEAOP-NMT) is a substituted tryptamine, tryptamine chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the structural analog, analogue of LSD in which two of LSD's carbon atoms in the ergoline ring (chemistry), ring, those at positions 9 and 10, have been removed. This in turn renders the ''N''-DEAOP-NMT molecule flexible and makes it a conformational constraint, non-rigid tryptamine rather than an ergoline. The compound is pharmacology, pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor, 5-HT2A receptor agonist, agonism and LSD- or hallucinogen-like effects. Pharmacology ''N''-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. However, in co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NDTDI
NDTDI, also known as 8,10-seco-LSD, is a tricyclic tryptamine derivative which is thought to act as a serotonin receptor agonist, though its pharmacology has not been studied in detail. It is a structurally simplified analogue of the psychedelic drug lysergic acid diethylamide (LSD) and is reported to retain similar effects, though with many times lower potency. NDTDI is specifically the analogue of LSD in which the carbon atom at position 9 of the ergoline ring system has been removed. It has been sold as a designer drug since 2016 and was first identified by a forensic laboratory in Slovenia in 2017. NDTDI was made illegal in Latvia in March 2017. The simplified analogue of NDTDI and LSD in which the carbons at positions 9 and 10 of the ergoline ring system have been removed, resulting in a fully non-rigid tryptamine derivative, is ''N''-DEAOP-NMT. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * Seco-LSD * RU-27849 * Bay R 1531 * DEIMD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LY-178210
LY-178210 is a selective and highly potent serotonin 5-HT1A receptor partial agonist. It has an affinity (Ki) of 0.67nM for the serotonin 5-HT1A receptor. The drug has high selectivity for this receptor over 12other assessed targets, including the serotonin 5-HT1D, 5-HT2A, 5-HT2C, and 5-HT3 receptors among others (Ki = ≥380–4,000nM). LY-178210 is a tricyclic simplified or partial ergoline and is structurally related to LSD. It was described as a potential clinical development candidate but was not further developed and was never marketed. The drug was first reported in the scientific literature by 1990. See also * Partial lysergamide * RU-27849 * RU-28306 * Bay R 1531 (LY-197206) * LY-293284 * NDTDI * 8-OH-DPAT 8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor, 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonis ... ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LY-293284
LY-293284 is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT1A receptor full agonist. It was derived through structural simplification of the ergoline based psychedelic LSD, but is far more selective for 5-HT1A with over 1000× selectivity over other serotonin receptor subtypes and other targets. It has anxiogenic effects in animal studies. See also * Partial lysergamide * LY-178210 * 8-OH-DPAT * RDS-127 * RU-27849 * RU-28306 * ''N''-DEAOP-NMT * CT-5252 CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent b ... References Alpha-Alkyltryptamines Anxiogenics N,N-Dialkyltryptamines Drugs developed by Eli Lilly and Company Ketones Partial ergolines Serotonin receptor agonists {{ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bay R 1531
Bay R 1531, also known as LY-197206, is a tricyclic tryptamine derivative. It acts as a selective serotonin 5-HT1A receptor agonist. It was investigated unsuccessfully for the treatment of stroke but continues to be used in scientific research. It shows very high affinity for the serotonin 5-HT1A receptor (Ki = 1.3nM). See also * Partial lysergamide * 8-OH-DPAT * RDS-127 RDS-127 is a drug which is used in scientific research. It acts as a D2-like receptor agonist and also has some serotonin and adrenergic agonist effects, as well as some anticholinergic action, and produces both anorectic and pro-sexual eff ... * RU-27849 * RU-28306 * LY-178210 * LY-293,284 * NDTDI * ''N''-DEAOP-NMT * CT-5252 References {{Tryptamines Alpha-Alkyltryptamines N,N-Dialkyltryptamines Heterocyclic compounds with 3 rings 5-Methoxytryptamines Partial ergolines Serotonin receptor agonists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-28251
RU-28251 is a tricyclic dopamine receptor agonist of the simplified or partial ergoline family. It is a selective D2-like receptor agonist. The drug inhibits prolactin secretion in animals. RU-28251 was first described in the literature by 1978. See also * Partial ergoline * Bay R 1531 (LY-197206) * LY-293284 * LY-178210 * RU-27849 * RU-28306 RU-28306 is a synthetic indole alkaloid derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT1 and 5-HT2 subtypes. It can be regarded as a conformationally restricted tricyclic derivative of DMT or a structurally simp ... References Alpha-Alkyltryptamines D2 receptor agonists N,N-Dialkyltryptamines Dipropylamino_compounds Dopamine agonists Heterocyclic compounds with 3 rings Partial ergolines Prolactin inhibitors {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
