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LY-293284
LY-293284 is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT1A receptor full agonist. It was derived through structural simplification of the ergoline based psychedelic LSD, but is far more selective for 5-HT1A with over 1000× selectivity over other serotonin receptor subtypes and other targets. It has anxiogenic effects in animal studies. See also * Partial lysergamide * LY-178210 * 8-OH-DPAT * RDS-127 * RU-27849 * RU-28306 * ''N''-DEAOP-NMT * CT-5252 CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent b ... References Alpha-Alkyltryptamines Anxiogenics N,N-Dialkyltryptamines Drugs developed by Eli Lilly and Company Ketones Partial ergolines Serotonin receptor agonists {{ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergolines
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ... and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-27849
RU-27849 is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship (SAR) studies of LSD. It shows affinity for serotonin receptors, including for the serotonin 5-HT1, 5-HT1A, and 5-HT2 receptors ( = 267–520nM, 325–326nM, and 1,964–2,900nM, respectively). RU-27849's affinities for serotonin receptors are similar to but lower than those of tryptamine and dimethyltryptamine (DMT). It shows very weak affinity for dopamine receptors and weak associated activity. The 6-methoxy derivative of RU-27849, which is to RU-27849 as 5-methoxytryptamine is to tryptamine, appears to have much higher affinity for serotonin receptors than RU-27849 itself ( ≈ 50nM). A number of other derivatives also exist, including FHATHBIN (6-hydroxy), RU-28306 (''N'',''N''-dimethyl), RU-28251 (''N'',''N''-dipropyl), Bay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LY-178210
LY-178210 is a selective and highly potent serotonin 5-HT1A receptor partial agonist. It has an affinity (Ki) of 0.67nM for the serotonin 5-HT1A receptor. The drug has high selectivity for this receptor over 12other assessed targets, including the serotonin 5-HT1D, 5-HT2A, 5-HT2C, and 5-HT3 receptors among others (Ki = ≥380–4,000nM). LY-178210 is a tricyclic simplified or partial ergoline and is structurally related to LSD. It was described as a potential clinical development candidate but was not further developed and was never marketed. The drug was first reported in the scientific literature by 1990. See also * Partial lysergamide * RU-27849 * RU-28306 * Bay R 1531 (LY-197206) * LY-293284 * NDTDI * 8-OH-DPAT 8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor, 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonis ... ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simplified/partial LSD Analogue
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company
Eli Lilly and Company, Trade name, doing business as Lilly, is an American multinational Medication, pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by Eli Lilly, a pharmaceutical chemist and Union army veteran during the American Civil War for whom the company was later named. As of October 2024, Lilly is the most valuable drug company in the world with a $842 billion market capitalization, the highest valuation ever achieved to date by a drug company. The company is ranked 127th on the Fortune 500, ''Fortune'' 500 with revenue of $34.12 billion. It is ranked 221st on the Forbes Global 2000, ''Forbes'' Global 2000 list of the world's largest publicly traded companies and 252nd on ''Forbes'' list of "America's Best Employers". Lilly is known for its Major depressive disorder, clinical depression drugs Prozac (fluoxetine) (1986), Cymbalta (duloxet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-28306
RU-28306 is a synthetic indole alkaloid derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT1 and 5-HT2 subtypes. It can be regarded as a conformationally restricted tricyclic derivative of DMT or a structurally simplified derivative of LSD. The binding affinity of racemic RU-28306 is closer to that of DMT than LSD, though with relatively higher affinity for 5-HT2 subtypes and lower for 5-HT1. It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017. It was subsequently patented by Delix Therapeutics in 2021. See also * Partial lysergamide * RU-27849 * Bay R 1531 * NDTDI * ''N''-DEAOP-NMT * CT-5252 CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent b ... * RU-24,969 * 4,5-DHP-DMT References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ketones
In organic chemistry, a ketone is an organic compound with the structure , where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group (a carbon-oxygen double bond C=O). The simplest ketone is acetone (where R and R' are methyl), with the formula . Many ketones are of great importance in biology and industry. Examples include many sugars (ketoses), many steroids, ''e.g.'', testosterone, and the solvent acetone. Nomenclature and etymology The word ''ketone'' is derived from ''Aketon'', an old German word for ''acetone''. According to the rules of IUPAC nomenclature, ketone names are derived by changing the suffix ''-ane'' of the parent alkane to ''-anone''. Typically, the position of the carbonyl group is denoted by a number, but traditional nonsystematic names are still generally used for the most important ketones, for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names, although some introd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drugs Developed By Eli Lilly And Company
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Classification Pharmaceutical drugs are often classified into drug classes—groups of related drugs that have simila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Alkyltryptamines
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
