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Phil S. Baran
Phil S. Baran (born August 10, 1977) is a synthetic organic chemist and Professor in the Department of Chemistry at the Scripps Research Institute. The region is bounded in the west by the J ..., and BASF Corporation. In 2014, Baran began a partnership witIKA well-known laboratory equipment manufacturer, to bring to market a revolutionary piece of equipment that promised to standardize electrochemical protocols and make electrochemistry accessible to the average organic chemist. Three years after the partnership began, the ElectraSyn wadebuted in a Steve Jobs-esque fashionat the American Chemical Society annual meeting, drawing a large crowd of eager chemists. In the seven years since, the ElectraSyn and subsequent ElectraSyn 2.0 have been widely adopted into the synthetic community and utilized towards hundreds of research articles and patents. The publicity surrounding Baran's (as well as Jin-Quan Yu's) partnership with IKA was highlighted with a memorable promotional videfo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denville, NJ
Denville Township is a Township (New Jersey), township in Morris County, New Jersey, Morris County, in the North Jersey, northern portion of the U.S. state of New Jersey. It is a commuter town of New York City in the New York metropolitan area, located west of Manhattan. As of the 2020 United States census, the township's population was 17,107, its highest decennial count ever and an increase of 472 (+2.8%) from the 2010 United States census, 2010 census count of 16,635, which in turn had reflected an increase of 811 (+5.1%) from the 15,824 counted at the 2000 United States census, 2000 census. Located at the center of the county, Denville's access to major transportation routes has made it known as the ''Hub of Morris County''.Denville profile ''Daily Record (New Jersey), Daily Record''. Accessed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jin-Quan Yu
Jin-Quan Yu () is a Chinese-born American chemist. He is the Frank and Bertha Hupp Professor of Chemistry at Scripps Research, where he also holds the Bristol Myers Squibb Endowed Chair in Chemistry. He is a 2016 recipient of the MacArthur Fellowship, and is a member of the American Academy of Arts and Sciences, American Association for the Advancement of Science, and the Royal Society of Chemistry. Yu is a leader in the development of C–H bond activation reactions in organic chemistry, and has reported many C–H activation reactions that could be applicable towards the synthesis of drug molecules and other biologically active compounds. He also co-founded Vividion Therapeutics in 2016 with fellow Scripps chemists Benjamin Cravatt and Phil Baran, and is a member of the scientific advisory board of Chemveda Life Sciences. Early life and education Yu was born on January 10, 1966, in Zhejiang, China. He received his B.Sc. in chemistry at East China Normal University in 1987. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thapsigargin
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase ( SERCA). Structurally, thapsigargin is classified as a guaianolide, and is extracted from a plant, '' Thapsia garganica''. It is a tumor promoter in mammalian cells. Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into the sarcoplasmic and endoplasmic reticula. Store-depletion can secondarily activate plasma membrane calcium channels, allowing an influx of calcium into the cytosol. Depletion of ER calcium stores leads to ER stress and activation of the unfolded protein response The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved between mammalian species, as well as yeast and worm organisms. The UPR is activated in response t .... Non-resolved ER stress can cumulatively lead to cell death. Prolonged store depletion c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxol
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an protein-bound paclitaxel, albumin-bound formulation. Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other side effects include heart problems, increased risk of infection, and pneumonitis, lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division. Paclitaxel was isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made from precursors, and through cell c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maximiscin
Maximiscin is a polyketide-shikimate chemical compound isolated from ''Tolypocladium'' that shows tumor growth suppression in an animal model. The discovery of maximiscin was the result of a citizen scientist crowdsourcing project by the University of Oklahoma. The soil sample which yielded maximiscin was sent by a woman from Salcha, Alaska Salcha ( Tanana: ''Soł Chaget'', Tanacross: ''Saagescheeg'') is a census-designated place (CDP) in Fairbanks North Star Borough in the U.S. state of Alaska. It is part of the Fairbanks, Alaska Metropolitan Statistical Area. The population was 1, .... References Methyl esters Lactams Polyketides Cyclohexenes {{Ether-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tagetitoxin
Tagetitoxin (TGT) is a bacterial phytotoxin produced by ''Pseudomonas syringae pv. tagetis''. Chemical structure When TGT was first isolated, it was only partially characterized. The first proposed chemical structure of TGT involved an eight-membered ring, but this was revised shortly afterward to a bicyclic structure (shown at right) based on NMR and mass spectrometry. This structure, however, has been questioned. The absolute configuration remains undetermined, and attempts at confirming the structure by organic synthesis Organic synthesis is a branch of chemical synthesis concerned with the construction of organic compounds. Organic compounds are molecules consisting of combinations of covalently-linked hydrogen, carbon, oxygen, and nitrogen atoms. Within the gen ... are underway. Recently Porter et al. published a revised structure of TGT based on extensive 2D NMR data. Mechanism of action TGT interferes with development of chloroplasts in young plant leaves thereby c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcipotriol
Calcipotriol, also known as calcipotriene and sold under the brand name Dovonex among others, is a synthetic derivative of calcitriol, a form of vitamin D. It is used in the treatment of psoriasis. It was patented in 1985 and approved for medical use in 1991. It is on the World Health Organization's List of Essential Medicines. Calcipotriol is also available with the synthetic corticosteroid betamethasone dipropionate as the fixed-dose combination medication calcipotriol/betamethasone dipropionate for the treatment of plaque psoriasis. Medical uses Chronic plaque psoriasis is the chief medical use of calcipotriol. It has also been used successfully in the treatment of alopecia areata. Contraindications Hypersensitivity, use on face, hypercalcaemia, or evidence of vitamin D toxicity are the only contraindications for calcipotriol use. Cautions include exposure to excessive natural or artificial light, due to the potential for calcipotriol to cause photosensitivity. Adve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Darobactin
Darobactin is an experimental antibiotic compound that may be effective against Gram-negative bacteria. If it can be developed into a human-compatible form it would be the first to come from an animal microbiome. History The compound was discovered in ''Photorhabdus'' bacteria in 2019, living in the digestive systems of entomopathogenic nematodes. Researchers identified the nematode as a possible host because they feed on insects by targeting their larvae and releasing bacteria that then confront pathogens similar to those found in humans. In experiments, it cured mice of infections with ''Escherichia coli'' and ''Klebsiella pneumoniae'', both members of the Enterobacteriaceae, without toxic side effects. Gram-negative bacteria Gram-negative bacteria have a characteristic architecture for the cell envelope, with an inner membrane, an outer membrane, and a periplasmic space in between. In this arrangement, the peptidoglycan layer is relatively thin and does not retain the crys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portimine A
Portimine A is a cyclic imine natural product produced by the dinoflagellate microalgae '' Vulcanodinium rugosum''. It is a drug lead due to its anti-cancer activity. It seemingly inhibits ribosomal translation activity through an interaction with NMD3, leading to activation of the inflammasome. It is suspected to be causal toxin behind an severe inflammatory skin disease in Senegalese Demographic features of the population of Senegal include population density, ethnicity, education level, health of the populace, economic status, religious affiliations and other aspects of the population. About 42% of Senegal's population i ... fishermen in 2020 and 2021. References {{Reflist Nitrogen heterocycles Oxygen heterocycles Heterocyclic compounds with 5 rings ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopamine
Cyclopamine (11-deoxojervine) is a naturally occurring steroidal alkaloid. It is a teratogenic component of corn lily ('' Veratrum californicum''), which when consumed during gestation has been demonstrated to induce birth defects, including the development of a single eye (cyclopia) in offspring. The molecule was named after this effect, which was originally observed by Idaho lamb farmers in 1957 after their herds gave birth to cycloptic lambs. It then took more than a decade to identify corn lily as the culprit. Later work suggested that differing rain patterns had changed grazing behaviours, which led to a greater quantity of corn lily to be ingested by pregnant sheep. Cyclopamine interrupts the sonic hedgehog signalling pathway, instrumental in early development, ultimately causing birth defects. Discovery and naming In 1957, Idaho sheep ranchers contacted the US Department of Agriculture (USDA) after their sheep gave birth to lambs with a fatal singular eye deformity. Aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BASF
BASF SE (), an initialism of its original name , is a European Multinational corporation, multinational company and the List of largest chemical producers, largest chemical producer in the world. Its headquarters are located in Ludwigshafen, Germany. BASF comprises subsidiary, subsidiaries and joint ventures in more than 80 countries, operating six integrated production sites and 390 other production sites across Europe, Asia, Australia, the Americas and Africa. BASF has customers in over 190 countries and supplies products to a wide variety of industries. Despite its size and global presence, BASF has received relatively little public attention since it abandoned the manufacture and sale of BASF-branded consumer electronics products in the 1990s. The company began as a dye manufacturer in 1865. Fritz Haber worked with Carl Bosch, one of its employees, to invent the Haber-Bosch, Haber-Bosch process by 1912, after which the company grew rapidly. In 1925, the company merged with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilead Sciences
Gilead Sciences, Inc. () is an American biopharmaceutical company headquartered in Foster City, California, that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS, hepatitis B, hepatitis C, influenza, and COVID-19, including ledipasvir/sofosbuvir and sofosbuvir. Gilead is a member of the Nasdaq-100 and the S&P 100. Gilead was founded in 1987 under the name Oligogen by Michael L. Riordan. The original name was a reference to oligonucleotides, small strands of DNA used to target genetic sequences. Gilead held its initial public offering in 1992, and successfully developed drugs like Tamiflu and Vistide that decade. In the 2000s, Gilead received approval for drugs including Viread and Hepsera, among others. It began evolving from a biotechnology company into a pharmaceutical company, acquiring several subsidiaries, though it still relied heavily on contracting to manufacture its drugs. The company continued its growth in the 2010s. Howev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
