Maximiscin
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Maximiscin
Maximiscin is a polyketide-shikimate chemical compound isolated from ''Tolypocladium'' that shows tumor growth suppression in an animal model. The discovery of maximiscin was the result of a citizen scientist crowdsourcing project by the University of Oklahoma. The soil sample which yielded maximiscin was sent by a woman from Salcha, Alaska Salcha ( Tanana: ''Soł Chaget'', Tanacross: ''Saagescheeg'') is a census-designated place (CDP) in Fairbanks North Star Borough in the U.S. state of Alaska. It is part of the Fairbanks, Alaska Metropolitan Statistical Area. The population was 1, .... References Methyl esters Lactams Polyketides Cyclohexenes {{Ether-stub ...
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Polyketide
In organic chemistry, polyketides are a class of natural products derived from a Precursor (chemistry), precursor molecule consisting of a Polymer backbone, chain of alternating ketone (, or Carbonyl reduction, its reduced forms) and Methylene group, methylene () groups: . First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century ...
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Shikimate
Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. It is an important biochemical metabolite in plants and microorganisms. Its name comes from the Japanese flower ''shikimi'' (, the Japanese star anise, ''Illicium anisatum''), from which it was first isolated in 1885 by Johan Fredrik Eykman. The elucidation of its structure was made nearly 50 years later. Biosynthesis Phosphoenolpyruvate and erythrose-4-phosphate condense to form 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP), in a reaction catalyzed by the enzyme DAHP synthase. DAHP is then transformed to 3-dehydroquinate (DHQ), in a reaction catalyzed by DHQ synthase. Although this reaction requires nicotinamide adenine dinucleotide (NAD) as a cofactor, the enzymic mechanism regenerates it, resulting in the net use of no NAD. : DHQ is dehydrated to 3-dehydroshikimic acid by the enzyme 3-dehydroquinate dehydratase, which is reduced to shi ...
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Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken or new bonds formed or both. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, usin ...
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Tolypocladium
''Tolypocladium'' is a genus of fungi within the family Ophiocordycipitaceae. It includes species that are parasites of other fungi, insect pathogens, rotifer pathogens and soil inhabiting species with uncertain ecological roles. ''Tolypocladium'' was originally circumscribed as a genus containing anamorphic fungi. It was later determined that some ''Cordyceps''-like teleomorphic fungi were the teleomorphs of ''Tolypocladium'' species. These species were considered to belong in the genus ''Cordyceps'' until molecular phylogenetics studies found these species to be more closely related to '' Ophiocordyceps'' and were considered to belong in that genus before they were transferred to the new genus ''Elaphocordyceps'' by Sung and colleagues in 2007. However, under the ICN's 2011 " one fungus, one name" principle, fungi can not have different names for their anamorphic and teleomorphic stages if they are found to be the same taxon. Quandt and colleagues formally synonymized ''Tolypo ...
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Animal Model
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. There are three main types of animal models: Homologous, Isomorphic and Predictive. Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. Isomorphic animals share the same symptoms and treatments, only. Predictive models are similar to a particular human disease in only a couple of aspects. However, these are useful in isolating ...
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Crowdsourcing
Crowdsourcing involves a large group of dispersed participants contributing or producing goods or services—including ideas, votes, micro-tasks, and finances—for payment or as volunteers. Contemporary crowdsourcing often involves digital platforms to attract and divide work between participants to achieve a cumulative result. Crowdsourcing is not limited to online activity, however, and there are various historical examples of crowdsourcing. The word crowdsourcing is a portmanteau of "crowd" and "outsourcing". In contrast to outsourcing, crowdsourcing usually involves less specific and more public groups of participants. Advantages of using crowdsourcing include lowered costs, improved speed, improved quality, increased flexibility, and/or increased scalability of the work, as well as promoting diversity. Crowdsourcing methods include competitions, virtual labor markets, open online collaboration and data donation. Some forms of crowdsourcing, such as in "idea competiti ...
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University Of Oklahoma
The University of Oklahoma (OU) is a Public university, public research university in Norman, Oklahoma, United States. Founded in 1890, it had existed in Oklahoma Territory near Indian Territory for 17 years before the two territories became the state of Oklahoma. In Fall 2024, the university had 34,523 students enrolled, most at its main campus in Norman. Employing nearly 4,000 faculty members, the university offers 174 Bachelor's degree, baccalaureate programs, 199 Master's degree, master's programs, 101 Doctorate, doctoral programs, and 88 certificate programs. The university is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity", with over $416 million in research expenditures across its three campuses in 2022. Its Norman campus has two prominent museums, the Fred Jones Jr. Museum of Art, specializing in French Impressionism and Native Americans in the United States, Native American artwork, ...
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Salcha, Alaska
Salcha ( Tanana: ''Soł Chaget'', Tanacross: ''Saagescheeg'') is a census-designated place (CDP) in Fairbanks North Star Borough in the U.S. state of Alaska. It is part of the Fairbanks, Alaska Metropolitan Statistical Area. The population was 1,095 at the 2010 census, up from 854 in 2000. Geography Salcha is located at (64.520455, -147.011452). The village was first reported in 1898 by the U.S. Geological Survey as "Salchaket", deriving from the Tanana name ''Soł Chaget'' meaning "the mouth of Salcha". It is about south of Fairbanks on the Richardson Highway. It is next to the Salcha River, a popular fishing destination. It is also next to the Tanana River. Salcha has its own post office. The ZIP code for Salcha is 99714. The Salcha Seismic Zone underlies the community. According to the United States Census Bureau, the CDP has a total area of , of which is land and , or 2.59%, is water. Climate Salcha has a dry-winter continental subarctic climate (Köppen Dwc). Demog ...
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Methyl Esters
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom chemical bond, bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula ). In chemical formula, formulas, the group is often skeletal formula#Pseudoelement symbols, abbreviated as Me. This hydrocarbon group occurs in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, bonded to the rest of the molecule by a single covalent bond (), it can be found on its own in any of three forms: methanide anion (), methylium cation () or methyl radical (chemistry), radical (). The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed. Methyl cation, anion, and radical Methyl cation The methylium cation () exists in the gas phase, but is otherwise not encountered. Some compounds are considered to be sources ...
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Lactams
A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words '' lactone'' + ''amide''. Nomenclature Greek prefixes in alphabetical order indicate ring size. This ring-size nomenclature stems from the fact that hydrolysis of an α-lactam gives an α-amino acid and that of a β-Lactam gives a β-amino acid, and so on. Synthesis General synthetic methods are used for the organic synthesis of lactams. Beckmann rearrangement Lactams form by the acid-catalyzed rearrangement of oximes in the Beckmann rearrangement. Schmidt reaction Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction. Cyclohexanone with hydrazoic acid, forms ε - Caprolactum, which upon treatment with excess acid forms Cardiazole, a heart stimulant. Cyclization of amino acids Lactams can be formed from cyclisation of amino acids via the coupling between an amine and a carboxylic acid within the s ...
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Polyketides
In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (, or its reduced forms) and methylene () groups: . First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by ...
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