Maximiscin is a
polyketide
In organic chemistry, polyketides are a class of natural products derived from a Precursor (chemistry), precursor molecule consisting of a Polymer backbone, chain of alternating ketone (, or Carbonyl reduction, its reduced forms) and Methylene gro ...
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shikimate
Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. It is an important biochemical metabolite in plants and microorganisms. Its name comes from the Japanese flower ''shik ...
chemical compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element ...
isolated from ''
Tolypocladium
''Tolypocladium'' is a genus of fungi within the family Ophiocordycipitaceae. It includes species that are parasites of other fungi, insect pathogens, rotifer pathogens and soil inhabiting species with uncertain ecological roles.
''Tolypocladium ...
'' that shows tumor growth suppression in an
animal model
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of ha ...
. The discovery of maximiscin was the result of a citizen scientist
crowdsourcing
Crowdsourcing involves a large group of dispersed participants contributing or producing goods or services—including ideas, votes, micro-tasks, and finances—for payment or as volunteers. Contemporary crowdsourcing often involves digit ...
project by the
University of Oklahoma
The University of Oklahoma (OU) is a Public university, public research university in Norman, Oklahoma, United States. Founded in 1890, it had existed in Oklahoma Territory near Indian Territory for 17 years before the two territories became the ...
. The soil sample which yielded maximiscin was sent by a woman from
Salcha, Alaska
Salcha ( Tanana: ''Soł Chaget'', Tanacross: ''Saagescheeg'') is a census-designated place (CDP) in Fairbanks North Star Borough in the U.S. state of Alaska. It is part of the Fairbanks, Alaska Metropolitan Statistical Area. The population was 1, ...
.
References
Methyl esters
Lactams
Polyketides
Cyclohexenes
{{Ether-stub