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Multiple Scattering Low Coherence Interferometry
Multiple scattering low coherence interferometry (ms/LCI) is an imaging technique that relies on analyzing multiply scattered light in order to capture depth-resolved images from optical scattering media. With current applications primarily in medical imaging, has the advantage of a higher range since forward scattered light attenuates less with depth when compared to the specular reflection, specularly reflected light that is assessed in more conventional imaging methods such as optical coherence tomography. This allows ms/LCI to image through up to 90 mean free scattering paths, compared to roughly 27 scattering MFPs in OCT and 1–2 scattering MFPs in confocal microscopy. Design Time-domain implementation Early implementations of ms/LCI were in the time domain using lock-in amplifier, lock-in detection in order to take advantage of long scanning depths as well narrow detection bandwidths. As in traditional OCT, the beam wave interference, interference coherence gates the li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Imaging
Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues ( physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging. Measurement and recording techniques that are not primarily designed to produce images, such as electroencephalography (EEG), magnetoencephalography (MEG), electrocardiography (ECG), and others, represent other technologies that produce data susceptible to representation as a parameter graph versus time or maps that contain data about the measurement ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Specular Reflection
Specular reflection, or regular reflection, is the mirror-like reflection of waves, such as light, from a surface. The law of reflection states that a reflected ray of light emerges from the reflecting surface at the same angle to the surface normal as the incident ray, but on the opposing side of the surface normal in the plane formed by the incident and reflected rays. This behavior was first described by Hero of Alexandria ( AD c. 10–70). Specular reflection may be contrasted with diffuse reflection, in which light is scattered away from the surface in a range of directions. Law of reflection When light encounters a boundary of a material, it is affected by the optical and electronic response functions of the material to electromagnetic waves. Optical processes, which comprise reflection and refraction, are expressed by the difference of the refractive index on both sides of the boundary, whereas reflectance and absorption are the real and imaginary parts of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optical Coherence Tomography
Optical coherence tomography (OCT) is an imaging technique that uses low-coherence light to capture micrometer-resolution, two- and three-dimensional images from within optical scattering media (e.g., biological tissue). It is used for medical imaging and industrial nondestructive testing (NDT). Optical coherence tomography is based on low-coherence interferometry, typically employing near-infrared light. The use of relatively long wavelength light allows it to penetrate into the scattering medium. Confocal microscopy, another optical technique, typically penetrates less deeply into the sample but with higher resolution. Depending on the properties of the light source (superluminescent diodes, ultrashort pulsed lasers, and supercontinuum lasers have been employed), optical coherence tomography has achieved sub-micrometer resolution (with very wide-spectrum sources emitting over a ~100 nm wavelength range). Optical coherence tomography is one of a class of optical tom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Confocal Microscopy
Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser confocal scanning microscopy (LCSM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a sample enables the reconstruction of three-dimensional structures (a process known as optical sectioning) within an object. This technique is used extensively in the scientific and industrial communities and typical applications are in life sciences, semiconductor inspection and materials science. Light travels through the sample under a conventional microscope as far into the specimen as it can penetrate, while a confocal microscope only focuses a smaller beam of light at one narrow depth level at a time. The CLSM achieves a controlled and highly limited depth of field. Basic concept The principle of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time Domain
Time domain refers to the analysis of mathematical functions, physical signals or time series of economic or environmental data, with respect to time. In the time domain, the signal or function's value is known for all real numbers, for the case of continuous time, or at various separate instants in the case of discrete time. An oscilloscope is a tool commonly used to visualize real-world signals in the time domain. A time-domain graph shows how a signal changes with time, whereas a frequency-domain graph shows how much of the signal lies within each given frequency band over a range of frequencies. Though most precisely referring to time in physics, the term ''time domain'' may occasionally informally refer to position in space when dealing with spatial frequencies, as a substitute for the more precise term ''spatial domain''. Origin of term The use of the contrasting terms ''time domain'' and '' frequency domain'' developed in U.S. communication engineering in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lock-in Amplifier
A lock-in amplifier is a type of amplifier that can extract a signal with a known carrier wave from an extremely noisy environment. Depending on the dynamic reserve of the instrument, signals up to a million times smaller than noise components, potentially fairly close by in frequency, can still be reliably detected. It is essentially a homodyne detector followed by low-pass filter that is often adjustable in cut-off frequency and filter order. The device is often used to measure phase shift, even when the signals are large, have a high signal-to-noise ratio and do not need further improvement. Recovering signals at low signal-to-noise ratios requires a strong, clean reference signal with the same frequency as the received signal. This is not the case in many experiments, so the instrument can recover signals buried in the noise only in a limited set of circumstances. The lock-in amplifier is commonly believed to have been invented by Princeton University physicist Robert H. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wave Interference
In physics, interference is a phenomenon in which two waves combine by adding their displacement together at every single point in space and time, to form a resultant wave of greater, lower, or the same amplitude. Constructive and destructive interference result from the interaction of waves that are correlated or coherent with each other, either because they come from the same source or because they have the same or nearly the same frequency. Interference effects can be observed with all types of waves, for example, light, radio, acoustic, surface water waves, gravity waves, or matter waves. Etymology The word ''interference'' is derived from the Latin words ''inter'' which means "between" and ''fere'' which means "hit or strike", and was coined by Thomas Young in 1801. Mechanisms The principle of superposition of waves states that when two or more propagating waves of the same type are incident on the same point, the resultant amplitude at that point is equal to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optical Path Length
In optics, optical path length (OPL, denoted ''Λ'' in equations), also known as optical length or optical distance, is the product of the geometric length of the optical path followed by light and the refractive index of homogeneous medium through which a light ray propagates; for inhomogeneous optical media, the product above is generalized as a path integral as part of the ray tracing procedure. A difference in OPL between two paths is often called the optical path difference (OPD). OPL and OPD are important because they determine the phase of the light and governs interference and diffraction of light as it propagates. Formulation In a medium of constant refractive index, ''n'', the OPL for a path of geometrical length ''s'' is just :\mathrm = n s .\, If the refractive index varies along the path, the OPL is given by a line integral :\mathrm = \int_C n \mathrm d s,\quad where ''n'' is the local refractive index as a function of distance along the path ''C''. An e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diffuse Reflection
Diffuse reflection is the reflection of light or other waves or particles from a surface such that a ray incident on the surface is scattered at many angles rather than at just one angle as in the case of specular reflection. An ''ideal'' diffuse reflecting surface is said to exhibit Lambertian reflection, meaning that there is equal luminance when viewed from all directions lying in the half-space adjacent to the surface. A surface built from a non-absorbing powder such as plaster, or from fibers such as paper, or from a polycrystalline material such as white marble, reflects light diffusely with great efficiency. Many common materials exhibit a mixture of specular and diffuse reflection. The visibility of objects, excluding light-emitting ones, is primarily caused by diffuse reflection of light: it is diffusely-scattered light that forms the image of the object in the observer's eye. Mechanism Diffuse reflection from solids is generally not due to surface roughness. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lens (optics)
A lens is a transmissive optical device which focuses or disperses a light beam by means of refraction. A simple lens consists of a single piece of transparent material, while a compound lens consists of several simple lenses (''elements''), usually arranged along a common axis. Lenses are made from materials such as glass or plastic, and are ground and polished or molded to a desired shape. A lens can focus light to form an image, unlike a prism, which refracts light without focusing. Devices that similarly focus or disperse waves and radiation other than visible light are also called lenses, such as microwave lenses, electron lenses, acoustic lenses, or explosive lenses. Lenses are used in various imaging devices like telescopes, binoculars and cameras. They are also used as visual aids in glasses to correct defects of vision such as myopia and hypermetropia. History The word '' lens'' comes from '' lēns'', the Latin name of the lentil (a seed of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contrast Agent
A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. Contrast agents absorb or alter external electromagnetism or ultrasound, which is different from radiopharmaceuticals, which emit radiation themselves. In x-ray imaging, contrast agents enhance the radiodensity in a target tissue or structure. In magnetic resonance imaging, contrast agents shorten (or in some instances increase) the relaxation times of nuclei within body tissues in order to alter the contrast in the image. Contrast agents are commonly used to improve the visibility of blood vessels and the gastrointestinal tract. The types of contrast agent are classified according to their intended imaging modalities. Radiocontrast media For radiography, which is based on X-rays, iodine and barium are the most common types of contrast agent. Various sorts of iodinated contrast agents exist, with variations occurring between the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Supercontinuum
In optics, a supercontinuum is formed when a collection of nonlinear processes act together upon a pump beam in order to cause severe spectral broadening of the original pump beam, for example using a microstructured optical fiber. The result is a smooth spectral continuum (see figure 1 for a typical example). There is no consensus on how much broadening constitutes a supercontinuum; however researchers have published work claiming as little as 60 nm of broadening as a supercontinuum. There is also no agreement on the spectral flatness required to define the bandwidth of the source, with authors using anything from 5 dB to 40 dB or more. In addition the term supercontinuum itself did not gain widespread acceptance until this century, with many authors using alternative phrases to describe their continua during the 1970s, 1980s and 1990s. During the last decade, the development of supercontinua sources has emerged as a research field. This is largely due to new ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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