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Karelian Bear Dog
The Karelian Bear Dog ( ) is a Finland, Finnish dog breed, breed of dog. In its home country, it is seen by many as a national treasure. Karelian Bear Dogs will hunt a variety of animals. Its quick reflexes and fearless nature have made it very popular for hunting large game including brown bears, moose, and wild boar. It was the breed's ability to hunt bears that earned the breed its name. The Karelian Bear Dog is among the top 10 most common dog breeds in Finland. History The Karelian Bear Dog originated from the Komi dog. Basic stock dogs originated from the Ladoga Karelia, Olonets Karelia, and East Karelia where they were used for hunting. The breeding was started in 1936 to create a sturdy dog which would bark at big game, and named the Karelian Bear Dog. The first standard was established in 1945 and the first dogs were registered in 1946. The Karelian Bear Dog was used mainly for hunting small fur-bearing animals, such as squirrels and marten. Like the Norwegian Elkhound, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Finland
Finland, officially the Republic of Finland, is a Nordic country in Northern Europe. It borders Sweden to the northwest, Norway to the north, and Russia to the east, with the Gulf of Bothnia to the west and the Gulf of Finland to the south, opposite Estonia. Finland has a population of 5.6 million. Its capital and largest city is Helsinki. The majority of the population are Finns, ethnic Finns. The official languages are Finnish language, Finnish and Swedish language, Swedish; 84.1 percent of the population speak the first as their mother tongue and 5.1 percent the latter. Finland's climate varies from humid continental climate, humid continental in the south to boreal climate, boreal in the north. The land cover is predominantly boreal forest biome, with List of lakes of Finland, more than 180,000 recorded lakes. Finland was first settled around 9000 BC after the Last Glacial Period, last Ice Age. During the Stone Age, various cultures emerged, distinguished by differen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Shepherd Dog
The German Shepherd, also known in Britain as an Alsatian, is a German breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various traditional German herding dogs from 1899. It was originally bred as a herding dog, for herding sheep. It has since been used in many other types of work, including disability assistance, search-and-rescue, police work, and warfare. It is commonly kept as a companion dog, and according to the Fédération Cynologique Internationale had the second-highest number of annual registrations in 2013. History During the 1890s, attempts were being made to standardise dog breeds. Dogs were being bred to preserve traits that assisted in their job of herding sheep and protecting their flocks from predators. In Germany this was practised within local communities, where shepherds selected and bred dogs. It was recognised that the breed had the necessary skills for herding sheep, such as intelligence, spee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LHX3
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the ''LHX3'' gene. Function ''LHX3'' encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene. Clinical significance Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Interactions LHX3 has been shown to interact with Ldb1 LIM domain-binding protein 1 is a protein that in humans is encoded by the ''LDB1'' gene. Interactions LDB1 has been shown to interact with other proteins such as LMO4, TCF3 Transcription factor 3 (E2A immunoglobulin enhancer-binding factor .... References Further reading * * * * * * * * * * * * * * * * * * External links * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ITGA10
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ''ITGA10'' gene. Function Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. Related gene problems *TAR syndrome TAR syndrome (thrombocytopenia with absent radius) is a rare genetic disorder that is characterized by the absence of the radius bone in the forearm and a dramatically reduced platelet count. It is associated with cardiac defects, dysmorphic f ... * 1q21.1 deletion syndrome * 1q21.1 duplication syndrome References Further reading * * * * * * * * * External linksITGA10Info with links in thCell Migration Gateway Integrins {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonsense Mutation
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a ''nonsense codon'', or a premature stop codon in the transcribed mRNA, and leads to a truncated, incomplete, and possibly nonfunctional protein product. Nonsense mutations are not always harmful; the functional effect of a nonsense mutation depends on many aspects, such as the location of the stop codon within the coding DNA. For example, the effect of a nonsense mutation depends on the proximity of the nonsense mutation to the original stop codon, and the degree to which functional subdomains of the protein are affected. As nonsense mutations leads to premature termination of polypeptide chains; they are also called chain termination mutations. Missense mutations differ from nonsense mutations since they are point mutations that exhibit a single nucleotide change to cause substitution of a different amino acid. A nonsense mutation also differs from a nonstop mutation, which is a point muta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recessive
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and the second is called recessive. This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes ( autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, there are other forms of dominance, such as incompl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ossification
Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue ( mesenchyme), while endochondral ossification involves cartilage as a precursor. In fracture healing, endochondral osteogenesis is the most commonly occurring process, for example in fractures of long bones treated by plaster of Paris, whereas fractures treated by open reduction and internal fixation with metal plates, screws, pins, rods and nails may heal by intramembranous osteogenesis. Heterotopic ossification is a process resulting in the formation of bone tissue that is often atypical, at an extraskeletal location. Calcification is often confused with ossification. Calcificatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carpal Valgus
Angular limb deformity is a pathological deformity in the spatial alignment of any limb in quadrupedal animals. The term encompasses any condition in such an animal wherein a limb is not straight. It most commonly occurs in the carpal joint of the forelimbs, manifesting as the limb pointing outward (''carpal valgus'') or inward (''carpal varus''), deviating from normal development. Causes Angular limb deformity usually occurs due to outside factors during developmental years, including blunt force trauma, unbalanced nutrition, or excessive exercise. They are less likely to develop in hind limbs, except in certain animals, such as dachshunds. Rarely, they can also occur from a genetic predisposition to premature growth plate closure. The exact aetiology of the deformity is unknown. Symptoms and Diagnosis Significant angular limb deformity is often apparent visually from looking at the limbs in front of, behind, or from the side of the animal. Diagnosis is usually made through phys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chondrodysplasia
An osteochondrodysplasia,Etymology: . or skeletal dysplasia, is a disorder of the development of bone and cartilage. Osteochondrodysplasias are rare diseases. About 1 in 5,000 babies are born with some type of skeletal dysplasia. Nonetheless, if taken collectively, genetic skeletal dysplasias or osteochondrodysplasias comprise a recognizable group of genetically determined disorders with generalized skeletal affection. These disorders lead to disproportionate short stature and bone abnormalities, particularly in the arms, legs, and spine. Skeletal dysplasia can result in marked functional limitation and even mortality. Osteochondrodysplasias or skeletal dysplasia subtypes can overlap in clinical aspects, therefore plain radiography is absolutely necessary to establish an accurate diagnosis. Magnetic resonance imaging can provide further diagnostic insights and guide treatment strategies especially in cases of spinal involvement. As some disorders that cause skeletal dysplasia have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karelian Bear Dogs With Canine Pituitary Dwarfism C
Karelian refers to something from or related to the region of Karelia, in present-day Russia and Finland. * Karelians, an ethnic group in Russia speaking the Karelian language * Karelians (Finns), a subgroup of Finns * Karelian language, a Baltic Finnic language * Karelian dialects, a group of Southeast Finnish dialects See also * Karelia (other) * Kurilian (other) Kurilian means 'of or having to do with the Kuril Islands'. It may specifically refer to: * The geography or other features of the Kuril Islands (also called ''Kurile'', ''Kurilsky'', ''Kurilskiye'', or ''Chishima Islands'') * Peoples of the Kuril ... {{disambig Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
