Integrin alpha-10 also known as ITGA10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''ITGA10''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Integrins
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...
are
integral membrane protein
An integral, or intrinsic, membrane protein (IMP) is a type of membrane protein that is permanently attached to the biological membrane. All ''transmembrane proteins'' are IMPs, but not all IMPs are transmembrane proteins. IMPs comprise a sign ...
s composed of an alpha chain and a beta chain, and are known to participate in
cell adhesion
Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indir ...
as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (
ITGB1) to form a novel
collagen type II-binding integrin expressed in
cartilage tissue.
Related gene problems
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TAR syndrome
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1q21.1 deletion syndrome
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1q21.1 duplication syndrome
References
Further reading
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External links
ITGA10Info with links in th
Cell Migration Gateway
Integrins
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