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Fred Sherman (scientist)
Fred Sherman (May 21, 1932 – September 16, 2013) was an American scientist who pioneered the use of the budding yeast ''Saccharomyces cerevisiae'' as a model for studying the genetics, molecular biology, and biochemistry of eukaryotic cells. His research encompassed broad areas of yeast biology including gene expression, protein synthesis, messenger RNA processing, bioenergetics, and mechanisms of mutagenesis. He also contributed extensively to the genetics of the opportunistic pathogen ''Candida albicans.'' Sherman was a strong proponent of the use of baker's yeast as a genetic model system and played a major role in the adoption of yeast genetic approaches by scientists around the world. This was partly through his role for 17 years as co-instructor, with Gerald Fink, of a summer course in yeast genetics at Cold Spring Harbor Laboratory that trained many scientists who went on to make their own seminal contributions in broad areas of biology. Born in Minnesota, Sherman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892. Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and bioche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerald Fink
Gerald Ralph Fink (born July 1, 1940) is an American biologist, who was Director of the Whitehead Institute at MIT from 1990 to 2001. He graduated from Amherst College in 1962 and received a Ph.D. from Yale University in 1965, having elucidated the histidine pathway in budding yeast, ''Saccharomyces cerevisiae''. After postdoctoral study at the National Institutes of Health with Bruce Ames on the regulation of the histidine operon of Salmonella, in 1967 he joined Cornell University where he became a Professor of Genetics and pursued the study of the HIS4 region of yeast. In 1982 he became a founding member of the Whitehead Institute and Professor of Genetics at MIT. Dr. Fink was elected to the United States National Academy of Sciences in 1981, to the Institute of Medicine in 1996, and to the American Philosophical Society in 2003. Fink taught a course in the Molecular Biology of Yeast at Cold Spring Harbor Laboratory for 16 years. Many of these students as well as his unive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Society Of America
The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the American Society of Zoologists and the Botanical Society of America. An Abridged History of the Genetics Society of America GSA members conduct fundamental and applied research using a wide variety of s to enhance understanding of living systems. Some of the systems of study include '''' (fruit flies), '' |
George Wells Beadle
George Wells Beadle (October 22, 1903 – June 9, 1989) was an American geneticist. In 1958 he shared one-half of the Nobel Prize in Physiology or Medicine with Edward Tatum for their discovery of the role of genes in regulating biochemical events within cells. He served as the 7th president of the University of Chicago from 1961 to 1968. Beadle and Tatum's key experiments involved exposing the bread mold ''Neurospora crassa'' to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments led them to propose a direct link between genes and enzymatic reactions, known as the One gene-one enzyme hypothesis. Education and early life George Wells Beadle was born in Wahoo, Nebraska. He was the son of Chauncey Elmer Beadle and Hattie Albro, who owned and operated a farm nearby. George was educated at the Wahoo High School and might himself have become a farmer if one of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, botany, genomics, and quantitative biology. It is located in Laurel Hollow, New York, in Nassau County, on Long Island. It is one of 68 institutions supported by the Cancer Centers Program of the U.S. National Cancer Institute (NCI) and has been an NCI-designated Cancer Center since 1987. The Laboratory is one of a handful of institutions that played a central role in the development of molecular genetics and molecular biology. It has been home to eight scientists who have been awarded the Nobel Prize in Physiology or Medicine. CSHL is ranked among the leading basic research institutions in molecular biology and genetics, with Thomson Reuters ranking it first in the world. CSHL was also ranked first in research output worldwide by ''Nature''. The Laboratory is led by Bruce Stillman, a biochemist and cancer researcher. Since its incepti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heme
Heme (American English), or haem (Commonwealth English, both pronounced /Help:IPA/English, hi:m/ ), is a ring-shaped iron-containing molecule that commonly serves as a Ligand (biochemistry), ligand of various proteins, more notably as a Prosthetic group, component of hemoglobin, which is necessary to bind oxygen in the bloodstream. It is composed of four pyrrole rings with 2 Vinyl group, vinyl and 2 propionic acid side chains. Heme is biosynthesized in both the bone marrow and the liver. Heme plays a critical role in multiple different redox reactions in mammals, due to its ability to carry the oxygen molecule. Reactions include oxidative metabolism (cytochrome c oxidase, succinate dehydrogenase), xenobiotic detoxification via cytochrome P450 pathways (including Drug metabolism, metabolism of some drugs), gas sensing (Guanylate cyclase, guanyl cyclases, nitric oxide synthase), and microRNA processing (DGCR8). Heme is a coordination complex "consisting of an iron ion coordinated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transfer RNA
Transfer ribonucleic acid (tRNA), formerly referred to as soluble ribonucleic acid (sRNA), is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes). In a cell, it provides the physical link between the genetic code in messenger RNA (mRNA) and the amino acid sequence of proteins, carrying the correct sequence of amino acids to be combined by the protein-synthesizing machinery, the ribosome. Each three-nucleotide codon in mRNA is complemented by a three-nucleotide anticodon in tRNA. As such, tRNAs are a necessary component of translation, the biological synthesis of new proteins in accordance with the genetic code. Overview The process of translation starts with the information stored in the nucleotide sequence of DNA. This is first transformed into mRNA, then tRNA specifies which three-nucleotide codon from the genetic code corresponds to which amino acid. Each mRNA codon is recognized by a particular type of tRNA, which docks to it along ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boris Ephrussi
Boris Ephrussi (; 9 May 1901 – 2 May 1979), Professor of Genetics at the University of Paris, was a Russo- French geneticist. Ephrussi was born on 9 May 1901 into a Jewish family. His father, Samuel Osipovich Ephrussi, was a chemical engineer; his grandfather, Joseph Ephrusi (Efrusi), was the founder of a banking dynasty in Kishinev. He published two papers in November 1966 which represented a key step in a decade of research in his laboratory. This research helped transform mammalian, and especially human, genetics. Boris started his scientific training as a Russian émigré in 1920. He studied the initiation and regulation of embryological processes by intracellular and extracellular factors. A major strand of his early research concerned the effect of temperature on the development of fertilized sea urchin eggs. In this work he used a micromanipulator, which was developed by Robert Chambers, an American biologist. During Ephrussi's time, writing a second dissertation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
