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Cucurbitacin E
Cucurbitacin E is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the family Cucurbitaceae, most of them coming from traditional Chinese medicinal plants, but also in other plants such as pumpkins and gourds. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Specific modifications in this molecule under certain conditions can form other types of cucurbitacins such as cucurbitacin I, J, K and L. , it is being investigated for its potential biological effects. Cucurbitacin E has been found to increase activity of anti-cancer drugs in certain types of cancers. It selectively increases chemosensitivity of nutrient receptors, on or inside cancer cells, to anti-cancer drug molecules, thereby decreasing binding of the nutrients to cancer cells, and decreasing their growth, leading to selective cell death of cancer cells. Research Anti-inflammatory Cucurbitacin E anti-inflammatory activiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cucurbitacin
Cucurbitacin is a class of biochemical compounds that some plants – notably members of the pumpkin and gourd family, Cucurbitaceae – produce and which function as a defence against herbivores. Cucurbitacins are chemically classified as triterpenes, formally derived from cucurbitane, a triterpene hydrocarbon – specifically, from the unsaturated variant cucurbit-5-ene, or 19(10→9β)-abeo-10α-lanost-5-ene. They often occur as glycosides. They and their derivatives have been found in many plant families (including Brassicaceae, Cucurbitaceae, Scrophulariaceae, Begoniaceae, Elaeocarpaceae, Datiscaceae, Desfontainiaceae, Polemoniaceae, Primulaceae, Rubiaceae, Sterculiaceae, Rosaceae, and Thymelaeaceae), in some mushrooms (including Russula and Hebeloma) and even in some marine mollusks. Cucurbitacins may be a taste deterrent in plants foraged by some animals and in some edible plants preferred by humans, like cucumbers and zucchinis. In laboratory researc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linoleic Acid
Linoleic acid (LA) is an organic compound with the formula COOH(CH2)7CH=CHCH2CH=CH(CH2)4CH3. Both alkene groups are ''cis''. It is a fatty acid sometimes denoted 18:2 (n-6) or 18:2 ''cis''-9,12. A linoleate is a salt or ester of this acid. Linoleic acid is a polyunsaturated omega-6 fatty acid. It is a colorless liquid that is virtually insoluble in water but soluble in many organic solvents. It typically occurs in nature as a triglyceride (ester of glycerin) rather than as a free fatty acid. It is one of two essential fatty acids for humans, who must obtain it through their diet, and the most essential, because the body uses it as a base to make the others. The word "linoleic" derives from the Latin ''linum'' "flax" + ''oleum'' "oil", reflecting the fact that it was first isolated from linseed oil. History In 1844, F. Sacc, working at the laboratory of Justus von Liebig, isolated linoleic acid from linseed oil. In 1886, K. Peters determined the existence of two double ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PC (cell Line)
PC or pc may refer to: Arts and entertainment * Player character or playable character, a fictional character controlled by a human player, usually in role-playing games or computer games * ''Port Charles'', an American daytime TV soap opera * Production code number, a designation used to identify television episodes * ''Pretty Cure'', a Japanese anime franchise Business and finance * Percentage (pc), numeric ratio signifier * Prime cost or variable cost * Principal Consultant, a management consulting position * Professional corporation, a type of corporate entity for licensed professionals (attorneys, architects, physicians, engineers, etc.) Organizations Businesses * Pearl-Continental Hotels & Resorts, a hotel chain in Pakistan * Pirelli & C. (stock symbol: PC) * President's Choice, a private label product brand of the Canadian supermarket chain Loblaw Companies ** PC Mobile, a Canadian mobile virtual network operator ** PC Optimum, a Canadian rewards program ** President ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HL-60
The HL-60 cell line is a human leukemia cell line that has been used for laboratory research on blood cell formation and physiology. HL-60 proliferates continuously in suspension culture in nutrient and antibiotic chemicals. The doubling time is about 36–48 hours. The cell line was derived from a 36-year-old woman who was originally reported to have acute promyelocytic leukemia at the MD Anderson Cancer Center. HL-60 cells predominantly show neutrophilic promyelocytic morphology. Subsequent evaluation, including the karyotype that showed absence of the defining t(15;17) translocation, concluded that HL-60 cells are from a case of AML FAB-M2 (now referred to as AML with maturation (WHO)). Proliferation of HL-60 cells occurs through the transferrin and insulin receptors, which are expressed on cell surface. The requirement for insulin and transferrin is absolute, as HL-60 proliferation immediately ceases if either of these compounds is removed from the serum-free culture medi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U937 (cell Line)
U-937 cells are a pro-monocytic model cell line used in biomedical research. They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. Due to the relative uniformity of expanded cultures and lower maintance requirements these cells have been since used as an important tool for studying phagocyte differentiation and different kinds of cell-to-cell interactions. U-937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of monocytes, macrophages or dendritic cells. U-937 cells are of myeloid lineage and thus secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF for example independently promote IL-10 production in U937 cells. This cell line is therefore widely used for cytokine level read-outs as a result of exposure to various chemical compounds. Namely, production of IL-1β, IL-6, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HT1080
HT1080 is a fibrosarcoma cell line which has been used extensively in biomedical research. The cell line was created from tissue taken in a biopsy of a fibrosarcoma present in a 35-year-old human male. The patient who supplied the sample had not undergone radio or chemotherapy, making it less likely that unwanted mutations were introduced into the cell line. The cell line carries an IDH1 Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the ''IDH1'' gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two ... mutation and an activated N-ras oncogene. References External linksCellosaurus entry for HT1080 Cancer research Human cell lines {{oncology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HeLa
HeLa (; also Hela or hela) is an immortalized cell line used in scientific research. It is the oldest and most commonly used human cell line. The line is derived from cervical cancer cells taken on February 8, 1951, named after Henrietta Lacks, a 31-year-old African-American mother of five, who died of cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific, which allows it to be used extensively in scientific study. The cells from Lacks's cancerous cervical tumor were taken without her knowledge or consent, which was common practice in the United States at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Cells from Lacks's tumor behaved differently. History Origin In 1951, a patient named Henrietta Lacks was admitted to the Johns Hopkins Hospital with symptoms of irregular vaginal bleeding, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
KB (cell Line)
KB, kB or kb may stand for: Businesses and organizations Banks * KB Kookmin Bank, South Korea * Kaupthing Bank, Iceland * Komerční banka, Czech Republic * Kasikornbank, Thailand * Karafarin Bank, Iran Libraries * National Library of Sweden ( sv, links=no, Kungliga biblioteket) * National Library of the Netherlands ( nl, links=no, Koninklijke Bibliotheek) Sport * Kalix BF, a Swedish bandy club * Kjøbenhavns Boldklub, a sports club, Copenhagen, Denmark Other businesses and organizations * KB Home, a US house builder * KB Lager, Australia * KB Toys, US * K&B, a New Orleans, Louisiana, US drugstore * Druk Air (IATA code: ''KB''), Bhutan airline People * Kevin Bartlett (Australian rules footballer) (born 1947) * KB (rapper) (born 1988), Kevin Elijah Burgess * KB Killa Beats (born 1983), Zambian record producer Science and technology Biology * Kilo-base pair (kb or kbp), length of D/RNA molecule Computing * Kilobit (kb), 1,000 bits * Kilobyte (kB), 1,000 bytes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SF-268
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity. Purpose The screening procedure is called the NCI-60 Human Tumor Cell Lines Screen, and it is one of the Discovery & Development Services of NCI's Developmental Therapeutics Program (DTP). The screening rates for each cell line the cytostatic and cytotoxic impact of tested substances. Due to the diversity of the cell lines, it is possible to compare tested compounds by their effect patterns, high correlation potentially corresponding to similar effect mechanisms. An automated comparison against a database of more than 88,000 pure compounds and more than 34,000 crude extracts () is provided by the COMPARE tool, which shows a list of substances ranked by the Pearson correlation coefficients for a given test substance. The same panel is used in the Molecular Target Program for the ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZR-75-1
ZR-75-1 is a human breast cancer cell line An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cell .... References External links Cellosaurus entry for ZR-75-1 Cancer research Human cell lines {{Cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MCF-7
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute. Prior to MCF-7, it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months. The patient, Frances Mallon died in 1970. Her cells were the source of much of current knowledge about breast cancer. At the time of sampling, she was a nun in the convent of Immaculate Heart of Mary in Monroe, Michigan under the name of Sister Catherine Frances. MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline-based survey. Characteristics o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NCI-H460
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity. Purpose The screening procedure is called the NCI-60 Human Tumor Cell Lines Screen, and it is one of the Discovery & Development Services of NCI's Developmental Therapeutics Program (DTP). The screening rates for each cell line the cytostatic and cytotoxic impact of tested substances. Due to the diversity of the cell lines, it is possible to compare tested compounds by their effect patterns, high correlation potentially corresponding to similar effect mechanisms. An automated comparison against a database of more than 88,000 pure compounds and more than 34,000 crude extracts () is provided by the COMPARE tool, which shows a list of substances ranked by the Pearson correlation coefficients for a given test substance. The same panel is used in the Molecular Target Program for the cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
