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BGC20-761
BGC20-761 (5-MeO-2-phenyl-DMT, PMDT) is an experimental drug which acts as an antagonist of the 5-HT6, 5-HT2 family, and dopamine D2 receptors, with strongest affinity for 5-HT6. In animal studies it has antipsychotic-like effects, but also memory enhancing action attributed to its 5-HT6 affinity. See also * EMDT * ST-1936 ST-1936, also known as 2-methyl-5-chloro-''N'',''N''-dimethyltryptamine (2-methyl-5-chloro-DMT), is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 13 nM, and much weake ... References {{Tryptamines 5-Methoxytryptamines N,N-Dialkyltryptamines Experimental drugs Serotonin receptor modulators ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EMDT
2-Ethyl-5-methoxy-''N'',''N''-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16nM, and was one of the first selective agonists developed for this receptor. Its affinities for many other targets have also been reported. EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885. Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant. See also * 2-Methyltryptamine * BGC20-761 * EMD-386,088 * ST-1936 ST-1936, also known as 2-methyl-5-chloro-''N'',''N''-dimethyltryptamine (2-methyl-5-chloro-DMT), is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 13 nM, and much weake ... References {{DEFAULTSORT:Ethyl-5-met ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipsychotic
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay, together with mood stabilizers, in the treatment of bipolar disorder. Moreover, they are also used as adjuncts in the treatment of Treatment-resistant depression, treatment-resistant major depressive disorder. The use of antipsychotics may result in many unwanted side effects such as Extrapyramidal symptoms, involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce List of long term side effects of antipsychotics, adverse effects such as tardive dyskinesia, tardive dystonia, Akathisia, tardive akathisia, and brain tissue volume reduction. The long term use of antipsychotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ST-1936
ST-1936, also known as 2-methyl-5-chloro-''N'',''N''-dimethyltryptamine (2-methyl-5-chloro-DMT), is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 13 nM, and much weaker action at 5-HT2B and 5-HT7 subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects. See also * 2-Methyltryptamine 2-Methyltryptamine (2-MT, 2-Me-T, or 2-methyl-T) is a serotonin receptor agonist of the substituted tryptamine, tryptamine family. It shows dramatically reduced activity at serotonin receptors compared to tryptamine and mixed effects in terms of ... * EMD-386,088 * EMDT * 5-Bromo-DMT * 5-Chloro-AMT References {{Tryptamines 5-HT6 agonists 2-Alkyltryptamines Chloroarenes N,N-Dialkyltryptamines 5-Halotryptamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-Methoxytryptamines
5-Methoxytryptamine (5-MT, 5-MeO-T, or 5-OMe-T), also known as serotonin methyl ether or ''O''-methylserotonin and as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. It has been shown to occur naturally in the body in low levels, especially in the pineal gland. It is formed via ''O''-methylation of serotonin or ''N''-deacetylation of melatonin. 5-MT is a highly potent and non-selective serotonin receptor agonist and shows serotonergic psychedelic-like effects in animals. However, it is inactive in humans, at least orally, likely due to rapid metabolism by monoamine oxidase (MAO). The levels and effects of 5-MT are dramatically potentiated by monoamine oxidase inhibitors (MAOIs) in animals. Biosynthesis 5-MT can be formed by ''O''-methylation of serotonin mediated by hydroxyindole ''O''-methyltransferase (HIOMT) or by ''N''-deacetylation of melatonin. It is also a precursor of 5-MeO-DMT in some species. Pharmacology Ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experimental Drugs
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
