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4-HO-DALT
4-HO-DALT, also known as 4-hydroxy-''N'',''N''-diallyltryptamine or as dalocin, is a serotonin receptor agonist and serotonergic psychedelic of the tryptamine and 4-hydroxytryptamine families. It binds to many of the serotonin receptors, including the serotonin 5-HT2A receptor, as well as other targets. The drug acts as a potent full agonist of the serotonin 5-HT2A and 5-HT2B receptors, whereas it showed 60-fold lower potency as an agonist of the serotonin 5-HT2C receptor compared to the serotonin 5-HT2A receptor. It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents. 4-HO-DALT was first described in the literature by Alexander Shulgin in ''TiHKAL'' in 1997. "Another direction possible for modifying the structure would be to relocate the oxygen in indole ring over to the 4-position. 4-Methoxytryptamine is commercially available, and it should be directly substitutable for the 5-methoxytryptamine used in this synthetic process givin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-AcO-DALT
4-Acetyloxy-''N,N''-diallyltryptamine (or 4-AcO-DALT) is a tryptamine derivative (chemistry), derivative. It has been sold as a designer drug, but little other information is available. It was first officially identified in seized drug samples in 2012. 4-HO-DALT and 4-AcO-DALT produce the head-twitch response, a behavioral proxy of psychedelic drug, psychedelic-like effects, in rodents. The receptor (biochemistry), receptor interactions of 4-HO-DALT and 4-AcO-DALT have been studied. See also * 4-HO-DALT * DALT * 5-MeO-DALT References External links 4-AcO-DALT - Isomer Design4-HO-DALT - Isomer DesignThe Big & Dandy 4-AcO-DALT Thread - BluelightThe Small & Handy 4-HO-DALT Thread - Bluelight Acetate esters 4-Acyloxytryptamines Designer drugs N,N-Dialkyltryptamines Diallylamino compounds Psychedelic tryptamines {{Psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Tryptamine
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Hydroxytryptamines
4-Hydroxytryptamine (4-HT, 4-HTA), also known as ''N'',''N''-didesmethylpsilocin, is a naturally occurring tryptamine alkaloid. It is closely related chemically to the neurotransmitter serotonin, the psychedelic psilocin, and is the active form of the tryptamine alkaloid norbaeocystin. The compound is a serotonin receptor agonist, including of the serotonin 5-HT2A receptor, but in contrast to certain closely related compounds like psilocin, appears to be non-hallucinogenic. 4-HT may occur naturally in '' Psilocybe baeocystis'' and ''Psilocybe cyanescens''. It may serve as an alternative precursor in the biosynthesis of psilocybin (4-PO-DMT) in psilocybin mushrooms. Pharmacology 4-HT is a potent agonist of the serotonin 5-HT2A receptor similarly to psilocin ( = 38nM and 21nM, respectively). It also shows affinity for the serotonin 5-HT2C receptor (Ki = 40nM), the serotonin 5-HT1A receptor (Ki = 95nM), and the serotonin 5-HT1B receptor (Ki = 1,050nM). The drug produces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-MeO-DALT
5-MeO-DALT, also known as ''N'',''N''-diallyl-5-methoxytryptamine, or as foxtrot, is a psychedelic drug of the substituted tryptamine, tryptamine and substituted 5-methoxytryptamine, 5-methoxytryptamine families. It was first chemical synthesis, synthesized and described by Alexander Shulgin, who disclosed the compound in 2004. The drug has been encountered as a novel designer drug, designer and recreational drug. Use and effects According to Alexander Shulgin, the dosage of 5-MeO-DALT is 12 to 20mg oral administration, orally and its duration of action, duration is 2 to 4hours. A wider dose range of 12 to 25mg has also been reported. It is said to onset of action, onset and peak remarkably quickly via the oral route, with an onset of less than 15minutes and a peak of 30minutes. The effects of 5-MeO-DALT were reported by Shulgin to include positive emotional changes, lightheadedness, increased appreciation of music and sex, and closed-eye visuals. There was said to be a lack of o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DALT
''N'',''N''-Diallyltryptamine (DALT) is a tryptamine derivative which has been identified as a new psychoactive substance. It has been used as an intermediate in the preparation of radiolabeled diethyltryptamine. Use and effects According to Alexander Shulgin in ''TiHKAL'', the dosage of DALT is >40mg orally and its duration is unknown. Its effects have not been described. According to Stephen Szara and colleagues however, DALT and other extended ''N'',''N''-dialkyltryptamines produce similar effects to dimethyltryptamine (DMT) but are longer-lasting, with durations of up to 3hours. Pharmacology The receptor interactions of DALT have been studied. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. History DALT was first described in the scientific literature by Stephen Szara and colleagues by 1962. See also * Substituted tryptamine * 4-HO-DALT * 4-AcO-DALT * 5-MeO-DALT 5-MeO-DALT, also known as ''N'',''N''-diallyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin Receptor Agonist
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors. Non-selective agonists Serotonergic psychedelics such as tryptamines (e.g., psilocybin, psilocin, , 5-MeO-DMT, bufotenin), lysergamides (e.g., , ergine ()), phenethylamines (e.g., mescaline, 2C-B, 25I-NBOMe), and amphetamines (e.g., , ) are non-selective agonists of serotonin receptors. Their hallucinogenic effects are specifically mediated by activation of the 5-HT2A receptor. Drugs that increase extracellular serotonin levels such as serotonin reuptake inhibitors (e.g., fluoxetine, venlafaxine), serotonin releasing agents (e.g., fenfluramine, ), and monoamine oxidase inhibitors (e.g., phenelzine, moclobemide) are indirect non-selective serotonin receptor agonists. They are used variously as antidepressant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drugs
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2C Agonists
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. Most of the body's serotonin—about 90%—is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1–2% is found in the CNS. Serotonin acts as both a vasoconstrictor and v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
