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Phenoxyethylamines
Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-dichloro-5-methoxyphenoxyethylamine), CT-5126, and ORG-37684. It is also a parent compound of other drugs like the α-adrenergic receptor antagonist phenoxybenzamine, the α2-adrenergic receptor modulators lofexidine, allyphenyline, and cyclomethyline, the β-adrenergic receptor agonists dextrofemine and isoxsuprine, the beta blocker carvedilol, the antihistamine phenyltoloxamine, the sodium channel blocker mexiletine Mexiletine ( INN; sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, ..., and the coronary vasodilator fenalcomine, among others. Reference ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-4719
CT-4719, also known as 2,4-dichloro-5-methoxyphenoxyethylamine, is a claimed hallucinogen related to psychedelic phenethylamines like mescaline. It is not technically a phenethylamine itself but is a close analogue of this family. The drug was reported to produce behavioral and electrocorticography (ECoG) effects very similar to but twice as potent as those of mescaline in cats. CT-4719 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-5126, have also been described. CT-4719 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. An analogue of CT-4719 and of mescaline, 3,4,5-trimethoxyphenoxyethylamine, has also been described. "One additional manipulation with some of these structures has been made and should be mentioned. These are the analogues with an oxygen atom inserted between the aromatic ring and the aliph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5126
CT-5126 is a cyclized phenethylamine and tetrahydrobenzopyranylamine related to psychedelic phenethylamines like mescaline. In contrast to its non- cyclized analogue CT-5172 (2,6-dimethoxy-3,5-dichlorophenethylamine), the drug was found to have negligible hallucinogen-like effects in cats. CT-5126 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-4719, have also been described. CT-5126 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. See also * Phenoxyethylamine * TFMBOX * DOM-AT * DOM-CR DOM-CR, or DOM/CR, an acronym of "DOM-conformationally restrained", is a tetrahydroisoquinoline (THIQ) and cyclized phenethylamine related to the psychedelics DOM and 2C-D. It is a cyclized THIQ analogue of DOM and 2C-D. DOM-CR shows more than ... References External links CT-5126 - Isomer Design Benzopyrans C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORG-37684
ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, including of the serotonin 5-HT2C, 5-HT2B, and 5-HT2A receptors, in that order of potency. It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans. ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans. See also * Phenoxyethylamine * CT-4719 * ORG-12962 * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first describ ... References 5-HT2A agonists 5-HT2B agonists 5-HT2C agonists Indanes Phenoxyethylamines Psychedelic drugs Pyrrolidines Serotonin receptor agonists {{gastrointestinal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dextrofemine
Dextrofemine (), sold under the brand names Marsyl and Dysmalgine, is a uterine spasmolytic and muscle relaxant of the amphetamine family. It is the dextrorotatory enantiomer of racefemine. The drug acts as a β-adrenergic receptor agonist and sympathomimetic. It was marketed in France in 1966 but appears to no longer be marketed. Other tocolytics with similar chemical structures as phenethylamines or amphetamines include bedoradrine, buphenine, fenoterol, hexoprenaline, isoxsuprine, ritodrine, and terbutaline. See also * Phenoxyethylamine Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-d ... References {{Phenethylamines Abandoned drugs Beta-adrenergic agonists Phenoxyethylamines Substituted amphetamines Sympathomimetics Tocolytics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken or new bonds formed or both. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, usin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronary Vasodilator
Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel walls are composed of endothelial tissue and a basal membrane lining the lumen of the vessel, concentric smooth muscle layers on top of endothelial tissue, and an adventitia over the smooth muscle layers. Relaxation of the smooth muscle layer allows the blood vessel to dilate, as it is held in a semi-constricted state by sympathetic nervous system activity. Vasodilation is the opposite of vasoconstriction, which is the narrowing of blood vessels. When blood vessels dilate, the flow of blood is increased due to a decrease in vascular resistance and increase in cardiac output. Vascular resistance is the amount of force circulating blood must overcome in order to allow perfusion of body tissues. Narrow vessels create more vascular resistance, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mexiletine
Mexiletine ( INN; sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea. It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications. Medical uses Mexiletine has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia. It is of particular use when treating arrhythmias caused by long QT syndrome. The LQT3 form of long QT syndrome is amenable to treatment with mexiletine as this form is caused by defective sodium channels that continue to release a sustained current rather than fully inactivating, however other forms of long QT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Channel Blocker
Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels. Extracellular The following naturally-produced substances block sodium channels by binding to and occluding the extracellular pore opening of the channel: * Alkaloids: ** Saxitoxin (STX) ** Neosaxitoxin (NSTX) ** Tetrodotoxin (TTX) Intracellular Drugs which block sodium channels by blocking from the intracellular side of the channel include: * Local anesthetics: ''lidocaine'' * Class I antiarrhythmic agents * Various anticonvulsants: ''phenytoin, oxcarbazepine (derivative of carbamazepine)'' Unknown mechanism * Calcium has been shown to block sodium channels which explains the effects of hypercalcemia and hypocalcemia. * Lamotrigine is known to block sodium channels but it is not known whether it is extracellular or intracellular. * Cannabidiol (CBD) has been shown to cause inhibitory effects on sodium currents. This voltage-dependent inhibition is non-selective in natu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenyltoloxamine
Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is available in combination with other drugs such as paracetamol (acetominophen). Common use Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action. Phenyltoloxamine is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions. Adverse effects Common adverse effects are those associated with most anticholinergics, with effects being more pronounced in childr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antihistamine
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. Antihistamines are usually for short-term treatment. Chronic allergies increase the risk of health problems which antihistamines might not treat, including asthma, sinusitis, and lower respiratory tract infection. Consultation of a medical professional is recommended for those who intend to take antihistamines for longer-term use. Although the general public typically uses the word "antihistamine" to describe drugs for treating allergies, physicians and scientists use the term to describe a class of drug that opposes the activity of histamine receptors in the body. In this sense of the word, antihistamines are subc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carvedilol
Carvedilol, sold under the brand name Coreg among others, is a beta blocker medication, that may be prescribed for the treatment of high blood pressure (hypertension) and chronic heart failure with reduced ejection fraction (also known as HFrEF or systolic heart failure). Beta-blockers as a collective medication class are not recommended as routine first-line treatment of high blood pressure for all patients, due to evidence demonstrating less effective cardiovascular protection and a less favourable safety profile when compared to other classes of blood pressure-lowering medications. Common side effects include dizziness, tiredness, joint pain, low blood pressure, nausea, and shortness of breath. Severe side effects may include bronchospasm. Safety during pregnancy or breastfeeding is unclear. Use is not recommended in those with liver problems. Carvedilol is a nonselective beta blocker and alpha-1 blocker. How it improves outcomes is not entirely clear but may involve dila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
