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CT-4719
CT-4719, also known as 2,4-dichloro-5-methoxyphenoxyethylamine, is a claimed hallucinogen related to psychedelic phenethylamines like mescaline. It is not technically a phenethylamine itself but is a close analogue of this family. The drug was reported to produce behavioral and electrocorticography (ECoG) effects very similar to but twice as potent as those of mescaline in cats. CT-4719 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-5126, have also been described. CT-4719 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. An analogue of CT-4719 and of mescaline, 3,4,5-trimethoxyphenoxyethylamine, has also been described. "One additional manipulation with some of these structures has been made and should be mentioned. These are the analogues with an oxygen atom inserted between the aromatic ring and the aliph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenoxyethylamines
Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-dichloro-5-methoxyphenoxyethylamine), CT-5126, and ORG-37684. It is also a parent compound of other drugs like the α-adrenergic receptor antagonist phenoxybenzamine, the α2-adrenergic receptor modulators lofexidine, allyphenyline, and cyclomethyline, the β-adrenergic receptor agonists dextrofemine and isoxsuprine, the beta blocker carvedilol, the antihistamine phenyltoloxamine, the sodium channel blocker mexiletine Mexiletine ( INN; sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, ..., and the coronary vasodilator fenalcomine, among others. Reference ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5126
CT-5126 is a cyclized phenethylamine and tetrahydrobenzopyranylamine related to psychedelic phenethylamines like mescaline. In contrast to its non- cyclized analogue CT-5172 (2,6-dimethoxy-3,5-dichlorophenethylamine), the drug was found to have negligible hallucinogen-like effects in cats. CT-5126 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-4719, have also been described. CT-5126 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. See also * Phenoxyethylamine * TFMBOX * DOM-AT * DOM-CR DOM-CR, or DOM/CR, an acronym of "DOM-conformationally restrained", is a tetrahydroisoquinoline (THIQ) and cyclized phenethylamine related to the psychedelics DOM and 2C-D. It is a cyclized THIQ analogue of DOM and 2C-D. DOM-CR shows more than ... References External links CT-5126 - Isomer Design Benzopyrans C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORG-37684
ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, including of the serotonin 5-HT2C, 5-HT2B, and 5-HT2A receptors, in that order of potency. It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans. ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans. See also * Phenoxyethylamine * CT-4719 * ORG-12962 * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first describ ... References 5-HT2A agonists 5-HT2B agonists 5-HT2C agonists Indanes Phenoxyethylamines Psychedelic drugs Pyrrolidines Serotonin receptor agonists {{gastrointestinal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenoxyethylamine
Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-dichloro-5-methoxyphenoxyethylamine), CT-5126, and ORG-37684. It is also a parent compound of other drugs like the α-adrenergic receptor antagonist phenoxybenzamine, the α2-adrenergic receptor modulators lofexidine, allyphenyline, and cyclomethyline, the β-adrenergic receptor agonists dextrofemine and isoxsuprine, the beta blocker carvedilol, the antihistamine phenyltoloxamine, the sodium channel blocker Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels. Extracellular The following naturally-produced substances block sodium channels by binding to and occluding the extracellular pore opening ... mexiletine, and the coronary vasodilator fenalcomine, among others. Referen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5172
CT-5172, also known as 2,6-dimethoxy-3,5-dichlorophenethylamine, is a claimed hallucinogen of the phenethylamine family. It is an analogue of the serotonergic psychedelics mescaline and the 2C series but with an unusual substitution pattern on the benzene ring that includes methoxy groups at the 2 and 6 positions and chlorine atoms at the 3 and 5 positions. The drug was reported to have significant but relatively weak mescaline-like effects in cats. CT-5172 was first described in the scientific literature by 1969. Various related analogues, such as CT-5126 and CT-4719, have also been described. CT-5172 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. See also * Ψ-2C-T-4 2C-T-4, also known as 4-isopropylthio-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and is used as entheogenic recre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mescaline
Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found in Cactus, cacti like peyote (''Lophophora williamsii'') and San Pedro cactus, San Pedro (certain species of the Echinopsis genus) and known for its Serotonin, serotonergic Hallucinogen, hallucinogenic effects. Mescaline is typically taken orally and used recreationally, spiritually, and medically, with psychedelic effects occurring at doses from 100 to 1,000 mg, including microdosing below 75 mg, and it can be consumed in pure form or via mescaline-containing cacti. Mescaline induces a psychedelic experience characterized by vivid visual patterns, altered perception of time and self, synesthesia, and spiritual effects, with an onset of 0.5–0.9 hours and a duration that increases with dose, ranging from about 6 to 14 hours. Mescaline h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrocorticography
Electrocorticography (ECoG), a type of intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. In contrast, conventional electroencephalography (EEG) electrodes monitor this activity from outside the skull. ECoG may be performed either in the operating room during surgery (intraoperative ECoG) or outside of surgery (extraoperative ECoG). Because a craniotomy (a surgical incision into the skull) is required to implant the electrode grid, ECoG is an invasive procedure. History ECoG was pioneered in the early 1950s by Wilder Penfield and Herbert Jasper, neurosurgeons at the Montreal Neurological Institute. The two developed ECoG as part of their groundbreakinMontreal procedure a surgical protocol used to treat patients with severe epilepsy. The cortical potentials recorded by ECoG were used to identify epileptogen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, alprazolam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness nor more side effects nor less side effects. Types of potency The International Union of Basic and Clinical Pharmacology (IUPHAR) has stated that "potency is an imprecise term that should always be further defined", and lists of types of potency as follows: Miscellaneous Lysergic acid diethylamide (LSD) is one of the most potent psychoactive drug A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical contributions. These papers serve as essential sources of knowledge and are commonly referred to simply as "the literature" within specific research fields. The process of academic publishing involves disseminating research findings to a wider audience. Researchers submit their work to reputable journals or conferences, where it undergoes rigorous evaluation by experts in the field. This evaluation, known as peer review, ensures the quality, validity, and reliability of the research before it becomes part of the scientific literature. Peer-reviewed publications contribute significantly to advancing our understanding of the world and shaping future research endeavors. Original scientific research first published in scientific journals co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hallucinogen
Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Hallucinogens are often categorized as either being psychedelics, dissociatives, or deliriants, but not all hallucinogens fall into these three classes. Examples of hallucinogens include psychedelics or serotonin 5-HT2A receptor agonists like LSD, psilocybin, mescaline, and DMT; dissociatives or NMDA receptor antagonists like ketamine, PCP, DXM, and nitrous oxide; deliriants or antimuscarinics like scopolamine and diphenhydramine; cannabinoids or cannabinoid CB1 receptor agonists like THC, nabilone, and JWH-018; κ-opioid receptor agonists like salvinorin A and pentazocine; GABAA receptor agonists like muscimol and gaboxadol; and oneirogens like ibogaine and harmaline, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Phenethylamine
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative (chemistry), derivative compounds of phenethylamine which can be formed by replacing, or substitution reaction, substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens. Structural classification The structural formula of any substituted phenethylamine contains a phenyl group, phenyl ring that is joined to an amino group, amino (NH) group via a two-carbon substituent, sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen atom, hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a moiety (chemistry), specific group of at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
