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CT-5126
CT-5126 is a cyclized phenethylamine and tetrahydrobenzopyranylamine related to psychedelic phenethylamines like mescaline. In contrast to its non- cyclized analogue CT-5172 (2,6-dimethoxy-3,5-dichlorophenethylamine), the drug was found to have negligible hallucinogen-like effects in cats. CT-5126 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-4719, have also been described. CT-5126 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. See also * Phenoxyethylamine * TFMBOX * DOM-AT * DOM-CR DOM-CR, or DOM/CR, an acronym of "DOM-conformationally restrained", is a tetrahydroisoquinoline (THIQ) and cyclized phenethylamine related to the psychedelics DOM and 2C-D. It is a cyclized THIQ analogue of DOM and 2C-D. DOM-CR shows more than ... References External links CT-5126 - Isomer Design Benzopyrans C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclized Phenethylamine
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens. Structural classification The structural formula of any substituted phenethylamine contains a phenyl ring that is joined to an amino (NH) group via a two-carbon sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a specific group of atoms. Several classes of substances can be considered phenylethylamine derivatives such as Substituted amphetamines, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5172
CT-5172, also known as 2,6-dimethoxy-3,5-dichlorophenethylamine, is a claimed hallucinogen of the phenethylamine family. It is an analogue of the serotonergic psychedelics mescaline and the 2C series but with an unusual substitution pattern on the benzene ring that includes methoxy groups at the 2 and 6 positions and chlorine atoms at the 3 and 5 positions. The drug was reported to have significant but relatively weak mescaline-like effects in cats. CT-5172 was first described in the scientific literature by 1969. Various related analogues, such as CT-5126 and CT-4719, have also been described. CT-5172 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. See also * Ψ-2C-T-4 2C-T-4, also known as 4-isopropylthio-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and is used as entheogenic recre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOM-CR
DOM-CR, or DOM/CR, an acronym of "DOM-conformationally restrained", is a tetrahydroisoquinoline (THIQ) and cyclized phenethylamine related to the psychedelics DOM and 2C-D. It is a cyclized THIQ analogue of DOM and 2C-D. DOM-CR shows more than 20-fold reduced affinity for the serotonin 5-HT2A receptor compared to DOM (Ki = 2,150nM vs. 100nM, respectively). In contrast to DOM, DOM-CR does not substitute for DOM in rodent drug discrimination tests, suggesting that it lacks psychedelic effects. Similarly, DOM-CR does not substitute for dextroamphetamine or MDMA, suggesting that it likewise lacks stimulant or entactogenic effects. However, DOM-CR does substitute for TDIQ (MDTHIQ), a selective α2-adrenergic receptor ligand. At high doses, DOM-CR produces behavioral disruption in drug discrimination tests. In contrast to DOM and amphetamine, DOM-CR does not produce hyperlocomotion in rodents. DOM-CR was first described in the scientific literature by Richard Glennon and colleag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOM-AT
DOM-AT, or DOMAT, also known as 5,8-dimethoxy-6-methyl-2-aminotetralin, is a cyclized phenethylamine and 2-aminotetralin related to the psychedelic substituted amphetamine, amphetamine DOM (drug), DOM. It is specifically the cyclized 2-aminotetralin structural analog, analogue of DOM. The compound has been found to be a more potency (pharmacology), potent agonist of human body, peripheral serotonin receptors than DOM ''in vitro''. This activity was blocked by the serotonin receptor antagonist cinanserin and by the non-hallucinogenic serotonin receptor modulator 2-bromo-LSD (BOL-148). However, DOM-AT was not tested for hallucinogen-type activity in animals or humans in these studies. Subsequently, DOM-AT did not appear to show a typical hallucinogen-like profile in behavioral tests in rats (e.g., the conditioned avoidance response test). In cats, DOM-AT produced a rage reaction, while in rabbits, it produced stimulant, behavioral excitation and hyperthermia. In later research, DOM- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TFMBOX
TFMBOX is a putative serotonergic psychedelic of the phenethylamine and benzoxepin ("BOX") families. It is the cyclized phenethylamine analogue of DOTFM and 2C-TFM in which the α carbon has been connected to the 2-methoxy group via an ethyl chain to form a benzoxepin ring system. The drug was assessed at and showed affinity for the serotonin 5-HT2A and 5-HT1A receptors, with Ki values of 340nM and 1,300nM, respectively. Its affinity for the serotonin 5-HT2A receptor was about 15-fold lower than that of DOB and DOI, whereas its affinity for the serotonin 5-HT1A receptor was the same as that of DOI and was about half that of DOB. TFMBOX also very weakly inhibited the reuptake of serotonin ( = 9,900nM), but did not affect dopamine or norepinephrine reuptake ( = >50,000–100,000nM). The drug fully substituted for LSD in rodent drug discrimination tests, albeit with about one-third of the potency of DOB and 2C-B. TFMBOX was first described in the scientific literature by N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenoxyethylamine
Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-dichloro-5-methoxyphenoxyethylamine), CT-5126, and ORG-37684. It is also a parent compound of other drugs like the α-adrenergic receptor antagonist phenoxybenzamine, the α2-adrenergic receptor modulators lofexidine, allyphenyline, and cyclomethyline, the β-adrenergic receptor agonists dextrofemine and isoxsuprine, the beta blocker carvedilol, the antihistamine phenyltoloxamine, the sodium channel blocker Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels. Extracellular The following naturally-produced substances block sodium channels by binding to and occluding the extracellular pore opening ... mexiletine, and the coronary vasodilator fenalcomine, among others. Referen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-4719
CT-4719, also known as 2,4-dichloro-5-methoxyphenoxyethylamine, is a claimed hallucinogen related to psychedelic phenethylamines like mescaline. It is not technically a phenethylamine itself but is a close analogue of this family. The drug was reported to produce behavioral and electrocorticography (ECoG) effects very similar to but twice as potent as those of mescaline in cats. CT-4719 was first described in the scientific literature by 1969. Various related analogues, such as CT-5172 and CT-5126, have also been described. CT-4719 and related compounds were developed at the Laboratoire de Chimie Thérapeutique (CT; Therapeutic Chemistry Laboratory) of the Pasteur Institute in Paris, France. An analogue of CT-4719 and of mescaline, 3,4,5-trimethoxyphenoxyethylamine, has also been described. "One additional manipulation with some of these structures has been made and should be mentioned. These are the analogues with an oxygen atom inserted between the aromatic ring and the aliph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenethylamines
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative (chemistry), derivative compounds of phenethylamine which can be formed by replacing, or substitution reaction, substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens. Structural classification The structural formula of any substituted phenethylamine contains a phenyl group, phenyl ring that is joined to an amino group, amino (NH) group via a two-carbon substituent, sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen atom, hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a moiety (chemistry), specific group of at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical contributions. These papers serve as essential sources of knowledge and are commonly referred to simply as "the literature" within specific research fields. The process of academic publishing involves disseminating research findings to a wider audience. Researchers submit their work to reputable journals or conferences, where it undergoes rigorous evaluation by experts in the field. This evaluation, known as peer review, ensures the quality, validity, and reliability of the research before it becomes part of the scientific literature. Peer-reviewed publications contribute significantly to advancing our understanding of the world and shaping future research endeavors. Original scientific research first published in scientific journals co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Compound
A cyclic compound (or ring compound) is a term for a compound in the field of chemistry in which one or more series of atoms in the compound is connected to form a ring. Rings may vary in size from three to many atoms, and include examples where all the atoms are carbon (i.e., are carbocycles), none of the atoms are carbon (inorganic cyclic compounds), or where both carbon and non-carbon atoms are present ( heterocyclic compounds with rings containing both carbon and non-carbon). Depending on the ring size, the bond order of the individual links between ring atoms, and their arrangements within the rings, carbocyclic and heterocyclic compounds may be aromatic or non-aromatic; in the latter case, they may vary from being fully saturated to having varying numbers of multiple bonds between the ring atoms. Because of the tremendous diversity allowed, in combination, by the valences of common atoms and their ability to form rings, the number of possible cyclic structures, even of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
