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Ccdc60
Coiled-coil domain containing 60 is a protein that in humans is encoded by the CCDC60 gene that is most highly expressed in the trachea, salivary glands, bladder, cervix, and epididymis. Gene The gene that encodes CCDC60 is located on the plus strand of chromosome 12 (12q24.23) and contains 14 exons. The gene spans positions 119334712-119541047. The first record of the gene that encodes CCDC60 in the NCBI nucleotide database originated from a data set containing 15,000 human and mouse full-length cDNA sequences. Protein CCDC60 is made up of 550 amino acids. The computational isoelectric point of CCDC60 is 9.17 and the computational molecular weight is approximately 63kDa. Western blots of RT-4 and U-251 cell lines support the predicted molecular weight. The predicted subcellular location of CCDC60 is the mitochondria. The secondary structure of CCDC60 contains a namesake coiled-coil domain in addition to predicted alpha helices and coils. Regulation Gene expression The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase C
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. In biochemistry, the PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenal Gland
The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer adrenal cortex, cortex which produces steroid hormones and an inner Adrenal medulla, medulla. The adrenal cortex itself is divided into three main zones: the zona glomerulosa, the zona fasciculata and the zona reticularis. The adrenal cortex produces three main types of steroid hormones: mineralocorticoids, glucocorticoids, and androgens. Mineralocorticoids (such as aldosterone) produced in the zona glomerulosa help in the regulation of blood pressure and osmoregulation, electrolyte balance. The glucocorticoids cortisol and cortisone are synthesized in the zona fasciculata; their functions include the regulation of metabolism and immune system suppression. The innermost layer of the cortex, the zona reticularis, produces androgens that are converted to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tarsier
Tarsiers ( ) are haplorhine primates of the family Tarsiidae, which is the lone extant family within the infraorder Tarsiiformes. Although the group was prehistorically more globally widespread, all of the existing species are restricted to Maritime Southeast Asia, predominantly in Brunei, Indonesia, Malaysia and the Philippines.They are found primarily in forested habitats, especially forests that have liana, since the vine gives tarsiers vertical support when climbing trees. Evolutionary history Fossil record Fossils of tarsiiform primates have been found in Asia, Europe, and North America (with disputed fossils from Northern Africa), but extant tarsiers are restricted to several Southeast Asian islands. The fossil record indicates that their dentition has not changed much, except in size, over the past 45 million years. Within the family Tarsiidae, there are two extinct genera—''Xanthorhysis'' and '' Afrotarsius''; however, the placement of ''Afrotarsius'' is not certai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippine Tarsier
The Philippine tarsier (''Carlito syrichta''), known locally as ''mawumag'' in Cebuano and other Visayan languages, and ''magô'' in Waray, is a species of tarsier endemic to the Philippines. It is found in the southeastern part of the archipelago, particularly on the islands of Bohol, Samar and Leyte. It is a member of the approximately 45-million-year-old family Tarsiidae, whose name is derived from its elongated " tarsus" or ankle bone. Formerly a member of the genus '' Tarsius'', it has since been listed as the only member of the genus ''Carlito'', a new genus named after the conservationist Carlito Pizarras. Its geographic range also includes Maripipi Island, Siargao Island, Basilan Island and Dinagat Island. Tarsiers have also been reported in Sarangani, although they may be different subspecies. Tribal people like the B'laans and T'bolis have been, for a long time, reporting sightings in the province of Sarangani. Unfortunately, these reports were merely discarded ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hominidae
The Hominidae (), whose members are known as the great apes or hominids (), are a taxonomic Family (biology), family of primates that includes eight Neontology#Extant taxa versus extinct taxa, extant species in four Genus, genera: ''Orangutan, Pongo'' (the Bornean orangutan, Bornean, Sumatran orangutan, Sumatran and Tapanuli orangutan); ''Gorilla'' (the Eastern gorilla, eastern and western gorilla); ''Pan (genus), Pan'' (the chimpanzee and the bonobo); and ''Homo'', of which only Human, modern humans (''Homo sapiens'') remain. Numerous revisions in classifying the great apes have caused the use of the term ''hominid'' to change over time. The original meaning of "hominid" referred only to humans (''Homo'') and their closest extinct relatives. However, by the 1990s humans and other apes were considered to be "hominids". The earlier restrictive meaning has now been largely assumed by the term ''Hominini, hominin'', which comprises all members of the human clade after the split ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human
Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing#Evolution of hairlessness, hairlessness, bipedality, bipedalism, and high Human intelligence, intelligence. Humans have large Human brain, brains, enabling more advanced cognitive skills that facilitate successful adaptation to varied environments, development of sophisticated tools, and formation of complex social structures and civilizations. Humans are Sociality, highly social, with individual humans tending to belong to a Level of analysis, multi-layered network of distinct social groups — from families and peer groups to corporations and State (polity), political states. As such, social interactions between humans have established a wide variety of Value theory, values, norm (sociology), social norms, languages, and traditions (co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Invertebrate
Invertebrates are animals that neither develop nor retain a vertebral column (commonly known as a ''spine'' or ''backbone''), which evolved from the notochord. It is a paraphyletic grouping including all animals excluding the chordata, chordate subphylum Vertebrata, i.e. vertebrates. Well-known Phylum, phyla of invertebrates include arthropods, molluscs, annelids, echinoderms, flatworms, cnidarians, and sponges. The majority of animal species are invertebrates; one estimate puts the figure at 97%. Many invertebrate taxon, taxa have a greater number and diversity of species than the entire subphylum of Vertebrata. Invertebrates vary widely in size, from 10 Micrometre, μm (0.0004 in) myxozoans to the 9–10 m (30–33 ft) colossal squid. Some so-called invertebrates, such as the Tunicata and Cephalochordata, are actually sister chordate subphyla to Vertebrata, being more closely related to vertebrates than to other invertebrates. This makes the "invertebrates" para ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthropod
Arthropods ( ) are invertebrates in the phylum Arthropoda. They possess an arthropod exoskeleton, exoskeleton with a cuticle made of chitin, often Mineralization (biology), mineralised with calcium carbonate, a body with differentiated (Metamerism (biology), metameric) Segmentation (biology), segments, and paired jointed appendages. In order to keep growing, they must go through stages of moulting, a process by which they shed their exoskeleton to reveal a new one. They form an extremely diverse group of up to ten million species. Haemolymph is the analogue of blood for most arthropods. An arthropod has an open circulatory system, with a body cavity called a haemocoel through which haemolymph circulates to the interior Organ (anatomy), organs. Like their exteriors, the internal organs of arthropods are generally built of repeated segments. They have ladder-like nervous systems, with paired Anatomical terms of location#Dorsal and ventral, ventral Ventral nerve cord, nerve cord ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prokaryote
A prokaryote (; less commonly spelled procaryote) is a unicellular organism, single-celled organism whose cell (biology), cell lacks a cell nucleus, nucleus and other membrane-bound organelles. The word ''prokaryote'' comes from the Ancient Greek (), meaning 'before', and (), meaning 'nut' or 'kernel'. In the earlier two-empire system arising from the work of Édouard Chatton, prokaryotes were classified within the empire Prokaryota. However, in the three-domain system, based upon molecular phylogenetics, prokaryotes are divided into two domain (biology), domains: Bacteria and Archaea. A third domain, Eukaryote, Eukaryota, consists of organisms with nuclei. Prokaryotes evolution, evolved before eukaryotes, and lack nuclei, mitochondria, and most of the other distinct organelles that characterize the eukaryotic cell. Some unicellular prokaryotes, such as cyanobacteria, form colony (biology), colonies held together by biofilms, and large colonies can create multilayered microbial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sponge
Sponges or sea sponges are primarily marine invertebrates of the animal phylum Porifera (; meaning 'pore bearer'), a basal clade and a sister taxon of the diploblasts. They are sessile filter feeders that are bound to the seabed, and are one of the most ancient members of macrobenthos, with many historical species being important reef-building organisms. Sponges are multicellular organisms consisting of jelly-like mesohyl sandwiched between two thin layers of cells, and usually have tube-like bodies full of pores and channels that allow water to circulate through them. They have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. They do not have complex nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes, usually via flagella movements of the so-called " collar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphimedon Queenslandica
''Amphimedon queenslandica'' (formerly known as ''Reniera'' sp.) is a sponge native to the Great Barrier Reef. Its genome has been sequenced. It has been the subject of various studies on the evolution of metazoan development. ''A. queenslandica'' was first discovered in 1998 on Heron Island Reef by Sally Leys when looking for sponges with larvae to study polarity, and was formally described by John Hooper and Rob van Soest in 2006. Like most sponges it has a biphasic life cycle, passing through a planktonic phase whilst a larva, but later becoming a benthic dweller. It is hermaphroditic, and reproduces via spermcast spawning, meaning it releases sperm into water but retains eggs, which are fertilised internally. The embryos develop in brood chambers until they reach a certain size, then disperse as parenchymella larvae. During this larval stage, they have a strong preference for darkness. The sponge is difficult or impossible to maintain in captivity. Genetics The genome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
