The mesonephric duct, also known as the Wolffian duct, archinephric duct, Leydig's duct or nephric duct, is a paired

organ Organ and organs may refer to: Biology * Organ (biology), a group of tissues organized to serve a common function * Organ system, a collection of organs that function together to carry out specific functions within the body. Musical instruments ...

that develops in the early stages of

embryonic development In developmental biology, animal embryonic development, also known as animal embryogenesis, is the developmental stage of an animal embryo. Embryonic development starts with the fertilization of an egg cell (ovum) by a sperm, sperm cell (spermat ...

in humans and other mammals. It is an important structure that plays a critical role in the formation of

male reproductive organs The male reproductive system consists of a number of sex organs that play a role in the process of human reproduction. These organs are located on the outside of the body, and within the pelvis. The main male sex organs are the penis and the scr ...

. The duct is named after

Caspar Friedrich Wolff Caspar Friedrich Wolff (18 January 1733 – 22 February 1794) was a German physiologist and embryologist who is widely regarded as one of the pioneers of modern embryology. Life Wolff was born in Berlin, Brandenburg. In 1759 he graduated as an ...

, a German

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...

and

embryologist Embryology (from Greek ἔμβρυον, ''embryon'', "the unborn, embryo"; and -λογία, ''-logia'') is the branch of animal biology that studies the prenatal development of gametes (sex cells), fertilization, and development of embryos and ...

who first described it in 1759. During embryonic development, the mesonephric ducts form as a part of the

urogenital system The genitourinary system, or urogenital system, are the sex organs of the reproductive system and the organ (biology), organs of the urinary system. These are grouped together because of their proximity to each other, Development of the urinary a ...

Structure

The mesonephric duct connects the primitive kidney, the ''

mesonephros The mesonephros () is one of three excretory system, excretory organs that develop in vertebrates. It serves as the main excretory organ of aquatic vertebrates and as a temporary kidney in reptiles, birds, and mammals. The mesonephros is included ...

'', to the

cloaca A cloaca ( ), : cloacae ( or ), or vent, is the rear orifice that serves as the only opening for the digestive (rectum), reproductive, and urinary tracts (if present) of many vertebrate animals. All amphibians, reptiles, birds, cartilagin ...

. It also serves as the

primordium A primordium (; : primordia; synonym: anlage), in embryology, is an Organ (anatomy), organ or tissue in its earliest recognizable stage of development. Cell (biology), Cells of the primordium are called primordial cells. A primordium is the simp ...

for male

urogenital The genitourinary system, or urogenital system, are the sex organs of the reproductive system and the organ (biology), organs of the urinary system. These are grouped together because of their proximity to each other, Development of the urinary a ...

structures including the

epididymides The epididymis (; : epididymides or ) is an elongated tubular genital organ attached to the posterior side of each one of the two male reproductive glands, the testicles. It is a single, narrow, tightly coiled tube in adult humans, in length; ...

vasa deferentia The vas deferens (: vasa deferentia), ductus deferens (: ductūs deferentes), or sperm duct is part of the male reproductive system of many vertebrates. In mammals, spermatozoa are produced in the seminiferous tubules and flow into the epididyma ...

, and

seminal vesicle The seminal vesicles (also called vesicular glands or seminal glands) are a pair of convoluted tubular accessory glands that lie behind the urinary bladder of male mammals. They secrete fluid that largely composes the semen. The vesicles are 5 ...

Development

In both males and females, the mesonephric ducts develop into the

trigone of urinary bladder The trigone of urinary bladder (also known as the vesical trigone) is a smooth triangular region of the urinary bladder formed by the two ureteric orifices and the internal urethral orifice. Between the ureteric openings, there is a fold of mu ...

, a part of the bladder wall, but the sexes differentiate in other ways during development of the

urinary The human urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressu ...

and

reproductive The reproductive system of an organism, also known as the genital system, is the biological system made up of all the anatomical organs involved in sexual reproduction. Many non-living substances such as fluids, hormones, and pheromones are al ...

organs.

Male

In a

male Male (Planet symbols, symbol: ♂) is the sex of an organism that produces the gamete (sex cell) known as sperm, which fuses with the larger female gamete, or Egg cell, ovum, in the process of fertilisation. A male organism cannot sexual repro ...

, they develop into a system of connected organs between the

efferent ducts The efferent ducts (also efferent ductules, ductuli efferentes, ductus efferentes, or vasa efferentia) connect the rete testis with the initial section of the epididymis.Hess 2018 There are two basic designs for efferent ductule structure: * a ...

of the

testis A testicle or testis ( testes) is the gonad in all male bilaterians, including humans, and is Homology (biology), homologous to the ovary in females. Its primary functions are the production of sperm and the secretion of Androgen, androgens, p ...

and the prostate, namely the

epididymis The epididymis (; : epididymides or ) is an elongated tubular genital organ attached to the posterior side of each one of the two male reproductive glands, the testicles. It is a single, narrow, tightly coiled tube in adult humans, in length; ...

, the

vas deferens The vas deferens (: vasa deferentia), ductus deferens (: ductūs deferentes), or sperm duct is part of the male reproductive system of many vertebrates. In mammals, spermatozoa are produced in the seminiferous tubules and flow into the epididyma ...

, and the

. The

prostate The prostate is an male accessory gland, accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. It is found in all male mammals. It differs between species anatomically, chemica ...

forms from the

urogenital sinus The urogenital sinus is a body part of a human or other Placentalia, placental only present in the development of the urinary system, development of the urinary and development of the reproductive organs, reproductive organs. It is the ventral p ...

and the efferent ducts form from the

mesonephric tubules Mesonephric tubules are genital ridges that are next to the mesonephros. In males, some of the mesonephric kidney tubules, instead of being used to filter blood like the rest, "grow" over to the developing testes, penetrate them, and become conne ...

. For this, it is critical that the ducts are exposed to

testosterone Testosterone is the primary male sex hormone and androgen in Male, males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testicles and prostate, as well as promoting se ...

during

embryogenesis An embryo ( ) is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male ...

. Testosterone binds to and activates

androgen receptor The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in th ...

, affecting intracellular signals and modifying the expression of numerous genes. In the mature male, the function of this system is to store and mature

sperm Sperm (: sperm or sperms) is the male reproductive Cell (biology), cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm ...

, and provide accessory

semen Semen, also known as seminal fluid, is a bodily fluid that contains spermatozoon, spermatozoa which is secreted by the male gonads (sexual glands) and other sexual organs of male or hermaphrodite, hermaphroditic animals. In humans and placen ...

fluid.The mesonephric duct (precursor of the male reproductive system) forms around the 3-4th week of pregnancy, present before the paramesonephric duct (precursor of the female reproductive system).

Female

In the

female An organism's sex is female ( symbol: ♀) if it produces the ovum (egg cell), the type of gamete (sex cell) that fuses with the male gamete (sperm cell) during sexual reproduction. A female has larger gametes than a male. Females and ...

, with the absence of

anti-Müllerian hormone Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to Activin and inhibin, inhibin and activin from the transforming growth factor beta superfamily, whose key roles a ...

secretion by the

Sertoli cells Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis (the production of sperm) as a structural component of the seminiferous tubules. They are activated by follicle-sti ...

and subsequent Müllerian

apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...

, the mesonephric ducts regress, although inclusions may persist. The vestigial

epoophoron The epoophoron or epoöphoron (also called organ of RosenmüllerJ. C. Rosenmüller. De ovariis embryonum et foetuum humanorum. 1802. or the parovarium; : epoophora) is a remnant of the mesonephric duct that can be found next to the ovary and fall ...

arises from these ducts. Also, lateral to the wall of the vagina, a

Gartner's duct Gartner's duct, also known as Gartner's canal or the ductus longitudinalis epoophori, is a potential embryological remnant in human female development of the mesonephric duct in the development of the urinary and reproductive organs. It was dis ...

could develop as a remnant. Normal regression starts with the action of

COUP-TFII COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the ''NR2F2'' gene. The COUP acronym stands for chicken ovalbumin upstream promoter. Functio ...

in the Woffian mesenchyme. The mesonephric duct produces

WNT9B Protein WNT9B (formerly WNT15) is a protein that in humans is encoded by the ''WNT9B'' gene. The WNT family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, WNT9B codes for the ...

, which is required for the elongation of the Müllerian/paramesonephric ducts (this happens before sex specification). The

mesenchyme Mesenchyme () is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood, or bone. The interactions between mesenchyme and epithelium help to form nearly ever ...

of the mesonephric duct is retained in female reproductive tissue after sexual differentiation. As the Woffian regresses, they undergo significant chromatin remodeling and move to surround the Müllerian. Cells from the Woffian mesenchyme occur in a layer around the inner epithelium, where the Müllerian mesenchyme cells also reside. The two can be distinguished by their gene expression profile: cells derived from the Woffian mesenchyme expresses AR, while those from the Müllerian mesenchyme expresses AMHR2. Both types of mesenchyme become smooth muscle and fibroblasts. They appear quite evenly mixed in the oviduct, but remain clearly separated the uterus, with the Woffian mesenchyme settling in the mesometrial side.

Function

Sexual differentiation

History

It is named after

who described the

and its ducts in his dissertation in 1759.

Additional images

File:Gray29.png, Diagram of a transverse section, showing the mode of formation of the amnion in the chick File:Gray986.png, Reconstruction of a human embryo of 17 mm File:Gray992.png, Cloaca of human embryo from twenty-five to twenty-seven days old File:Gray1116.png, Tail end of human embryo thirty-two to thirty-three days old File:Gray1117.png, Tail end of human embryo; from eight and a half to nine weeks old

References

External links

How the Body Works / Sex Development / Sexual Differentiation / Duct Differentiation
- The Hospital for Sick Children (GTA - Toronto, Ontario, Canada)