A temporary class drug is a relatively new status for
controlled drugs, which has been adopted in some jurisdictions, notably
New Zealand
New Zealand () is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and List of islands of New Zealand, over 600 smaller islands. It is the List of isla ...
and the
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotlan ...
, to attempt to bring newly synthesised
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
s under legal control. The controlled drug legislation in these jurisdictions requires drug scheduling decisions to follow an evidence-based process, where the harms of the drug are assessed and reviewed so that an appropriate legal status can be assigned. Since many designer drugs sold in recent years have had little or no published research that could help inform such a decision, they have been widely sold as "legal highs", often for months, before sufficient evidence accumulates to justify placing them on the controlled drug schedules.
This situation has been deemed to be undesirable, as every time a designer drug has been banned, novel compounds with similar effects have been quickly developed and brought to market, often with worse health consequences reported than the original compound. The temporary class drug status has been developed to circumvent the evidential requirements and allow drugs to be banned temporarily as soon as they are deemed by authorities to be causing harm to individuals or society. The temporary ban lasts for a period of 1 year, after which the drug would in theory be made legal again, if sufficient evidence to ban it permanently had not been forthcoming. During the period of the temporary ban, the temporary class drugs are treated equivalently to established illegal drugs, though with reduced or absent penalties for personal use amounts, and the main focus of enforcement being on importation and sale of the drugs.
United Kingdom
The
Secretary of State has the authority to make temporary class drug orders under the Misuse of Drugs Act section 2A(1).
Initially, only the
dissociative
Dissociatives, colloquially dissos, are a subclass of hallucinogens that distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self. Although many kinds of drugs are capable of ...
arylcyclohexylamine derivative
methoxetamine
Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in ...
was banned as a temporary class drug in the UK, effective from 5 April 2012. On 26 February 2013 methoxetamine was banned as a Class B drug under the Misuse of Drugs Act along with a large number of other arylcyclohexylamine derivatives under a 'catch-all' chemical structure clause. "In an attempt to prevent legal high manufacturers looking for a new ketamine analogue to sell, the government has placed countless other ketamine analogues into Class B and Schedule 1."
On 10 June 2013, a total of 10 benzofuran and indole analogues and four NBOMe hallucinogens were classified as Temporary Class Drugs in the UK following an ACMD recommendation. Specifically these include
5-APB,
6-APB,
5-APDB,
6-APDB and their N-methyl derivatives
5-MAPB,
6-MAPB,
5-MAPDB and
6-MAPDB, as well as
5-IT and its isomer
6-IT, plus
NBOMe-2C-C,
NBOMe-2C-B,
NBOMe-2C-I and
NBOMe-2C-D.
This means that sale and import of the named substances are criminal offences and are treated as for Class B drugs.
On 31 March 2015, five derivatives of
methylphenidate
Methylphenidate, sold under the brand names Ritalin ( ) and Concerta ( ) among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It may be taken Oral adm ...
were recommended to be banned in the UK as Temporary Class Drugs following their sale as uncontrolled
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
drugs. The compounds listed for control were
ethylphenidate,
propylphenidate,
isopropylphenidate,
methylnaphthidate and
3,4-Dichloromethylphenidate.
On 25 June 2015, two more derivatives of methylphenidate,
4-Methylmethylphenidate and
ethylnaphthidate, were recommended to be banned in the UK as Temporary Class Drugs following their sale as uncontrolled
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
drugs.
Following the ban on ethylphenidate authorities noticed that
methiopropamine had replaced it as the stimulant of choice for injecting users.
A TCDO was announced a week later and it was banned 48 hours after this.
New Zealand
In New Zealand, 35 drugs have been banned as temporary class drugs since August 2011, 24 of which have subsequently had the temporary ban renewed for a further year after reaching the end of the initial one-year ban period. These include;
JWH-018
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effe ...
, JWH-022,
JWH-073,
JWH-081,
JWH-122, JWH-201,
JWH-203
JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM a ...
,
JWH-210,
JWH-250
JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the Cannabinoid receptor 1, CB1 and Cannabinoid receptor 2 (macrophage), CB2 receptors, w ...
,
JWH-302,
AM-694
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
Pharmacolog ...
,
AM-2201,
RCS-4
RCS-4, or 1-pentyl-3-(4-methoxybenzoyl)indole, is a synthetic cannabinoid drug sold under the names SR-19, BTM-4, or Eric-4 (later shortened to E-4), but originally, OBT-199.
Pharmacology
RCS-4 is a potent cannabinoid receptor agonist, with EC ...
, RCS-4 butyl homologue, 2-methoxy isomer of RCS-4, and 2-methoxy isomer of RCS-4 butyl homologue, which were banned on 16 August 2011,
JWH-019,
JWH-200 and
AM-1220, which were banned on 14 October 2011,
AM-2233, banned on 29 December 2011,
AM-1248,
AM-2232
AM-2232 (1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole) is a drug that acts as a potent but unselective agonist for the cannabinoid receptors, with a ''K''i of 0.28 nM at CB1 and 1.48 nM at CB2.
In the United States, all CB1 receptor ...
and
UR-144
UR-144 (TMCP-018, KM-X1, MN-001, YX-17) is a drug invented by Abbott Laboratories, that acts as a selective full agonist of the peripheral cannabinoid receptor CB2, but with much lower affinity for the psychoactive CB1 receptor.
Pharmacology
U ...
, banned on 6 April 2012, and the stimulant
methylhexanamine
Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed ...
, banned on 9 April 2012. Another four cannabinoid compounds, namely
CB-13,
MAM-2201,
AKB48
AKB48 (pronounced ''A.K.B. Forty-Eight'') is a Japanese idol musical girl group named after the Akihabara area in Tokyo, where the group's theater is located. AKB48 has sold more records than any other female musical act in Japanese history. AK ...
and
XLR-11
XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related t ...
, were banned on 13 July 2012. A further cannabinoid compound
NNE1 was banned from 8 November 2012. Two more cannabinoids
APICA (also known as 2NE1) and its 5-fluoropentyl derivative
STS-135
STS-135 ( ISS assembly flight ULF7) was the 135th and final mission of the American Space Shuttle program. It used the orbiter '' Atlantis'' and hardware originally processed for the STS-335 contingency mission, which was not flown. STS-135 ...
were banned from 22 November 2012. Another cannabinoid
EAM-2201 was banned from 6 December 2012. Another stimulant, the
phenyltropane derivative
RTI-126, was banned from 27 December 2012. Two more cannabinoids
QUCHIC (also known as BB-22) and
5F-AKB48 were banned from 9 May 2013.
On 18 July 2013, the
Psychoactive Substances Act 2013 came into effect in New Zealand. This superseded the Temporary Class Drug scheme, as all novel psychoactive substances are restricted by default, except where specifically licensed. This Act promises to introduce strict toxicity testing and quality control standards for recreational psychoactive substances, with products that are proved to meet the safety criteria being allowed to be sold legally. Products that were on sale immediately prior to the introduction of the Act were allowed to continue to be on sale while the safety testing regime is implemented, but can be removed from sale if significant adverse events are reported. A number of interim licenses have been refused or revoked under this process, and by January 2014 a total of twelve more synthetic cannabis products had been removed from sale, containing ingredients such as ADB-CHMICA (SGT-7),
5F-PB-22, SGT-55 (CUMYL-BICA), SGT-56 (
CUMYL-PICA), 4-F-AM-2201,
4-Cl-AM-2201 and
PB-22.
On 27 April 2014 it was announced that all 41 remaining untested "legal high" products, which had been allowed to continue to be on sale during an interim period, were to be banned on 9 May 2014. These were mainly
synthetic cannabis
Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that bind to the same receptors to which cannabinoids ( THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be co ...
products containing ingredients such as
AB-FUBINACA
AB-FUBINACA ( AMB-FUBINACA) is a psychoactive drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. I ...
, PB-22 (
QUPIC
PB-22 (QUPIC, SGT-21 or 1-pentyl-1''H''-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. PB-22 represent ...
),
5F-PB-22, SGT-24 (
CUMYL-PINACA),
CP 55,244, 4-F-AM-2201, 4-Cl-AM-2201,
5F-ADBICA and
AB-005. There was also one cannabinoid pill containing SGT-42 (
CUMYL-THPINACA), and several "party pill" products containing mixtures of ingredients such as
caffeine
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class and is the most commonly consumed Psychoactive drug, psychoactive substance globally. It is mainly used for its eugeroic (wakefulness pr ...
,
hordenine,
synephrine and
kava
Kava or kava kava (''Piper methysticum'': Latin 'pepper' and Latinized Ancient Greek, Greek 'intoxicating') is a plant in the Piperaceae, pepper family, native to the Pacific Islands. The name ''kava'' is from Tongan language, Tongan and Marqu ...
.
No "legal high" products will be allowed back on sale in New Zealand under the Psychoactive Substances Act until they have been tested in a manner yet to be determined, and found to present a "low risk of harm". This process is expected to take at least 18 months or more. Six of the synthetic cannabis products were ordered to be immediately removed from sale by emergency recall on 1 May 2014, to ensure that users would not be able to stockpile supplies of these products before the general ban took effect on 9 May.
See also
*
Designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
References
{{reflist
Drug control law