is a Japanese

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

, best known for research on

apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...

, the process of programmed cell death occurring in multi-cellular organisms.

Contribution

Nagata identified

Interferon Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten ...

in 1980 and

Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Function ...

in 1986. He also identified a death factor (

Fas receptor The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the ''FAS'' gene. Fas ...

) in 1991 and its ligand (

Fas ligand Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB ...

) in 1993, and elucidated their physiological and pathological roles in

Biography

Nagata was born in Kanazawa, Japan, and completed his PhD under the supervision of Yoshito Kaziro at

the University of Tokyo The University of Tokyo (, abbreviated as in Japanese and UTokyo in English) is a public research university in Bunkyō, Tokyo, Japan. Founded in 1877 as the nation's first modern university by the merger of several pre-westernisation era ins ...

in 1977.CV of Shigekazu Nagata, JST (pdf)
/ref> Nagata served as a

postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

under

Charles Weissmann Charles Weissmann (born 14 October 1931) is a Hungarian-Swiss molecular biologist. Weissmann is particularly known for the first cloning and expression of interferon and his contributions to the unraveling of the molecular genetics of neurogenera ...

University of Zurich The University of Zurich (UZH, ) is a public university, public research university in Zurich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 from the existing colleges of the ...

, where he worked on sequencing the cDNA of

gene between 1977 and 1981. He was assistant professor at the Institute of Medical Science, the University of Tokyo between 1982 and 1987, and Head of Department of

molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

at Osaka Bioscience Institute between 1987 and 1998, where

Osamu Hayaishi , was a Japanese biochemist, physiologist, and military physician. He discovered Oxygenases at the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health in 1955. Citing his "outstanding and pioneering contributi ...

served as president at that time. Nagata became Professor of

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

Osaka University The , abbreviated as UOsaka or , is a List of national universities in Japan, national research university in Osaka, Japan. The university traces its roots back to Edo period, Edo-era institutions Tekijuku (1838) and Kaitokudō, Kaitokudo (1724), ...

Medical School between 1995 and 2007, before being appointed as Professor of

medical chemistry Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and developmen ...

at the Graduate School of Medicine,

Kyoto University , or , is a National university, national research university in Kyoto, Japan. Founded in 1897, it is one of the former Imperial Universities and the second oldest university in Japan. The university has ten undergraduate faculties, eighteen gra ...

in 2007. After retiring from Kyoto University and becoming Professor Emeritus in 2015, Nagata has been Professor of

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

and

immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...

at the Immunology Frontier Research Center, Osaka University.

Honors and awards

* 1994: Emil von Boehring Prize,

Marburg University The Philipps University of Marburg () is a public research university located in Marburg, Germany. It was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protes ...

* 1995:

Robert Koch Prize The Robert Koch Medal and Award are two prizes awarded annually by the German for excellence in the biomedical sciences. These awards grew out of early attempts by German physician Robert Koch to generate funding to support his research into the ...

* 1996: Prix Lacassagne, French Cancer League * 1998:

Asahi Prize The , established in 1929, is an award presented by the Japanese newspaper ''Asahi Shimbun'' and Asahi Shimbun Foundation to honor individuals and groups that have made outstanding accomplishments in the fields of arts and academics and have greatl ...

* 2000:

Imperial Prize of the Japan Academy The is a prestigious honor conferred to two of the recipients of the Japan Academy Prize (academics), Japan Academy Prize. Overviews It is awarded in two categories: humanities and natural sciences. The Emperor of Japan, Emperor and Empress ...

* 2001:

Person of Cultural Merit is an official Japanese recognition and honour which is awarded annually to select people who have made outstanding cultural contributions. This distinction is intended to play a role as a part of a system of support measures for the promotion of ...

* 2004: Cell Death Society Prize, International Cell Death Society * 2010: Member of the

Japan Academy The Japan Academy ( Japanese: 日本学士院, ''Nihon Gakushiin'') is an honorary organisation and science academy founded in 1879 to bring together leading Japanese scholars with distinguished records of scientific achievements. The Academy is ...

* 2012: Honorary Doctorate,

* 2012: Tomizo Yoshida Award, Japanese Cancer Association and Tomizo Yoshida Memorial Hall * 2012: Debrecen Award for Molecular Medicine * 2013:

Keio Medical Science Prize The Keio Medical Science Prize ( Japanese: 慶應医学賞) is a Japanese prize in medical sciences. Introduction The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences. And these c ...

* 2015: Foreign Associate of the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

* 2016:

Asian Scientist 100 The Asian Scientist 100 is an annually published list of 100 prize-winning Asian researchers, academicians, innovators and business leaders from across the Asia-Pacific region and a range of scientific disciplines. Recipients "must have received ...

, ''

Asian Scientist ''Asian Scientist'' is an English language science and technology magazine published in Singapore. History and profile ''Asian Scientist'' was launched as a blog in March 2011 by Juliana Chan. The blog's popularity eventually led to a partnersh ...

External links

Shigekazu Nagata, Member of the Japan Academy

Shigekazu Nagata, Foreign Associate of the National Academy of Science

References

{{DEFAULTSORT:Nagata, Shigekazu 1949 births Living people Japanese cell biologists 21st-century Japanese biochemists Japanese immunologists Japanese molecular biologists Laureates of the Imperial Prize Foreign associates of the National Academy of Sciences Academic staff of Kyoto University University of Tokyo alumni People from Kanazawa, Ishikawa Scientists from Ishikawa Prefecture