Robert C. Green is an American medical geneticist, physician, and public health researcher. He directs the Genomes2People Research Program in translational genomics and health outcomes in the Division of Genetics at

Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...

and the

Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institu ...

, and is Director of the Preventive Genomics Clinic at

. Research led by Green includes clinical and research aspects of genomic and precision medicine, including the development and disclosure of Alzheimer's disease risk estimates (the REVEAL Study) and one of the first prospective studies of direct-to-consumer

genetic testing Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression, or ...

services (the PGen Study). He has studied the implementation of medical sequencing in healthy adults (the MedSeq Project), newborns (the BabySeq Project), and active duty military personnel (the MilSeq Project). As of 2020, he is leading the first research collaboration to explore return of genomic results and better understand penetrance in a population-based cohort of underrepresented minorities. He has led the Preventive Genomics Clinic at

since its creation in 2019.

Education

Green was born in Richmond, Virginia, and received an undergraduate degree from

Amherst College Amherst College ( ) is a Private college, private Liberal arts colleges in the United States, liberal arts college in Amherst, Massachusetts, United States. Founded in 1821 as an attempt to relocate Williams College by its then-president Zepha ...

in 1976, and then attended the

University of Virginia School of Medicine The University of Virginia School of Medicine (UVA SOM or more commonly known as UVA Medicine) is the graduate medical school of the University of Virginia. The school's facilities are on the University of Virginia grounds adjacent to The Lawn, ...

, and earned a Masters of Public Health in Epidemiology from

Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

School of Public Health. He completed a residency in neurology at Harvard Medical School's Longwood Neurology Program, and research fellowships at

Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School and one of the founding members of Beth Israel Lahey Health. It was formed out of the 1996 merger of Beth Israel Hospital (f ...

and

Boston Children's Hospital Boston Children's Hospital (formerly known as Children's Hospital Boston until 2013) is the main pediatric training and research hospital of Harvard Medical School, Harvard University. It is a nationally ranked, freestanding acute care children ...

. Green is board-certified in neurology and medical genetics. He was previously on the faculty at

Emory University School of Medicine The Emory University School of Medicine is the graduate medical school of Emory University and a component of Emory’s Robert W. Woodruff Health Sciences Center. Emory University School of Medicine traces its origins back to 1915 when the Atl ...

and the Boston University School of Medicine.

Genomic research projects and contributions

Green served as principal investigator of the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study, which explored the behavioral, and health-related impact of disclosing genetic risk for Alzheimer's disease. The study was a series of multi-site, randomized, controlled clinical trials that provide empirical data to address ethical, social and translational issues in genetic susceptibility testing for common diseases. Green also co-led (with J. Scott Roberts, Ph.D.) the Impact of Personal Genomics (PGen) Study, one of the first to investigate the characteristics of consumers; the behavioral and health impact; and the translational and social issues associated with personal genomic testing services. He co-led the incidental findings working group for the American College of Medical Genetics and Genomics and was lead author on the controversial recommendations for reporting incidental and secondary findings in clinical exome and genome sequencing. Green also contributed to the design of a variant classification pipeline, and a single page summary for reporting clinically relevant results of whole genome sequencing to physicians. Green currently leads and co-leads the first

NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

funded randomized trials of sequencing in adults (MedSeq Project), newborns (BabySeq Project), and active duty US military personnel (MilSeq Project). With continuous funding from NIH for 26 years, he has published more than 300 papers with an h index of 90. Green co-chaired the steering committee of both the Clinical Sequencing Exploratory Research program (18 NIH grants, over 300 investigators), and the steering committee of the Newborn Sequencing in Genomic Medicine and Public Health program (4 NIH grants, over 100 investigators). He is a currently a co-investigator on the Boston site within the

Electronic Medical Records and Genomics Network The Electronic Medical Records and Genomics Network (abbreviated the eMERGE Network) is a consortium of American medical institutions dedicated to advancing the use of electronic medical records for genomics research. It was established in 2007 and ...

(eMERGE). He is Associate Director for Research of Partners HealthCare Personalized Medicine, and is leading the development of protocols for return of genomic results for the

All of Us (initiative) The All of Us Research Program (previously known as the Precision Medicine Initiative Cohort Program) is a precision medicine research program created in 2015 under the Obama Administration with $130 million in funding that aims to make advances ...

Research Program of the United States Precision Medicine Initiative and the Google/Verily Project

Baseline Study Project Baseline is a broad effort to map human health led by Verily Life Sciences (formerly Google Life Sciences), Alphabet, Inc.'s health sciences division, and was announced in the Wall Street Journal on July 24, 2014. It begins with the Proje ...

Professional Affiliations and Awards

Green directs the Genomes2People Research Program at Brigham Health and is the founding director of the

Brigham Preventive Genomics Clinic Brigham may refer to: Places * Brigham, Cumbria, England * Brigham, East Riding of Yorkshire, England * Brigham City, Utah, USA * Brigham, Wisconsin, USA * Brigham, Quebec, Canada People * Brigham (surname), including a list of people with the ...

. He is Associate Director for Research of Partners HealthCare Personalized Medicine and a member of the executive committee for the Partners BioBank. He is a board member of the

Council for Responsible Genetics The Council for Responsible Genetics (CRG) was a nonprofit NGO with a focus on biotechnology. History The Council for Responsible Genetics was founded in 1983 in Cambridge, Massachusetts. An early voice concerned about the social and ethica ...

. He was previously co-chair of the steering committee of the NIH Consortium in Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT). Green is a member of the Consortium on Electronic Medical Records and Genomics (eMERGE). He served on the Institute of Medicine Committee on the "Evidence Base for Genetic Testing," and has collaborated on research studies with

Illumina (company) Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological funct ...

, 23andMe, Pathway and Google. Green received the 2014 Coriell Award for Scientific Achievement in Personalized Medicine. BIS Research named Green one of the 25 most influential voices in precision medicine in 2019.

References

{{DEFAULTSORT:Green, Robert C. Living people American geneticists Harvard Medical School faculty Amherst College alumni University of Virginia School of Medicine alumni 1954 births Rollins School of Public Health alumni