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Replication protein A 70 kDa DNA-binding subunit is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''RPA1''
gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.


Interactions

Replication protein A1 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizat ...
with: *
BRCA2 ''BRCA2'' and BRCA2 () are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) ...
, * BLM, *
MCM2 DNA replication licensing factor MCM2 is a protein that in humans is encoded by the ''MCM2'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the ini ...
, *
MCM4 DNA replication licensing factor MCM4 is a protein that in humans is encoded by the ''MCM4'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the i ...
, * MCM6, *
MCM7 DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
, *
MUTYH ''MUTYH'' (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbo ...
, *
ORC2L Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. Function The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA rep ...
, *
ORC6L Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene. Background The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA repl ...
, *
P53 p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...
, *
RPA2 RPA may refer to: Companies * RPA (Rubin Postaer and Associates), advertising agency, Santa Monica, California, US * Republic Airways, ICAO code: RPA Political groups * Republican Party of Arkansas, the affiliate of the Republican Party in Ar ...
, *
RPA3 Replication protein A 14 kDa subunit is a protein that in humans is encoded by the ''RPA3'' gene. Interactions RPA3 has been shown to interact with replication protein A1 and replication protein A2. See also * Single-stranded binding protein ...
, *
TIPIN TIMELESS-interacting protein is a protein that in humans is encoded by the ''TIPIN'' gene. Interactions TIPIN has been shown to interact with Replication protein A1 Replication protein A 70 kDa DNA-binding subunit is a protein that in huma ...
, *
TP53BP1 Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the ''TP53BP1'' gene. Clinical significance 53BP1 is underexpressed in most cases of triple-negative breast cancer. ...
, and * XPA.


See also

*
Replication protein A Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. RPA is required in replication, recombinatio ...
*
Replication protein A2 Replication protein A 32 kDa subunit is a protein that in humans is encoded by the ''RPA2'' gene. Interactions RPA2 has been shown to interact with: * Cyclin O, * DNA-PKcs, * Ku70, * MEN1, * RPA3, * Replication protein A1, * STAT3 ...
*
Replication protein A3 Replication protein A 14 kDa subunit is a protein that in humans is encoded by the ''RPA3'' gene. Interactions RPA3 has been shown to interact with replication protein A1 and replication protein A2. See also * Single-stranded binding protein * ...
*
Single-stranded binding protein Single-stranded binding proteins (SSBs) are a class of proteins that have been identified in both viruses and organisms from bacteria to humans. Viral SSB Although the overall picture of ''human cytomegalovirus'' (HHV-5) DNA synthesis appears ...


References


Further reading

* * * * * * * * * * * * * * * * * * {{DNA replication