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Replication Protein A3
Replication may refer to: Science * Replication (scientific method), one of the main principles of the scientific method, a.k.a. reproducibility ** Replication (statistics), the repetition of a test or complete experiment ** Replication crisis * Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself ** DNA replication or DNA synthesis, the process of copying a double-stranded DNA molecule *** Semiconservative replication, mechanism of DNA replication ** Viral replication Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome ..., the process by which viruses produce copies of themselves * Replication (metallography), the use of thin plastic films to duplicate the microstructure of a component * Self-replicating machines Computing * Repl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (scientific Method)
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method. For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated. There are different kinds of replication but typically replication studies involve different researchers using the same methodology. Only after one or several such successful replications should a result be recognized as scientific knowledge. History The first to stress the importance of reproducibility in science was the Anglo-Irish chemist Robert Boyle, in England in the 17th century. Boyle's air pump was designed to generate and study vacuum, which at the time was a very controversial concept. Indeed, distinguished philosophers such as René Descartes and Thomas Hobbes denied the very possibility of vacuum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (statistics)
In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions. It is a crucial step to test the original claim and confirm or reject the accuracy of results as well as for identifying and correcting the flaws in the original experiment. ASTM, in standard E1847, defines replication as "... the repetition of the set of all the treatment combinations to be compared in an experiment. Each of the repetitions is called a ''replicate''." For a full factorial design, replicates are multiple experimental runs with the same factor levels. You can replicate combinations of factor levels, groups of factor level combinations, or even entire designs. For instance, consider a scenario with three factors, each having two levels, and an experiment that tests every possible combination of these levels (a full factorial design). One complete replication of this design would comprise 8 runs (2^3). The design can be executed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Crisis
The replication crisis, also known as the reproducibility or replicability crisis, refers to the growing number of published scientific results that other researchers have been unable to reproduce or verify. Because the reproducibility of empirical results is an essential part of the scientific method, such failures undermine the credibility of theories that build on them and can call into question substantial parts of scientific knowledge. The replication crisis is frequently discussed in relation to psychology and medicine, wherein considerable efforts have been undertaken to reinvestigate the results of classic studies to determine whether they are reliable, and if they turn out not to be, the reasons for the failure. Data strongly indicate that other natural science, natural and social sciences are also affected. The phrase "replication crisis" was coined in the early 2010s as part of a growing awareness of the problem. Considerations of causes and remedies have given rise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-replication
Self-replication is any behavior of a dynamical system that yields construction of an identical or similar copy of itself. Biological cells, given suitable environments, reproduce by cell division. During cell division, DNA is replicated and can be transmitted to offspring during reproduction. Biological viruses can replicate, but only by commandeering the reproductive machinery of cells through a process of infection. Harmful prion proteins can replicate by converting normal proteins into rogue forms. Computer viruses reproduce using the hardware and software already present on computers. Self-replication in robotics has been an area of research and a subject of interest in science fiction. Any self-replicating mechanism which does not make a perfect copy (mutation) will experience genetic variation and will create variants of itself. These variants will be subject to natural selection, since some will be better at surviving in their current environment than others and will o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all life, living organisms, acting as the most essential part of heredity, biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential. DNA is made up of a nucleic acid double helix, double helix of two Complementary DNA, complementary DNA strand, strands. DNA is often called double helix. The double helix describes the appearance of a double-stranded DNA which is composed of two linear strands that run opposite to each other and twist together. During replication, these strands are separated. Each strand of the original DNA molecule then serves as a template for the production of its counterpart, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Semiconservative Replication
Semiconservative replication describes the mechanism of DNA replication in all known cells. DNA replication occurs on multiple origins of replication along the DNA template strands. As the DNA double helix is unwound by helicase, replication occurs separately on each template strand in antiparallel directions. This process is known as semi-conservative replication because two copies of the original DNA molecule are produced, each copy conserving (replicating) the information from one half of the original DNA molecule. Each copy contains one original strand and one newly synthesized strand. (Both copies should be identical, but this is not entirely assured.) The structure of DNA (as deciphered by James D. Watson and Francis Crick in 1953) suggested that each strand of the double helix would serve as a template for synthesis of a new strand. It was not known how newly synthesized strands combined with template strands to form two double helical DNA molecules. Discovery Multiple ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Replication
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes involved in them. Most DNA viruses assemble in the nucleus while most RNA viruses develop solely in cytoplasm. Viral production / replication Viruses multiply only in living cells. The host cell must provide the energy and synthetic machinery and the low-molecular-weight precursors for the synthesis of viral proteins and nucleic acids. Virus replication occurs in seven stages: # Attachment # Entry (penetration) # Uncoating # Replication # Assembly # Maturation # Release (liberation stage). Attachment It is the first step of viral replication. Some viruses attach to the cell membrane of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (metallography)
Replication, in metallography, is the use of thin plastic films to nondestructively duplicate the microstructure of a component. The film is then examined at high magnifications. Replication is a method of copying the topography of a surface by casting or impressing material onto the surface. It is the commonly used technique to duplicate surfaces that are inaccessible in metrology to other forms of nondestructive testing. Replicas can be used in biology as well: The replicas may be imaged in the light microscope or coated with heavy metals, the replicating film melted away, and the heavy metal replica imaged in a Transmission Electron Microscope (TEM). The same materials, cellulose acetate films, are used for creating replicas of biological materials such as bacteria. Metallurgy Nondestructive testing Field Metallurgical Replication (FMR), in field metallography, is the use of metallurgical preparation on surfaces in the field, by polishing to a mirror image, along with app ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-replicating Machine
A self-replicating machine is a type of autonomous robot that is capable of reproducing itself autonomously using raw materials found in the environment, thus exhibiting self-replication in a way analogous to that found in nature. The concept of self-replicating machines has been advanced and examined by Homer Jacobson, Edward F. Moore, Freeman Dyson, John von Neumann, Konrad Zuse and in more recent times by K. Eric Drexler in his book on nanotechnology, '' Engines of Creation'' (coining the term clanking replicator for such machines) and by Robert Freitas and Ralph Merkle in their review ''Kinematic Self-Replicating Machines'' which provided the first comprehensive analysis of the entire replicator design space. The future development of such technology is an integral part of several plans involving the mining of moons and asteroid belts for ore and other materials, the creation of lunar factories, and even the construction of solar power satellites in space. The von Neuman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (computing)
Replication in computing refers to maintaining multiple copies of data, processes, or resources to ensure consistency across redundant components. This fundamental technique spans databases, file systems, and distributed systems, serving to improve availability, fault-tolerance, accessibility, and performance. Through replication, systems can continue operating when components fail ( failover), serve requests from geographically distributed locations, and balance load across multiple machines. The challenge lies in maintaining consistency between replicas while managing the fundamental tradeoffs between data consistency, system availability, and network partition tolerance – constraints known as the CAP theorem. Terminology Replication in computing can refer to: * ''Data replication'', where the same data is stored on multiple storage devices * ''Computation replication'', where the same computing task is executed many times. Computational tasks may be: ** ''Replicated in s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (optical Media)
In optical disc manufacturing, replication is the process of producing discs via methods that do not involve "burning" blank CD, DVD or other discs; the latter is known as duplication. The replication of optical discs involves: # the creation of a glass master from a client original master. # the creation of a nickel stamper from that glass master. # the injection molding of clear optical-grade polycarbonate substrates (clear discs) from that stamper. # the metallizing and lacquer Lacquer is a type of hard and usually shiny coating or finish applied to materials such as wood or metal. It is most often made from resin extracted from trees and waxes and has been in use since antiquity. Asian lacquerware, which may be c ...ing of those substrates to produce compact discs and DVDs. References * Bennett, Hugh. " The Demise of Low-Run CD Replication." ''EMedia Professional'' Aug 1999. How compact discs are made -- Explained by a layman for the laymenKevin McCormick 12 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
