ICE in the context of
chemotherapy is an
acronym for one of the
chemotherapy regimens, used in salvage
treatment of
relapsed or
refractory non-Hodgkin's lymphoma and
Hodgkin lymphoma.
In case of
CD20-positive
B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or ...
lymphoid malignancies the ICE regimen is often combined today with
rituximab. This regimen is then called ICE-R or R-ICE or RICE.
ICE regimen consists of:
#
Rituximab - an
anti-CD20 monoclonal
Monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus "monoclonal cells" can be said to form a single clone. The term ''monoclonal'' comes from the Ancient Greek ''monos'', meaning "alone" o ...
antibody, which is able to kill both normal and
malignant CD20-bearing
B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or ...
s;
#
Ifosfamide - an
alkylating antineoplastic agent of the oxazafosforine group;
#
Carboplatin - a
platinum-based antineoplastic
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. ...
drug, also an
alkylating antineoplastic agent;
#
Etoposide - a
topoisomerase inhibitor.
Dosing regimen
Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with
autologous stem-cell transplantation
Autologous stem-cell transplantation (also called autogenous, autogeneic, or autogenic stem-cell transplantation and abbreviated auto-SCT) is autologous transplantation of stem cells—that is, transplantation in which stem cells ( undifferentiate ...
follows (if the patient is considered eligible for HDCT and ASCT).
Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma
/ref>
References
{{Reflist
Chemotherapy regimens used in lymphoma